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Open Journal of Orthopedics 2012年第4期2卷 155-158页

作者： Calum H. C. Arthur Alexander M. Wood charles leeson-payne Steffen J. Breusch Orthopaedic Department Royal Infirmary of Edinburgh Edinburgh UK

Good perioperative analgesia following total knee arthroplasty facilitates rehabilitation and may reduce hospital stay. We present the patient analgesic requirements and rehabilitation of a prospective single surgeon series after the introduction of a multimodal drug injection during his total knee arthroplasty. Basic epidemiological data as well as analgesic, antiemetic requirements and time to straight leg raised was collected on 27 consecutive patients (group 1) whom received the multimodal drug injection, consisting of levobupivacaine, ketorolac and adrenaline at the time of their total knee arthroplasty under spinal anaesthesia. Their rehabilitation was compared to a retrospective review of patients who were case matched by age and sex (group 2n = 26), whom had received the unit standard of spinal anaesthetic and a femoral and sciatic block at the time of their operation. Patients in group 1 had significantly lower analgesic and antiemetic requirements than group 2. Group 1 also had a significantly shorter hospital stay. We have demonstrated that periarticular multimodal drug injection can improve perioperative analgesia and mobilisation following total knee arthroplasty as well as reducing opioid requirements and side effects.

关键词： Analgesia Total Knee Replacement Multimodal Drug Injection Peripheral Nerve Blocks Rehabilitation

Comparason of Peri-Articular Multimodal Drug Injection with Femoral and Sciatic Nerve Block after Total Knee Arthroplasty

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Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess

Open Journal of Orthopedics（矫形学期刊） 2012年第4期

作者： Calum H. C. Arthur Alexander M. Wood charles leeson-payne Steffen J. Breusch Orthopaedic Department Royal Infirmary of Edinburgh

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 28-40页

作者： Daniel T.payne Mandeep KChahal Vaclav Brezina Whitney A.Webre Katsuhiko Ariga Francis D’Souza Jan Labuta Jonathan P.Hill WPI Center for Materials Nanoarchitectonics National Institute for Materials ScienceIbaraki 305-0044Japan Department of Macromolecular Physics Faculty of Mathematics and PhysicsCharles University18000 PragueCzech Republic Department of Chemistry University of North TexasDentonTX 76203USA Department of Advanced Materials Science Graduate School of Frontier SciencesThe University of TokyoChiba 277-8561Japan

Chiral 1,1’-binaphthyl-linked diporphyrin‘tweezers’(R)-1/(S)-1 and the corresponding zinc(II)complexes(R)-2/(S)-2 were prepared as chiral host molecules,and their utility for chiral analyses(especially enantiomeric excess(ee)determinations)were ***(1-n-dodecyl)porphyrins were used for the first time as the interacting *** capabilities of the diporphyrin tweezers were investigated by titrations with(R,R)-and(S,S)-cyclohexane-1,2-diamine(CHDA).The host molecules could be used as multichannel probes of ee by using UVvis,circular dichroism(CD),fluorescence emission and 1H nuclear magnetic resonance(1 H-NMR)*** configurations could also be differentiated using CD or 1HNMR *** three optical techniques give good resolution of ee with reasonable sensitivity considering the low concentrations used(ca.10^-6 mol·L^-1).The ee determination of CHDA enantiomers using NMR spectroscopy is also possible because of the reasonably well separated resonances in the case of(R,R)-and(S,S)-***-metallated(R)-1/(S)-1 hosts could not be used to detect chiral information in a strongly acidic chiral *** work demonstrates the utility of 1,1’-binapthyllinked chiral hosts for chiral analysis of ditopically interacting enantiomers.

关键词： porphyrin dimer chirality enantiomeric excess CD fluorescence

Molecular rotor based on an oxidized resorcinarene

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Organic Chemistry Frontiers 2022年第1期9卷 39-50页

作者： Daniel T.payne Jan Labuta Zdeněk Futera Václav Březina Lenka Hanyková Mandeep K.Chahal Jonathan P.Hill International Center for Materials Nanoarchitectonics National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan bInternational Center for Young Scientists National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan Institute of Physics Faculty of ScienceUniversity of South BohemiaBranišovská1760ČeskéBudějovice 37005Czech Republic Faculty of Mathematics and Physics Charles UniversityV Holešovičkách 218000 Prague 8Czech Republic

