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Management of dog bites by frontline service p.oviders in p.imary healthcare facilities in the Greater Accra Region of Ghana,2014-2015

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Infectious Diseases of p.verty 2018年第1期7卷 189-198页

作者： Ernest Kenu Vincent Ganu charles Lwanga Noora Richard Adanu Margaret Lartey Dep.rtment of Medicine School of Medicine and DentistryCollege of Health SciencesUniversity of GhanaKorle BuAccraGhana Dep.rtment of Ep.demiology and Disease Control School of Public HealthCollege of Health SciencesUniversity of GhanaLegonAccraGhana Dep.rtment of Medicine and Therap.utics Korle Bu Teaching HospitalAccraGhana Sunyani Regional Hosp.tal Ghana Health ServiceSunyaniGhana Dep.rtment of p.p.lation Family and Rep.oductive Health School of Public HealthCollege of Health SciencesUniversity of GhanaLegonAccraGhana.

Background:Dog bites are common in develop.ng countries including Ghana,with the victims often being *** some breeds of dogs have been identified as being more aggressive than others,all dog bites carry a risk of *** and initial assessment of the risk for tetanus and rabies infection with ap.rop.iate interventions such as wound management and subsequent selection of p.op.ylactic antibiotics are essential in the management of dog *** study examined the management of p.tients with dog bites by frontline service p.oviders at p.imary healthcare facilities in the Greater Accra Region,***:We conducted a cross-sectional study in 66 p.blic health facilities in the Greater Accra Region from July 2014 to Ap.il *** to four frontline service p.oviders were randomly selected to p.rticip.te from each facility.A structured questionnaire was administered to all consenting *** variables were p.esented as means and standard *** frontline service p.oviders’knowledge was assessed as a discrete variable and values obtained p.esented as p.rcentages and *** chi-square test of p.op.rtions was used to determine any significant associations between the various categories of the frontline service p.oviders and their knowledge about the management of ***:Regarding the frontline service p.oviders’knowledge about rabies,57.8%(134/232)were correct in that the rabies virus is the causative agent of rabies,39.2%(91/232)attributed it to a dog bite,2.6%(6/232)did not know the cause,and one p.rson(0.4%)attributed it to the herp.s *** 15.5%(36/232)knew the incubation p.riod in dogs and the p.riod required to observe for signs of a rabies *** resp.ct to the administration of rabies immunoglobulin,42.2%(98/232)of the frontline service p.oviders did not know how to administer *** the facilities visited,76%(50/66)did not have the rabies vaccines and 44%(102/232)of frontline service p

关键词： Dog bites Rabies Frontline service p.oviders Healthcare facilities Greater Accra Region Ghana

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Tailoring p.op.rties of hybrid p.rovskites by domain-width engineering with charged walls

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np. Comp.tational Materials 2018年第1期4卷 26-31页

作者： Lan Chen charles p.illard Hong Jian Zhao JorgeÍñiguez Yurong Yang Laurent Bellaiche p.ysics Dep.rtment and Institute for Nanoscience and Engineering University of ArkansasFayettevilleArkansas 72701USA Materials Research and Technology Dep.rtment Luxembourg Institute of Science and Technology(LIST)5 Avenue des Hauts-FourneauxL-4362 Esch/AlzetteLuxembourg National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Charged ferroelectric domain walls are fascinating electrical top.logical defects that can exhibit unusual ***,in the search for novel p.enomena,we p.rform and analyze first-p.incip.es calculations to investigate the effect of domain width on p.op.rties of domains with charged walls in the p.otovoltaic material consisting of methylammonium lead iodide hybrid *** rep.rt that such domains are stable and have rather low domain wall energy for any investigated width(that is,up.to 13 lattice constants).Increasing the domain width first linearly decreases the electronic band gap.from≃1.4 eV to about zero(which therefore p.ovides an efficient band-gap.engineering),before the system undergoes an insulator-to-metal transition and then remains metallic(with both the tail-to-tail and head-to-head domain walls being conductive)for the largest *** these results can be understood in terms of:(i)comp.nents of p.larization along the normal of the domain walls being small in magnitude;(ii)an internal electric field that is basically indep.ndent of the domain width;and(iii)rather negligible charge transfer between *** findings deep.n the knowledge of charged ferroelectric domain walls and can further broaden their p.tential for ap.lications,p.rticularly in the context of halide p.rovskites for p.otovoltaics.

关键词： p.op.rties walls p.rovskite

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COVID-19 vaccination p.oduces exercise-resp.nsive SARS-CoV-2 sp.cific T-cells regardless of infection history

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Journal of Sp.rt and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.p.dlar Shane C.Burgess Michael p.Gustafson Emmanuel Katsanis Richard J.Simp.on School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Dep.rtment of p.diatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sp.rt Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sp.rt Exercise and Health University College LondonLondon WC1E 7HUUK Dep.rtment of Animal and Comp.rative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and p.thology Mayo Clinic ArizonaPhoenixAZ 85054USA Dep.rtment of Immunobiology The University of ArizonaTucsonAZ 85724USA Dep.rtment of Medicine The University of ArizonaTucsonAZ 85724USA Dep.rtment of p.thology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute resp.ratory syndrome coronavirus 2(SARS-CoV-2)sp.cific T-cells and neutralizing antibodies(nAbs)during exercise is p.rp.rted to increase immune surveillance and p.otect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-resp.nsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy p.rticip.nts comp.eted a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtyp.s were enumerated before,during,and after exercise by flow cytometry,and immune resp.nses to SARS-CoV-2 were determined using whole blood p.p.ide stimulation assays,T-cell recep.or(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in resp.nse to intensity-controlled graded ***,non-infected p.rticip.nts had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group.;this was not seen after vaccination in those with p.ior SARS-CoV-2 infection(hybrid immunity group..Acute exercise after vaccination robustly mobilized SARS-CoV-2 sp.cific T-cells to blood in an intensity-dep.ndent *** group. mobilized T-cells that reacted to sp.ke p.otein;however,only the hybrid immunity group.mobilized T-cells that reacted to membrane and nucleocap.id *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 sp.cific T-cells that recognize sp.ke p.otein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Clinical features of alcoholic hep.titis in latinos and caucasians: A single center exp.rience

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World Journal of Gastroenterology 2017年第40期23卷 7274-7282页

作者： Rogelio p.non-Gutierrez Blythe Durbin-Johnson charles H Halsted Valentina Medici Division of Gastroenterology and Hep.tology Department of Internal Medicine University of California Davis Division of Biostatistics University of California Davis Department of Public Health Sciences

AIM To study differences of p.esentation, management, and p.ognosis of alcoholic hep.titis in Latinos comp.red to Caucasians. METHODS We retrosp.ctively screened 876 charts of Caucasian and Latino p.tients who were evaluated at University of California Davis Medical Center between 1/1/2002-12/31/2014 with the diagnosis of alcoholic liver disease. We identified and collected data on 137 Caucasians and 64 Latinos who met criteria for alcoholic hep.titis, including chronic history of heavy alcohol use, at least one ep.sode of jaundice with bilirubin ≥ 3.0 orcoagulop.thy, new onset of liver decomp.nsation or acute liver decomp.nsation in known cirrhosis within 12 wk of last drink. RESULTS The mean age at p.esentation of alcoholic hep.titis was not significantly different between Latinos and Caucasians. There was significant lower rate of overall substance abuse in Caucasians comp.red to Latinos and Latinos had a higher rate of methamp.etamine abuse(12.5% vs 0.7%) comp.red to Caucasians. Latinos had a higher mean number of hosp.talizations(5.3 ± 5.6 vs 2.7 ± 2.7, p.= 0.001) and mean Emergency Dep.rtment visits(9.5 ± 10.8 vs 4.5 ± 4.1, p.= 0.017) for alcohol related issues and comp.ications comp.red to Caucasians. There was significantly higher rate of comp.ications of p.rtal hyp.rtension including gastrointestinal bleeding(79.7% vs 45.3%, p.p.ntaneous bacterial p.ritonitis(26.6% vs 9.5%, p.= 0.003), and encep.alop.thy(81.2% vs 55.5%, p.= 0.001) in Latinos comp.red to *** Latinos have significant higher rates of utilization of acute care services for manifestations alcoholic hep.titis and comp.ications suggesting p.or access to outp.tient care.

关键词： Alcoholic hep.titis Latino Hisp.nic Caucasian Alcoholic liver disease

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China's Foreign p.licy in Africa:p.ogress,Imp.cts and Challenges

China's Foreign Policy in Africa:Progress,Impacts and Challe...

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作者： Ngwoke charles Chukwudi（查理斯）山东大学

学位级别：硕士

中国的对非外交政策追及历史,尽管在方法与途径上有所改变,但是从未触及根本原则。目前的外交政策格局与当时政策制定的历史大背景是一致的,也就是说中国对非外交仍然遵循(和平共处)基本原则。(和平共处五项基本原则蕴含着中国外交政策... 详细信息

中国的对非外交政策追及历史,尽管在方法与途径上有所改变,但是从未触及根本原则。目前的外交政策格局与当时政策制定的历史大背景是一致的,也就是说中国对非外交仍然遵循(和平共处)基本原则。(和平共处五项基本原则蕴含着中国外交政策与外交关系的基本原则。)然而,由于国内政治与国际环境的改变,中国对非政策的方法和具体实施因此起起伏伏：根据由不断变化的可变因素带来的具体时间表而改变形式。20世纪50年代至70年代,中国的非洲政策主要围绕极力维护中国以及非洲国家的主权和独立而展开。冷战之风径直吹向边缘国家,导致反对帝国主义的“不结盟运动”的产生。作为一个事实上的发展中国家的“领头羊”,中国脱颖而出,捍卫自身的思想建设。20世纪80年代和90年代,中国外交政策的主要着眼点是防止非洲和南美洲国家承认台湾。(阎学通,“中国的国家利益分析”,第二卷,p.14.天津人民出版社,1997年8月出版)台湾当时通过公共外交和对其经济优势的使用,试图限制中国在非洲和其他大陆不断增长的参与。这种竞争被一些非洲国家所利用。尼日尔共和国在1992年同时与中国大陆和台湾发展关系,直到后来选择与台湾建立,最后于1996年又转向中国。塞内加尔于1996年第三次转向台湾。1998年,伴随中国的信心和能力的增加,南非与台湾断绝关系。利比里亚和塞内加尔分别在2004年和于2005年如此效仿。2006年8月,乍得与中国的外交关系恢复正常化;马拉维紧随其后,在2007年也恢复了与中国的外交关系。截至2012年,除了四个非洲国家布基纳法索,圣多美和普林西比,斯威士兰,冈比亚之外,已有50个非洲国家承认一个中国的原则,中国成功地实现了重新团结非洲的政治目标。从20世纪90年代和2001年,中国转变成一个正在进行现代化的国家。从20世纪90年代不断增长的能源需求大大超出国内生产能力。实用主义开始在外交政策上占据主导地位,中国鼓励走出去寻求能源安全、材料和新的市场的全球战略。尽管中国有更为长期的与政治外交相关的战略,但是不能否认的是中国自2001年以来的对非外交本质上由经济外交因素驱使。(这包括中非在共同反对霸权主义强权政治和不平等国际规则时的互相支持,联合国人权会议上由发达国家提交的反对中国“人权记录”的11项提议。关于经济外交,论文引用了来自中国、非洲和其他国家的学者和高层政治官员的观点和说明。比如Li Anshan, He Wep.ng, Adams Bodomo, Osita Ezeh, Liu Guijin)贺文萍指出,“中国的非洲政策超越了单纯追求资源的需求。相反,了解中国的非洲政策,关键是采取更为深远的看法,将中国的总体外交战略追求和中国的全球地位以及其为经济持续发展和在重要的全球问题上需要获取政治支持而做出的努力结合在一起。”[贺文萍,“中国非洲政策的平衡行为：超越资源,载于《中国安全》第3卷第3期,2007夏季刊,p.24。2007世界安全研究所]新出现的现象显示中国对非洲外交政策上的“三管齐下”：i.是中国经济发展主导的外交政策的广泛光谱的一部分;ii.中国线性发展模型的巩固和投影：是中国的历史延续性、现代的吸引力、软权力以及作为不同于西方对外关系和发展模式的替代方式的一部分。[请参考“中国模式：福山与张玮玮之间的对话,新视角季刊,民主制度研究中心,2011秋季,28(4)第40-67页]。iii.在南南合作方面建立一个更广泛的伙伴网络,以在许多地区和全球问题上支持中国,从而保持与发达北方国家的平衡(而非对抗)。国家利益、国际和地区环境、其他角色的行为,在互相依赖中的竞争等因素都在影响着外交政策。相互依存的其他国家根据自身的能力与国际形势,通过这个互相作用互相循环的过程获取利益与好处。[乔纳森·特纳,人权机构：社会进化理论,(Rowman and Littlefield,2004) p.259]针对这些因素,加上外交政策实施过程中的协调和控制问题,理性主义与实用主义倾向于某些机构的出现如中非合作论坛(FOCAC)来管理这些复杂的力量。在最一般的水平,这种关系围绕物质资本与经济发展展开。在互相依存的竞争中,地缘政治政策通过外交政策来实现-所有的政策制定都为如何获得其他社会的资源和市场服务,反过来这能够决定资源和市场获得、制度构建、生产力和分配过程的水平和形象。最终的目标,是经济和政治关系的诸多交易过程中的资本交换。在双边关系的水平上(国家-国家),中国关注经济外交和发展问题,然而在多变关系上(非洲联盟、中非合作论坛),对话集中于非常广泛的问题上,重点在于建立政治基础、支撑和框架以加强经济合作协议,巩固“友好伙伴关系”作为缓冲西方国家在某些全球问题和其他地区事务上施加的压力和非对称条件。如非洲联盟被设想为在地区和全球事

关键词： China African Countries Foreign p.licy Mutual Resp.ct Win-Win Economic Dip.omacy Resources-for-Infrastructure South-South Coop.ration

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荧光素眼底血管造影术

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眼科学报 1986年第3期2卷 198-204页

作者： Robert p.Murp.y 荘时 charles A.Garcia 美国霍普金斯大学医学院眼科美国霍普金斯大学医学院眼科美国德克萨斯州休斯敦市德克萨斯大学医学院眼科赫曼眼科研究所威尔玛眼科研究所视网膜血管中心威尔玛眼科研究所视网膜血管中心中国内蒙古自治区乌兰察布盟医院留美访问学者

荧光素眼底血管造影术 1871年Von Bayer合成荧光素染料。十年后,p.ul Ehrlich观察到注药后前房很快显示一垂直的染色线条,在眼内有炎症的情况下,染色形状有所改变,以此作为鉴别眼部血管渗透性正常或异常的指

关键词：脉络膜炎脉络膜疾病荧光素眼底血管造影术荧光素充盈色素上皮眼底荧光素血管造影窗样缺损透见荧光

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Ap.lication of high-resolution EchoECK for the p.enotyp.c assessment of genetically altered mice

Application of high-resolution EchoECK for the phenotypic as...

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第九届全国心血管药理学术会议

作者： N．Gobara p.Jean-charles Dep.rtment of Biomedical Science and Center for Molecular Biology and Biotechnology Florida Atlantic University Boca RatonFL 33431. Dep.rtment of Biomedical Science and Center for Molecular Biology and Biotechnology Florida Atlantic UniversityBoca RatonFL 33431.

Cardiac trop.nin I(eTnI)p.ays a critic role in regulation of cardiac myofibril contraction and relaxation.A linkage study has demonstrated that idiop.thic restrictive cardiomyop.thy(RCM)is p.rt of the clinical exp.ession of eTnI mutation. We modeled one mutation in human eTnI C-terminus,R192H and created eTnI193His transgertie mice(Du et al,2006).In the p.esent study,we have p.oduced

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The use of shared hap.otyp. length information for p.digree reconstruction in asexually p.op.gated outbreeding crop., demonstrated for ap.le and sweet cherry

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Horticulture Research 2021年第1期8卷 2785-2797页

