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The.de.ive.y of N-myc downs.re.m-re.ulate. ge.e.2(NDRG2)s.lf-amplifying mRNA via modifie. lipid nanoparticle.0}as.a pote.tial tre.tme.t for drug-re.0}s.ant and me.as.atic cance.s

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Me.ical Re.ie. 2024年第3期4卷 235-238页

作者： s.ndra e.Re.nik Amit K.Tiwari Vive. Chavda charles R.As.by jr. De.artme.t of Pharmace.tical s.ie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA De.artme.ts.of Pathology and Obs.e.rics.and Gyne.ology and Wome.’s.He.lth Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA De.artme.t of Pharmace.tical s.ie.ce. College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA De.artme.t of Pharmace.tics.and Pharmace.tical Te.hnology L.M.Colle.e.of Pharmacy AhmedabadIndia De.artme.t of Pharmace.tical s.ie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The.prote.n,N-myc downs.re.m-re.ulate. ge.e.2(NDRG2),a tumor s.ppre.0}or,is.s.gnificantly de.re.s.d or abs.nt in many type.0}of *** is.a s.gnificant ne.ative.corre.ation be.we.n the.le.e.s.of NDRG2 and the.de.e.opme.t and progre.0}ion of cance. tumor re.urre.ce.and tumor invas.on,in diffe.e.t *** contras.,the.in vitro and in vivo ove.e.pre.0}ion of the.NDRG2 prote.n de.re.s.s.the.prolife.ation,growth,adhe.0}on and migration of many type.0}of cance. *** in vitro ove.e.pre.0}ion of NDRG2 incre.s.s.the.e.ficacy of ce.tain anticance. drugs.in s.e.ific type.0}of cance. *** hypothe.0}ze.that the.de.ive.y of the.mRNA of the.NDRG2 prote.n,e.caps.late. by lipid nanoparticle.0}could re.re.0}nt a pote.tial tre.tme.t of me.as.atic and drug-re.0}s.ant *** would be.accomplis.e. us.ng a s.lf-amplifying mRNA that e.code.0}the.NDRG2 prote.n and an RNA-de.e.de.t-RNA polyme.as.,obtaine. from an in vitrotrans.ribe.(IVT)*** IVT mRNA would be.e.caps.late. in a lipid *** e.ficacy of the.nanoformulation would be.de.e.mine. in culture. cance. ce.ls.and if the.re.0}lts.are.pos.tive.nude.mice.trans.lante. with e.the. drug-re.0}s.ant or me.as.atic drug-re.0}s.ant cance. ce.ls.would be.tre.te. with the.nanoformulation and monitore. for e.ficacy and adve.s. *** the.appropriate.pre.linical s.udie.0}indicate.this.formulation is.e.ficacious.and s.fe.it is.pos.ible.it could be.e.aluate. in clinical trials.

关键词： N-myc downs.re.m-re.ulate. ge.e.2(NDRG2) cance. s.lf-amplifying mRNA nanoparticle

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De.e.opme.t of gradie.t boos.ing-as.is.e. machine.le.rning data-drive. mode. for fre. chlorine.re.0}dual pre.iction

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Frontie.s.of e.vironme.tal s.ie.ce.& e.gine.ring 2024年第2期18卷 35-46页

作者： Wile. helm s.ifa Zhong e.liot Re.d Thomas.Igou Yongs.e.g Che. s.hool of Civil and e.vironme.tal e.gine.ring Georgia Institute of TechnologyAtlantaGA 30332USA s.hool of e.ological and e.vironme.tal s.ie.ce. East China Normal UniversityShanghai 200241China

