检索结果-南通市图书馆

Single low-dose lipopolysaccharide preconditioning:neuroprotective against axonal injury and modulates glial cells

Neuroimmunology and Neuroinflammation 2017年第1期4卷 6-15页

作者： Ryan C.Turner Zachary J.Naser Brandon P.lucke-Wold Aric F.logsdon Reyna l.Vangilder Rae R.Matsumoto Jason D.Huber charles l.rosen Department of Neurosurgery West Virginia UniversitySchool of MedicineMorgantownWV26506USA Center for Neuroscience West Virginia UniversitySchool of MedicineMorgantownWV 26506USA Department of Basic Pharmaceutical Sciences West Virginia UniversitySchool of PharmacyMorgantownWV 26506USA Center for Health Restoration West Virginia UniversitySchool of NursingMorgantownWV 26506USA

Aim:Over 7 million traumatic brain injuries (TBI) are reported each year in the United ***,treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly *** (lPS) administration before controlled cortical impact can contribute to ***,the underlying mechanisms and whether lPS preconditioning confers neuroprotection against closed-head injuries remains ***:The authors hypothesized that preconditioning with a low dose of lPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight *** was administered 7 days prior to *** administration reduced locomotion,which recovered completely by time of ***:lPS preconditioning significantly reduced the post-injury gliosis response near the corpus callosum,possibly by downregulating the oncostatin M *** novel findings demonstrate a protective role of lPS preconditioning against diffuse axonal *** preconditioning successfully prevented neurodegeneration near the corpus callosum,as measured by fluorojade ***:Further work is required to elucidate whether lPS preconditioning confers long-term protection against behavioral deficits and to elucidate the biochemical mechanisms responsible for lPS-induced neuroprotective effects.

关键词： lipopolysaccharide preconditioning oncostatin M receptor diffuse axonal injury gliosis neuroprotection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

引用

Chinese Chemical letters 2015年第4期26卷 485-490页

作者： Shuai Wei charles l.Brooks Ⅲ Department of Chemistry University of Michigan Department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The skeleton gets a （reproductive） life

引用

Asian Journal of Andrology 2011年第5期13卷 651-652页

作者： charles M Allan David l Handelsman ANZAC Research Institute Concord Hospital Universityof Sydney Sydney NSW 2139 Australia

To most well-informed scientists who do not work on bone, the idea that bones determine anything other than your posture and location for the miseries of arthritis would come as quite a surprise. It would be like imagining that the walls of our home played something more than a passive role in the complexities of the lives conducted within. Yet something precisely as radical as that is what Karsenty and his colleagues boldly imagined,1 and then provocatively established in a series of studies over the past decade.20steocalcin （OCN） is a vitamin K- dependent peptide hormone secreted by the bone-formine osteoblasts.

关键词： reproductive David J Handelsman

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

less common neoplasms of the pancreas

引用

World Journal of Gastroenterology 2006年第20期12卷 3180-3185页

作者： Abby l Mulkeen Peter S Yoo charles Cha Department of Surgery Yale University School of Medicine New HavenCT and the VACT Healthcare SystemWest HavenCT330 Cedar StreetLH 118PO Box 208062New HavenCT06520-8062United States

Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct lesions which exhibit diverse biological behaviors and varying degrees of malignancy. These lesions include： endocrine neoplasms, cystic tumors, solid pseudopapillary tumors, acinar cell carcinoma, squamous cell carcinoma, primary lymphoma of the pancreas, and metastatic lesions to the pancreas. These less common neoplasms are being diagnosed more frequently as the number and sensitivity of diagnostic imaging studies increase. This review article discusses the clinical course, diagnosis, and treatment of these less common, but quite relevant, neoplasms of the pancreas.

关键词： Pancreas Neoplasms Ductal adenocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in the management of infertility in men with spinal cord injury

引用

Asian Journal of Andrology 2016年第3期18卷 382-390,I0007,I0008页

作者： Emad Ibrahim Nancy l Brackett charles M lynne The Miami Project to Cure Paralysis University of Miami Miller School of Medicine Miami FL USA Department of Urology University of Miami Miller School of Medicine Miami FL USA.

Couples with a spinal cord injured male partner require assisted ejaculation techniques to collect semen that can then be further used in various assisted reproductive technology methods to achieve a pregnancy. The majority of men sustaining a spinal cord injury regardless of the cause or the level of injury cannot ejaculate during sexual intercourse. Only a small minority can ejaculate by masturbation. Penile vibratory stimulation and electroejaculation are the two most common methods used to retrieve sperm. Other techniques such as prostatic massage and the adjunct application of other medications can be used, but the results are inconsistent. Surgical sperm retrieval should be considered as a last resort if all other methods fail. Special attention must be paid to patients with T6 and rostral levels of injury due to the risk of autonomic dysreflexia resulting from stimulation below the level of injury. Bladder preparation should be performed before stimulation if retrograde ejaculation is anticipated. Erectile dysfunction is ubiquitous in the spinal cord injured population but is usually easily managed and does not pose a barrier to semen retrieval in these men. Semen analysis parameters of men with spinal cord injury are unique for this population regardless of the method of retrieval, generally presenting as normal sperm concentration but abnormally low sperm motility and viability. When sperm retrieval is desired in this population, emphasis should be placed on initially trying the simple methods of penile vibratory stimulation or electroejaculation before resorting to more advanced and invasive surgical procedures.

