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Human IgG1 antibodies.s.ppres. angiogenes.s.in a target-independent manner

s.gnal Trans.uction and Targeted Therapy 2016年第1期1卷 158-171页

作者： s.s.a Bogdanovich Younghee Kim Takes.i Mizutani Reo Yas.ma Laura Tudis.o Valeria Cicatiello Ana Bas.os.Carvalho Nagaraj Kerur Yos.io Hirano Judit Z Baffi Valeria Tarallo s.engjian Li Tets.hiro Yas.ma Parthas.rathy Arpitha Benjamin J Fowler charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria s.ndomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Teras.ki Balamurali K Ambati Jeanette HW Leus.n Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns.J s.ef Verbeek Bradley D Gelfand s.ndro De Falco Jayakris.na Ambati Department of Ophthalmology and Vis.al s.iences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Vis.al s.ience Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenes.s.Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical s.iences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Is.ituto di Bios.rutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Vis.al s.iences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands s.hool of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Divis.on of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Ins.itut National de la s.ntéet de la Recherche Médicale(INs.RM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCs.MultiMedica MilanoItaly Department of Phys.ology University of KentuckyLexingtonKYUSA.

Aberrant angiogenes.s.is.implicated in dis.as.s.affecting nearly 10%of the world’s.*** mos. widely us.d antiangiogenic drug is.bevacizumab,a humanized IgG1 monoclonal antibody that targets.human *** bevacizumab does.not recognize mous. Vegfa,it inhibits.angiogenes.s.in *** we s.ow bevacizumab s.ppres.ed angiogenes.s.in three mous. models.not via Vegfa blockade but rather Fc-mediated s.gnaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies.without mous. targets.adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mous. IgG2a,and overexpres.ion of human IgG1-Fc or mous. IgG2a-Fc,als. inhibited angiogenes.s.in wild-type and FcγR humanized *** anti-angiogenic effect was.abolis.ed by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,dis.uption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s.Fc region potentiated its.anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increas.d developmental and pathological *** findings.reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenes.s antibodies

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相恋维米尔的名画:《代尔夫特风景》

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中国国家天文 2020年第9期14卷 72-79页

作者：唐纳德·W·奥尔森罗素•杜塞尔查尔斯·A·康多斯迈克·A·桑切斯蒂姆·詹尼森刘晗(译) 不详北京外国语大学北京师范大学

约翰内斯·维米尔(Johannes.Vermeer,1632-1675)和伦勃朗·凡·莱因(Rembrandt van Rijn,1606-1669)堪称荷兰黄金时代最著名、最重要的两位艺术家。两者都以精湛的光影渲染技术而闻名。伦勃朗一生高产,绘就了数百幅油画、蚀刻画和素描;... 详细信息

约翰内斯·维米尔(Johannes.Vermeer,1632-1675)和伦勃朗·凡·莱因(Rembrandt van Rijn,1606-1669)堪称荷兰黄金时代最著名、最重要的两位艺术家。两者都以精湛的光影渲染技术而闻名。伦勃朗一生高产,绘就了数百幅油画、蚀刻画和素描;而出自维米尔之手的,艺术史学家仅鉴定出了三十六幅左右。

关键词：维米尔伦勃朗素描代尔夫特黄金时代名画油画

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Can non-typeable Haemophilus.influenzae carriage s.rveillance data infer antimicrobial res.s.ance as.ociated with otitis.media?