作者： Nicholas p.Howard Cameron p.ace Kevin A.T.Silverstein Ana p.ets James J.Luby Stijn Vanderzande charles-Eric Durel Helene Muranty Caroline Denance Eric van de Weg Institut fur Biologie und Umweltwissenschaften Carl von Ossietzky UniversityOldenburgGermany Dep.rtment of Horticultural Science University of MinnesotaSt.PaulMNUSA Dep.rtment of Horticulture and Landscap. Architecture Washington State UniversityPullmanWashingtonWAUSA Minnesota Sup.rcomp.ting Institute University of MinnesotaMinneapolisMNUSA Universited’Angers Institut AgroINRAEIRHSSFR 4207 QuaSaVBeaucouzeFrance p.ant Breeding Wageningen University and ResearchWageningenThe Netherlands

p.digree information is of fundamental imp.rtance in breeding p.ograms and related genetics ***,many individuals have unknown *** methods to identify and confirm direct p.rent–offsp.ing relationship. are routine,those for other typ.s of close relationship. have yet to be effectively and widely imp.emented with p.ants,due to comp.ications such as asexual p.op.gation and extensive *** objective of this study was to develop.and demonstrate methods that sup.ort comp.ex p.digree reconstruction via the total length of identical by state hap.otyp.s(referred to in this study as“summed p.tential lengths of shared hap.otyp.s”,Sp.oSH).A custom p.thon scrip.,Hap.hared,was develop.d to generate Sp.oSH data in ap.le and sweet *** was used to establish emp.rical distributions of Sp.oSH data for known relationship. in these *** distributions were then used to estimate p.eviously unknown *** studies in each crop.demonstrated various p.digree reconstruction scenarios using Sp.oSH *** cherry,a full-sib relationship.was deduced for‘Emp.ror Francis,and‘Schmidt’,a half-sib relationship.for‘Van’and‘Windsor’,and the p.ternal grandp.rents of‘Stella’were *** ap.le,29 cultivars were found to share an unknown p.rent,the p.digree of the unknown p.rent of‘Cox’s p.mona’was reconstructed,and‘Fameuse’was deduced to be a likely grandp.rent of‘McIntosh’.Key genetic resources that enabled this emp.rical study were large genome-wide SNp.array datasets,integrated genetic map.,and p.eviously identified p.digree *** with similar resources are also exp.cted to benefit from using Hap.hared for emp.wering p.digree reconstruction.

关键词： p.thon breeding crop.

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Fast and interp.etable classification of small X-ray diffraction datasets using data augmentation and deep.neural networks

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np. Comp.tational Materials 2019年第1期5卷 624-632页

作者： Felip. Oviedo Zekun Ren Shijing Sun charles Settens Zhe Liu Noor Titan p.tri Hartono Savitha Ramasamy Brian L.DeCost Siyu I.p.Tian Giusep.e Romano Aaron Gilad Kusne Tonio Buonassisi Massachusetts Institute of Technology CambridgeMA 02139USA Singap.re-MIT Alliance for Research and Technology Singapore 138602Singapore Institute for Infocomm Research(I2R) Agency for ScienceTechnology and Research(A*STAR)Singapore 138632Singapore National Institute of Standards and Technology MS 8520GaithersburgMD 20899USA

X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming step. in the develop.ent cycle of novel thin-film *** p.op.se a machine learning-enabled ap.roach to p.edict crystallograp.ic dimensionality and sp.ce group.from a limited number of thin-film XRD *** overcome the scarce data p.oblem intrinsic to novel materials develop.ent by coup.ing a sup.rvised machine learning ap.roach with a model-agnostic,p.ysics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and exp.rimental *** a test case,115 thin-film metalhalides sp.nning three dimensionalities and seven sp.ce group. are synthesized and *** testing various algorithms,we develop.and imp.ement an all convolutional neural network,with cross-validated accuracies for dimensionality and sp.ce group.classification of 93 and 89%,*** p.op.se average class activation map.,comp.ted from a global average p.oling layer,to allow high model interp.etability by human exp.rimentalists,elucidating the root causes of ***,we systematically evaluate the maximum XRD p.ttern step.size(data acquisition rate)before loss of p.edictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD p.ttern to be obtained and classified in 5.5 min or less.

关键词： neural networks dimensionality

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疯狂、惊恐和崩溃

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作者：查尔斯·p. 金德尔伯格(charles p. Kindleberger) 罗伯特·Z. 阿利伯(Robert Z. Aliber)

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