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MEMS-actuated terahertz metamaterials driven by phase-transition materials

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Frontiers of Optoelectronics 2024年第2期17卷 23-32页

作者： Zhixiang Huang Weipeng Wu Eric Herrmann Ke Ma Zizwe A.chase Thomas A.Searles M.Benjamin Jungfleisch Xi Wang Department of Materials Science and Engineering College of EngineeringUniversity of DelawareNewarkDE 19716USA Department of Physics and Astronomy College of Arts and SciencesUniversity of DelawareNewarkDE 19716USA Department of Electrical and Computer Engineering College of EngineeringUniversity of Illinois ChicagoChicagoIL 60607USA

The non-ionizing and penetrative characteristics of terahertz(THz)radiation have recently led to its adoption across a variety of *** effectively utilize THz radiation,modulators with precise control are *** most recent THz modulators manipulate the amplitude,frequency,or phase of incident THz radiation,considerably less progress has been made toward THz polarization *** methods for polarization control suffer from high driving voltages,restricted modulation depth,and narrow band capabilities,which hinder device performance and broader ***,an ideal THz modulator that offers high modulation depth along with ease of processing and operation is *** this paper,we propose and realize a THz metamaterial comprised of microelectromechanical systems(MEMS)actuated by the phase-transition material vanadium dioxide(VO_(2)).Simulation and experimental results of the three-dimensional metamaterials show that by leveraging the unique phase-transition attributes of VO_(2),our THz polarization modulator offers notable advancements over existing designs,including broad operation spectrum,high modulation depth,ease of fabrication,ease of operation condition,and continuous modulation *** enhanced features make the system a viable candidate for a range of THz applications,including telecommunications,imaging,and radar systems.

关键词： Metamaterials MEMS THz VO_(2) Phase-transition material

Unique Clinical Features of Curaderm when Treating Skin Cancers

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Journal of Cancer Therapy 2024年第1期15卷 13-27页

作者： Tania Robyn chase Kai Elliot Cham Bill Elliot Cham Australasian Medical Research Port Vila Republic of Vanuatu

Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Consequences of these treatments include body-image issues, anxiety, post-traumatic stress disorder, depression, and poorer quality of social and family life. A progressive topical cream formulation, Curaderm, containing the natural BEC glycoalkaloids, have shown to have advantages over conventional treatments. However, comprehensive clinical features of the skin cancer lesions during treatment with Curaderm have to date not been reported. This report shows that using unpublished data from a large number of patients with varying sizes, types and locations of basal cell carcinomas when treated with Curaderm in a phase 3 trial, an initial increase in size of the lesions occur, followed by a reverse course, leading to complete removal of the skin cancer. The specificity and mode of action of Curaderm explains the superior cosmetic outcomes when compared with conventional therapies.

关键词： Curaderm Skin Cancer Basal Cell Carcinoma BEC Glycoalkaloids Conventional Treatments

The Value of Excipients and the Required Understanding of the Biological System in Product Development: An Impactful Example of Curaderm, a Topical Skin Cancer Treatment

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International Journal of Clinical Medicine 2024年第2期15卷 68-87页

作者： Tania Robyn chase Kai Elliot Cham Bill Elliot Cham Australasian Medical Research Port Vila Republic of Vanuatu

The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.

关键词： Curaderm BEC Solasodine Glycosides Solamargine Apoptosis Skin Cancer Actinic Keratosis Keratoacanthoma Basal Cell Carcinoma Squamous Cell Carcinoma

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

AI Cannot Understand Memes:Experiments with OCR and Facial Emotions

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Computers, Materials & Continua 2022年第1期70卷 781-800页

作者： Ishaani Priyadarshini chase Cotton Department of Electrical and Computer Engineering University of DelawareNewark19716DEUnited States

The increasing capabilities of Artificial Intelligence(AI),has led researchers and visionaries to think in the direction of machines outperforming humans by gaining intelligence equal to or greater than humans,which may not always have a positive impact on the *** gone rogue,and Technological Singularity are major concerns in academia as well as the *** is necessary to identify the limitations of machines and analyze their incompetence,which could draw a line between human and machine *** memes are an amalgam of pictures,videos,underlying messages,ideas,sentiments,humor,and experiences,hence the way an internet meme is perceived by a human may not be entirely how a machine comprehends *** this paper,we present experimental evidence on how comprehending Internet Memes is a challenge for *** use a combination of Optical Character Recognition techniques like Tesseract,Pixel Link,and East Detector to extract text from the memes,and machine learning algorithms like Convolutional Neural Networks(CNN),Region-based Convolutional Neural Networks(RCNN),and Transfer Learning with pre-trained denseNet for assessing the textual and facial emotions *** evaluate the performance using Sensitivity and *** results show that comprehending memes is indeed a challenging task,and hence a major limitation of *** research would be of utmost interest to researchers working in the areas of Artificial General Intelligence and Technological Singularity.

关键词： Technological singularity optical character recognition transfer learning convolutional neural networks(CNN) region-based convolutional neural networks(RCNN)

Technological advances expand our knowledge of lysosomal dysfunction in neurodegeneration

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Neural Regeneration Research 2023年第3期18卷 539-540页

作者： chase Chen Yu Chen Ellen Sidransky Medical Genetics Branch National Institutes of HealthNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In the almost seven decades since the initial discovery of the lysosome as an organelle,our understanding of the role of lysosomes has greatly *** now know lysosomal function encompasses far more than its traditionally described role as the cell’s“garbage disposal”,referring to its well-established catabolic *** are integral to maintaining cellular health and viability,and they act as a major signaling hub within the cell(Ballabio and Bonifacino,2020).

