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基于进化规划的新型生物地理学优化算法研究

系统工程理论与实践 2010年第6期30卷 1106-1112页

作者：蔡之华龚文引 ling charles-x 中国地质大学(武汉)计算机学院武汉430074 西安大略大学计算机系

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜... 详细信息

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜索性与利用性的平衡.通过13个高维标准测试函数对算法进行测试,验证了新算法的有效性.与基本生物地理学优化算法和两种经典的进化规划算法进行比较,结果表明新算法优于所比较的三种算法.此外,新算法在收敛速度上优于基本生物地理学优化算法.

关键词：生物地理学优化进化规划全局优化混合算法实数编码

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代价敏感分类器的比较研究(英文)

计算机学报 2007年第8期30卷 1203-1212页

作者：凌晓峰 SHENG Victor S. 加拿大西安大略大学计算机科学系

简要地回顾了代价敏感学习的理论和现有的代价敏感学习算法.将代价敏感学习算法分为两类,分别是直接代价敏感学习和代价敏感元学习,其中代价敏感元学习可以将代价不敏感的分类器转换为代价敏感的分类器.提出了一种简单、通用、有效的元... 详细信息

简要地回顾了代价敏感学习的理论和现有的代价敏感学习算法.将代价敏感学习算法分为两类,分别是直接代价敏感学习和代价敏感元学习,其中代价敏感元学习可以将代价不敏感的分类器转换为代价敏感的分类器.提出了一种简单、通用、有效的元学习算法,称为经验阈值调整算法(简称ETA).评估了各种代价敏感元学习算法和ETA的性能.ETA几乎总是得到最低的误分类代价,而且它对误分类代价率最不敏感.还得到了一些关于元学习的其它有用结论.文章是"Thresholding for Making Classifiers Cost-sensitive"的改进和扩展版本,原文章由Victor ***和charles ***完成,发表于AAAI2006国际会议.

关键词：代价敏感学习元学习经验阈值调整

Transfer learning aided high-throughput computational design of ox.gen evolution reaction catalysts in acid conditions

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Journal of Energy Chemistry 2023年第5期80卷 744-757,I0015页

作者： Siwen Wang Honghong Lin Yui Wakabayashi Li Qin Zhou charles A.Roberts Debasish Banerjee Hongfei Jia Chen ling Toyota Research Institute of North America Ann ArborMI 48105USA

Sluggish ox.gen evolution reaction(OER)in acid conditions is one of the bottlenecks that prevent the wide adoption of proton ex.hange membrane water electrolyzer for green hydrogen *** recent advancements in developing high-performance catalysts for acid OER,the current electrocatalysts still rely on iridium-and ruthenium-based materials,urging continuous efforts to discover better performance catalysts as well as reduce the usage of noble *** structured ox.de is a family of potential high-performance acid OER catalysts with a flex.ble compositional space to tune the electrochemical ***,ex.loring the large composition space of pyrochlore compounds demands an imperative approach to enable efficient *** we present a highthroughput screening pipeline that integrates density functional theory calculations and a transfer learning approach to predict the critical properties of pyrochlore *** high-throughput screening recommends three sets of candidates for potential acid OER applications,totaling 61 candidates from 6912 pyrochlore *** addition to 3d-transition metals,p-block metals are identified as promising dopants to improve the catalytic activity of pyrochlore *** work demonstrates not only an efficient approach for finding suitable pyrochlores towards acid OER but also suggests the great compositional flex.bility of pyrochlore compounds to be considered as a new materials platform for a variety of applications.

关键词： Pyrochlore Acid OER High-throughput Machine learning

Phylogeny and Evolution of Bracts and Bracteoles in Tacca (Dioscoreaceae)

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Journal of Integrative Plant Biology 2011年第11期53卷 901-911页

作者： ling Zhang Hong-Tao Li Lian-Ming Gao Jun-Bo Yang De-Zhu Li charles H. Cannon Jin Chen Qing-Jun Li Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden the Chinese Academy of Sciences Menglun Mengla Yunnan 666303 China Key Laboratory of Biodiversity and Biogeography and Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China Department of Biology Texas Tech University Lubbock TX 79390 USA

Most species in the genus Tacca （Dioscoreaceae） feature green to black purple, conspicuous inflorescence involucral bracts with variable shapes, motile filiform appendages （bracteoles）, and diverse types of inflorescence morphology. To infer the evolution of these inflorescence traits, we reconstructed the molecular phylogeny of the genus, using DNA sequences from one nuclear, one mitochondrial, and three plastid loci （Internal Transcribed Spacer （ITS）, atpA, rbcL, trnL-F, and trnH-psbA）. Involucres and bracteoles characters were mapped onto the phylogeny to analyze the sequence of inflorescence trait evolution. In all analyses, species with showy involucres and bracteoles formed the most derived clade, while ancestral Tacca had small and plain involucres and short bracteoles, namely less conspicuous inflorescence structures. Two of the species with the most elaborate inflorescence morphologies （T. chantrieri in southeast China and T. integrifolia in Tibet）, are predominantly self-pollinated, indicating that these conspicuous floral displays have other functions rather than pollinator attraction. We hypothesize that the motile bracteoles and involucres may facilitate selfing; display photosynthesis in the dim understory, and protect flowers from herbivory.

关键词： atpA bracteoles bracts ITS molecular phylogeny rbcL Tacca trnH-psbA trnL-F.

Reviewing immunosuppressive regimens in animal models for vascularized composite allotransplantation

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Plastic and Aesthetic Research 2018年第3期5卷 17-26页

作者： Aline Yen ling Wang charles Yuen Yung Loh Center for Vascularized Composite Allotransplantation Chang Gung Memorial HospitalTaoyuan 333Taiwan St Andrew’s Center for Burns and Plastic Surgery Chelmsford CM1 7THUK

The development of vascularized composite allotransplantation (VCA) and its clinical need has led to the need for more animal models to study and perform the research required to further this specialty in terms of functional recovery and immunomodulatory improvements. Much of the animal models are reported in individual series in the literature but there has not been a review as such of these models. Here we present a compilation of the animal models reported in the literature thus far in VCA. A comprehensive review of the literature was performed for any studies which involved the use of animal models in various aspects of VCA research. The models were organized according to the type of VCA transplant, whether they were orthotopic or heterotopic, immunosuppressive regimen each study used and investigation purpose. Twenty-one facial transplant models were reported, 3 abdominal wall transplants, 4 penile transplantations, 21 uterus transplantations, 12 hindlimb transplantations and 4 myocutaneous flap transplantation animal models were reported. Primates, swine, rats, mice, rabbits, sheep and dog animal models in VCA were also reported. The most used immunosuppressive drugs are calcineurin inhibitor such as cyclosporin A and tacrolimus in these VCA animal models. They can significantly suppress lymphocyte function by blocking the phosphatase activity of calcineurin of lymphocytes. They are sometimes used combined with mycophenolate mofetil or steroids or antilymphocyte serum. The review of ex.sting animal models will allow further research to be focused in other areas of VCA where there is a current paucity of literature. The immunosuppressive regimens used in each animal model can also be reviewed to determine which regimen works in which type of animal model which will save time and resources for future research.

关键词： Animal models vascularized composite allotransplantation immunosuppressive regimens

Benefits of Conservation Agriculture on Soil and Water Conservation and Its Progress in China

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Agricultural Sciences in China 2011年第6期10卷 850-859页

作者： LI ling-ling HUANG Gao-bao ZHANG Ren-zhi Bill Bellotti Guangdi Li Kwong Yin Chan Gansu Provincial Key Laboratory of Aridland Crop Science/Faculty of Agronomy Gansu Agricultural University Lanzhou 730070 P.R. China Faculty of Resource and Environment Gansu Agricultural University Lanzhou 730070 P.R.China School of Natural Sciences University of Western Sydney NSW 1797 Australia EH Graham Centre for Agricultural Innovation （Alliance Between Investment ＆ Industry NSW and charles Sturt University） Wagga Wagga Agricultural Institute NSW 2650 Australia Investment ＆ Industry NSW NSW 2753 Australia

Conservation agriculture has been practised for three decades and has been spread widely. There are many nomenclatures surrounding conservation agriculture and differ to each other lightly. Conservation agriculture （CA） is a system approach to soil and water conservation, high crop productivity and profitability, in one word, it is a system approach to sustainable agriculture. Yet, because conservation agriculture is a knowledge-intensive and a complex.system to learn and implement, and also because of traditions of intensive cultivation, adoption rates have been low, since to date, only about seven percent of the world＇s arable and permanent cropland area is farmed under conservation agriculture. The practice and wider ex.ention of conservation agriculture thus requires a deeper understanding of its ecological underpinnings in order to manage its various elements for sustainable intensification, where the aim is to conserve soil and water and improve sustainability over the long term. This paper described terms related to conservation agriculture, presented the effects of conservation agriculture on soil and water conservation, crop productivity, progress and adoption of CA worldwide, emphasized obstacles and possible ways to increase CA adoption to accelerate sustainable development of China agriculture.

关键词： China conservation tillage crop residue mulch no-till soil and water conservation sustainability

RED CELL ADHERENCE TEST FOR DETECTING H SUBSTANCE IN SALIVA

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四川大学学报(医学版) 1984年第2期15卷 190-193页

作者： Wu Meiyun Lee Chang-ling Department of Forensic Medicine.Blood Center,charles Hymen Medical Center,Chicago,U.S.A.

