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Effect of a region-wide incorporation of an algorithm based on the 2012 international consensus guideline on the practice pattern for the management of pancreatic cystic neoplasms in an integrated health system

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World Journal of Clinical Cases 2018年第13期6卷 624-631页

作者： Andrew Khoi Nguyen Agathon Girgis Timnit Tekeste Karen Chang Mopelola Adeyemo Armen Eskandari Emilio Alonso Priyanka Yaramada Charles chaya Albert Ko Edmund Burke Isaiah Roggow Rebecca Butler Aniket Kawatkar Brian S Lim School of Medicine University of California Department of Gastroenterology Kaiser Permanente Riverside Medical Center Department of Surgery Kaiser Permanente Riverside Medical Center Department of Research and Evaluation Southern California Permanente Medical Group

AIM To examine the practice pattern in Kaiser Permanente Southern California(KPSC), i.e., gastroenterology(GI)/surgery referrals and endoscopic ultrasound(EUS), for pancreatic cystic neoplasms(PCNs) after the regionwide dissemination of the PCN management *** Retrospective review was performed; patients with PCN diagnosis given between April 2012 and April 2015(18 mo before and after the publication of the algorithm) in KPSC(integrated health system with 15 hospitals and 202 medical offices in Southern California) were ***2558(1157 pre-and 1401 post-algorithm) received a new diagnosis of PCN in the study period. There was no difference in the mean cyst size(pre-19.1 mm vs post-18.5 mm, P = 0.119). A smaller percentage of PCNs resulted in EUS after the implementation of the algorithm(pre-45.5% vs post-34.8%, P < 0.001). A smaller proportion of patients were referred for GI(pre-65.2% vs post-53.3%, P < 0.001) and surgery consultations(pre-24.8% vs post-16%, P < 0.001) for PCN after the implementation. There was no significant change in operations for PCNs. Cost of diagnostic care was reduced after the implementation by 24%, 18%, and 36% for EUS, GI, and surgery consultations, respectively, with total cost saving of 24%.CONCLUSION In the current healthcare climate, there is increased need to optimize resource utilization. Dissemination of an algorithm for PCN management in an integrated health system resulted in fewer EUS and GI/surgery referrals, likely by aiding the physicians ordering imaging studies in the decision making for the management of PCNs. This translated to cost saving of 24%, 18%, and 36% for EUS, GI, and surgical consultations, respectively, with total diagnostic cost saving of 24%.

关键词： Pancreatic cyst Algorithm incorporation Pancreas Optimization of resource utilization Fukuoka criteria Sendai criteria Pancreatic cancer Intraductal papillary mucinous neoplasm Practice management Algorithm

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ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model

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Cancer Drug Resistance 2021年第3期4卷 620-633页

作者： Jordan M.Hotz Joanna R.Thomas Emily N.Katz Robert W.Robey Sachi Horibata Michael M.gottesman Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Zebrafish Core Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentBethesdaMD 20892USA

The brain is protected from toxins by a tightly regulated network of specialized cells,including endothelial cells,pericytes,astrocyes,and neurons,known collectively as the blood-brain barrier(BBB).This selectively permeable barrier permits only the most crucial molecules essential for brain function to enter and employs a number of different mechanisms to prevent the entry of potentially harmful toxins and *** addition to a physical barrier comprised of endothelial cells that form tight junctions to restrict paracellular transport,there is an active protective mechanism made up of energy-dependent transporters that efflux compounds back into the *** of these ATP-binding cassette(ABC)transporters are highly expressed at the BBB:P-glycoprotein(P-gp,encoded by the ABCB1 gene)and ABCG2(encoded by the ABCG2 gene).Although a number of in vitro and in vivo systems have been developed to examine the role that ABC transporters play in keeping compounds out of the brain,all have inherent advantages and ***(Danio rerio)have become a model of interest for studies of the BBB due to the similarities between the zebrafish and mammalian BBB *** this review,we discuss what is known about ABC transporters in zebrafish and what information is still needed before the zebrafish can be recommended as a model to elucidate the role of ABC transporters at the BBB.

关键词： ABC transporters blood-brain barrier ABCG2 P-glycoprotein zebrafish

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Impact of land use and land cover changes on carbon storage in rubber dominated tropical Xishuangbanna,South West China

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Ecosystem Health and Sustainability 2021年第1期7卷 121-134页

