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Selective Cytotoxic Effect of ZnO Nanoparticles on Glioma Cells

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Nano Research 2009年第11期2卷 882-890页

作者： Stella Ostrovsky Gila Kazimirsky Aharon Gedanken chaya Brodie Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University Center for Advanced Materials and Nanotechnology Bar-Ilan UniversityRamat-Gan 52900Israel The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan UniversityRamat-Gan 52900Israel

In this study we examined the cytotoxic effect of ZnO nanoparticles on various human cancer and normal *** found that the ZnO nanoparticles exerted a cytotoxic effect on the human glioma cell lines A172,U87,LNZ308,LN18,and LN229,whereas no cytotoxic effect was observed on normal human ***,the ZnO nanoparticles induced cell death in breast and prostate cancer cell lines while no major effect was observed in the respective normal breast and prostate cell *** the fl uorescent dye 2,7-dichlorofl uorescein diacetate,we found that treatment of the glioma cells with ZnO nanoparticles induced a large increase in the generation of reactive oxygen species(ROS)and treatment of the cells with N-acetyl cysteine decreased the cytotoxic effect of the ZnO *** contrast,a smaller effect on ROS generation was observed in the normal *** results suggest that ZnO nanoparticles may be employed as a selective cytotoxic agent for the eradication of cancer cells.

关键词： ZnO nanoparticles sonochemistry cancer cells

Estimation of successful capping with complete aspiration of bladder via nephroureterostomy tube

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World Journal of Clinical Urology 2020年第1期9卷 1-8页

作者： Majid Maybody Wesley K Shay Deborah A Fleischer Meier Hsu chaya Moskowitz Department of Radiology Interventional Radiology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNY 10065United States Department of Biostatistics and Epidemiology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065United States

BACKGROUND Ureteral stent and nephroureterostomy tube(NUT)are treatments of ureteral *** stent provides better quality of *** of NUT is desired whenever *** To assess outcomes of capping trial among cancer patients with complete aspiration of retained contrast from bladder via *** Our Institutional Review Board approved retrospective review of all NUT placement,NUT exchange and conversion of nephrostomy catheter into NUT performed during June 2013 to June 2015(n=578).Cases were excluded due to lack of imaging of bladder(n=37),incomplete aspiration of bladder(n=324),no attempt at capping NUT(n=166),and patients with confounding factors interfering with results of capping trial including non-compliant bladder,bladder outlet obstruction and catheter malposition(n=14).Study group consisted of 37 procedures in 34 patients(male 19,female 15,age 2-83 years,average 58,median 61)most with cancer(prostate 8,endometrial 5,bladder 4,colorectal 4,breast 2,gastric 2,neuroblastoma 2,cervical 1,ovarian 1,renal 1,sarcoma 1,urothelial 1 and testicular 1)and one with Crohn’s *** records were reviewed to assess outcomes of capping *** 95%confidence intervals(95%CI)were *** Among patients with complete aspiration of retained contrast,30(81%,95%CI:0.65-0.92)catheters were successfully capped(range 12-94 d,average 40,median 24.5)until planned conversion to internal stent(23),routine exchange(5),removal(1)or death unrelated to catheter(1).Seven capping trials(19%,95%CI:0.08-0.35)were unsuccessful(range 2-22 d,average 12,median 10)due to leakage(3),elevated creatinine(2),fever/hematuria(1)and nausea/vomiting(1).CONCLUSION Capping trial success among patients with complete aspiration of retained contrast/urine from bladder via NUT appears high.

关键词： Nephroureterostomy tube Ureteral stent Capping trial Internalization Conversion Percutaneous nephrostomy

Effect of a region-wide incorporation of an algorithm based on the 2012 international consensus guideline on the practice pattern for the management of pancreatic cystic neoplasms in an integrated health system

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World Journal of Clinical Cases 2018年第13期6卷 624-631页

作者： Andrew Khoi Nguyen Agathon Girgis Timnit Tekeste Karen Chang Mopelola Adeyemo Armen Eskandari Emilio Alonso Priyanka Yaramada Charles chaya Albert Ko Edmund Burke Isaiah Roggow Rebecca Butler Aniket Kawatkar Brian S Lim School of Medicine University of California Department of Gastroenterology Kaiser Permanente Riverside Medical Center Department of Surgery Kaiser Permanente Riverside Medical Center Department of Research and Evaluation Southern California Permanente Medical Group