关键词： assisted reproductive technology ejaculation electroejaculation male infertility paraplegia penile vibratory stimulation semen sperm spinal cord injury surgical sperm retrieval

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analyzing neural degeneration of the retina with connectomics

引用

Neural Regeneration Research 2022年第1期17卷 113-114页

作者： charles l.Zucker John E.Dowling Department of Molecular and Cellular Biology Harvard UniversityCambridgeMAUSA

Electron microscopy(EM)provides a unique ability to visualize structural detail with a resolution orders of magnitude better than other imaging *** conventionally,its limitation is that each acquired image represents a small area with a section thickness significantly less than 100 ***,techniques have been developed that allow thousands of relatively large serial-sections to be collected and efficiently imaged at full EM resolution,with the images then being stitched back together to produce a 3D volume.

关键词： neural image Applied

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Androgen deprivation therapy-associated vasomotor symptoms

引用

Asian Journal of Andrology 2012年第2期14卷 193-197页

作者： Jason M Jones Manish Kohli charles l loprinzi Department of Medical Oncology Mayo Clinic Rochester MN 55905 USA

Androgen deprivation therapy （ADT） is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.

关键词： androgen deprivation therapy hot flashes vasomotor symptoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Displacement Current in Domain Walls of Bismuth Ferrite

引用

npj Computational Materials 2018年第1期4卷 597-605页

作者： Sergey Prosandeev Yurong Yang charles Paillard l.Bellaiche Physics Department and Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Institute of Physics and Physics Department of Southern Federal UniversityRostov-na-Donu 344090Russia

In 1861,Maxwell conceived the idea of the displacement current,which then made laws of electrodynamics more complete and also resulted in the realization of devices exploiting such displacement ***,it is presently unknown if such displacement current can result in large intrinsic ac current in ferroic systems possessing domains,despite the flurry of recent activities that have been devoted to domains and their corresponding conductivity in these ***,we report firstprinciples-based atomistic simulations that predict that the transverse(polarization-related)displacement currents of 71°and 109°domains in the prototypical BiFeO_(3) multiferroic material are significant at the walls of such domains and in the GHz regime,and,in fact,result in currents that are at least of the same order of magnitude than previously reported dc currents(that are likely extrinsic in nature and due to electrons).Such large,localized and intrinsic ac currents are found to originate from low-frequency vibrations at the domain walls,and may open the door to the design of novel devices functioning in the GHz or THz range and in which currents would be confined within the domain wall.

关键词： currents regime magnitude

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contemporary Approaches for Identifying Rare Bone Disease Causing Genes

引用

Bone Research 2013年第4期1卷 301-310页

作者： charles R.Farber Thomas l.Clemens Center for Public Health Genomics University of Virginia Departments of Public Health Sciences and Biochemistry and Molecular Genetics University of Virginia Department of Orthopaedic Surgery Johns Hopkins School of Medicine Baltimore Veterans Administration Medical Center

Recent improvements in the speed and accuracy of DNA sequencing, together with increasingly sophisti- cated mathematical approaches for annotating gene networks, have revolutionized the field of human genetics and made these once time consuming approaches assessable to most investigators. In the field of bone research, a particularly active area of gene discovery has occurred in patients with rare bone disorders such as osteogenesis imperfecta （OI） that are caused by mutations in single genes. In this perspective, we highlight some of these technological advances and describe how they have been used to identify the genetic determinants underlying two previously unexplained cases of OI. The widespread availability of advanced methods for DNA sequencing and bioinformatics analysis can be expected to greatly facilitate identification of novel gene networks that normally function to control bone formation and maintenance.

关键词： exome sequencing genome sequencing bioinformatics osteogenesis imperfect pigment epithelium-derived factor (PEDF) bone restricted ifitm-like protein (Bril)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strain control of layer-resolved negative capacitance in superlattices

引用

npj Computational Materials 2020年第1期6卷 127-130页

作者： Raymond Walter Sergey Prosandeev charles Paillard l.Bellaiche Department of Physics and Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Department of Mathematical Sciences University of ArkansasFayettevilleAR 72701USA Identity Engineering Kinesso LLCConwayAR 72032USA Institute of Physics and Physics Department of Southern Federal University Rostov-na-Donu 344090Russia laboratoire Structures Propriétés et Modélisation des SolidesCentraleSupélecUMR CNRS 8580UniversitéParis-Saclay91190 Gif-sur-YvetteFrance

Negative capacitance in BaTiO_(3)/SrTiO_(3) superlattices is investigated by Monte Carlo simulations in an atomistic effective Hamiltonian model,using fluctuation formulas for responses to the local macroscopic field that incorporates depolarizing *** show that epitaxial strain can tune the negative capacitance of the BaTiO_(3) ferroelectric layer and the overall capacitance of the *** addition,we predict and explain an original switching of the negative capacitance from the BaTiO3 layer to the SrTiO_(3) layer at low temperatures for intermediate strains.

关键词： capacitance layer resolved

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：