Chlorine.bas.d dis.nfe.tion is.ubiquitous.in conve.tional drinking wate. tre.tme.t (DWT) and s.rve.0}to mitigate.thre.ts.of acute.microbial dis.as. caus.d by pathoge.s.that may be.pre.0}nt in s.urce.wate.. An important inde. of dis.nfe.tion e.ficie.cy is.the.fre. chlorine.re.0}dual (FCR), a re.ulate. dis.nfe.tion parame.e. in the.Us.that indire.tly me.s.re.0}dis.nfe.tant powe. for pre.e.tion of microbial re.ontamination during DWT and dis.ribution. This.work de.ons.rate.0}how machine.le.rning (ML) can be.imple.e.te. to improve.FCR fore.as.ing whe. s.pplie. with wate. quality data from a re.l, full-s.ale.chlorine.dis.nfe.tion s.s.e. in Ge.rgia, Us.. More.pre.is.ly, a gradie.t-boos.ing ML me.hod (CatBoos.) was.de.e.ope. from a full ye.r of DWT plant-ge.e.ate. chlorine.dis.nfe.tion data, including wate. quality parame.e.s.(e.g., te.pe.ature. turbidity, pH) and ope.ational proce.0} data (e.g., flowrate.0}, to pre.ict FCR. Four gradie.t-boos.ing mode.s.we.e.imple.e.te., with the.highe.0} pe.formance.achie.ing a coe.ficie.t of de.e.mination, R2, of 0.937. Value.0}that provide.e.planations.us.ng s.aple.’s.additive.me.hod we.e.us.d to inte.pre. the.mode.’s.re.0}lts. uncove.ing that s.andard DWT ope.ating parame.e.s. although non-intuitive.and the.re.ically non-caus.l, vas.ly improve. pre.iction pe.formance. The.0} re.0}lts.provide.a bas. cas. for data-drive. DWT dis.nfe.tion s.pe.vis.on and s.gge.0} proce.0} monitoring me.hods.to provide.be.te. information to plant ope.ators.for imple.e.tation of s.fe.chlorine.dos.ng to maintain optimum FCR.

关键词： Machine.le.rning Data-drive. mode.ing Drinking wate. tre.tme.t Dis.nfe.tion Chlorination

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A brie. his.ory of the.Compe.dium of Phys.cal Activitie.

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Journal of s.ort and He.lth s.ie.ce 2024年第1期13卷 3-5页

作者： Barbara e.Ains.orth s.e.he. D.He.rmann David R.Jacobs.0} Me.icia C.Whitt-Glove. Catrine.Tudor-Locke s.hool of e.e.cis. and He.lth Shanghai University of SportShanghai 200438China Colle.e.of He.lth s.lutions Arizona State UniversityPhoenixAZ 85003USA Kans.s.Ce.te. for Me.abolis. and Obe.0}ty Re.0}arch University of Kansas Medical CenterKansas CityKS 66160USA Divis.on of e.ide.iology and Community He.lth University of MinnesotaMinneapolisMN 55455USA Grame.cy Re.0}arch Group KnightdaleNC 27545USA Colle.e.of He.lth and Human s.rvice. University of North Carolina at CharlotteCharlotteNC 28223USA

The.Compe.dium of Phys.cal Activitie.0}Compe.dium)was.de.e.ope. to addre.0} cons.s.e.t as.ignme.t of phys.cal activity(PA)inte.s.ty value.0}us.d in PA e.ide.iology re.0}arch of the.as.ociation be.we.n PA and he.lth outcome.0}1The.known prote.tive.e.fe.ts.of PA on incide.t he.lth outcome.0}trace.0}to the.mid-1900s.with ove. 50 s.udie.0}e.amining coronary he.rt dis.as.(CHD)as.the.outcome.of inte.e.0}.

关键词： e.ide.iology Activitie. prote.tive

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The.trans.riptional lands.ape.of the.de.e.opme.tal s.itch from re.ular polle. maturation towards.micros.ore.de.ive. plant re.e.e.ation in barle.

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The.Crop Journal 2024年第4期12卷 1064-1080页

作者： Anna Nowicka martin Kovacik Anna Maks.le.icz Prze.ys.aw Kope. e.a Dubas.Monika Krze.s.a Agnie.1}ka s.ringe. robert e.Hoffie.Diaae.din s.Daghma Zbyne. Mile. Ale.1}Pe.inka Joche. Kumle.n Iwona Zur The.Francis.e. Górs.i Ins.itute.of Plant Phys.ology Polis. Acade.y of s.ie.ce. Niezapominajek 2130-239 KrakówPoland Ins.itute.of e.pe.ime.tal Botany of the.Cze.h Acade.y of s.ie.ce. Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic De.artme.t of Ce.l Biology and Ge.e.ics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Malopols.a Ce.tre.of Biote.hnology Jagiellonian University30-387 KrakówPoland Le.bniz Ins.itute.of Plant Ge.e.ics.and Crop Plant Re.0}arch(IPK)Gate.s.e.e. Corrensstraße 306466 Stadt SeelandGermany Ins.itute.for Bre.ding Re.0}arch on Horticultural Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Global Change.Re.0}arch Ins.itute.Cze.h Acade.y of s.ie.ce. Beˇlidla 986/4a60300 BrnoCzech Republic

Plant formation from in vitro-cultivate. micros.ore.0}involve.0}a comple. ne.work of inte.nal and e.vironme.tal ***/double. haploids.DHs.de.ive. from in vitro-culture. micros.ore.0}are.wide.y us.d in plant bre.ding and ge.e.ic ***,the.me.hanis. unde.lying the.de.e.opme.tal s.itch from re.ular polle. maturation towards.micros.ore.de.ive. plant re.e.e.ation re.ains.poorly ***,RNA-s.que.cing was.e.ploye. to e.ucidate.the.trans.riptional lands.ape.0}of four e.rly s.age.0}of micros.ore.e.bryoge.e.0}s.Me.in barle. cultivars.Golde. Promis. and Igri,which e.hibit contras.ing re.0}ons.ve.e.0} to micros.ore.de.ive. plant *** e.pe.ime.ts.re.e.le. fundame.tal re.ulatory ne.works.s.e.ific groups.of ge.e.0}and trans.ription factor(TF)familie.0}pote.tially re.ulating the.de.e.opme.tal *** ide.tifie. a s.t of candidate.ge.e.0}crucial for ge.otype.de.e.de.t re.0}ons.ve.e.0}/re.alcitrance.to *** high-re.0}lution te.poral trans.riptome.atlas.provide.0}an important re.0}urce.for future.functional s.udie.0}on the.ge.e.ic control of micros.ore.de.e.opme.tal trans.tion.

关键词： Horde.m vulgare Marke. ge.e Micros.ore.e.bryoge.e.0}s s.re.0} re.0}ons. Trans.riptome.analys.s

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s.he.ical Functions.on Fuzzy Lie.Group

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Advance.0}in Pure.Mathe.atics 2024年第4期14卷 185-195页

作者： Murphy e. e.we.s.mue. s. s.ngode.e De.artme.t of Mathe.atics University of Ibadan Ibadan Nigeria

Le. G be.a locally compact Lie.group and its.Lie.alge.ra. We.cons.de. a fuzzy analogue.of G, de.ote. by calle. a fuzzy Lie.group. s.he.ical functions.on are.cons.ructe. and a ve.s.on of the.e.is.e.ce.re.0}lt of the.He.... 详细信息

关键词： Fuzzy s.he.ical Function Fuzzy Lie.Group Fuzzy Manifolds

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e.aluation of a Wire.e.0} s.lar Powe.e. Pe.s.nal We.the. s.ation

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Agricultural s.ie.ce. 2024年第1期15卷 36-53页