AIM To examine the practice pattern in Kaiser Permanente Southern California(KPSC), i.e., gastroenterology(GI)/surgery referrals and endoscopic ultrasound(EUS), for pancreatic cystic neoplasms(PCNs) after the regionwide dissemination of the PCN management *** Retrospective review was performed; patients with PCN diagnosis given between April 2012 and April 2015(18 mo before and after the publication of the algorithm) in KPSC(integrated health system with 15 hospitals and 202 medical offices in Southern California) were ***2558(1157 pre-and 1401 post-algorithm) received a new diagnosis of PCN in the study period. There was no difference in the mean cyst size(pre-19.1 mm vs post-18.5 mm, P = 0.119). A smaller percentage of PCNs resulted in EUS after the implementation of the algorithm(pre-45.5% vs post-34.8%, P < 0.001). A smaller proportion of patients were referred for GI(pre-65.2% vs post-53.3%, P < 0.001) and surgery consultations(pre-24.8% vs post-16%, P < 0.001) for PCN after the implementation. There was no significant change in operations for PCNs. Cost of diagnostic care was reduced after the implementation by 24%, 18%, and 36% for EUS, GI, and surgery consultations, respectively, with total cost saving of 24%.CONCLUSION In the current healthcare climate, there is increased need to optimize resource utilization. Dissemination of an algorithm for PCN management in an integrated health system resulted in fewer EUS and GI/surgery referrals, likely by aiding the physicians ordering imaging studies in the decision making for the management of PCNs. This translated to cost saving of 24%, 18%, and 36% for EUS, GI, and surgical consultations, respectively, with total diagnostic cost saving of 24%.

关键词： Pancreatic cyst Algorithm incorporation Pancreas Optimization of resource utilization Fukuoka criteria Sendai criteria Pancreatic cancer Intraductal papillary mucinous neoplasm Practice management Algorithm

Impact of land use and land cover changes on carbon storage in rubber dominated tropical Xishuangbanna,South West China

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Ecosystem Health and Sustainability 2021年第1期7卷 121-134页

作者： chaya Sarathchandra Yirga Alemu Abebe Fiona Ruth Worthy Iresha Lakmali Wijerathne Huaixia Ma Bi Yingfeng Guo Jiayu Huafang Chen Qiaoshun Yan Yanfei Geng Dayani SWeragoda Li-Li Li Yang Fengchun Sriyani Wickramasinghe Jianchu Xu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China Department of Biological Science Faculty of Applied SciencesRajarata University of Sri LankaMihintale Sri Lanka State Key Laboratory of Super Lattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing China Department of Electrical and computer engineering Faculty of Electrical EngineeringInstitute of TechnologyHawassa UniversityHawassaEthiopia World Agroforestry Centre(ICRAF) East and Central Asia Regional OfficeKunming YunnanChina Ailaoshan Station for Subtropical Forest Ecosystem Studies Chinese Academy of SciencesJingdongYunnan College of Tea Science Guizhou UniversityGuiyang China Carbon Consulting Company Colombo Sri Lanka Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnanChina Yibin Vocational and Technical College YibinSichuanChina School of Chinese Medicinal Material Resources Guangdong Pharmaceutical UniversityChina

Land use and land cover(LULC)play a significant role in carbon ***-China accounts for~65%of China’s carbon *** Xishuangbanna(South-China),rubber is expanding rapidly creating an urgent need to understand and monitor LULC change and how spatial variation affects carbon storage(CS).This is vital for the formation and implementation of better land use management *** studied LULC changes of 22-year period;addressing how these changes have affected the *** quantified LULC changes between1988 and 2010 using remote sensing methods and calculated CS changes using *** showed that between 1988 and 2010,the rate of deforestation accelerated to 203.2 km^(2)y^(−1)and~23%of forest were *** of natural forest to rubber was responsible for 78%of this *** expansion rate was 153.4 km^(2)y^(−1).Changes to LULC drove a temporal CS reduction 0.223 Tg C/km^(2).Local stakeholders have strong economic interest in converting land to more profitable *** efforts is required to control land conversion through new policies and incentives to retain natural *** of specific potential land use change will be required to avoid promoting the conversion of high carbon storage land uses to low carbon storage land uses.

