检索结果-南通市图书馆

Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection

World Journal of Stem Cells 2021年第9期13卷 1248-1277页

作者： Quang Le Vedavathi Madhu Joseph M Hart charles r Farber Eli r Zunder Abhijit S Dighe Quanjun Cui Department of Orthopaedic Surgery University of Virginia School of MedicineCharlottesvilleVA 22908United States Orthopaedic Surgery research Thomas Jefferson UniversityPhiladelphiaPA 19107United States Center for Public Health Genomics University of VirginiaCharlottesvilleVA 22908United States Departments of Public Health Sciences and Biochemistry and Molecular Genetics University of VirginiaCharlottesvilleVA 22908United States Department of Biomedical Engineering University of VirginiaCharlottesvilleVA 22908United States

Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-Dr- is beinginvestigated as an attractive therapy for bone regeneration throughout the *** isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCr4, and PDGFrα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cell

关键词： Mesenchymal stem cells Adipose-derived stem cells Endogenous stem cells Skeletal stem cells Bone regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Global Boundary Stratotype Section and Point （GSSP） for the base of Changhsingian Stage （Upper Permian）

引用

Episodes 2006年第3期29卷 175-182页

作者： Yugan Jin Yue Wang charles Henderson Bruce r. Wardlaw Shuzhong Shen Changqun Cao State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 39 East Beijing Road Nanjing 210008 China Department of Geology and Geophysics University of Calgary Calgary Alberta Canada T2N 1N4 U.S. Geological Survey Reston 12201 Sunrise Valley Drive National Center VA 22092 USA

The Global Stratotype Section and Point （GSSP） for the base-Changhsingian Stage is defined at the First Appearance Datum （FAD） of the conodont Clarkina wangi within the lineage from C. longicuspidata to C. wangi at a point 88 cm above the base of the Changxing Limestone in the lower part of Bed 4 （base of 4α-2） at Meishan D section, Changxing County, Zhejiang Province, South China. This level is consistent with the first appearance of Changhsingian index fusulinid Palaeofusulina sinensis and tapashanitid ammonoids. The speciation event from Clarkina longicuspidata to C. wangi occurs just above the flooding surface of the second parasequence in the Changxing Limestone. In addition, the boundary interval is clearly recognizable by the depletion of isotopic carbon ratios and the normal polarity zone appearing above the Late Wuchiapingian reversed polarity zone. Section C, about 300 m to the west of Section D, exposes more of the upper Longtan Formation. It clearly shows the transitional nature of deposition across the Longtan/Changxing formational boundary, and thus is described as a supplementary reference section.

关键词：二叠纪石灰石全球界线层型剖面和节点沉积作用牙形石

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PHGDH as a mechanism for resistance in metabolically-driven cancers

引用

Cancer Drug resistance 2020年第4期3卷 762-774页

作者： richa rathore charles r.Schutt Brian A.Van Tine Division of Medical Oncology Washington University in St.LouisSt.LouisMO 63110USA Siteman Cancer Center St.LouisMO 63110USA

At the forefront of cancer research is the rapidly evolving understanding of metabolic reprogramming within cancer *** expeditious adaptation to metabolic inhibition allows cells to evolve and acquire resistance to targeted treatments,which makes therapeutic exploitation complex but achievable.3-phosphoglycerate dehydrogenase(PHGDH)is the rate-limiting enzyme of de novo serine biosynthesis and is highly expressed in a variety of cancers,including breast cancer,melanoma,and Ewing’s *** review will investigate the role of PHGDH in normal biological processes,leading to the role of PHGDH in the progression of *** an understanding of the molecular mechanisms by which PHGDH expression advances cancer growth,we will highlight the known mechanisms of resistance to cancer therapeutics facilitated by PHGDH biology and identify avenues for combatting PHGDH-driven resistance with inhibitors of PHGDH to allow for the development of effective metabolic therapies.

关键词： PHGDH cancer metabolism serine one-carbon metabolism folate cycle drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Capabilities and limitations of 3D printed microserpentines and integrated 3D electrodes for stretchable and conformable biosensor applications

引用

Microsystems & Nanoengineering 2020年第1期6卷 1078-1092页

作者： charles Didier Avra Kundu Swaminathan rajaraman Nanoscience Technology Center(NSTC) University of Central FloridaOrlandoFL 32826USA Burnett School of Biomedical Sciences University of Central FloridaOrlandoFL 32827USA Department of Materials Science&Engineering University of Central FloridaOrlandoFL 32816USA Department of Electrical&Computer Engineering University of Central FloridaOrlandoFL 32816USA

We explore the capabilities and limitations of 3D printed microserpentines(µserpentines)and utilize these structures to develop dynamic 3D microelectrodes for potential applications in in vitro,wearable,and implantable microelectrode arrays(MEAs).The device incorporates optimized 3D printedµserpentine designs with out-of-plane microelectrode structures,integrated on to a flexible Kapton®package with micromolded PDMS *** flexibility of the optimized,printedµserpentine design was calculated through effective stiffness and effective strain equations,so as to allow for analysis of various designs for enhanced *** optimized,down selectedµserpentine design was further sputter coated with 7–70 nm-thick gold and the performance of these coatings was studied for maintenance of conductivity during uniaxial strain ***/conforming analysis of the final devices(3D MEAs with a Kapton®package and PDMS insulation)were performed to qualitatively assess the robustness of the finished device toward dynamic MEA applications.3D microelectrode impedance measurements varied from 4.2 to 5.2 kΩduring the bending process demonstrating a small change and an example application with artificial agarose skin composite model to assess feasibility for basic transdermal electrical recording was further demonstrated.