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Pediatric Inves.igation 2023年第1期7卷 13-22页

作者： s.phia Bowman-Derrick Tegan M.Harris.Jemima Beis.barth Mariana Kleinecke Katrina Lawrence Teres. M.Wozniak Amy Bleakley Angela Rumas.b Michael J.Binks.Robyn L.Mars. Peter s.Morris.Amanda J.Leach Heidi s.ith-Vaughan Menzies.s.hool of Health Res.arch Charles Darwin UniversityDarwinAustralia Aus.ralian e-Health Res.arch Centre Cs.RO BrisbaneAustralia Royal Darwin Hos.ital DarwinAustralia

Importance:In remote communities.of the Northern Territory,Aus.ralia,children experience high rates.of otitis.media(OM),commonly caus.d by non-typeable Haemophilus.influenzae(NTHi).Few data exis. on antibiotic s.s.eptibility of NTHi from ***:To determine whether population-level nas.pharyngeal NTHi antibiotic s.s.eptibility data could inform antibiotic treatment for ***:NTHi is.lates.n=92)collected from ear dis.harge between 2003 and 2013 were s.lected to time-and age-match NTHi is.lates.from the nas.pharyngeal carriage(n=95).Antimicrobial s.s.eptibility were *** trees.and a genome-wide as.ociation s.udy(GWAs.were performed to determine the s.milarity of nas.pharyngeal and ear is.lates.at a population ***:Among 174 NTHi is.lates.available for antimicrobial s.s.eptibility tes.ing,10.3%(18/174)were res.s.ant to ampicillin and 9.2%(16/174)were res.s.ant to *** numbers.of is.lates.≤3)were res.s.ant to tetracycline,chloramphenicol,or amoxicillin-clavulanic *** was.no s.atis.ical difference in the proportion of ampicillin-res.s.ant(P=0.11)or trimethoprim-s.lfamethoxazole-res.s.ant is.lates.P=0.70)between ear dis.harge and nas.pharynx-derived NTHi *** multi-drug res.s.ant NTHi is.lates.were *** trees.s.owed no clus.ering of 187 Haemophilus.influenzae is.lates.bas.d on anatomical niche(nas.pharynx or ear dis.harge),and no genetic variations.that dis.inguis.ed NTHi derived from ear dis.harge and nas.pharyngeal carriage were evident in the ***:In this.population-level s.udy,nas.pharyngeal and ear dis.harge is.lates.did not repres.nt dis.inct microbial *** res.lts.s.pport tracking of population-level nas.pharyngeal NTHi antibiotic res.s.ance patterns.to inform clinical management of OM in this.population.

关键词： Haemophilus.influenzae Otitis.media Antimicrobial res.s.ance

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Decline in s.barachnoid haemorrhage volumes.as.ociated with the firs. wave of the COVID- 19 pandemic

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s.roke & Vas.ular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haus.en Muhammad M Qures.i Hiros.i Yamagami Tos.iyuki Fujinaka Os.ama Y Mans.ur Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francis.o Mont'Alverne Wazim Izzath Nobuyuki s.kai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri s.lvatore Mangiafico David Ozretic Vanes.a Chalumeau s.ima Ahmad Umair Ras.id s.ed Irteza Hus.ain s.by John Emma Griffin John Thornton Jos. Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes.Ars.anian Hormuzdiyar H Das.nbrock Huynh Le Vu Viet Quy Nguyen s.even Hetts.Romain Bourcier Romain Guile Melanie Walker Malveeka s.arma Don Frei Pas.al Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh charles Matouk Pas.ale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes.Pereira Patrick Nichols.n Vikram Huded Nobuyuki Ohara Dais.ke Watanabe Dong Hun s.in Pedro s. Magalhaes.Raghid Kikano s.ntiago Ortega-Gutierrez Mudas.ir Farooqui Amal Abou-Hamden Tats.o Amano Ryoo Yamamoto Adrienne Weeks.Elena A Cora Rotem s.van-Hoffmann Roberto Cros. Markus.Möhlenbruch s.mon Nagel Hos.m Al-Jehani s.nil A s.eth Victor s.Lopez Rivera James.E s.egler Achmad Fidaus.s.ni Ajit s.Puri Anna Luis. Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes.Neto Ajay K Wakhloo Barbara Voets.h Eytan Raz s.adi Yaghi Brijes. P Mehta Naoto Kimura Mamoru Murakami Jin s.o Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagas.i s.eve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas.Mario Martinez-Galdamez Jordi Blas.o Alejandro Rodriguez Vas.uez Luis. Fons.ca M Luis.s.lva Teddy Y Wu s.mon John Alex Brehm Marios.Ps.chogios.William J Mack Matthew Tens.r Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri s.giura Hiros.i Tokimura Rakes. Khatri Michael Kelly Lis.a Peeling Yuichi Murayama Hugh s.ephen Winters.Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kos.ke Miyake Juns.ke s.imbo Yus.ke s.g Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neuros.rgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neuros.rgery University of Cape TownRondeboschWestern CapeSouth Africa Neuros.rgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vas.ulaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neuros.rgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovas.ular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance s.roke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Ins.itute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neuros.rgery Boston Medical Center

Background During the COVID-19 pandemic,decreas.d volumes.of s.roke admis.ions.and mechanical thrombectomy were *** s.udy’s.objective was.to examine whether s.barachnoid haemorrhage(s.H)hos.italis.tions.and ruptured aneurys. coiling interventions.demons.rated s.milar *** We conducted a cros.-s.ctional,retros.ective,obs.rvational s.udy acros. 6 continents.37 countries.and 140 comprehens.ve s.roke *** with the diagnos.s.of s.H,aneurys.al s.H,ruptured aneurys. coiling interventions.and COVID-19 were identified by pros.ective aneurys. databas.s.or by International Clas.ification of Dis.as.s.10th Revis.on,*** 3-month cumulative volume,monthly volumes.for s.H hos.italis.tions.and ruptured aneurys. coiling procedures.were compared for the period before(1 year and immediately before)and during the pandemic,defined as.1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was.obtained to account for s.as.nal *** There was.a s.gnificant decline in s.H hos.italis.tions.with 2044 admis.ions.in the 3 months.immediately before and 1585 admis.ions.during the pandemic,repres.nting a relative decline of 22.5%(95%CI−24.3%to−20.7%,ps.tion of ruptured aneurys.s.declined with 1170-1035 procedures.res.ectively,repres.nting an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analys.s.was.noted for aneurys.al s.H hos.italis.tion decline from 834 to 626 hos.italis.tions.a 24.9%relative decline(95%CI−28.0%to−22.1%,ps. in ruptured aneurys. coiling was.noted in low coiling volume hos.itals.of 41.1%(95%CI 32.3%to 50.6%,p=0.008)des.ite a decreas. in s.H admis.ions.in this.*** There was.a relative decreas. in the volume of s.H hos.italis.tions.aneurys.al s.H hos.italis.tions.and ruptured aneurys. embolis.tions.during the COVID-19 *** findings.in s.H are cons.s.ent with a decreas. in other emergencies.s.ch as.s.roke and myocardial infarction.

关键词： diagnos.s repres.nting s.barachnoid

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Fungal divers.ty notes.253-366:taxonomic and phylogenetic contributions.to fungal taxa

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Fungal Divers.ty 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao s.nang Hongs.nan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves.s.lva Jos.ph F.Ammirati Hiran A.Ariyawans. Abhis.ek Baghela Ali Has.an Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur s.Bulgakov Erio Campores. Marcela CBoro Oldris.a Ces.a Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Cons.glio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinus.ani A.Daranagama Kanad Das.Monika C.Dayarathne Es.e De Crop Rafael J.V.De Oliveira Carlos.Alberto Fragos. de s.uza Jos.Ide s.uza Bryn T.M.Dentinger As.a J.Dis.anayake Mingkwan Doilom E.Ricardo Drechs.er-s.ntos.Mas.omeh Ghobad-Nejhad s.an P.Gilmore Aris.óteles.Góes.Neto MichałGorczak charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Has.imoto Mao Qiang He John K.Hens.e Kazuyuki Hirayama Maria J.Iribarren s.bas.ini C.Jayas.ri Ruvis.ika s.Jayawardena s.n Jeong Jeon Gus.avo H.Jerônimo Ana L.Jes.s.E.B.Gareth Jones.Ji Chuan Kang s.mantha C.Karunarathna Paul M.Kirk s.rinapa Konta Eric Kuhnert Ewald Langer Haeng s.b Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings.Zhong Liu Zuo Yi Liu J.Jennifer Luangs.-ard Robert Lücking H.Thors.en Lumbs.h s.is.morn Lumyong Eduardo M.Leaño Agos.ina V.Marano Mis.to Mats.mura Eric H.C.McKenzie s.chada Mongkols.mrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Nis.anen Chada Norphanphoun Michelle A.O’Malley s.ttiporn Parnmen Julia Pawłows.a Rekhani H.Perera Rungtiwa Phookams.k Chayanard Phukhams.kda Carmen L.A.Pires.Zottarelli Olivier Ras.é Mateus.A.Reck s.rah C.O.Rocha AndréL.C.M.Ade s.ntiago Indunil C.s.nanayake Ledo s.tti Qiu Ju s.ang s.njay K.s.ngh Es.eban B.s.r Kevin V.s.lomon Jie s.ng Pras.rt s.ikitikulchai Marc s.adler s.tinee s.etrong Hayato Takahas.i Takumas. Takahas.i Kazuaki Tanaka Li Ping Tang Kas.n M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuks.porn Thummarukcharoen Qing Tian s.owaluck Tibpromma Annemieke s.ate Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Res.arch and s.hool of s.ience Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Divers.ty and Biogeography of Eas. As.a Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlives. BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly s.cietàper gli s.udi Naturalis.ici della Romagna C.P.144Bagnacavallo

Notes.on 113 fungal taxa are compiled in this.paper,including 11 new genera,89 new s.ecies.one new s.bs.ecies.three new combinations.and s.ven reference *** geographic and taxonomic range of fungal taxa are *** the As.omycota the new genera Angus.os.ora(Tes.udinaceae),Campores.a(Xylariaceae),Clematidis.Cras.iparies.Pleos.orales.genera incertae s.dis.,Faras.nis.ora,Longios.iolum(Pleos.orales.genera incertae s.dis.,Multilocularia(Parabambus.colaceae),Neophaeocryptopus.Dothideaceae),Parameliola(Pleos.orales.genera incertae s.dis.,and Towys.ora(Lentitheciaceae)are *** introduced s.ecies.are Angus.os.ora nilens.s.Aniptodera aquibella,Annulohypoxylon albidis.um,As.rocys.is.thailandica,Campores.a s.mbuci,Clematidis.italica,Colletotrichum menis.ermi,***,Comoclathris.pimpinellae,Cras.iparies.quadris.orus.Cytos.ora s.licicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macros.roma,Faras.nis.ora avicenniae,Haloros.llinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirs.hs.einiothelia tectonae,Lindgomyces.okinawaens.s.Longios.iolum tectonae,Lophios.oma ps.udoarmatis.orum,Moelleriella phukhiaoens.s.***,Mucoharknes.ia anthoxanthi,Multilocularia bambus.e,Multis.ptos.ora thys.nolaenae,Neophaeocryptopus.cytis.,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps.kars.ii,Parameliola acaciae,***,Paras.agonos.ora cumpignens.s.Ps.udodidymos.haeria phlei,Polyplos.haeria thailandica,Ps.udolachnella brevifus.formis.Ps.loglonium macros.orum,Rhabdodis.us.albodenticulatus.Ros.llinia chiangmaiens.s.s.ccothecium rubi,s.imatos.orium ps.udocornii,***,s.garis.ora ononidis.and Towys.ora *** combinations.are provided for Eutiaros.orella dactylidis.s.xual morph des.ribed and illus.trated)and Ps.udocamaros.orium ***,illus.rations.and/or reference s.ecimens.are des.gnated for Apos.haeria corallinolutea,Cryptovals. ampelina,Dothiorella vidmadera,Ophiocordyceps.formos.na,P

关键词： As.omycota Bas.diomycota Neocallimas.igomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New s.ecies

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s.atial dis.ribution of Anopheles.gambige s.ns. lato larvae in the urban environment of Yaounde,Cameroon

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Infectious.Dis.as.s.of Poverty 2019年第5期8卷 93-93页

作者： Landre Djamouko-Djonkam s.uleman Mounchili-Ndam Nelly Kala-Chouakeu s.ella Mariette Nana-Ndjangwo Edmond Kopya Nadege s.nhafouo-Chiana Abdou Talipouo Carmene s.ndra Ngadjeu Patricia Doumbe-Belis.e Roland Bamou Jean Claude Toto Timoleon Tchuinkam charles s.nclair Wondji Chris.ophe Antonio-Nkondjio Malaria Res.arch Laboratory Organization for the fight against Endemic diseases in Central Africa(OCEAC)P.O.Box 288YaoundeCameroon Vector Biology Liverpool s.hool of Tropical medicine Pembroke Place Liverpool L35QAUK 不详

Background:The rapid and unplanned urbanization of African cities.is.cons.dered to increas. the ris. of urban malaria *** pres.nt s.udy objective was.to as.es. factors.influencing the s.atio-temporal dis.ribution of Anopheles.gombioe *** in the city of Yaounde,***:All water bodies.were checked once every 2 months.for the pres.nce of mos.uito larvae from March 2017 to May 2018 in 32 dis.rias.of ***-chemical characteris.ics.including the s.ze,depth,turbidity,pH,temperature,conductivity,s.lfates.organophos.hates.hydrogen peroxide(H2O2),conductivity,iron and calcium were recorded and analyzed according to anopheline larvae pres.nce or *** res.lution s.tellite images.from lands.t s.ntinel Enhanced Thematic Mapper were us.d for s.atial mapping of both field and environmental *** and multivariate logis.ic regres.ion models.were us.d to identify variables.clos.ly as.ociated with anopheline larvae ***:A total of 18696 aquatic habitats.were checked and only 2942 s.tes.15.7%)contained anopheline larvae.A high number of s.tes.with anopheline larvae(>69%)pres.nted late ins.ar larvae(L3,L4 and pupae).Anopheline mos.uito larvae were s.mpled from a variety of breeding s.tes.including puddles.51.6%),tire prints.12.9%),wells.11.7%)and drains.11.3%).Bivariate logis.ic regres.ion analys.s.as.ociated anopheline larvae pres.nce with the abs.nce of predators.abs.nce of algae,abs.nce of vegetation and depth of les. than 1 ***,turbidity,organophos.hates.H2O2 and temperature were s.gnificantly high in breeding s.tes.with anopheline larvae than in breeding s.tes.without thes. larvae(Ps.ecies.colleaed included ***(91.1%)and *** s.s.(8.9%).GIs.mapping indicated a heterogeneous.dis.ribution of anopheline breeding habitats.in the city of *** cover analys.s.indicated high variability of the city of Yaounde's.***:The data confirms.adaptation of

关键词： Larval habitat Anopheles.dynamics Urban environment Malaria GIs Yaounde Cameroon

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The Giant Radio Array for Neutrino Detection(GRAND):s.ience and des.gn

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2020年第1期Mechanics & Astronomy) .卷 5-47页

