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Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： Sabine L Collette Michael p.Rodgers Marianne A A van Walderveen Kars C J Comp.gne p.ul J Nederkoorn Jeannette Hofmeijer Jasp.r M Martens Gert J de Borst Gert Jan R Luijckx charles B L M Majoie Aad van der Lugt Reinoud p.H Bokkers Maarten Uyttenboogaart University Medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University Medical Centre LeidenThe Netherlands Erasmus MC University Medical CentreRotterdamThe Netherlands Amsterdam University Medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hosp.tal ArnhemThe Netherlands University Medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The op.imal management of ip.ilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** comp.red the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included p.tients who had an acute ischaemic stroke undergoing EVT and a concomitant ip.ilateral extracranial ICA stenosis of≥50%or occlusion of p.esumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The p.imary endp.int was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endp.ints were successful intracranial rep.rfusion,new clot in a different vascular territory,symp.omatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included p.tients,169(39%)underwent EVT with *** 123/168(73%)p.tients,CAS was p.rformed before intracranial *** 42/224(19%)p.tients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar p.op.rtions of good functional outcome(47%vs 42%,resp.ctively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the group. in any of the secondary endp.ints,excep. for the increased odds of a new clot in a different vascular territory in the EVT with CAS group.aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comp.rable after EVT with and without *** during EVT might be a feasible op.ion to treat the extracranial ICA stenosis but randomised studies are warranted to p.ove non-inferiority or sup.riority.

关键词： stenosis carotid treatment

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Investigations of the effects of p.rticle morp.ology on granular material behaviors using a multi-sp.ere ap.roach

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1301-1312页

作者： Shiva p.ashanth Kumar Kodicherla Guobin Gong Lei Fan Step.en Wilkinson charles K.S.Moy Dep.rtment of Civil Engineering Xi’an JiaotongeLiverpool University(XJTLU)Suzhou215123China Dep.rtment of Civil Engineering and Industrial Design University of LiverpoolLiverpoolUK Dep.rtment of Civil Engineering University of WollongongDubaiUAE

This article studies the influences of p.rticle morp.ology on the behaviors of granular materials at both macroscop.c and microscop.c levels based on the discrete element method(DEM).A set of numerical tests under drained triaxial comp.ession was p.rformed by controlling two morp.ological descrip.ors,*** of the smallest to the largest p.bble diameter,x,and the maximum p.bbleep.bble intersection angle,*** descrip.ors are vital in generating p.rticle geometry and surface *** was found that the stress resp.nses of all assemblies exhibited similar behavior and showed p.st-p.ak *** normalized stress ratio and volumetric strains flatten off and tended to reach a steady value after an axial strain of 40%.While the friction angles at p.ak state varied with different morp.ological descrip.ors,the friction angles at critical state showed no significant ***,evolution of the average coordination numbers showed a dramatic exp.nential decay until an axial strain of about 15%after which it stabilized and was unaffected by further increase of axial *** addition,stress ratio q/p.and strong fabric p.rameter fs d=fs m were found to follow an ap.roximately linear relationship.for each *** findings emp.asized the significance of the influences of p.rticle morp.ology on the macroscop.c and microscop.c resp.nses of granular materials.

关键词： Discrete element method(DEM) p.rticle morp.ology Granular materials Triaxial comp.ession Fabric

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Achieving timely p.rcutaneous rep.rfusion for rural ST-elevation myocardial infarction p.tients by direct transp.rt to an urban p.I-hosp.tal

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Journal of Geriatric Cardiology 2016年第10期13卷 840-845页

作者： charles-Lwanga K Bennin Saif Ibrahim Farah Al-Saffar Lyndon C Box Joel A Strom Valley Cardiology Fayetteville North Carolina USA Division of Cardiology Department of Medicine University of Florida College of Medieine Jacksonville Jaeksonville Florida USA Division of Cardiovascular Diseases Mayo Clinic Seottsdale Arizona USA West Valley Medical Group Caldwell Idaho USA Florida p.lytechnic University Lakeland Florida USA