关键词： microelectrode insulation utilize

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compressively sampling the optical transmission matrix of a multimode fibre

引用

Light(Science & Applications) 2021年第5期10卷 916-930页

作者： Shuhui Li charles Saunders Daniel J.Lum John Murray-Bruce Vivek K Goyal TomášČižmár David B.Phillips School of Physics and Astronomy University of ExeterExeterEX44QLUK Wuhan National Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan430074HubeiChina Department of Electrical and Computer Engineering Boston UniversityBostonMA02215USA Department of Physics and Astronomy University of Rochester500 Wilson BlvdRochesterNY14618USA Department of Computer Science and Engineering University of South FloridaTampaFL33620USA Leibniz Institute of Photonic Technology Albert-Einstein-Straße 907745JenaGermany Institute of Scientific Instruments of CAS Královopolská14761264BrnoCzech Republic

The measurement of the optical transmission matrix(TM)of an opaque material is an advanced form of space-variant aberration *** imaging,TM-based methods are emerging in a range of fields,including optical communications,micro-manipulation,and *** many cases,the TM is very sensitive to perturbations in the configuration of the scattering medium it ***,applications often require an up-to-the-minute characterisation of the fragile TM,typically entailing hundreds to thousands of probe ***,we explore how these measurement requirements can be relaxed using the framework of compressive sensing,in which the incorporation of prior information enables accurate estimation from fewer measurements than the dimensionality of the TM we aim to *** of such priors include knowledge of a memory effect linking the input and output fields,an approximate model of the optical system,or a recent but degraded TM *** demonstrate this concept by reconstructing the full-size TM of a multimode fibre supporting 754 modes at compression ratios down to∼5%with good *** show that in this case,imaging is still possible using TMs reconstructed at compression ratios down to∼1%(eight probe measurements).This compressive TM sampling strategy is quite general and may be applied to a variety of other scattering samples,including diffusers,thin layers of tissue,fibre optics of any refractive profile,and reflections from opaque *** approaches offer a route towards the measurement of high-dimensional TMs either quickly or with access to limited numbers of measurements.

关键词： scattering fibre matrix

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Considering calcium-binding proteins in invertebrates: multi-functional proteins that shape neuronal growth

引用

Neural regeneration research 2016年第2期11卷 208-209页

作者： charles r.Tessier Department of Medical and Molecular Genetics Indiana University School of Medicine-South Bend

Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic *** this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering *** can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.

关键词： Considering calcium-binding proteins in invertebrates multi-functional proteins that shape neuronal growth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Factors associated with non-adherence to scheduled medical follow-up appointments among Cameroonian children requiring HIV care: a case-control analysis of the usual-care group in the MOrE CArE trial

引用

Infectious Diseases of Poverty 2014年第1期3卷 415-422,414页

作者： Jean Joel r Bigna Jean Jacques N Noubiap Claudia S Plottel charles Kouanfack Sinata Koulla-Shiro Faculty of Medicine and Biomedical Sciences University of Yaoundé1P.O.Box 1364YaoundéCameroon Faculty of Medicine University of Montpellier 1MontpellierFrance Preventing Mother to Child Transmission Unit Goulfey District HospitalGoulfeyCameroon Internal Medicine Unit Edéa Regional HospitalEdéaCameroon Department of Medicine New York University Langone Medical CenterNew YorkUSA Accredited Treatment Centre Yaoundé Central HospitalYaoundéCameroon Infectious Diseases Unit Yaoundé Central HospitalYaoundéCameroon

Background:A better understanding of why HIV-exposed/infected children fail to attend their scheduled follow-up medical appointments for HIV-related care would allow for interventions to enhance the delivery of *** aim of this study was to determine characteristics of the caregiver-child dyad(CCD)associated with children’s non-adherence to scheduled follow-up medical appointments in HIV programs in ***:We conducted a case-control analysis of the usual-care group of CCDs from the MOrE CArE trial,in which the effect of mobile phone reminders for HIV-exposed/infected children in attending follow-up appointments was assessed from January to March *** this study,the absence of a child at their appointment was considered a case and the presence of a child at their appointment was defined as a *** used three multivariate binary logistic regression *** best-fit model was the one which had the smallest chi-square value with the Hosmer-Lemeshow test(HLχ^(2)).Magnitudes of associations were expressed by odds ratio(Or),with a p-valuered as statistically ***:We included 30 cases and 31 *** best-fit model which considered the sex of the adults and children separately(HLχ^(2)=3.5)showed that missing scheduled medical appointments was associated with:lack of formal education of the caregiver(Or 29.1,95%CI 1.1-777.0;p=0.044),prolonged time to the next appointment/follow-up(Or[1 week increase]1.4,95%CI 1.03-2.0;p=0.032),and being a female child(Or 5.2,95%CI 1.2-23.1;p=0.032).One model(HLχ^(2)=10.5)revealed that woman-boy pairs adhered less to medical appointments compared to woman-girl pairs(Or 4.9,95%CI 1.05-22.9;p=0.044).Another model(HLχ^(2)=11.1)revealed that man-boy pairs were more likely to attend appointments compared to woman-girl pairs(Or 0.23,95%CI 0.06-0.93;p=0.039).There were no statistical associations for the ages of the children or the caregivers,the study sites,or the HIV status(confirmed vs.

关键词： MOrE CArE Lost to follow-up(LTFU) Appointment Adherence Children Cameroon HIV AIDS Preventing mother-to-child transmission(PMTCT) Missed scheduled medical appointment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sigma-1 receptor: culprit and rescuer in motor neuron diseases

引用

Neural regeneration research 2021年第1期16卷 106-107页

作者： Jean-charles Liévens Tangui Maurice MMDN Univ MontpellierINSERMEPHEMontpellierFrance

Initially,the Sigma-1 receptor(S1r)was incorrectly categorized as one of the opioid *** it has since become clear that S1r is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1r is a 223 amino-acid long protein that shares no clear homology with any other known mammalian proteins,its closest homolog being the fungal ErG2 sterol *** its pharmacological counterpart,the Sigma-2 receptor that was only recently cloned,is genetically distinct.S1r is more likely considered as an atypical ligand-modulated chaperone protein.S1r is widely expressed in many organs including brain where its function has mainly been explored.

关键词： organs opioid Sigma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review of Three-Dimensional Medical Image Visualization

引用

Health Data Science 2022年第1期2022卷 83-101页

作者： Liang Zhou Mengjie Fan charles Hansen Chris r.Johnson Daniel Weiskopf National Institute of Health Data Science Peking UniversityBeijingChina Scientific Computing and Imaging Institute University of UtahSalt Lake CityUSA Visualization research Center(VISUS) University of StuttgartStuttgartGermany

Importance. Medical images are essential for modern medicine and an important research subject in visualization. However,medical experts are often not aware of the many advanced three-dimensional (3D) medical image visualization techniques thatcould increase their capabilities in data analysis and assist the decision-making process for specific medical problems. Ourpaper provides a review of 3D visualization techniques for medical images, intending to bridge the gap between medicalexperts and visualization researchers. Highlights. Fundamental visualization techniques are revisited for various medicalimaging modalities, from computational tomography to diffusion tensor imaging, featuring techniques that enhance spatialperception, which is critical for medical practices. The state-of-the-art of medical visualization is reviewed based on aprocedure-oriented classification of medical problems for studies of individuals and populations. This paper summarizes freesoftware tools for different modalities of medical images designed for various purposes, including visualization, analysis, andsegmentation, and it provides respective Internet links. Conclusions. Visualization techniques are a useful tool for medicalexperts to tackle specific medical problems in their daily work. Our review provides a quick reference to such techniques giventhe medical problem and modalities of associated medical images. We summarize fundamental techniques and readily availablevisualization tools to help medical experts to better understand and utilize medical imaging data. This paper could contributeto the joint effort of the medical and visualization communities to advance precision medicine.

关键词： Image utilize Medical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Buoyancy and turbulence-driven atmospheric circulation over urban areas

引用

Journal of Environmental Sciences 2017年第9期29卷 63-71页

作者： Yifan Fan Julian charles roland Hunt Yuguo Li Department of Mechanical Engineering The University of Hong KongHong KongChina Department of Earth Sciences University College LondonLondonWC1E6BTUK Malaysian Commonwealth Studies Centre CambridgeCB23RFUK

In the buoyancy and turbulence-driven atmospheric circulations（BTDAC） that occur over urban areas where the approach means wind speeds are very low（less than turbulent fluctuations and typically 3 m/sec）, the surface temperatures are significantly higher than those in the external rural areas, and the atmosphere above the mixing layer is stably stratified. In this paper, the mechanisms of BTDAC formation are studied through laboratory experiments and modelling, with additional low-level inflow from external rural areas and a divergent outflow in the opposite direction in the upper part of the mixed layer. Strong turbulent plumes in the central region mix the flow between lower and higher levels up to the inversion height. There are shear-driven turbulent eddies and weaker buoyant plumes around the periphery of the urban area. As the approach flow is very weak,the recirculating streamlines within the dome restrict the ventilation, and the dispersion of pollution emitted from sources below the inversion height leading to a rise in the mean concentration. Low-level air entrained from rural areas can, however, improve ventilation and lower this concentration. This trend can also be improved if the recirculating structure of the BTDAC flow pattern over urban areas breaks down as a result of the surface temperature distribution not being symmetrical, or as the approach wind speed increases to a level comparable with the mean velocity of circulation, or（except near the equator） the urban area is large enough that the Coriolis acceleration is significant.

关键词： Urban heat island Buoyancy and turbulence-driven Eddy structures Atmospheric circulation Pollutant dispersion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：