作者： chaya Sarathchandra Yirga Alemu Abebe Fiona Ruth Worthy Iresha Lakmali Wijerathne Huaixia Ma Bi Yingfeng Guo Jiayu Huafang Chen Qiaoshun Yan Yanfei Geng Dayani SWeragoda Li-Li Li Yang Fengchun Sriyani Wickramasinghe Jianchu Xu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China Department of Biological Science Faculty of Applied SciencesRajarata University of Sri LankaMihintale Sri Lanka State Key Laboratory of Super Lattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing China Department of Electrical and computer engineering Faculty of Electrical EngineeringInstitute of TechnologyHawassa UniversityHawassaEthiopia World Agroforestry Centre(ICRAF) East and Central Asia Regional OfficeKunming YunnanChina Ailaoshan Station for Subtropical Forest Ecosystem Studies Chinese Academy of SciencesJingdongYunnan College of Tea Science Guizhou UniversityGuiyang China Carbon Consulting Company Colombo Sri Lanka Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnanChina Yibin Vocational and Technical College YibinSichuanChina School of Chinese Medicinal Material Resources Guangdong Pharmaceutical UniversityChina

Land use and land cover(LULC)play a significant role in carbon ***-China accounts for~65%of China’s carbon *** Xishuangbanna(South-China),rubber is expanding rapidly creating an urgent need to understand and monitor LULC change and how spatial variation affects carbon storage(CS).This is vital for the formation and implementation of better land use management *** studied LULC changes of 22-year period;addressing how these changes have affected the *** quantified LULC changes between1988 and 2010 using remote sensing methods and calculated CS changes using *** showed that between 1988 and 2010,the rate of deforestation accelerated to 203.2 km^(2)y^(−1)and~23%of forest were *** of natural forest to rubber was responsible for 78%of this *** expansion rate was 153.4 km^(2)y^(−1).Changes to LULC drove a temporal CS reduction 0.223 Tg C/km^(2).Local stakeholders have strong economic interest in converting land to more profitable *** efforts is required to control land conversion through new policies and incentives to retain natural *** of specific potential land use change will be required to avoid promoting the conversion of high carbon storage land uses to low carbon storage land uses.

关键词： Carbon storage deforestation economic plantations ecosystem services land cover changes land use

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托尔金轶事七则

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新东方英语(中学生) 2013年第5期 11-13页

作者： Brian gottesman 赵青奇

20世纪50年代,J.R.R.托尔金创作的奇幻小说《魔戒》横空出世,引来无数粉丝竞相追捧,成了史上最畅销的小说之一。而随着《魔戒》的风靡,托尔金的同系列小说《霍比特人》与其他相关作品也大受欢迎,使他一举成为奇幻文学史上不朽的传奇人... 详细信息

20世纪50年代,J.R.R.托尔金创作的奇幻小说《魔戒》横空出世,引来无数粉丝竞相追捧,成了史上最畅销的小说之一。而随着《魔戒》的风靡,托尔金的同系列小说《霍比特人》与其他相关作品也大受欢迎,使他一举成为奇幻文学史上不朽的传奇人物。缔造这一佳话的托尔金究竟是个什么样的人?他又有什么样的精彩故事呢?请看下文分解。

关键词：托尔金刘易斯天主教伊迪丝《魔戒》

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MESA Conference+为Microsoft Mail锦上添花

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个人电脑 1995年第9期1卷 24-25页

作者： Ben gottesman 伍颖文

由于Lotus Notes日渐流行,人们已越发认识到小组讨论带来的沟通和创造性方案的价值。尽管Notes、Collabra Share和Trax Software的TeamTalk占尽风光,TheMESA Group的Conference+软件已在市场悄然站稳脚跟——据MESA称,该软件上市不足一... 详细信息

由于Lotus Notes日渐流行,人们已越发认识到小组讨论带来的沟通和创造性方案的价值。尽管Notes、Collabra Share和Trax Software的TeamTalk占尽风光,TheMESA Group的Conference+软件已在市场悄然站稳脚跟——据MESA称,该软件上市不足一年即发售了100000多份拷贝。

关键词： MicrosoftMail MESA 邮件系统消息数据库 LotusNotes 服务器电子表格应用电子邮件 Windows 管理员

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在微观结构基础上骨的粘弹性性能分析

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力学进展 1984年第1期 70-79页

作者： T.gottesman ,Z.Hashin ,周鸿康

引言晚近,骨结构的清晰图象已经得到。密质骨是复合材料,它由骨单位、间质系统和把二者粘结在一起的有机粘弹性粘结物质所组成。Ascenzi,Bonucci(1967)(1972)首次将骨单位分离出来;之后,Frasca等(1976)用改进了的技术又作了分离。骨单... 详细信息

引言晚近,骨结构的清晰图象已经得到。密质骨是复合材料,它由骨单位、间质系统和把二者粘结在一起的有机粘弹性粘结物质所组成。Ascenzi,Bonucci(1967)(1972)首次将骨单位分离出来;之后,Frasca等(1976)用改进了的技术又作了分离。骨单位为空心柱体(图1),它由胶原纤维及羟磷灰石晶体构成。胶原分子为长链结构,它们排列成称为胶原