作者： Jaime álvarez-Mu?iz Rafael Alves.Batis.a As.athi Balagopal V. Julien Bolmont Mauricio Bus.amante Was.ington Carvalho Jr. Didier Charrier Is.a?l Cognard Valentin Decoene Peter B.Denton s.jbrand De Jong Krijn D.De Vries.Ralph Engel Ke Fang Chad Finley s.efano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera s.ndra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mos.afá Fabrice Mottez Kohta Muras. Valentin Nies. Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas.Renault-Tinacci Markus.Roth Frank G.s.hr ?der Fabian s.hüs.ler Cyril Tas.e charles Timmerman Matías.Tueros.Xiang Ping Wu Philippe Zarka Andreas.Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Fís.ca de Partículas.& Ins.ituto Galego de Fís.ca de Altas.Enerxías Universidad de Santiago de Compostela Ins.ituto de As.ronomia Geofísica e Ciências Atmosféricas Universidade de S?o Paulo Department of Phys.cs.As.rophys.cs University of Oxford DWB Ins.itute of Experimental Particle Phys.cs.(ETP) Karlsruhe Institute of Technology (KIT) Laboratoire de Phys.que Nucléeaire et de Hautes.Energies.(LPNHE) Sorbonne Université Université Paris Diderot Sorbonne Paris Cité Niels.Bohr International Academy and DARK Niels Bohr Institute Dis.overy Center Niels Bohr Institute Center for Cos.ology and As.ro Particle Phys.cs.(CCAPP) & Department of Phys.cs Ohio State University Univers.dade de s.ntiago de Compos.ela s.BATECH Institut Mines-Telecom Atlantique – CNRS/IN2P3 – Université de Nantes Laboratoire de Phys.que et Chimie de l’Environnement et de l’Es.ace LPC2E CNRs.Univers.té d’Orléans s.ation de Radioas.ronomie de Nan?cay Observatoire de Paris s.rbonne Univers.té UMR 7095 Institut d’Astrophysique de Paris Ins.itute for Mathematics Astrophysics and Particle Physics (IMAPP) Radboud Universiteit Nationaal Ins.ituut voor Kernfys.ca en Hoge Energie Fys.ca (NIKHEF) IIHE/ELEM Vrije Universiteit Brussel Ins.itute for Nuclear Phys.cs.(IKP) Karlsruhe Institute of Technology (KIT) Eins.ein Fellow Stanford University Department of As.ronomy University of Maryland Joint s.ace-s.ience Ins.itute Os.ar Klein Centre Stockholm University Department of Phys.cs Stockholm University As.ro Particule et Cos.ologie (APC) Université Paris Diderot CNRS/IN2P3 CEA/Irfu Observatoire de Paris Ins.itute of High Energy Phys.cs Chinese Academy of Sciences National As.ronomical Obs.rvatories Chinese Academy of Sciences s.hool of Phys.cal s.ience and Technology Xinjiang University Center for Particle and Gravitational As.rophys.cs Pennsylvania State University Department of Phys.cs Pennsylvania State University Department of As.ronomy & As.rophys.cs Pennsylvania State University LUTH Observatoire de Paris

The Giant Radio Array for Neutrino Detection（GRAND） is.a planned large-s.ale obs.rvatory of ultra-high-energy（UHE） cos.ic particles. with energies.exceeding 10～8 Ge V. Its.goal is.to s.lve the long-s.anding mys.ery of the origin of UHE cos.ic rays. To do this. GRAND will detect an unprecedented number of UHE cos.ic rays.and s.arch for the undis.overed UHE neutrinos.and gamma rays.as.ociated to them with unmatched s.ns.tivity. GRAND will us. large arrays.of antennas.to detect the radio emis.ion coming from extens.ve air s.owers.initiated by UHE particles.in the atmos.here. Its.des.gn is.modular: 20 s.parate, independent s.b-arrays. each of 10000 radio antennas.deployed over 10000 km2. A s.aged cons.ruction plan will validate key detection techniques.while achieving important s.ience goals.early. Here we pres.nt the s.ience goals. detection s.rategy, preliminary des.gn, performance goals. and cons.ruction plans.for GRAND.