Molecular rotors are an important class of dynamic molecules which have been studied not only for their possible uses as components of molecular machines but also because of potential applications as probes of local viscosity in biological media,especially self-assembled *** the former,factors affecting rotational motility are critical while for the latter the rotor activity must be complexed with an output signal(often fluorescence)for reporting of local *** single stator-double rotor activity of an oxidized resorcinarene(fuchsonarene)macrocycle containing unsaturated hemiquinonoid groups at its meso positions was *** contain two hemiquinonoid substituents at diagonally-opposed meso-positions with two electron rich phenol groups at the remaining meso-positions between the hemiquinonoid *** meso-substituents are in proximity at one side of the resorcinarene macrocycle(so-called rccc-type isomer)with rotational activity of the phenol *** rates of the phenol moieties can be controlled by varying temperature,solvent polarity and acidity of the medium of study with rotation being thermally activated in neutral and acidic media and tunable in the range from 2 s^(−1) to 20000 s^(−1).Experimental and computational data indicate that rotation of the mobile phenol meso-substituents is remotely affected by interactions with acidic solvents at the carbonyl CvO groups of macrocyclic acetyloxy groups,which occurs with the emergence of a lower energy electronic absorption band whose intensity is correlated with both the acidity of the medium and the rotation rate of the phenol ***-dependent DFT calculations suggest that the low energy band is due to a molecular conformational adjustment affecting electronic conjugation caused by strong interaction of macrocyclic acetyloxy carbonyl groups with the acid *** work presents a molecular mechanical model for estimating solution acidity a

关键词： substituent rotation oxidized

Discovery of novel genetic networks associated with 19 economically important traits in beef cattle

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Discovery of novel genetic networks associated with 19 econo...

中国畜牧兽医学会第七届养牛学分会2009年学术研讨会

作者： Jennifer J.Michal Tyler F.Daniels Tanja Kunej charles T.Gaskins Jan R.Busboom leeson J.Alexander Raymond W.Wright Michael D.MacNeil Department of Animal Sciences Washington State UniversityPullmanWA 99164-6351 USDA-ARS Fort Keogh Livestock and Range Research LaboratoryMiles CityMT 59301

Quantitative or complex traits are determined by the combined effects of many loci,and are affected by genetic networks or molecular *** the present study,we genotyped a total of 138 mutations,mainly single nucleotide polymorphisms derived from 71 functional genes on a Wagyu x Limousin reference *** hundred forty six F animals were measured for 5 carcass,6 eating quality and 8 fatty acid composition traits.A total of 2,280 single marker-trait association runs with 120 tagged mutations selected based on the HAPLOVIEW analysis revealed 144 significant associations(P<0.05),but 50 of them were removed from the analysis due to the small number of animals(≤9) in one genotype group or absence of one genotype among three *** remaining 94 single-trait associations were then placed into three groups of quantitative trait modes(QTMs) with additive,dominant and overdominant *** significant markers and their QTMs associated with each of these 19 traits were involved in a linear regression model analysis,which confirmed single-gene associations for 4 traits,but revealed two-gene networks for 8 traits and three-gene networks for 5 *** genetic networks involving both genotypes and QTMs resulted in high correlations between predicted and actual values of performance,thus providing evidence that the classical Mendelian principals of inheritance can be applied in understanding genetic complexity of complex *** present study also indicated that carcass, eating quality and fatty acid composition traits rarely share genetic ***,marker-assisted selection for improvement of one category of these traits would not interfere with improvement of another.

关键词： Quantitative traits quantitative trait modes genetic networks beef cattle

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中国积极抑制影子银行风险的实践

中国货币市场 2014年第7期 12-18页

作者：郭丰 Bejoy Das Gupta charles Collyns Kevin Sanker payne Simpson

文章分析了2009年以来中国影子银行业规模迅速扩张的原因，分析了中国政府的相关应对措施，并提出需建立全面清晰的金融改革框架以应对影子银行相关的多重挑战，包括识别并重组困难影子银行，进一步放松对正规银行业的规制，协调运用政... 详细信息

文章分析了2009年以来中国影子银行业规模迅速扩张的原因，分析了中国政府的相关应对措施，并提出需建立全面清晰的金融改革框架以应对影子银行相关的多重挑战，包括识别并重组困难影子银行，进一步放松对正规银行业的规制，协调运用政策工具应对风险等。

关键词：影子银行风险金融改革

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid