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^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy

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Cancer Biology & Medicine 2019年第1期16卷 157-165页

作者： Janice S.H.Tan charles x.y.goh yen Sin Koh youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua Division of Radiation Oncology National Cancer Centre Singapore Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Radiological Sciences Academic Clinical Programme Duke-NUS Medical School Oncology Academic Clinical Programme Duke-NUS Medical School Department of Urology Singapore General Hospital Department of Surgery Sengkang General Hospital Division of Medical Oncology National Cancer Centre Singapore Division of Medical Sciences National Cancer Centre Singapore

Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian *** is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad ***: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with ***: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT ***: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(ymetastatic disease.

关键词： ^68Ga PSMA PET/CT prostate cancer Asian diagnostic recurrence prostatectomy salvage radiotherapy

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Deep learning framework for material design space exploration using active transfer learning and data augmentation

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npj Computational Materials 2021年第1期7卷 1261-1267页

作者： yongtae Kim youngsoo Kim charles yang Kundo Park Grace x.Gu Seunghwa Ryu Department of Mechanical Engineering&KI for the NanoCentury Korea Advanced Institute of Science and Technology(KAIST)Yuseong-guDaejeonRepublic of Korea Department of Nature-Inspired System and Application Korea Institute of Machinery and MaterialsDaejeonRepublic of Korea Department of Mechanical Engineering University of CaliforniaBerkeleyCAUSA

Neural network-based generative models have been actively investigated as an inverse design method for finding novel materials in a vast design ***,the applicability of conventional generative models is limited because they cannot access data outside the range of training *** generative models that were devised to overcome the limitation also suffer from the weak predictive power on the unseen *** this study,we propose a deep neural network-based forward design approach that enables an efficient search for superior materials far beyond the domain of the initial training *** approach compensates for the weak predictive power of neural networks on an unseen domain through gradual updates of the neural network with active transfer learning and data augmentation *** demonstrate the potential of our framework with a grid composite optimization problem that has an astronomical number of possible design *** show that our proposed framework can provide excellent designs close to the global optima,even with the addition of a very small dataset corresponding to less than 0.5%of the initial training dataset size.

关键词： neural Deep network

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Tag recommendation for open source software

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Frontiers of Computer Science 2014年第1期8卷 69-82页

作者： Tao WANG Huaimin WANG Gang yIN charles x. LING xiao LI Peng ZOU National Laboratory for Parallel and Distributed Processing College of Computer Department of Computer Science The University of Western Ontario London N6A5B7 Canada Academy of Equipment Beijing 101400 China

Nowadays open source software becomes highly popular and is of great importance for most software engi- neering activities. To facilitate software organization and re- trieval, tagging is extensively used in open source communi- ties. However, finding the desired software through tags in these communities such as Freecode and ohloh is still chal- lenging because of tag insufficiency. In this paper, we propose TRG （tag recommendation based on semantic graph）, a novel approach to discovering and enriching tags of open source software. Firstly, we propose a semantic graph to model the semantic correlations between tags and the words in software descriptions. Then based on the graph, we design an effec- tive algorithm to recommend tags for software. With com- prehensive experiments on large-scale open source software datasets by comparing with several typical related works, we demonstrate the effectiveness and efficiency of our method in recommending proper tags.

关键词： open source software semantic graph tag rec-ommendation

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Assessment of physically-based and data-driven models to predict microbial water quality in open channels

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Journal of Environmental Sciences 2010年第6期22卷 851-857页

作者： Minyoung Kim charles P.Gerba Christopher y.Choi Agricultural Safety Engineering Division Department of Agricultural EngineeringNational Academy of Agricultural ScienceRural Development Administration(Korea) Department of Soil Waterand Environmental Sciencethe University of Arizona Department of Agricultural and Biosystems Engineering the University of Arizona

In the present study, a physically-based hydraulic modeling tool and a data-driven approach using artificial neural networks （ANNs） were evaluated for their ability to simulate the fate and transport of microorganisms in a water system. To produce reliable data, a pipe network was constructed and a series of experiments using a fecal coliform indicator （Escherichia coli 15597） was conducted. For the physically-based model, morphological （pipe size, link length, slope, etc.） and hydraulic （flow rate） conditions were used as input variables, and for ANNs, water quality parameters （conductivity, pH, and turbidity） were used. Both approaches accurately described the fate and transport of microorganisms （physically-based model： correlation coefficient （R） in the range of 0.914 - 0.977 and ANNs： R in the range of 0.949 - 0.980）, with the exception of one case at a low flow rate （q = 31.56 cm^3/sec）. This study also indicated that these approaches could be complementarily utilized to assess the vulnerability of water facilities and to establish emergency plans based on hypothetical scenarios.