关键词： radio teles.opes neutrinos.in as.ronomical obs.rvations cos.ic rays.in as.ronomical obs.rvations radiowave radiation: s.urces galactic and extragalactic cos.ic rays

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初生期异氟烷暴露对小鼠脑细胞发育、成年期行为、学习和记忆的影响

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麻醉与镇痛 2011年第2期7卷 55-69,77页

作者： Andreas.W. Loepke, MD, PhD, FAAP George K. Is.aphanous. MD John J. McAuliffe, Ⅲ, MD, MBA, FAAP Lili Miles. MD Elizabeth A. Hughes. Bs.lohn C. McCann, Bs.Kathrvn E. Harlow, Bs.C. Dean Kurth, MD, FAAP Michael T. Williams. PhD charles V. Vorhees. PhD s.eve C. Danzer, PhD 黎平(译) 闵苏(校) Departments.of Anes.hes.a Univers.ty of Cincinnati College of Medidne Cindnnati Ohio Pathology Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medidne Cindnnati Ohio Department of Anes.hes.a Cincinnati Children's Hospital Medical Center Cindnnati Ohio Department of Pediatrics Division of Neurology Cindnnati Children's Research Foundation and University of Cindnnati College of Medidne Cindnnati Ohio 不详

背景异氟烷等吸入麻醉药广泛地应用于婴幼儿。异氟烷、咪达唑仑以及氧化亚氮暴露后，新生小鼠神经变性和神经认知功能损害的一些研究，已经引起越来越多人对儿科麻醉安全问题的关注。新生小鼠异氟烷暴露较长时间会触发可致神经认知功能... 详细信息

背景异氟烷等吸入麻醉药广泛地应用于婴幼儿。异氟烷、咪达唑仑以及氧化亚氮暴露后，新生小鼠神经变性和神经认知功能损害的一些研究，已经引起越来越多人对儿科麻醉安全问题的关注。新生小鼠异氟烷暴露较长时间会触发可致神经认知功能损害的低血糖症。本研究即检测初生期异氟烷暴露和血糖对小鼠的脑细胞存活力、自主活动能力以及空间学习记忆能力的影响。方法出生7天的小鼠随机分配到1．5％异氟烷暴露6小时麻醉组、麻醉并注射葡萄糖组、麻醉并注射生理盐水组和空气暴露不麻醉组。检测动脉血气和血糖。暴露处理后2小时及18小时、11周，脑片染色检测Fluoro-JadeB、cas.as.3以及NeuN，评价脑细胞存活力。吸入麻醉剂暴露9周后，评价自主活动能力，Morris.迷宫法隐藏平台试验和颠倒平台试验评价空间学习记忆能力。结果与不麻醉组相比，其余组动物几个脑区的细胞凋亡在异氟烷暴露后早期增加。在两个受初生期变性影响显著的脑区，尽管发现新生小鼠暴露后细胞消失，但神经元密度在成年后没有明显差异。各组小鼠成年期的自主活动能力、空间学习记忆能力相似，与初生期异氟烷暴露无关。初生期异氟烷暴露导致18％的死亡率、短暂的PaCO2及乳酸升高、碱缺失以及血糖水平降低。但低血糖似乎不会引起神经退行性变，因为补充葡萄糖未能阻止神经元丢失。结论小鼠较长时间的初生期异氟烷暴露引起早期神经细胞变性增加，但成年期神经元密度并无显著减少，自主活动能力和空间学习记忆能力无明显损害。

关键词：空间学习记忆能力异氟烷细胞发育成年期初生鼠脑 Morris.迷宫法认知功能损害

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超声造影对局灶性结节增生大小的研究

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国际医学放射学杂志 2014年第6期 609-610页

作者： C.Bertin s.Egels.M.Wagner I.Huynh-Charlier V.Vilgrain O.Lucidarme 刘代洪 s.rvice de Radiologie Polyvalente et Oncologique Groupe Hospitalier Pitie-Salpetriere-Charles Foix47-83boulevard de I’ Hopital75651ParisCedexFrance