关键词： function. function traditionally

Multimode vibrational strong coupling in direct laser written mid-IR plasmonic MIM nano-patch antennas

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Photonics Research 2023年第12期11卷 2136-2148页

作者： NICHOLAS V.PROSCIA MICHAEL A.MEEKER NICHOLAS SHARAC FRANK K.PERKINS chase T.ELLIS PAUL D.CUNNINGHAM JOSEPH G.TISCHLER NRC Postdoc residing at U.S.Naval Research Laboratory WashingtonD.C.20375USA U.S.Naval Research Laboratory WashingtonD.C.20375USA Current address:Rigetti Computing FreemontCalifornia 94538USA Current address:Homer L.Dodge Department of Physics and Astronomy The University of OklahomaNormanOklahoma 73019USA

Strong coupling of mid-infrared(mid-IR)vibrational transitions to optical cavities provides a means to modify and control a material’s chemical reactivity and offers a foundation for novel chemical detection ***,the relatively large volumes of the mid-IR photonic cavities and weak oscillator strengths of vibrational transitions restrict vibrational strong coupling(VSC)studies and devices to large ensembles of molecules,thus representing a potential limitation of this nascent ***,we experimentally and theoretically investigate the mid-IR optical properties of 3D-printed multimode metal-insulator-metal(MIM)plasmonic nanoscale cavities for enabling strong light-matter interactions at a deep subwavelength *** observe strong vibration-plasmon coupling between the two dipolar modes of the L-shaped cavity and the carbonyl stretch vibrational transition of the polymer *** cavity mode volume is half the size of a typical square-shaped MIM geometry,thus enabling a reduction in the number of vibrational oscillators to achieve strong *** resulting three polariton modes are well described by a fully coupled multimode oscillator model where all coupling potentials are *** 3D printing technique of the cavities is a highly accessible and versatile means of printing arbitrarily shaped submicron-sized mid-IR plasmonic cavities capable of producing strong light–matter interactions for a variety of photonic or photochemical ***,similar MIM structures fabricated with nanoscopic voids within the insulator region could constitute a promising microfluidic plasmonic cavity device platform for applications in chemical sensing or photochemistry.

关键词： coupling vibrational shaped

An Early Clinical Case of COVID-19 in New York

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Case Reports in Clinical Medicine 2022年第8期11卷 330-336页

作者： Peter Capainolo Ronald M. chase Division of Vertebrate Zoology American Museum of Natural History New York NY USA 551 Rylane Street DeLeon Springs FL USA

SARS-CoV-2, a novel coronavirus that causes the human disease COVID-19, was determined to be the cause of a cluster of pneumonia cases in Wuhan, China which began in December 2019 [1]. The first case in the United States reportedly occurred on 20 January 2020 in Washington state in a patient with a history of travel to Wuhan [2]. We report an earlier case of COVID-19 in Queens, New York in November 2019. While it is not perfectly clear from the initial November 2019 emergency department case presentation, if the patient had influenza alone, COVID-19 alone, or combined influenza and COVID-19 infection, presenting lung lesions and constitutional symptoms, later follow-up antibody and immune cell analyses, and the possibility of false-positive RIDT, do strongly suggest initial COVID-19 infection (with or without initial influenza infection). This clinical paper becomes important, because it may describe the earliest now-reported COVID-19 case in the United States, and because emergency department and post-emergency department treatments contributed to a successful patient outcome.

关键词： SARS-COV-2 COVID-19 New York November 2019

Analyzing Some Elements of Technological Singularity Using Regression Methods

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Computers, Materials & Continua 2021年第6期67卷 3229-3247页

作者： Ishaani Priyadarshini Pinaki Ranjan Mohanty chase Cotton Department of Electrical and Computer Engineering University of DelawareNewarkDE19716USA Department of Computer Science Purdue UniversityWest LafayetteIN47907USA

Technological advancement has contributed immensely to human life and *** like industrial robots,artificial intelligence,and machine learning are advancing at a rapid *** the evolution of Artificial Intelligence has contributed significantly to the development of personal assistants,automated drones,smart home devices,etc.,it has also raised questions about the much-anticipated point in the future where machines may develop intelligence that may be equal to or greater than humans,a term that is popularly known as Technological *** technological singularity promises great benefits,past research works on Artificial Intelligence(AI)systems going rogue highlight the downside of Technological Singularity and assert that it may lead to catastrophic ***,there is a need to identify factors that contribute to technological advancement and may ultimately lead to Technological Singularity in the *** this paper,we identify factors such as Number of scientific publications in Artificial Intelligence,Number of scientific publications in Machine Learning,Dynamic RAM(Random Access Memory)Price,Number of Transistors,and Speed of Computers’Processors,and analyze their effects on Technological Singularity using Regression methods(Multiple Linear Regression and Simple Linear Regression).The predictive ability of the models has been validated using PRESS and k-fold *** study shows that academic advancement in AI and ML and Dynamic RAM prices contribute significantly to Technological *** the factors would help researchers and industry experts comprehend what leads to Technological Singularity and,if needed,how to prevent undesirable outcomes.

关键词： Technological growth technological singularity regression analysis artificial intelligence superintelligence PRESS k-fold validation