The red cell adherence test currentlyused for detecting A, B, and H antigensin tissues has been successfully adaptedfor detecting the same antigens in thesaliva using two procedures. The glassslide method can detect all three antigensand has been useful for resolving ABOproblems in special cases. The microtiterplate method is able to handle 96 samplesat one time and has been valuable indetermining secretor status in paternitytesting.

关键词： RED CELL ADHERENCE TEST FOR DETECTING H SUBSTANCE IN SALIVA TBS test

Ectopic ex.ression of neurotrophic peptide derived from saposin C increases proliferation and upregulates androgen receptor ex.ression and transcriptional activity in human prostate cancer cells

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Asian Journal of Andrology 2007年第5期9卷 601-609页

作者： Yan Ding Hui-Qing Yuan Feng Kong x.ao-Yan Hu Kai Ren Jie Cai x.ao-ling Wang charles Y. E Young Department of Biochemistry and Molecular Biology School of Medicine Shandong University Jinan 250012 China Departments of Urology and Biochemistry and Molecular Biology Mayo Graduate School Mayo Clinic Rochester MN55905 USA

Aim： To determine the effects of the functional domain of saposin C （neurotrophic peptide [NP]） on androgen receptor （AR） ex.ression and transcriptional activity. Methods： We constructed DNA vectors ex.ressing NP or a chimeric peptide of the viral TAT transduction domain and NP （TAT-NP） using gene cloning technology. The effects of ectopic ex.ression of NP or TAT-NP on cell growth were ex.mined by 3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyl-2H-tetrazolium bromide （MTT） assay. Reverse transcription-polymerase chain reaction （RT-PCR）, Western blot, transient transfection and reporter gene assays were used to determine the effects of NP on AR ex.ression and activation. Results： NP stimulated proliferation of androgen responsive LNCaP cells in the absence of androgens. RT-PCR and Western blot analyses showed that ectopic ex.ression of NP resulted in induction of AR gene ex.ression, and that the NP-stimulated ex.ression of AR could be synergistically enhanced in the presence of androgens. Furthermore, reporter gene assay results showed that NP could enhance AR transactivation by increasing androgen-inducible gene reporter activity. Conclusion： We provided evidence that ectopic ex.ression of saposin C-originated NP could upregulate AR gene ex.ression and activate the AR transcriptional function in an androgen-independent manner in prostate cancer cells.

关键词： neurotrophic peptide, androgen receptor saposin C prostate carcinoma cell lines

槲皮素对前列腺癌细胞增殖及转录因子Sp1功能的抑制作用

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中国生物化学与分子生物学报 2005年第5期21卷 673-678页

作者：苑辉卿杨玲玲姜安丽孔峰张建业 charles YF YOUNG 山东大学医学院生物化学与分子生物学教研室 Department of Urology Mayo Clinical College of MedicineMayo ClinicRochesterMN55905USA

雄激素受体(androgenreceptor,AR)作为核转录因子,其高表达、基因突变以及AR辅激活因子的过表达等造成AR的异常激活与前列腺癌细胞的增殖、恶化转移、多药耐药等密切相关.天然黄酮槲皮素(quercetin),是一很有潜力的预防和治疗前列腺肿... 详细信息

雄激素受体(androgenreceptor,AR)作为核转录因子,其高表达、基因突变以及AR辅激活因子的过表达等造成AR的异常激活与前列腺癌细胞的增殖、恶化转移、多药耐药等密切相关.天然黄酮槲皮素(quercetin),是一很有潜力的预防和治疗前列腺肿瘤的化合物.槲皮素不仅抑制前列腺癌细胞LNCaP的增殖,并呈剂量依赖性,而且下调前列腺癌中AR的表达、抑制AR的转录激活功能.GCbox.AR核心启动子的主要正调控元件,是转录因子Sp1的结合位点.细胞转染结果表明,槲皮素能抑制Sp1蛋白对AR启动子的激活作用,可能是槲皮素下调AR表达的机理之一.进一步研究显示,槲皮素还能明显抑制Sp1蛋白对AR转录激活功能的增强作用.Western印迹结果显示,槲皮素对Sp1蛋白表达无明显影响,但能够诱导c-Jun的高表达,而高表达的c-Jun蛋白能逆转Sp1蛋白对AR的转录激活作用,由此推测,槲皮素可能通过介导c-Jun与Sp1的蛋白质相互作用,抑制Sp1的功能,进而起到抑制AR表达和功能的作用.免疫沉淀结果又进一步证实了Sp1与c-Jun二者的相互作用.因此,槲皮素可能通过抑制前列腺癌细胞中AR的表达和功能抑制了细胞的增殖,其分子机理可能与槲皮素诱导的c-Jun与Sp1蛋白相互作用、降低Sp1对AR的转录激活作用有关.

关键词：槲皮素细胞增殖 Sp1 前列腺癌细胞抑制作用