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High efficacy of chlorfenapyr-based net Interceptor■G2 against pyrethroid-resistant malaria vectors from Cameroon

Infectious Diseases of Poverty 2023年第4期12卷 1-16页

作者： Magellan Tchouakui Riccado F.Thiomela Elysee Nchoutpouen Benjamin D.Menze Cyrille Ndo Dorothy Achu Raymond N.Tabue Flobert Njiokou Ateba Joel charles s.wondji Centre for Research in Infectious Diseases(CRID) P.O.Box 13501YaoundéCameroon Department of Animal Biology and Physiology Faculty of ScienceUniversity of Yaoundé1P.O.Box 812YaoundéCameroon Department of Biological sciences Faculty of Medicine and Pharmaceutical SciencesUniversity of DoualaP.O.Box 24157DoualaCameroon Ministry of Public Health National Malaria Control ProgrammeP.O.Box 14386YaoundeCameroon Department of Vector Biology Liverpool School of Tropical MedicinePembroke PlaceLiverpoolL35QAUK International Institute of Tropical Agriculture(IITA) P.O.Box 2008YaoundéCameroon

Background The increasing reports of resistance to pyrethroid insecticides associated with reduced efficacy of pyrethroid-only interventions highlight the urgency of introducing new non-pyrethroid-only control ***,we investigated the performance of piperonyl-butoxide(PBO)-pyrethroid[Permanet 3.0(P3.0)]and dual active ingredients(AI)nets[Interceptor G2(IG2):containing pyrethroids and chlorfenapyr and Royal Guard(RG):containing pyrethroids and pyriproxyfen]compared to pyrethroid-only net Royal sentry(Rs)against pyrethroid-resistant malaria vectors in *** The efficacy of these tools was firstly evaluated onAnopheles gambiae *** funestus *** Gounougou,Mibellon,Mangoum,Nkolondom,and Elende using cone/tunnel *** addition,experimental hut trials(EHT)were performed to evaluate the performance of unwashed and 20 times washed nets in semi-field ***,pyrethroid-resistant markers were genotyped in dead vs alive,blood-fed vs unfed mosquitoes after exposure to the nets to evaluate the impact of these markers on net *** XLsTAT software was used to calculate the various entomological outcomes and the Chi-square test was used to compare the efficacy of various *** odds ratio and Fisher exact test were then used to establish the statistical significance of any association between insecticide resistance markers and bed net *** Interceptor G2 was the most effective net against wild *** followed by Permanet *** EHT,this net induced up to 87.8%mortality[95%confidence interval(CI):83.5-92.1%)and 55.6%(95%CI:48.5-62.7%)after 20 washes whilst unwashed pyrethroid-only net(Royal sentry)killed just 18.2%(95%CI:13.4-22.9%)of *** unwashed Permanet 3.0 killed up to 53.8%(95%CI:44.3-63.4%)of field-resistant mosquitoes and 47.2%(95%CI:37.7-56.7%)when washed 20 times,and the Royal Guard 13.2%(95%CI:9.0-17.3%)for unwashed net and 8.5%(95%CI:5.7-11.4%)for t

关键词： Malaria Anopheles Insecticide resistance Dual active ingredient nets Interceptor G2

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Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa

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Infectious Diseases of Poverty 2022年第2期11卷 23-31页

作者： Magellan Tchouakui Tatiane Assatse Leon M.J.Mugenzi Benjamin D.Menze Daniel Nguifo-Nguete Williams Tchapga Jonathan Kayondo Francis Watsenga Emile Zola Manzambi Michael Osae charles s.wondji Centre for Research in Infectious Diseases(CRID) P.O.Box 13501YaoundeCameroon Parasitology and Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaounde 1P.O.Box 812YaoundeCameroon Institut National de Recherche Biomedicale KinshasaDemocratic Republic of Congo Radiation Entomology and Pest Management Centre Biotechnology and Nuclear Agriculture Research InstituteGhana Atomic Energy CommissionP.O.Box LG80Legon-AccraGhana Department of Vector Biology Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK International Institute of Tropical Agriculture(IITA) P.O.Box 2008YaoundeCameroon Entomology Department Uganda Virus Research Institute(UVRI)P.O.Box 49EntebbeUganda.