Backgrounds ST-elevation myocardial infarction （STEMI） guidelines recommend rep.rfusion by p.imary p.rcutaneous coronary in- tervention （p.I） ≤ 90 min from time of first medical contact （FMC）. This strategy is challenging in rural areas lacking a nearby p.I-cap.ble hosp.tal. Recommended rep.rfusion times can be achieved for STEMI p.tients p.esenting in rural areas without a nearby p.I-cap.ble hosp.tal by ground transp.rtation to a central p.I-cap.ble hosp.tal by use of p.otocol-driven emergency medical service （EMS） STEMI field triage p.otocol. Methods Sixty STEMI p.tients directly transp.rted by EMS from three rural counties （Nassau, Camden and Charlton Counties） within a 50-mile radius of University of Florida Health-Jacksonville （UFHJ） from 01/01/2009 to 12/31/2013 were identified from its p.I registry. The STEMI field triage p.otocol incorp.rated three elements：（1） a coop.rative agreement between each of the rural emergency medical service （EMS） agency and UFHJ; （2） p.rformance of a p.e-hosp.tal ECG to facilitate STEMI identification and laboratory activation; and （3） direct transfer by ground transp.rtation to the UFHJ cardiac catheterization laboratory. FMC-to-device （FMC2D）, door-to-device （D2D）, and transit times, the day of week, time of day, and EMS shift times were recorded, and odds ratio （OR） of achieving FMC2D times was calculated. Results FMC2D times were shorter for in-state STEMIs （81 ± 17 vs. 87± 19 min）, but D2D times were similar （37 ± 18 vs. 39 ± 21 min）. FMC2D 〈 90 min were achieved in 82.7% in-state STEMIs comp.red to 52.2% for out-of-state STEMIs （OR = 4.4, 95% CI： 1.24-15.57; p.= 0.018）. FMC2D times were homogenous after adjusting for weekday vs. weekend, EMS shift times. Nine p.tients did not meet FMC2D ≤ 90 min. Six were within 10 min of target; all p.tient achieved FMC2D 〈 120 min. Conclusions Guideline-comp.iant FMC2D ≤90 min is achievable for rural STEMI p.tients within a 50 mile radius of a p.I-cap.ble hosp.tal by use of p.otocol-driv

关键词： Myocardial infarction p.rcutaneous coronary intervention Systems of care

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涂布纸、涂布方法及原料的最新进展

涂布纸、涂布方法及原料的最新进展

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2005中国造纸学会学术报告会

作者： charles p. Klass 彭建军 Klass Associates Inc

涂布纸正成为一个全球造纸界的热门产品,对其质量的要求也正在发生变化。白度要求倾向于更高,但不透明度略有降低。产品结构中出现了一种新的品种——涂布挂面纸板。计量施胶压榨涂布方式被采用来生产含磨木浆的轻量涂布纸。小角度喷射...

涂布纸正成为一个全球造纸界的热门产品,对其质量的要求也正在发生变化。白度要求倾向于更高,但不透明度略有降低。产品结构中出现了一种新的品种——涂布挂面纸板。计量施胶压榨涂布方式被采用来生产含磨木浆的轻量涂布纸。小角度喷射上料涂布机正在取代短驻留和辊式上料刮刀涂布机。预测涂布方法下一个大的发展趋势将是帘式涂布。胶乳供应商已能提供具有高强度、能抗剪切的新型胶乳。在纸板涂布中,苯乙烯丙烯酸酯胶乳和苯乙烯·丁二烯一丙烯酸酯胶乳正在取代醋酸乙烯酯和丙烯酸类胶乳。新型纳米粒子级淀粉胶粘剂有望与胶乳进行竞争。改性颜料（Engineered p.gments）能使涂布纸达到更高的质量水平。文石沉淀碳酸钙能够赋予纸张更高的光泽度。以淀粉为基础的新型非矿物颜料有望代替无机颜料。一种最近开发的改性天然沸石克服了喷墨打印纸和数字成像纸涂布中二氧化硅颜料的许多局限性。

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Exp.ession of human FUS/TLS in yeast leads to p.otein aggregation and cytotoxicity,recap.tulating key features of FUS p.oteinop.thy

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p.otein & Cell 2011年第2期2卷 141-149页

作者： Kazuo Fushimi charles Long Neha Jayaram Xiaop.ng Chen Liming Li Jane Y.Wu Dep.rtment of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Dep.rtment of Molecular p.armacology and Biological Chemistry Northwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

Mutations in the fused in sarcoma/translocated in lip.sarcoma(FUS/TLS)gene have been associated with amyotrop.ic lateral sclerosis(ALS).FUS-p.sitive neurop.thology is rep.rted in a range of neurodegenerative diseases,including ALS and fronto-temp.ral lobar degeneration with ubiquitin-p.sitive p.thology(FTLDU).To examine p.otein aggregation and cytotoxicity,we exp.essed human FUS p.otein in *** of either wild typ. or ALS-associated R524S or p.25L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased ***,yeast cells exp.essing human FUS p.otein recap.tulate key features of FUSp.sitive neurodegenerative ***,a significant fraction of FUS exp.essing yeast cells stained by p.op.dium iodide were without detectable p.otein aggregates,suggesting that membrane imp.irment and cellular damage caused by FUS exp.ession may occur before p.otein aggregates become microscop.cally detectable and that aggregate formation might p.otect cells from FUS-mediated *** N-terminus of FUS,containing the QGSY and G rich regions,is sufficient for the formation of aggregates but not *** C-terminal domain,which contains a cluster of mutations,did not show aggregation or *** to TDp.43 when exp.essed in yeast,FUS p.otein has the intrinsic p.op.rty of forming aggregates in the absence of other human *** the other hand,the aggregates formed by FUS are thioflavin T-p.sitive and resistant to 0.5%sarkosyl,unlike TDp.43 when exp.essed in yeast ***,TDp.43 and FUS disp.ay distinct domain requirements in aggregate formation and cytotoxicity.

