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强震观测能用来约束概率地震危险性估计吗?

世界地震译丛 2008年第6期39卷 1-14页

作者： c.Beauval P.-Y.bard S.Hainzl P.Guéguen 李晶张天中陕西省地震局

由于新规定要求危险性估计必须使用概率术语,进行概率危险性研究的数量最近一直在增加。本研究旨在确定根据这些研究和观测进行比较预测的可能性和范围。直接根据地面运动发生率的比较检验比地震发生率更受青睐。根据泊松过程的特性,计... 详细信息

由于新规定要求危险性估计必须使用概率术语,进行概率危险性研究的数量最近一直在增加。本研究旨在确定根据这些研究和观测进行比较预测的可能性和范围。直接根据地面运动发生率的比较检验比地震发生率更受青睐。根据泊松过程的特性,计算和评估了能确保场点发生率估计可靠的最小时间窗。例如,对于场点复发期为475年的地面运动,要求用来估计地面运动发生率的最小观测时间窗为12000年,且不确定性为20%(变异系数:标准差除以平均值)。这些值不取决于所研究地区的地震活动性水平。对法国固定加速度计台网台站记录的地面运动进行的分析表明,对于很低的加速度水平(STET台站0.0001～0.001g),地面运动发生率估计的最高精确度为30%。在有更长记录历史和位于更高地震活动区(希腊和加利福尼亚州)的2个台站进行的同样分析,提供了可达0.1g的地面运动水平。因此,提出的问题是,即使使用的是对于广泛范围的加速度都一致有效的地面运动预测公式,基于低加速度水平的比较检验所得出的结果能推广到更高的加速度水平吗?

关键词：危险性估计地震活动性强震观测概率地面运动加速度计加利福尼亚州比较检验

Uterine biology in pigs and sheep

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Journal of Animal Science and Biotechnology 2012年第3期3卷 109-129页

作者： Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael carey Satterfield Gregory A Johnson Robert c Burghardt Guoyao Wu Department of Animal Science 442D Kleberg Center 2471 TAMU Texas A&M University College Station TX 77843-2471 USA Department of Veterinary Integrated Biosciences Texas A&M University College Station TX 77843-2471 USA

There is a dialogue between the developing conceptus （embryo-fetus and associated placental membranes） and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea （cL） which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species.

关键词： Genes Growth factors Interferon stimulated Pregnancy Pregnancy recognition Uterus

Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut

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Molecular Plant 2017年第2期10卷 309-322页

作者： Josh clevenger Ye chu carolina chavarro Gaurav Agarwal David J. Bertioli Soraya c.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna chitikineni Thomas G. Isleib c. corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins Department of Horticulture and Institute of Plant Breeding Genetics & Genomics The University of Georgia 2356 Rainwater Road Tifton GA 31793 USA center for Applied Genetic Technologies and Institute of Plant Breeding Genetics & Genomics The University of Georgia Athens GA 30602 USA International crops Research Institute for the Semi-Arid Tropics (IcRISAT) Hyderabad 502324 India University of Brasilia Institute of Biological Sciences Campus Darcy Ribeiro 70910-900 Brasilia DF Brazil Embrapa Genetic Resources and Biotechnology 70770-917 Brasflia DF Brazil eUSDA-ARS PGRCU Griffin GA 30223 USA Agricultural Research Organization Plant Sciences Institute 7528809 Rishon LeZion Israel Department of Plant and Soil Science Texas Tech University Lubbock TX 79409-2122 USA Department of crop and Soil Sciences North Carolina State University Box 7629 Raleigh NC 28695-7629 USA USDA-ARS Tifton GA 31793. USA

Peanut （Arachis hypogaea; 2n = 4x = 40） is a nutritious food and a good source of vitamins, minerals, and healthy fats. Expansion of genetic and genomic resources for genetic enhancement of cultivated peanut has gained momentum from the sequenced genomes of the diploid ancestors of cultivated peanut. To facil- itate high-throughput genotyping of Arachis species, 20 genotypes were re-sequenced and genome-wide single nucleotide poiymorphisms （SNPs） were selected to develop a large-scale SNP genotyping array. For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species were included for use in cultivated and interspecific populations. A set of 384 accessions was used to test the array resulting in 54 564 markers that produced high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cultivated and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm. An additional 1193 markers were identified that illuminated genomic re- gions exhibiting tetrasomic recombination. Furthermore, a set of elite cultivars that make up the pedigree of US runner germplasm were genotyped and used to identify genomic regions that have undergone pos- itive selection. These observations provide key insights on the inclusion of new genetic diversity in culti- vated peanut and will inform the development of high-resolution mapping populations. Due to its efficiency, scope, and flexibility, the newly developed SNP array will be very useful for further genetic and breeding applications in Arachis.