Background:New insecticides with a novel mode of action such as neonicotinoids have recently been recommended for public health by *** monitoring of such novel insecticides requires a robust protocol to monitor the development of resistance in natural *** this study,we comparatively used three different solvents to assess the susceptibility of malaria vectors to neonicotinoids across ***:Mosquitoes were collected from May to July 2021 from three agricultural settings in Cameroon(Njombe-Penja,Nkolondom,and Mangoum),the Democratic Republic of Congo(Ndjili-Brasserie),Ghana(Obuasi),and Uganda(Mayuge).Using the CDC bottle test,we compared the effect of three different solvents(ethanol,acetone,MERO)on the efficacy of neonicotinoids againstAnopheles gambiae *** addition,TaqMan assays were used to genotype key pyrethroid-resistant markers *** and odds ratio based on Fisher exact test were used to evaluate potential cross-resistance between pyrethroids and ***:Lower mortality was observed when using absolute ethanol or acetone alone as solvent for clothianidin(11.4-51.9% mortality in Nkolondom,31.7-48.2% in Mangoum,34.6-56.1% in Mayuge,39.4-45.6% in Obuasi,83.7-89.3% in Congo and 71.1-95.9% in Njombe pendja)compared to acetone+MERO for which 100% mortality were observed for all the *** observations were done for imidacloprid and *** assays(PBO,DEM and DEF)with clothianidin revealed a significant increase of mortality suggesting that metabolic resistance mechanisms are contributing to the reduced susceptibility.A negative association was observed between the L1014F-kdr mutation and clothianidin resistance with a greater frequency of homozygote resistant mosquitoes among the dead than among survivors(OR=0.5;P=0.02).However,the I114T-GsTe2 was in contrast significantly associated with a greater ability to survive clothianidin with a higher frequency of homozygote resistant among surv

关键词： Malaria Anopheles Insecticide resistance Neonicotinoids Clothianidin Cross-resistance

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High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic

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Infectious Diseases of Poverty 2019年第6期8卷 39-50页

作者： sulaiman s.Ibrahim Amen N.Fadel Magellan Tchouakui Ebai Terence Murielle J.wondji Micareme Tchoupo Clement Kerah-Hinzoumbe samuel Wanji charles s.wondji Vector Biology Department Liverpool School of Tropical Medicine(LSTM)Liverpool L35 QAUK Department of Biochemistry Bayero UniversityKano PMB 3011Nigeria Centre for Research in Infectious Diseases(CRID) LSTM Research UnitP.O.Box 13591YaoundeCameroon Department of Microbiology and Parasitology University of BueaP.O.Box 63BueaCameroon National Malaria Control Program P.O.Box 2030N'djamenaChad

Background:The sahel region of Chad Republic is a prime candidate for malaria *** facilitate preelimination efforts in this region,two populations o f A nopheles coluzzii from Central Chad Republic were characterized,their insecticide resistance profile and the possible molecular mechanisms driving the resistance in the field ***:Bloodfed female Anopheles gom biae *** indoor,were collected at N'djamena and Massakory,Chad in 2018 and characterized for species composition,and infection rate was determined using the TaqMan *** to various insecticides was assessed using WHO tube *** bioassays were conducted using various long-lasting insecticidal nets(LLINs).Results were analysed using Chi square *** resistance(kdr)and ace-1 markers were investigated by TaqMan ***:Anopheles coluzzi was the major vector found in N’djamena(100%)and Massakory(〜94%).N〇Plasm odium was found in 147 bloodfed F0 ***(82 from N'djamena and 65 from Massakory).High intensity pyrethroid resistance was observed with mortalities ofsure to 10x diagnostic doses of deltamethrin and permethrin,*** both sites,s were observed with *** bioassays with piperonylbutoxide significantly recovered pyrethroid susceptibility in Massakory populations,implicating CYP450s(mortality=13.6%for permethrin,X^2=22.8,df=1,P=0.0006;mortality=13.0%for deltamethrin,x2:8.8,df=1,Pssays established complete loss of efficacy of the pyrethroid-based LLINs;and a 100%recovery of susceptibility following exposure to the roof of PermaNet®3.0/containing *** populations were susceptible to malathion,but high bendiocarb resistance was observed in Massakory *** absence o f a ce-1 mutation points to the role of metabolic resistance in the bendiocarb *** 1014F and

关键词： Anopheles coluzzii Malaria sahel Chad Insecticide Resistance Metabolic Kdr

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First detection of F1534C knockdown resistance mutation in Aedes aegypti(Diptera:Culicidae)from Cameroon

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Infectious Diseases of Poverty 2020年第6期9卷 51-62页