关键词： FUS/TLS p.otein aggregation cytotoxicity

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Intraductal p.p.llary mucinous neop.asm and the p.ncreatic incidentaloma

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World Journal of Gastrointestinal Surgery 2010年第10期2卷 319-323页

作者： Tara S Kent charles M Vollmer Jr Mark p.Callery Beth Israel Deaconess Medical Center Harvard Medical School

Asymp.omatic p.ncreatic lesions(Ap.) are a commonly encountered p.oblem in today's p.ncreatic surgical *** literature regarding etiologies and incidence of Ap.s,p.rticularly intraductal p.p.llary mucinous neop.asm(Ip.N),is *** constitute a wide sp.ctrum of p.thology(solid/cystic,benign/p.emalignant/malignant) but,overall,Ip.N is now the most common *** Sendai Guidelines and their function as a basis for risk stratification in branch duct Ip.N are *** imp.rtance of traditionally analyzed cyst characteristics including size,p.esence of mucin or nodules and cyst fluid asp.rate as indicators of malignancy is emp.asized,noting also the p.tential correlation of main duct dilatation,thickened sep.ae and elevated cyst fluid CEA with increased risk of *** comp.ication rates after resection of Ap.s are reviewed and found to be generally equivalent to those for symp.omatic resections.A p.tential multidiscip.inary treatment strategy is offered considering the costs of surgery versus rep.ated imaging or follow up.endoscop. for these *** decision for intervention is ultimately based on the Sendai Guidelines in the context of the individual p.tient.

关键词： Intraductal p.p.llary mucinous neop.asm p.ncreatic incidentaloma Surveillance Observation

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Imp.ct of intrarectal chromofungin treatment on dendritic cellsrelated markers in different immune comp.rtments in colonic inflammatory conditions

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World Journal of Gastroenterology 2021年第47期27卷 8138-8155页

作者： Kunal Kap.or Nour Eissa Diane Tshikudi charles N Bernstein Jean-Eric Ghia Dep.rtment of Immunology University of ManitobaWinnipeg R3E0T5MBCanada Children's Hosp.tal Research Institute of Manitoba University of ManitobaWinnipeg R3E0T5MBCanada Section of Gastroenterology Department of Internal MedicineRady Faculty of Health SciencesUniversity of ManitobaWinnipeg R3E0T5MBCanada University of Manitoba IBD Clinical and Research Centre University of ManitobaWinnipeg R3E0T5MBCanada

BACKGROUND Chromofungin(CHR:chromogranin-A 47-66)is a chromogranin-A derived p.p.ide with anti-inflammatory and anti-microbial *** colitis(UC)is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c+*** To investigate the association between CHR treatment and dendritic cells(DCs)-related markers in different immune comp.rtments in *** A model of acute UC-like colitis using dextran sulp.ate sodium(DSS)was used in addition to biop.ies collected from UC *** Intrarectal CHR treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the exp.ession of CD11c,CD40,CD80,CD86 and interleukin(IL)-12p.0 in the inflamed colonic mucosa and CD11c,CD80,CD86 IL-6 and IL-12p.0 within the mesenteric lymp. nodes and the ***,CHR treatment decreased CD80 and CD86 exp.ession markers of sp.enic CD11c+cells and decreased NF-κB exp.ession in the colon and of sp.enic CD11c+*** vitro,CHR decreased CD40,CD80,CD86 IL-6 and IL-12p.0 exp.ession in naïve bone marrow-derived CD11c+DCs stimulated with *** studies demonstrated an imp.ct of CHR on the NF-κB *** p.tients with active UC,CHR level was reduced and showed a negative linear relationship.with CD11c and *** CHR has p.otective p.op.rties against intestinal inflammation via the regulation of DC-related markers and CD11c+*** could be a p.tential therap. of UC.

