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Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

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World Journal of Hepatology 2015年第27期7卷 2757-2764页

作者： Satoshi Shakado Shotaro Sakisaka kazuaki chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu kumada Department of Gastro-enterology and Medicine Faculty of Medicine Fukuoka University Department of Gastroenterology and Metabolism Applied Life Sciences Graduate School of Biome-dical and Health SciencesHiroshima University Center of Gastroenterology and Hepatology Saiseikai Suita Hospital Department of Gastroenterology and Hepatology Sapporo Kousei Hospital Department of Gastroenterology and Hepatology Musashino Red-Cross Hospital Department of Medicine Shinshu University School of Medicine Department of Gastroenterology and Hepa-tology Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Kagoshima University Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University the Center for Liver Disease Shin-Kokura Hospital Department of Gastroenterology Yamagata University Department of Gastroenterology Faculty of Medicine Oita University Department of Hepatology Toranomon Hospital

AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance ***: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P k after the completion of IFN and ribavirin therapy(P k after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients.

关键词： Des-γ-carboxy prothrombin Hepatocellular carcinoma

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Impaired coronary microvascular endothelial function in men with metabolic syndrome

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World Journal of Cardiology 2010年第7期2卷 205-210页

作者： Hiroki Teragawa Naoya Mitsuba kenji Nishioka kentaro Ueda Shingo kono Yukihito Higashi kazuaki chayama Yasuki kihara Department of Cardiovascular Medicine Hiroshima General Hospital of West Japan Railway Company Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical Sciences Department of Radiology Hiroshima University Hospital Department of Cardiovascular Physiology and Medicine Hiroshima University Graduate School of Biomedical Sciences Department of Molecular Medicine Hiroshima University Graduate School of Biomedical Sciences

AIM: To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS: Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%). The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION: Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study.

关键词： Endothelial dysfunction Metabolic syndrome Doppler flow Conduit vessels Resistance vessels

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基因组和转录组测序整合分析揭示混合型肝癌的不同分子亚型

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科学新闻 2020年第2期 47-47页

作者：曾木圣白凡张宁薛瑞栋陈璐张冲藤田征志 Ruoyan Li Shu-Mei Yan Choon kiat Ong Xiwen Liao Qiang Gao Shota Sasagawa Yanmeng Li Jincheng Wang Hua Guo Qi-Tao Huang Qian Zhong Jing Tan Lisha Qi Wenchen Gong Zhixian Hong Meng Li Jingmin Zhao Tao Peng Yinying Lu kiat Hon Tony Lim Arnoud Boot Atushi Ono kazuaki chayama Zemin Zhang Steve George Rozen Bin Tean Teh Xin Wei Wang Hidewaki Nakagawa 中山大学肿瘤防治中心北京大学生物医学前沿创新中心(BIOPIC)生命科学学院北京大学第一医院北京大学医学部北京大学科研部天津肿瘤医院肝胆外科北京大学生物医学前沿创新中心日本理化研究所

文章简介原发性肝癌每年造成全球约70万病人死亡且过半死亡病例来自中国,其致死率在所有癌种中高居第二。肝癌主要分为3种类型:肝细胞癌(约80%)、肝内胆管癌(约15%)和混合型肝癌(约5%)。混合型肝癌兼具肝细胞癌和胆管细胞癌两种成分,是... 详细信息

文章简介原发性肝癌每年造成全球约70万病人死亡且过半死亡病例来自中国,其致死率在所有癌种中高居第二。肝癌主要分为3种类型:肝细胞癌(约80%)、肝内胆管癌(约15%)和混合型肝癌(约5%)。混合型肝癌兼具肝细胞癌和胆管细胞癌两种成分,是预后最差的一种肝癌。既往对混合型肝癌的基因组学研究较少,混合型肝癌的分子特

关键词：混合型肝癌分子遗传临床样本分子亚型肝细胞癌整合分析基因组

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