关键词： Carbon storage deforestation economic plantations ecosystem services land cover changes land use

元江-红河流域(中国段)过去57年(1962—2018)主要气候因子变化

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环境影响评价 2023年第5期45卷 115-121页

作者：杨逢春马秀花何琼代发文黄华平李叶构箭勇 Kritana Prueksakorn chaya Sarathchandra 文慧婷宜宾职业技术学院四川宜宾644003 竹类病虫防控与资源开发四川省重点实验室乐山614000 乐山师范学院四川乐山614000 中国热带农业科学院环境与植物保护研究所海南海口570100 云南省红河哈尼族彝族自治州气象局云南蒙自661100 玛希隆大学环境与资源研究系泰国佛统83000 斯里兰卡拉贾拉塔大学应用科学学院生物科学系斯里兰卡密亨塔勒50300

为研究元江-红河流域(中国段)气候环境的变化规律,本研究选取了气温、相对湿度、24小时降水量、蒸发量和日照百分率五个气候因子57年(1962-2018)的气象数据进行了线性回归、偏相关分析以及M-K检验。结果表明:(1)近57年来,该流域气温整... 详细信息

为研究元江-红河流域(中国段)气候环境的变化规律,本研究选取了气温、相对湿度、24小时降水量、蒸发量和日照百分率五个气候因子57年(1962-2018)的气象数据进行了线性回归、偏相关分析以及M-K检验。结果表明:(1)近57年来,该流域气温整体呈逐步上升趋势,中、下游地区年均温普遍高于上游地区;(2)相比于上游干暖河谷和中游干热河谷,空气相对湿度在下游湿热地区及中游高海拔湿凉地区明显偏高,但近57年来逐次降低;(3)24小时降水量下游地区远高于上游和中游,除中游干热河谷地区有逐年减小趋势外,其余地区年际变化不大;(4)蒸发量在中游干热河谷地区逐年增加,其他地区呈缓慢下降趋势,整体上看,上游和中游地区高于下游;(5)日照百分率年际波动较大,但是除了下游河口站呈缓慢减少趋势以外,57年来各站点总体上变化不大,下游地区低于上游和中游地区。研究证明元江-红河流域(中国段)主要气候因子波动变化幅度与周边地区及全球范围的趋势相一致或更高。干热河谷地区环境因子变化幅度均比较剧烈,属于生态敏感地区,应该引起更多关注。

关键词：元江-红河气候因子干热河谷生态敏感全球变化

元江干热河谷低海拔地带退化生态系统植物多样性及物种分布模式

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中国农学通报 2021年第36期37卷 87-96页

作者：杨逢春刘景欣黄华平构箭勇文慧婷李叶陈娴 KRITANA Prueksakorn HONG Anh Thi Nguyen chaya Sarathchandra 宜宾职业技术学院四川宜宾644003 中国科学院西双版纳热带植物园环境教育中心云南勐腊666302 中国热带农业科学院环境与植物保护研究所海口570100 云南省红河哈尼族彝族自治州气象局云南蒙自661100 宋卡王子大学国际教育创新社会参与和可持续发展中心泰国普吉83000 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 斯里兰卡拉贾拉塔大学应用科学学院生物科学系斯里兰卡密亨塔勒50300

元江干热河谷是一个低海拔的脆弱生态系统,以环境干旱、植被贫乏为主要特征。17世纪中期以前它曾经植被茂盛,但是17世纪末以后,它逐渐演变退化为一个典型的热带山地萨王纳类型。本研究旨在阐明元江干热河谷低海拔地带典型干热区植物的... 详细信息

