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紧急救援

环球科学 2024年第12期 18-25页

作者：查利·埃文斯不详

当灾难来临时,救援队员是如何与时间赛跑,拯救生命的?一支泰国少年足球队被困在了山洞里。这些孩子头埋在膝间,腿上盖着上衣,蜷成一团瑟瑟发抖。他们原本计划和教练在塔銮岩洞来一次刺激的探险之旅,但是在被困10天的当下,探险俨然已经... 详细信息

当灾难来临时,救援队员是如何与时间赛跑,拯救生命的?一支泰国少年足球队被困在了山洞里。这些孩子头埋在膝间,腿上盖着上衣,蜷成一团瑟瑟发抖。他们原本计划和教练在塔銮岩洞来一次刺激的探险之旅,但是在被困10天的当下,探险俨然已经变成了灾难。

关键词：紧急救援救援队员与时间赛跑足球队探险被困灾难教练

Principles and methods of rock support for rockburst control

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 46-59页

作者： charlie Chunlin Li Norwegian University of Science and Technology(NTNU) TrondheimNorway

This paper presents the principles of rock support for rockburst control and three rockburst support systems used in deep metal *** the principles of rock support are presented,rock fracture related to strain burst is first discussed with the help of photos taken on site,and the energy sources and transformations during bursting are illustrated through conceptual *** parallel extension fracture usually occurs in the ejected and surrounding rocks in a strain burst event,while the ejected rock in a fault-slip rockburst is often already pre-fractured before the *** must be excessive release energy available for rock *** excessive release energy comes from both the ejected rock itself and the surrounding *** prevent rock ejection in a rockburst,the support system must be able to dissipate the excessive release *** support devices in a support system for rockburst control must be able to dissipate energy,be firmly linked,and be compatible in deformability.A support system for rockburst control comprises surface-retaining devices and yield rockbolts as well as yield cablebolts when *** mesh on the top of shotcrete liner is a good practice to enhance the surfaceretaining capacity of the support ***-absorbing yield rockbolts dissipate energy either by stretching of the bolt shank or by sliding of the inner anchor in the ***,mesh strap and shotcrete are the surface-retaining devices widely used in the current rock support *** three types of rock support used for rockburst control at present are soft support system using Split Set bolts,hybrid support system using rebar and two-point anchored yield bolts,and entirely yieldable support system using strong yield bolts.

关键词： Rock support Rockburst Rockbolt Yield rockbolt Mesh Shotcrete

Principles of rockbolting design

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 14-32页

作者： charlie C. Li Department of Geoscience and Petroleum The Norwegian University of Science and Technology Norway

This article introduces the principles of underground rockbolting *** items discussed include underground loading conditions,natural pressure zone around an underground opening,design methodologies,selection of rockbolt types,determination of bolt length and spacing,factor of safety,and compatibility between support *** types of rockbolting used in engineering practise are also *** traditional principle of selecting strong rockbolts is valid only in conditions of low in situ stresses in the rock ***-absorbing rockbolts are preferred in the case of high in situ stresses.A natural pressure arch is formed in the rock at a certain distance behind the tunnel *** should be long enough to reach the natural pressure arch when the failure zone is *** bolt length should be at least 1 m beyond the failure *** the case of a vast failure zone,tightly spaced short rockbolts are installed to establish an artificial pressure arch within the failure zone and long cables are anchored on the natural pressure *** this case,the rockbolts are usually less than 3 m long in mine drifts,but can be up to 7 m in large-scale rock *** spacing is more important than bolt length in the case of establishing an artificial pressure *** addition to the factor of safety,the maximum allowable displacement in the tunnel and the ultimate displacement capacity of rockbolts must be also taken into account in the ***,rockbolts should be compatible with other support elements in the same support system in terms of displacement and energy absorption capacities.

关键词： Rockbolting design Pressure arch Bolt length Bolt spacing Factor of safety

MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich Win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

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流浪天体,行星还是恒星?