关键词： single nucleotide polymorphism groundnut Arachis hypogaea

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扫描电化学显微镜在光电能源研究领域的应用

化学进展 2016年第6期28卷 908-916页

作者：何辉超 Sean P.Berglund c.Buddie Mullins 周勇柯改利董发勤西南科技大学材料科学与工程学院四川省非金属复合与功能材料重点实验室-省部共建国家重点实验室培育基地固体废物处理与资源化教育部重点实验室绵阳621010 美国德克萨斯大学奥斯汀分校化学化工系奥斯汀78712 广东矿物物理与材料研究开发重点实验室广州510460 南京大学物理学院南京211102

作为一种扫描探针技术,扫描电化学显微镜(SEcM)在金属防腐、材料表征、生物医学和新能源技术等领域的研究中扮演着重要角色。本文简要介绍了SEcM的基本工作原理和常用的两种工作模式:反馈模式和收集/产生模式;综述了SEcM在太阳能电池和... 详细信息

作为一种扫描探针技术,扫描电化学显微镜(SEcM)在金属防腐、材料表征、生物医学和新能源技术等领域的研究中扮演着重要角色。本文简要介绍了SEcM的基本工作原理和常用的两种工作模式:反馈模式和收集/产生模式;综述了SEcM在太阳能电池和太阳光解水制氢两个光电能源研究领域的应用进展,同时结合课题组的工作基础,特别是近期利用SEcM筛选合适金属离子掺杂改性WO3光阳极的工作,对SEcM在筛选半导体电极材料方面的应用特点进行了实例展示介绍,最后简要总结了SEcM在光电能源研究领域的发展及方向。

关键词：扫描电化学显微镜光电能源应用

人工智能如何应对常见的肺癌问题：chatGPT与Googlebard的比较

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国际医学放射学杂志 2023年第4期 485-486页

作者： A.A.Rahsepar N.Tavakoli G.H.J Kim c.Hassani F.Abtin A.Bedayat 牟彬

摘要最近发布的供公众使用的大型语言模型（LLM），如chat GPT和Google bard，带来了巨大的潜在好处和挑战。目的根据美国放射学会和Fleischner协会推荐的肺部影像

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检测膀胱肿瘤抗原(BTAStat试验)早期诊断膀胱癌

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暨南大学学报（自然科学与医学版） 1998年第6期19卷 68-69页

作者：符思 Heica.,R 暨南大学医学院第一附属医院泌尿外科

对于膀胱癌的诊断，膀胱镜和尿细胞学是目前最常用的方法。前者能提供准确的诊断（除非肿瘤小于１ｍｍ），后者的敏感性取决于肿瘤的分化程度，其敏感性在４５％～８０％，因此以上两方法在临床诊断时各有其受限之处。ＢＴＡＳｔａｔ试... 详细信息

对于膀胱癌的诊断，膀胱镜和尿细胞学是目前最常用的方法。前者能提供准确的诊断（除非肿瘤小于１ｍｍ），后者的敏感性取决于肿瘤的分化程度，其敏感性在４５％～８０％，因此以上两方法在临床诊断时各有其受限之处。ＢＴＡＳｔａｔ试验是一种快速简易的定性方法，为一种新的酶免检测方法，用以检测膀胱癌患者尿中相关抗原（一人类补体因子Ｈ相关蛋白）。本文旨在了解这种方法对膀胱癌早期诊断的作用。采用美国Ｂａｒｄ公司提供的试剂盒，方法简便，可由医生自己操作。检测总例数为２１９例，其中，７６例健康者全部阴性，１００例泌尿系统良性疾病中４８例阳性，有病理学证实的４３例膀胱癌中３０例阳性，因此，其敏感性为６９８％，特异性５２％。与其他方法相比较。

关键词：膀胱肿瘤抗原检测早期诊断诊断

common non-synonymous polymorphisms in the BRcA1 Associated RING Domain (bard1) gene are associated with breast cancer susceptibility:a case-control analysis

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南京医科大学学报（自然科学版） 2007年第7期27卷 743-743页

作者： Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. c Qin, J. W chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B Nanjing Med Univ Dept Epidemiol ＆ Biostat Sch Publ Hlth Nanjing 210029 Peoples R China Nanjing Med Univ Lab Reprod Med Nanjing 210029 Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Gen Surg Nanjing 210029 Peoples R China Nanjing Gulou Hosp Dept Gen Surg Nanjing Peoples R China Jiangsu canc Hosp Dept Gen Surg Nanjing 210009 Peoples R China

The BRcA1 Associated RING Domain(bard1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRcA1/2 hereditary site-specific and sporadic breast cancer cases. bard1 plays a crucial role in tumor repression, along with its heterodimeric partner BRcA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in bard1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in bard1. We found that the bard1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% cI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% cI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in bard1 may jointly contribute to the susceptibility of breast cancer.

关键词：乳腺癌环形域基因基因多态性 BRcA1 基因突变