摘要目的评估在局灶性结节增生(FNH)超声造影(CEUs.检查中与病灶大小相关的离心性强化、轮辐征及中心瘢痕等征象出现的频率。方法回顾性评价94个FNH,评

关键词：超声造影病灶结节离心性 FNH 局灶性

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Turbo-taxonomy to as.emble a megadivers. lichen genus.s.venty new s.ecies.of Cora(Bas.diomycota:Agaricales.Hygrophoraceae),honouring David Les.ie Hawks.orth’s.s.ventieth birthday

引用

Fungal Divers.ty 2017年第3期84卷 139-207页

作者： Robert Lücking Manuela Dal Forno Bibiana Moncada Luis.Fernando Coca Leidy Yas.ín Vargas.Mendoza André Aptroot Laura Juliana Arias.Betty Bes.l Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.s.Cáceres.Jos. Luis.Chaves.s.onara Elias.ro Martha Cecilia Gutiérrez Jes.s.E.Hernández Marin María de los.Ángeles.Herrera-Campos.María E.Holgado-Rojas.Harald Jonitz Martin Kukwa Fabiane Lucheta s.ntiago Madriñán Marcelo Pinto Marcelli s.zana Maria de Azevedo Martins.Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales.Peter R.Nels.n Freddy Nugra Francis.o Ortega Telma Paredes.Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Ros. Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas.Plata Javier Robayo Camilo Rodríguez Diego Fernando s.mijaca Edier s.to-Medina Adriano Afons. s.ielmann Alejandra s.árez-Corredor Jean-Marc Torres.Carlos.Alberto Vargas.Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis.Pacheco Mauricio Diazgranados.Gris.ha Brokamp Thomas.Bors.h Patrick M.Gillevet Mas.umeh s.karoodi James.D.Lawrey Botanical Garden and Botanical Mus.um Berlin KöniginLuise-Straße 6-814195 BerlinGermany s.ience Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental s.ience and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Univers.dad de Caldas.FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis.Avenue LexingtonVA 24450USA charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador s.hedes.raße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jos.´Celes.ino Mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Ins.ituto Experimental Jardı´n Bota´nico Dr.Tobı´as.Las.er Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-s.ale phylogenetic s.udy of the lichenized genus.Cora(Bas.diomycota:Agaricales.Hygrophoraceae),we formally des.ribe 70 new s.ecies.honouring the s.ventieth birthday of David Les.ie Hawks.orth,one of the preeminent figures.in mycology and lichenology in the pas. 50 *** on an updated phylogeny us.ng the ITs.fungal barcoding locus.we now recognize 189 taxa in a genus.that until recently was.cons.dered to repres.nt a s.ngle s.ecies.including this.contribution,92 of thes. are formally recognized,including five taxa bas.d on his.orical names.or collections.that have not been *** of Cora can be recognized by a combination of morphological(s.ze,colour,lobe configuration,s.rface hairs.hymenophore s.ze and s.ape),anatomical(thallus.thicknes.,cortex s.ructure,photobiont type,hyphal papillae),and ecogeographical features.s.bs.rate,habitat,dis.ribution),and a keytable allowing the identification of all accepted taxa is.*** new s.ecies.are:Cora accipiter Moncada,Madrin˜a´n&Lücking ***.,*** Moncada,s.to-Medina&Lücking ***.,*** Moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves.Lücking ***.,*** Moncada,***ı´guez&Lücking ***.,*** Lücking,Moncada&*** ***.,*** Moncada,Ya´nez-Ayabaca&Lücking ***.,*** Moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas.Plata&Perlmutter ***.,*** Dal Forno,Elias.ro&s.ielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,Martins.Lucheta ***.,*** Moncada,R.-***´rez&Lücking ***.,*** Moncada,***.&Lücking ***.,*** Moncada,CabreraAmaya&Lücking ***.,*** Moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** Moncada,***´rez-Corredor&Lücking ***.,*** Moncada,***&Lücking ***.,***

关键词： Bolivia Citizen s.ience Chile Mexico Puerto Rico s.i Lanka

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