关键词：弹性性能等价骨单位横向各向同性流变模型粘弹性材料相对体积对应原理量子论横向剪切模量复合材料变换域蠕变函数力学性质机械性质物理性能方程复合纤维柱体

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人肿瘤细胞对多种化疗药物的抗药性

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国际肿瘤学杂志 1988年第6期15卷 353-355页

作者： gottesman M M ,Pasta IN ,南新升

筛选对细胞毒性天然药物抗药的培养细胞,可以获得交叉抗各种药物的变种细胞,这一现象称为多种药物的抗药性。最近,人们注意到,人肿瘤对化疗的耐受性有以下两种情况:许多肿瘤,包括结肠和肾脏的腺癌,恶性细胞对多种化疗药物开始就无反应,... 详细信息

筛选对细胞毒性天然药物抗药的培养细胞,可以获得交叉抗各种药物的变种细胞,这一现象称为多种药物的抗药性。最近,人们注意到,人肿瘤对化疗的耐受性有以下两种情况:许多肿瘤,包括结肠和肾脏的腺癌,恶性细胞对多种化疗药物开始就无反应,称为内在抗药性;另外,小儿白血病和神经母细胞瘤的初期化疗效果很好,但在化疗过程中,肿瘤细胞对所用药物及其他药物产生了抗药性,称为获得性抗药性。

关键词：抗药性 RNA 表型神经母细胞瘤耐药性成神经细胞瘤神经组织肿瘤肿瘤细胞化疗药物

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两种新型的32位远程控制软件

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个人电脑 1996年第7期2卷 34-35页

作者： Ben Z.gottesman 黄国胜

Symantec Corp.和Traveling Software都将它们流行的远程控制程序带进了32位世界。Symantec的Norton pcAnywhere 32 for Windows和Traveling Software的LapLink for Windows 95的报价均为149美元,它们都充分地利用了Windows 95的环境。... 详细信息

关键词：远程控制 pcAnywhere Windows95 多主机系统远程系统文件传输驱动程序估计市价 MODEM Norton

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The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers

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Cancer Drug Resistance 2023年第3期6卷 468-480页

作者： William J.E.Frye Lyn M.Huff JoséM.González Dalmasy Paula Salazar Rachel M.Carter Ryan T.Gensler Dominic Esposito Robert W.Robey Suresh V.Ambudkar Michael M.gottesman Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Protein Expression Laboratory Frederick National Laboratory for Cancer ResearchLeidos Biomedical ResearchIncFrederickMD 21704USA

Aim:Ferroptosis is a non-apoptotic form of cell death caused by lethal lipid *** small molecule ferroptosis inducers(FINs)have been reported,yet little information is available regarding their interaction with the ATP-binding cassette(ABC)transporters P-glycoprotein(P-gp,ABCB1)and *** thus sought to characterize the interactions of FINs with P-gp and ABCG2,which may provide information regarding oral bioavailability and brain penetration and predict drug-drug ***:Cytotoxicity assays with ferroptosis-sensitive A673 cells transfected to express P-gp or ABCG2 were used to determine the ability of the transporters to confer resistance to FINs;confirmatory studies were performed in OVCAR8 and NCI/ADR-RES *** ability of FINs to inhibit P-gp or ABCG2 was determined using the fluorescent substrates rhodamine 123 or purpuin-18,***:P-gp overexpression conferred resistance to FIN56 and the erastin derivatives imidazole ketone erastin and piperazine erastin.P-gp-mediated resistance to imidazole ketone erastin and piperazine erastin was also reversed in UO-31 renal cancer cells by CRISPR-mediated knockout of *** FINs ML-162,GPX inhibitor 26a,and PACMA31 at 10µM were able to increase intracellular rhodamine 123 fluorescence over 10-fold in P-gp-expressing MDR-19 *** inhibitor 26a was able to increase intracellular purpurin-18 fluorescence over 4-fold in ABCG2-expressing R-5 ***:Expression of P-gp may reduce the efficacy of these FINs in cancers that express the transporter and may prevent access to sanctuary sites such as the *** ability of some FINs to inhibit P-gp and ABCG2 suggests potential drug-drug interactions.

关键词： Ferroptosis drug resistance P-glycoprotein ABCG2

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Lotus和IBM的技术联姻

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个人电脑 1996年第5期2卷 27-28页

作者： Carol Levin Ben Z.gottesman 刘国田

在IBM兼并Lotus Development Corp.五个月后,便推出了两个公司的合作结晶。IBM Imaging Technologies和Lotus已经开发出结合双方技术的一系列应用程序,将IBM的高档图象归档功能ImagePlus提供给了Lotus Notes的用户。

关键词：图象处理系统 LotusNotes 应用程序图象归档数字照像机工作流 Notes文档消息平台图象服务图象应用

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