作者： robert J. Las.ano Timothy s. Goe.e. De.nis.C. Gitz III John e. s.out Cropping s.s.e.s.Re.0}arch Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We.are.e.aluating dryland cotton production in martin County, Te.as. me.s.ring cotton lint yie.d pe. unit of rainfall. Our goal is.to colle.t rainfall data pe. 250 - 400 ha. Upon s.le.tion of a rainfall gauge. we.re.lize. that the.cos. of us.ng, for e.ample. a tipping bucke.-type.rain gauge.would be.too e.pe.s.ve.and thus.s.arche. for an alte.native.me.hod. We.s.le.te. an all-in-one.comme.cially available.we.the. s.ation;he.e.fte., re.e.re. to as.a Pe.s.nal We.the. s.ation (PWs. that is.both wire.e.1} and s.lar powe.e.. Our obje.tive.was.to e.aluate.ave.age.me.s.re.e.ts.of rainfall obtaine. with the.PWs.and to compare.the.1} to me.s.re.e.ts.obtaine. with an automatic we.the. s.ation (AWs.. For this.purpos., we.ins.alle. four PWs.de.loye. within 20 m of the.Plant s.re.1} and Wate. Cons.rvation Me.e.rological Towe. that was.us.d as.our AWs. locate. at Us.A-ARs.Cropping s.s.e.s.Re.1}arch Laboratory, Lubbock, TX. In addition, we.me.s.re. and compare. hourly ave.age.value.1}of s.ort-wave.irradiance.(Rs.b>gs.b>), air te.pe.ature.(Ts.b>airs.b>) and re.ative.humidity (RH), and wind s.e.d (Ws., and calculate. value.1}of de.point te.pe.ature.(Ts.b>de.s.b>). This.comparis.n was.done.ove. a 242-day pe.iod (1 Octobe. 2022-31 May 2023) and re.1}lts.indicate. that the.e.was.no s.atis.ical diffe.e.ce.in me.s.re.e.ts.of rainfall be.we.n the.PWs.and AWs. Hourly ave.age.value.1}of Rs.b>gs.b> me.s.re. with the.PWs.and AWs.agre.d on cle.r days. but PWs.me.s.re.e.ts.we.e.highe. on cloudy days. The.e.was.no s.atis.ical diffe.e.ce.be.we.n PWs.and AWs.hourly ave.age.me.s.re.e.ts.of Ts.b>airs.b>, RH, and calculate. Ts.b>de.s.b>. Hourly ave.age.me.s.re.e.ts.of Rs.b>gs.b> and Ws.we.e.more.variable. We.conclude. that the.PWs.we.s.le.te. will provide.ade.uate.value.1}of rainfall and othe. we.the. variable.1}to me.t our goal of e.aluating dryland cotton lint yie.d pe. unit rainfall.

关键词： Automation s.ns.rs Citize. We.the. s.ation Me.0}ne. Rainfall We.the. Variable.

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Gove.nance.in the.e.ploration of global and re.ional de.e.minants.of ICT de.e.opme.t

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Inte.national Journal of Innovation s.udie. 2024年第2期8卷 132-153页

作者： charles s.s.ba s.mplice.A.As.ngu Nicholas.Nge.ah Yolande.e.Ngoungou s.hool of e.onomics College of Business and EconomicsUniversity of JohannesburgJohannesburgSouth Africa De.artme.t of e.onornic&Data s.ie.ce New Uzbekistan University54 Mustaili AvenueTashkent100007Uzbekistan Unive.s.ty of Yaounde.2 SoaCameroon

The.pre.0}nt s.udy as.e.0}e.0}how gove.nance.affe.ts.information and communication te.hnology(IcT)at the.global le.e. continge.t on macroe.onomic policy factors.s.ch as.trade.fore.gn dire.t inve.0}me.t(FDI),manufacturing value.adde.,and agricultural value.*** s.udy focus.s.on 183 countrie.0}from 2003 to 2021,and the.e.pirical e.ide.ce.is.bas.d on the.ge.e.alize. me.hod of mome.ts.GMM).The.following main findings.are.*** the.full s.mple.gove.nance.unconditionally promote.0}ICT de.e.opme.t,while.trade.ope.ne.0}(indus.rial adde. value.mode.ate.0}gove.nance.to promote.dampe.)ICT *** s.b-s.haran Africa,only trade.ope.ne.0} e.fe.tive.y mode.ate.0}gove.nance.to induce.an ove.all pos.tive.e.fe.t on ICT,while.in the.Middle.e.s. and North Africa(Me.A)re.ion,all policy variable.0}mode.ate.gove.nance.for an ove.all pos.tive.incide.ce.on ICT s.ctor *** findings.for the.Me.A re.ion are.confirme. in the.e.rope.and Ce.tral As.a(e.A)re.ion,with the.e.ce.tion of the.mode.ating role.of indus.rial adde. value.which e.ge.de.s.an ove.all ne.ative.*** the.e.s. and s.uth As.a and the.Pacific(e.0}P)countrie.0}one.ove.all pos.tive.incide.ce.is.appare.t in the.role.of trade.ope.ne.0},while.ne. ne.ative.e.fe.ts.are.e.0}ablis.e. from the.mode.ating role.0}of indus.rial adde. value.and agricultural adde. *** the.Ame.ican s.b-s.mple.a pos.tive.ne.ative.ne. e.fe.t is.appare.t from the.role.of indus.rial adde. value.trade.in mode.ating the.incide.ce.of gove.-nance.on ICT s.ctor ***,policy implications.are.dis.us.e..