作者： Aurelie P.Yougang Basile Kamgang Theodel A.Wilson Bahun Armel N.Tedjou Daniel Nguiffo-Nguete Flobert Njiokou charles s.wondji Centre for Research in Infectious Diseases P.O.Box 13591YaoundéCameroon Parasitology and Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé1P.O.Box 812YaoundéCameroon Laboratory of Vertebrate and Invertebrate Bioecology Faculty of Science and TechnologyMarien-Ngouabi UniversityBrazzavilleCongo Laboratory of Biology and Applied Ecology Department of Animal BiologyFaculty of ScienceUniversity of DschangP.O.Box 96DschangCameroon Liverpool school of Tropical Medicine Pembroke placeLiverpoolL35QAUK

Background: Aedes borne viral diseases,notably dengue,are increasingly reported in Cameroon with Aedes aegypti being a major *** on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in ***,we present the nationwide distribution of insecticide resistance in *** and investigate the potential resistance mechanisms ***:: Immature stages of *** were collected between March and July 2017 in 13 locations across Cameroon and reared until G1/G2/G3 ***,adult bioassays,and piperonyl butoxide(PBO)synergist assays were carried out according to World Health Organization guidelines.F1534C mutation was genotyped using allele specific polymerase chain reaction in field collected adults(Go)and the polymorphism of the sodium channel gene was ***χ2 test was used to compare the mortality rate between bioassays with insecticides only and bioassays after preexposure to PBO ***: Larval bioassay revealed that all the three populations tested with temephos were *** bioassays showed a good level of susceptibility toward both pyrethroids tested,0.25%permethrin and 0.05%deltamethrin,with six out of 10 populations ***,two populations(Douala and Edéa)were resistant(deltamethrin[73.2–92.5%mortality],permethrin[2.6–76.3%mortality]).The resistance to 4%dichlorodiphenyltrichloroethane was observed in four out of 10 populations tested(16.8–87.1%mortality).Resistance was also reported to carbamates including 0.1%propoxur(60.8–87.1%mortality)and to 0.1%bendiocarb(82.9%mortality).All populations tested were fully susceptible to 1%fenitrothion.A partial recovery of susceptibility was observed in the pyrethroid resistant population of Douala after pre-exposed to PBO suggesting the implication of cytochrome P450 monoxygenases permethrin *** and sequencing detected the F1534C kdr mutation in the two pyrethroid resistant

关键词： Aedes aegypti Insecticide resistance Kdr mutation Cameroon Arbovirus

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Contrasting resistance patterns to type Ⅰ and Ⅱ pyrethroids in two major arbovirus vectors Aedes aegypti and Aedes albopictus in the Republic of the Congo, Central Africa

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Infectious Diseases of Poverty 2020年第2期9卷 95-95页

作者： Basile Kamgang Theodel A.Wilson-Bahun Aurelie P.Yougang Arsene Lenga charles s.wondji Centre for Research in Infeaious Diseases Department of Medical EntomologyPO Box 15391YaoundeCameroon 不详

Background:In the Republic of Congo,with two massive outbreaks of chikungunya observed this decade,little is known about the insecticide resistance profile of the two major arbovirus vectors Aedes aegypti and Aedes ***,we established the resistance profile of both species to insecticides and explored the resistance mechanisms to help Congo to better prepare for future ***:Immature stages o f *** and *** were sampled in May 2017 in eight cities of the Republic of the Congo and reared to adult *** and adult bioassays,and synergist(piperonyl butoxide[PBO])assays were carried out according to WHO guidelines.F1534C mutation was genotyped in field collected adults in both species and the polymorphism of the sodium channel gene assessed in ***:All tested populations were susceptible to temephos after larval bioassays.A high resistance level was observed to 4%DDT in both species countrywide(21.9-88.3% mortality).All but one population(*** from Ngo)exhibited resistance to type I pyrethroid,permethrin,but showed a full susceptibility to type II pyrethroid(deltamethrin)in almost all *** was also reported to 1% propoxur in *** likewise in two *** populations(Owando and Ouesso),and the remaining were fully *** populations of both species were fully susceptible to 1%fenitrothion.A full recovery of susceptibility was observed in *** and *** when pre-exposed to PBO and then to propoxur and permethrin *** F1534C kdr mutation was not detected in either *** high genetic variability of the portion of sodium channel spanning the F1534C in *** further supported that knockdown resistance probably play no role in the permethrin ***:Our study showed that both Aedes species were susceptible to organophosphates(temephos and fenitrothion),while for other insecticide classes tested the profile of resistance vary a

关键词： Aedes oegypti Aedes albopictus Insecticide resistance Resistance mechanism Republic of the Congo

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： charles H.Nelson Udai B.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease sMN complex

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Governance in the exploration of global and regional determinants of ICT development

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International Journal of Innovation studies 2024年第2期8卷 132-153页

作者： charles s.saba simplice A.Asongu Nicholas Ngepah Yolande E.Ngoungou school of Economics College of Business and EconomicsUniversity of JohannesburgJohannesburgSouth Africa Department of Econornic&Data science New Uzbekistan University54 Mustaili AvenueTashkent100007Uzbekistan University of Yaounde 2 SoaCameroon

The present study assesses how governance affects information and communication technology(IcT)at the global level contingent on macroeconomic policy factors such as trade,foreign direct investment(FDI),manufacturing value added,and agricultural value *** study focuses on 183 countries from 2003 to 2021,and the empirical evidence is based on the generalized method of moments(GMM).The following main findings are *** the full sample,governance unconditionally promotes ICT development,while trade openness(industrial added value)moderates governance to promote(dampen)ICT *** sub-saharan Africa,only trade openness effectively moderates governance to induce an overall positive effect on ICT,while in the Middle East and North Africa(MENA)region,all policy variables moderate governance for an overall positive incidence on ICT sector *** findings for the MENA region are confirmed in the Europe and Central Asia(ECA)region,with the exception of the moderating role of industrial added value,which engenders an overall negative *** the East and south Asia and the Pacific(EsAP)countries,one overall positive incidence is apparent in the role of trade openness,while net negative effects are established from the moderating roles of industrial added value and agricultural added *** the American sub-sample,a positive(negative)net effect is apparent from the role of industrial added value(trade)in moderating the incidence of gover-nance on ICT sector ***,policy implications are discussed.

关键词： ICT Governance Trade FDI Industry Agriculture

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New evidence for the epigenetic regulation of skeletal stem cells

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science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao charles K.F.Chan Institute for stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

skeletal stem cells(ssCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of ssCs,highlighting the involvement of Ptip in regulating ssC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(ssCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MsCs).

关键词： skeletal involvement maintain

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William Morris,Establishing the Foundation for the Advancement of TCM in the Us

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Chinese Medicine and Culture 2024年第1期7卷 29-40页

作者： Ioannis solos charles Buck William Morris saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Graduate school of Integrative Medicine Austin 78745the United States of America

The interview was conducted on March 2nd, 2023 by Ioannis solos and charles Buck. William Morris has sustained practice since 1980. He has served on the California, Texas and Massachusetts Professional Associations, as well as the National Association. He has tendered 20 years of service to the field through academic medicine, earning a master’s degree in medical education to assist in developing Chinese medical doctoral programs and institutional review boards. He earned an OM.D. in 1988, a DAOM in 2002, and a Ph.D. focused on pulse diagnosis as clinical epistemology in 2009. He has published five books, including TCM Case studies Dermatology, Li shi-zhen Pulse studies: An Illustrated Guide, Neoclassical Pulse Diagnosis, Cycles in Medical Astrology, and Transformation: Treating Trauma with Acupuncture and Herbs.

关键词： Acupuncture sustained diagnosis

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A Conversation with Professor Ted Kaptchuk,a Key Architect of Modern TCM in the West

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Chinese Medicine and Culture 2024年第1期7卷 5-18页

作者： Ioannis solos charles Buck Ted Kaptchuk saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom Harvard Medical school Boston 02115the United States of America

The interview was conducted on November 20th,2022 by Ioannis solos and charles *** Kaptchuk(泰开阳)is a Professor of Medicine and a Professor of Global Health&social Medicine at Harvard Medical *** 1975,he graduated from the Macao Institute of Chinese Medicine,Macao,*** returning to the West,Ted taught Chinese medicine throughout the states,Europe,Latin America,and ***’s book,The Web that Has No Weaver:Understanding Chinese Medicine is a groundbreaking explanation of East Asian medicine that continues to shape the discourse of the Chinese medicine profession in the West and has been translated into 13 *** 1990,Ted was recruited in Harvard Medical school to help research Chinese *** encountering high placebo responses in multiple acupuncture clinical trials,Ted decided to switch his career to primarily studying *** has published over 300 peer-reviewed *** has been awarded the Lifetime Achievement Award from the society of Acupuncture Research(2015),the Lifetime Achievement Award from the society for Interdisciplinary Placebo studies(2021),and the William silen Lifetime Achievement Award in Mentoring from Harvard Medical school(2022).

关键词： Acupuncture acupuncture TCM

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