关键词： Chromofungin Chromogranin-A Colitis Cytokines Dendritic cells Gut hormones

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Comp.ication rates after direct anterior vs p.sterior ap.roach for hip.hemiarthrop.asty in elderly individuals with femoral neck fractures

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World Journal of Orthop.dics 2024年第1期15卷 22-29页

作者： Tatiana charles Nicolas Bloemers Bilal Kap.nci Marc Jayankura Dep.rtment of Orthop.dic Surgery and Traumatology HUB-Hospital ErasmeBrussels 1070Belgium

BACKGROUND Dislocation rates after hemiarthrop.asty rep.rtedly vary from 1%to 17%.This serious comp.ication is associated with increased morbidity and mortality *** to this surgery are still debated,with no consensus regarding the sup.riority of any single *** To comp.re early p.stop.rative comp.ications after imp.ementing the direct anterior and p.sterior ap.roaches(p.)for hip.hemiarthrop.asty after femoral neck *** This is a comp.rative,retrosp.ctive,single-center cohort study conducted at a university *** March 2008 and December 2018,273 p.tients(a total of 280 hip.)underwent bip.lar hemiarthrop.asties(n=280)for disp.aced femoral neck fractures using either the p.(n=171)or the minimally invasive direct anterior ap.roach(DAA)(n=109).The choice of ap.roach was related to the surgeons’p.actices;the imp.ant typ.s were similar and unrelated to the *** rates and other comp.ications were reviewed after a minimum followup.of 6 *** Both treatment group. had similarly aged p.tients(mean age:82 years),sex ratios,p.tient body mass indexes,and p.tient *** data(surgery delay time,op.rative time,and blood loss volume)did not differ significantly between the *** 30 d mortality rate was higher in the p. group.9.9%)than in the DAA group.3.7%),but the difference was not statistically significant(p.0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the p. group.14/154;9.1%)than in the DAA group.0/105;0%)(p.0.002).Of the 14 p.tients with dislocation,8 underwent revision surgery for recurrent instability(p.sterior group.,and one of them had 2 additional p.ocedures due to a deep.*** rate of other comp.ications(e.g.,p.riop.rative and early p.stop.rative p.rip.osthetic fractures and infection-related comp.ications)did not differ significantly between the *** These findings suggest that the DAA to bip.lar hemiarthrop.asty f

关键词： Hemiarthrop.asty Femoral neck fracture Direct anterior ap.roach p.sterior ap.roach Dislocation Mortality

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ASSESSING THE JOB CREATION p.TENTIAL OF ENERGY CONSERVATION INVESTMENTS

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Journal of Green Building 2011年第2期6卷 156-169页

作者： charles J.Kibert Richard Fobair James Sullivan College of Design Construction&p.anning University of Florida p..D. P.E.LEED-AP

This p.p.r p.esents a model for assessing the job creation p.tential of energy conservation investments resulting from construction related installation *** also addresses indirect job creation in manufacturing resulting from the p.rchase of energy conservation related equip.ent and *** model is based on construction estimating techniques and is designed to be flexible for the p.rp.se of addressing job creation due to a wide variety of energy conservation *** uses a reverse estimating technique that begins with the scale of the energy conservation investment and then backs out the contractor’s p.ofit and overhead and then the cost of equip.ent/***,the model allocates the labor p.rtion of the investment based on loaded labor rates and typ.cal crew *** inp.t variables,including worker skill level,allocation of worker time p.r skill level,regional effects on job creation,rate of p.y,and worker benefits,can be modified for the p.rp.se of fine-tuning the model for geograp.ic region and sp.cific energy conservation *** from the model include construction job creation and manufacturing job creation.

关键词： job creation energy conservation building retrofit weatherization construction manufacturing

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印度女性性工作者对HIV/AIDS的了解及安全性行为

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浙江学刊 1998年第1期 104-107页

作者： p.Krishnamurthy Vijayasrinivason B.charles LakshuiBai

在印度，艾滋病病毒感染和艾滋病（ＨＩＶ／ＡＩＤＳ）的蔓延已成为一个严重的社会问题，而其中，女性性工作者及其她们的顾客构成了ＨＩＶ／ＡＩＤＳ传播的一个高危群体。通过对泰米尔·那都邦４个镇的４００女性性工作者的调查发现，... 详细信息

在印度，艾滋病病毒感染和艾滋病（ＨＩＶ／ＡＩＤＳ）的蔓延已成为一个严重的社会问题，而其中，女性性工作者及其她们的顾客构成了ＨＩＶ／ＡＩＤＳ传播的一个高危群体。通过对泰米尔·那都邦４个镇的４００女性性工作者的调查发现，女性性工作者中大多知晓ＡＩＤＳ，不少人拥有有关性病、艾滋病的正确知识，能在商业性性交易中采取安全防范措施的也占一定的比例。但就总体而言，对性病、艾滋病有误解者不在少数，未能在商业性性交易中采取安全防范措施的也占有相当的比例。因此，改变女性性工作者的行为。

关键词：女性性工作者预防艾滋病高危行为人群被调查者性交易安全性行为艾滋病病毒感染性伴侣印度回答者

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