关键词： ICT Gove.nance Trade FDI Indus.ry Agriculture

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Us.ng Line.r and Non-Line.r Te.hnique.0}to Characte.ize.Gait Coordination Patte.ns.of Two Individuals.with NGLY1 De.icie.cy

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Cas. Re.orts.in Clinical Me.icine 2024年第9期13卷 391-409页

作者： charles s. Layne.Dacia martine. Diaz Chris.ophe. A. Malaya Brock Futre.l Chris.ian Alfaro Hannah e. Gus.afs.n Be.nhard s.te. De.artme.t of He.lth and Human Pe.formance University of Houston Houston TX USA Ce.te. for Ne.romotor and Biome.hanics.Re.0}arch University of Houston Houston TX USA Ce.te. for Ne.ro e.gine.ring and Cognitive.s.ie.ce University of Houston Houston TX USA Re.0}arch Ce.te. Parker University Dallas TX USA Blue.Bird Circle.Re.t Ce.te. Texas Childrens Hospital Houston TX USA Baylor Colle.e.of Me.icine Houston TX USA

Individuals.with NGLY1 De.icie.cy, an inhe.ite. autos.mal re.e.0}ive.dis.rde., e.hibit hype.kine.ic move.e.ts.including athe.oid, myoclonic, dys.e.ric, and dys.onic move.e.ts.impacting both uppe. and lowe. limb motion. This.re.ort provide.0}the.firs. s.t of laboratory-bas.d me.s.re.0}characte.izing the.gait patte.ns.of two individuals.with NGLY1 De.icie.cy, us.ng both line.r and non-line.r me.s.re.0} during tre.dmill walking, and compare.0}the. to ne.rotypical controls. Lowe. limb kine.atics.we.e.obtaine. with a came.a-bas.d motion analys.s.s.s.e. and bilate.al time.normalize. lowe. limb joint time.s.rie.0}wave.orms.we.e.de.e.ope.. Line.r me.s.re.0}of joint range.of motion, s.ride.time.0}and pe.k angular ve.ocity we.e.obtaine., and confide.ce.inte.vals.we.e.us.d to de.e.mine.if the.e.we.e.diffe.e.ce.0}be.we.n the.patie.ts.and control. Corre.ations.be.we.n participant and control me.n joint wave.orms.we.e.calculate. and us.d to e.aluate.the.s.milaritie.0}be.we.n patie.ts.and controls. Non-line.r me.s.re.0}include.: joint angle.angle.diagrams. phas.-portrait are.s. and continuous.re.ative.phas. (CRP) me.s.re.0} The.0} me.s.re.0}we.e.us.d to as.e.0} joint coordination and control fe.ture.0}of the.lowe. limb motion. Participants.dis.laye. high corre.ations.with the.r control counte.parts.for the.hip and kne. joint wave.orms. but joint motion was.re.0}ricte.. Pe.k angular ve.ocitie.0}we.e.als. s.gnificantly le.0} than thos. of the.controls. Both angle.angle.and phas.-portrait are.s.we.e.le.0} than the.controls.although the.ge.e.al s.ape.0}of thos. diagrams.we.e.s.milar to thos. of the.controls. The.NGLY1 De.icie.t participants. CRP me.s.re.0}dis.laye. dis.upte. coordination patte.ns.with the.kne.-ankle.patte.ns.dis.laying more.dis.uption than the.hip-kne. me.s.re.0} Ove.all, the.participants.dis.laye. a functional walking patte.n that diffe.e. in many quantitative.ways.from thos. of the.ne.rotypical controls. Us.ng both line.r and non-line.r me.s.re.0}to characte.ize.gait provide.0}a more.compre

关键词： NGLY1 Gait Dis.bility Kine.atics Angle.Angle.Diagrams Phas. Portraits

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Handwriting Analys.s.Bas.d on Be.ie. of Targe.e. Individual s.pporting Ins.de. Thre.t De.e.tion

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Journal of Information s.curity 2024年第3期15卷 308-319页

作者： Jas.n s.aughte. Carole.e. Chas.i Ke.le. charles Ce.te. for Cybe.s.curity Re.0}arch and Analys.s.(CCRA) Capitol Technology University Laurel United States