关键词： transport open channel artificial neural networks Escherichia coli

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David Jones and charles Olson in Time and Space

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Journal of Foreign Languages and Cultures 2020年第2期4卷 104-113页

作者： charles Alexander Chax Press/University of Houston-Victoria

David Jones and charles Olson concern themselves with large issues of space and time,and how humans are entwined with *** essay seeks to show that Olson's project of space and Jones's with time are very much of the same mettle,that both poems offer a kind of transcendence of one-dimensionality,that time expands to become space,and that,in space,one is confronted with the presence of all time as a *** essay addresses Jones's The Anathemata and a few of his maps and paintings,as well as Olson's Maximus Poems,particularly its visual/spatial poetics.

关键词： time space history map geography

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基于进化规划的新型生物地理学优化算法研究

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系统工程理论与实践 2010年第6期30卷 1106-1112页

作者：蔡之华龚文引 LING charles-x 中国地质大学(武汉)计算机学院武汉430074 西安大略大学计算机系

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜... 详细信息

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜索性与利用性的平衡.通过13个高维标准测试函数对算法进行测试,验证了新算法的有效性.与基本生物地理学优化算法和两种经典的进化规划算法进行比较,结果表明新算法优于所比较的三种算法.此外,新算法在收敛速度上优于基本生物地理学优化算法.

关键词：生物地理学优化进化规划全局优化混合算法实数编码

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Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy

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Protein & Cell 2011年第2期2卷 141-149页

作者： Kazuo Fushimi charles Long Neha Jayaram xiaoping Chen Liming Li Jane y.Wu Department of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Department of Molecular Pharmacology and Biological Chemistry Northwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in *** of either wild type or ALS-associated R524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased ***,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative ***,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated *** N-terminus of FUS,containing the QGSy and G rich regions,is sufficient for the formation of aggregates but not *** C-terminal domain,which contains a cluster of mutations,did not show aggregation or *** to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human *** the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast ***,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity.

关键词： FUS/TLS protein aggregation cytotoxicity

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Best practices for model-based and simulation-aided engineering of power transmission and motion control systems

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Chinese Journal of Aeronautics 2019年第1期32卷 186-199页

作者： Jean-charles MARE Institut Clément Ader (CNRS UMR 5312)

This paper deals with the modelling and simulation of aircraft systems, in particular for power transmission and control. It is intended to review, propose and disseminate best practices for making model-based/simulation-aided engineering more efficient at any phase of the system life cycle. The proposals are aimed at creating value, not only by increasing the performance of the product under study but also by shortening the time to market, capitalizing knowledge, mitigating risks and facilitating concurrent engineering. The needs associated with the engineering activities are firstly identified to define a set of requirements for the models. Then, these requirements are used to drive the considerations leading to model development, focusing in particular on the process,modelled physical effects, modelling level, model architecting and concurrent engineering. The third part deals with the model implementation, giving special consideration to the different types of models, causalities, parameterization, implementation and verification. Each part is illustrated by examples related to safety critical actuators.

关键词： Actuator Aerospace Architecture Causality Modelling Motion control Power transmission Simulation

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Gottfried Konecny:the ambassador of photogrammetry and remote sensing for 75 years

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Geo-Spatial Information Science 2021年第1期24卷 27-32,I0006页

作者： charles K.Toth Department of Civil Environmental and Geodetic EngineeringThe Ohio State UniversityColumbusOHUSA

A 90th birthday would be a milestone celebration for any person,but exceptionally rare if the person is still active after 75 years of working and serving the photogrammetric and remote sensing communities *** unprecedented career is the motivation to reflect on the technological developments of the past 75 years in the light of Gottfried Konecny’s lifetime achievements.I started to get to know Gottfried not long before he officially retired from the Institute for Photogrammetry and Engineering Surveys in ***,I was not even born when he,as a young and talented scholar supported by the Fulbright Scholarship from the US Government,arrived at the Ohio State University(OSU),which has been my professional home for three *** the second half of Gottfried’s 75-year career,the technological changes have been phenomenal,and,furthermore,shown an accelerating trend in the past few *** is absolutely remarkable how Gottfried has been able to keep up with these rapid changes and advancing technologies and exploits them for mapping and,in general,for all the users of the geospatial field at ***,his open-minded and kind personality has been always a major plus to his technical skills and experiences,and ultimately helped him assist many colleagues to advance their careers,and along the way developed and increased the use of geospatial data and systems in support of many countries worldwide.

关键词： Photogrammetry remote sensing space observation

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Thick Film Circuit Materials

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功能材料 1992年第5期 265-269页

作者： charles C.y.Kuo CTS Corporation 7 Swanson Manor Elkhart IN 46516 USA 本刊通讯编委 7 Swanson Manor Elkhart IN 46516 USA

THICK FILM CIRCUITS most commonly involve the screen printing process of forming a functional composition through a patterned mesh screen onto *** ceramics. The printed film is dried and fired, typically in the range of 500 to 900 ℃ (930 to 1650°F) to sinter the film and adhere it ro the substrate with the desired characteristics for circuit applications. The functional compositions in general include conductors, resistors, and dielectrics. The dielectrics may be used as overglazes, crossovers, capacitors, or multilayers. The term thick film originated from the term thin film. Thin films are deposited by vacuum technology, either by evaporation or sputtering. In the early 1960s, the Bell Tele-

关键词： high

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