元江干热河谷是一个低海拔的脆弱生态系统,以环境干旱、植被贫乏为主要特征。17世纪中期以前它曾经植被茂盛,但是17世纪末以后,它逐渐演变退化为一个典型的热带山地萨王纳类型。本研究旨在阐明元江干热河谷低海拔地带典型干热区植物的多样性及其分布状况,从而深入了解气温、降水、地下水等主要的环境因子对植物种类及种群的影响以及植物对干热环境的适应,以及植物种类及其组成对元江干热河谷环境的指示作用。考察的主要指标包括物种多样性α,生境多样性β,物种期望值Species_estimated,稀有指数Singletons和Uniques,以及物种丰富度指数ACE、ICE和Chao2等。结果显示:(1)在不同的样带设计中,以紧靠河流的样带和样方(0.500。(3)总体趋势上,干热河谷低海拔地带的植物对水分的依赖性表现得相当明显,在紧靠河道的样带,以及河流下游河漫滩发育地区,物种期望值Species_estimated、稀有种指数Singletons和Uniques以及物种丰富度指数ACE,ICE和Chao2都明显偏高。本研究研究证明干热河谷低海拔地区存在特殊水热条件,影响植物的种类和分布,同时阐明了干热河谷低海拔地区植物多样性及种类分布与河道周边的小生境密切相关,为脆弱生态环境环境变化监测提供建议。

关键词：元江干热河谷低海拔地带生物多样性物种分布指示种元江-红河

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大围山蕨类多样性及生境因子对干扰的响应

中国野生植物资源 2022年第12期41卷 98-105页

作者：杨逢春刘景欣黄华平构箭勇文慧婷李叶袁欣宇马秀花朱兴旺阳晓倩何琼 Prueksakorn Kritana Sarathchandra chaya 宜宾职业技术学院现代农业学院四川宜宾644003 中国科学院西双版纳热带植物园环境教育中心云南勐腊666302 中国热带农业科学院环境与植物保护研究所海南海口570100 云南省红河哈尼族彝族自治州气象局云南蒙自661100 玛希顿大学环境与资源研究系泰国佛统府73170 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 斯里兰卡拉贾拉塔大学应用科学学院生物科学系斯里兰卡密亨塔勒50300

目的:通过研究大围山云雾林蕨类的Alpha多样性指数、物种丰富度和稀有性指数,探讨了不同干扰程度下主要环境因子变化及林下蕨类植物生物多样性响应。方法:设置长100 m样带3条,样带内每隔10 m设置一个1 m×1 m样方,统计各样方内的蕨类植... 详细信息

目的:通过研究大围山云雾林蕨类的Alpha多样性指数、物种丰富度和稀有性指数,探讨了不同干扰程度下主要环境因子变化及林下蕨类植物生物多样性响应。方法:设置长100 m样带3条,样带内每隔10 m设置一个1 m×1 m样方,统计各样方内的蕨类植物的种类及数量,记录、采集标本;同时,检测林冠开阔度(Canopy openness,CO)、空气相对湿度(Relative humidity,RH)和表层土温(Surface temperature,ST)。结果:(1)重度干扰使林下光线和土壤表层温度改变,蕨类种类与数量均增加;(2)重度和中度干扰下,蕨类植物种类和数量在短时间内均增加,但可持续性差;(3)轻度干扰下,原始生境中的差异化未受破坏。结论:人为干扰在短期能丰富局地蕨类多样性,但可持续性差,且对森林整体而言多样性贡献率极小。分析表明攀缘卷柏、钝叶卷柏、华中瘤足蕨和蛇足石杉可作为大围山云雾林生境的指示种。

关键词：蕨类植物大围山云雾林多样性干扰

Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach

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World Journal of Transplantation 2016年第3期6卷 517-531页

作者： Lisa Wickerson Dmitry Rozenberg Tania Janaudis-Ferreira Robin Deliva Vincent Lo Gary Beauchamp Denise Helm chaya Gottesman Polyana Mendes Luciana Vieira Margaret Herridge Lianne G Singer Sunita Mathur Toronto Lung Transplant Program University Health Network Rehabilitation Services University Health Network Department of Physical Therapy University of Toronto Rehabilitation Sciences Institute University of Toronto School of Physical and Occupational Therapy McGill University Canadian National Transplant Research Program Department of Physiotherapy Hospital for Sick Children Department of General Surgery/Gastroen- terology/Plastics St. Michael’s Hospital Health Sciences and Technologies PhD Program University of Brasilia Faculty of Medicine University of Toronto

Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients. This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods. The target audience includes clinicians involved in pre- and posttransplant patient care and rehabilitation researchers.

关键词： Lung transplantation Rehabilitation Physical therapy Exercise training Physical activity