环球科学 2024年第9期 64-69页

作者：查理·伍德唐佳欣(译) 不详

最近发现了大量自由飘荡的天体,它们是出走的大质量行星,还是失败的恒星?这些疑问正迫使天文学家重新思考恒星和行星的形成理论。四百多年前,意大利帕多瓦大学的数学家伽利略·伽利莱(Galileo Galilei)用自己制作的望远镜对准了天空,目... 详细信息

最近发现了大量自由飘荡的天体,它们是出走的大质量行星,还是失败的恒星?这些疑问正迫使天文学家重新思考恒星和行星的形成理论。四百多年前,意大利帕多瓦大学的数学家伽利略·伽利莱(Galileo Galilei)用自己制作的望远镜对准了天空,目眼前的景象令他无比震惊——在猎户座中,除了当时人们熟悉的猎人腰带中的三颗星和剑中的六颗星外,他还看到了500多颗新的星星。

关键词：帕多瓦大学伽利略恒星行星天体望远镜

Genetic and molecular changes in ovarian cancer

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Cancer Biology & Medicine 2016年第2期13卷 236-247页

作者： Robert L Hollis charlie Gourley Edinburgh Cancer Research UK Centre MRC Institute of Genetics and Molecular Medicine University of Edinburgh

Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical ***, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.

关键词： ovarian cancer molecular genetics histological subtypes molecular subgrouping ovary

Plausible cloth animation using dynamic bending model

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Progress in Natural Science:Materials International 2008年第7期18卷 879-885页

作者： charlie C.L. Wang Department of Mechanical and Automation Engineering The Chinese University of Hong Kong Hong Kong China

Simulating the mechanical behavior of a cloth is a very challenging and important problem in computer animation. The models of bending in most existing cloth simulation approaches are taking the assumption that the cloth is little deformed from a plate shape. Therefore, based on the thin-plate theory, these bending models do not consider the condition that the current shape of the cloth under large deformations cannot be regarded as the approximation to that before deformation, which leads to an unreal static bending. [This paper introduces a dynamic bending model which is appropriate to describe large out-plane deformations such as cloth buckling and bending, and develops a compact implementation of the new model on spring-mass systems. Experimental results show that wrinkles and folds generated using this technique in cloth simulation, can appear and vanish in a more natural way than other approaches.]

关键词： Cloth animation Physically based animation Bending

Novel Approach for Automatic Region of Interest and Seed Point Detection in CT Images Based on Temporal and Spatial Data

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Computers, Materials & Continua 2019年第5期59卷 669-686页

作者： Zhe Liu charlie Maere Yuqing Song School of Computer Science and Telecommunication Jiangsu UniversityZhenjiangChina

Accurately finding the region of interest is a very vital step for segmenting organs in medical image *** propose a novel approach of automatically identifying region of interest in Computed Tomography Image(CT)images based on temporal and spatial *** method is a 3 stages approach,1)We extract organ features from the CT images by adopting the Hounsfield filter.2)We use these filtered features and introduce our novel approach of selecting observable feature candidates by calculating contours’area and automatically detect a seed point.3)We use a novel approach to track the growing region changes across the CT image sequence in detecting region of interest,given a seed point as our *** used quantitative and qualitative analysis to measure the accuracy against the given ground truth and our results presented a better performance than other generic approaches for automatic region of interest detection of organs in abdominal CT *** the results presented in this research work,our proposed novel sequence approach method has been proven to be superior in terms of accuracy,automation and robustness.

关键词： Computed tomography image continuously adaptive mean-shift hounsfield particle-size distribution

Erratum to Genetic and molecular changes in ovarian cancer

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Cancer Biology & Medicine 2017年第2期14卷 196-201页

作者： Robert L Hollis charlie Gourley Edinburgh Cancer Research UK Centre MRC Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh EH4 2XR UK

In the published article~, some errors appeared on page 238, Figure 1, and reference list. The editors and the authors apologize for the errors and for any confusion they may have caused. On page238, the sentence of ＂affecting 20% and 17.5% of cases＂ should be changed to ＂and that inactivation of these genes occurs in 17.5% and 20% of cases＂.

关键词：卵巢癌分子遗传勘误基因失活