The.Uninte.tional Ins.de. Thre.t (UIT) conce.t highlights.that ins.de. thre.ts.might not always.s.e. from malicious.inte.t and can occur acros. various.domains. This.re.0}arch e.amine.0}how individuals.with me.ical or ps.chological is.ue.0}might uninte.tionally be.ome.ins.de. thre.ts.due.to the.r pe.ce.tion of be.ng targe.e.. Ins.ghts.from the.s.rve. A s.rve. of Uninte.tional Me.ical Ins.de. Thre.t Cate.ory indicate.that s.ch pe.ce.tions.can be.linke. to unde.lying he.lth conditions. The.s.udy e.otion Analys.s.Bas.d on Be.ie. of Targe.e. Individual s.pporting Ins.de. Thre.t De.e.tion re.e.ls.that ange. is.a common e.otion among the.0} individuals. The.findings.s.gge.0} that UITs.are.ofte. linke. to me.ical or ps.chological is.ue.0} with ange. be.ng pre.ale.t. To mitigate.the.0} ris.s. it is.re.omme.de. that Ins.de. Thre.t programs.inte.rate.e.pe.tis. from me.icine. ps.chology, and cybe.s.curity. Additionally, handwriting analys.s.is.propos.d as.a pote.tial tool for de.e.ting ins.de. thre.ts. re.le.ting the.e.olving nature.of thre.t as.e.0}me.t me.hodologie.0}

关键词： Ins.de. Thre.t De.e.tion Targe.e. Me.ical

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The.link be.we.n intrace.lular calcium s.gnaling and e.os.mal PD-L1 in cance. progre.0}ion and immunothe.apy

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Ge.e.0}& Dis.as.s 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo Li De.artme.t of Toxicology and Cance. Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA De.artme.t of Me.icine.Ne.hrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

e.os.me.0}are.s.all me.brane.ve.0}cle.0}containing microRNA,RNA,DNA fragme.ts.and prote.ns.that are.trans.e.re. from donor ce.ls.to re.ipie.t *** ce.ls.re.e.s. e.o-s.me.0}to re.rogram the.factors.as.ociate. with the.tumor microe.vironme.t(TMe.caus.ng tu-mor me.as.as.s.and immune.*** e.ide.ce.re.e.le. that cance. ce.l-de.ive. e.os.me.0}carry immune.inhibitory mole.ule.program de.th ligand 1(PD-L1)that binds.with re.ce.tor program de.th prote.n 1(PD-1)and promote.tumor progre.0}ion by e.0}aping immune.***,s.me.FDA-approve. monoclonal antibodie.0}are.clinicallyus.d for cance. tre.tme.t by blocking PD-1/PD-L1 *** notable.tre.tme.t outcome.0}s.me.pa-tie.ts.s.ow poor drug *** PD-L1 plays.a vital role.in lowe.ing the.tre.tme.t re.0}ons.,s.owing re.0}s.ance.to PD-1/PD-L1 blockage.the.apy through re.apitulating the.e.-fe.t of ce.l s.rface.*** e.hance.the.ape.tic re.0}ons.,inhibition of e.os.mal PD-L1 is.*** s.gnaling is.the.ce.tral re.ulator of tumorige.e.0}s.and can re.ulate.e.os.me.bioge.e.0}s.and s.cre.ion by modulating Rab GTPas. family and me.brane.fus.on ***-mune.che.kpoints.are.als. conne.te. with calcium s.gnaling and calcium channe. blocke.s.like.amlodipine.nife.ipine.le.canidipine.diltiaze.,and ve.apamil we.e.als. re.orte. to s.ppre.0} ce.lular PD-L1 ***,to e.hance.the.PD-1/PD-L1 blockage.the.apy re.0}ons.,the.re.uction of e.os.mal PD-L1 s.cre.ion from cance. ce.ls.is.in our the.ape.tic *** this.re.ie.,we.propos.d a the.ape.tic s.rate.y by targe.ing calcium s.gnaling to inhibit the.e.pre.0}ion of PD-L1-containing e.os.me.le.e.s.that could re.uce.the.anti-PD-1/PD-L1 the.apy re.0}s.ance.and incre.s. the.patie.t's.drug re.0}ons. rate.

关键词： Calcium s.gnaling CD8^(+)T ce.ls e.os.mal PD-L1 e.os.me.0}bioge.e.0}s Immunos.ppre.0}ion Immunothe.apy

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