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Endoscopic therapies of gastroesophageal reflux disease

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World j.urnal of Gastroenterology 2006年第17期12卷 2641-2655页

作者： Atif Iqbal Vanessa Salinas charles j.filipi Department of Surgery University of Missouri Columbia One Hospital DriveColumbiaMO 65211United States Department of Surgery Creighton University 601 N 30th StreetOmaha NE 68131United States

The high prevalence of gastroesophageal reflux disease （GERD） in Western societies has accelerated the need for new modalities of treatment. Currently, medical and surgical therapies are widely accepted among patients and physicians. New potent antisecretory drugs and the development of minimally invasive surgery for the management of GERD are at present the pivotal and largely accepted approaches to treatment. The minimally invasive treatment revolution, however, has stimulated several new endoscopic techniques for GERD. Up to now, the data is limited and further studies are necessary to compare the advantages and disadvantages of the various endoscopic techniques to medical and laparoscopic management of GERD. New j.urnal articles and abstracts are continuously being published. The Food and Drug Administration has approved 3 modalities, thus gastroenterologists and surgeons are beginning to apply these techniques. Further trials and device refinements will assist clinicians. This article will present an overview of the various techniques that are currently on study. This review will report the efficacy and durability of various endoscopic therapies for gastroesophageal reflux disease （GERD）. The potential for widespread use of these techniques will also be discussed. Articles and abstracts published in English on this topic were retrieved from Pubmed. Due to limited number of studies and remarkable differences between various trials, strict criteria were not used for the pooled data presented, however, an effort was made to avoid bias by including only studies that used off-PPI scoring as baseline and intent to treat.

关键词： Endoscopic Treatment Gastroesophageal reflux disease

Effects of grid size on predictions of bed expansion in bubbling fluidized beds of Geldart B particles： A generalized rule for a grid-independent solution of TFM simulations

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Particuology 2017年第5期15卷 61-69页

作者： M. Helal Uddin charles j. Coronella Department of Chemical and Materials Engineering University of Nevada Reno NV 89557 USA

Numerical simulations of gas-solid fluidized beds based on the kinetic theory of granular flow exhibit a significant dependence on domain discretization. Bubble formation, bubble size and shape all vary greatly with the discretization, and the use of an inappropriate scale resolution leads to inaccurate predictions of fluidization hydrodynamics. In this study, grid-independent solutions of the two fluid model were examined by comparing the bed expansions obtained from numerical simulations with experimental results and empirical predictions, based on bubbling fluidized beds of Geldart B particles. Grid indepen- dence was achieved with a grid resolution equal to 18 times the particle diameter. The simulation results were compared with previously published data for verification purposes. The results of this work should provide a guideline for choosing the appropriate grid size and thereby minimize the time and expense associated with large simulations.

关键词： Mesh effectHydrodynamicsComputational fluid dynamicsEuler-Euler method MFIX

Release, Recycle, Rebuild： Cell-Wall Remodeling, Autodegradation, and Sugar Salvage for New Wall Biosynthesis during Plant Development

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Molecular Plant 2018年第1期11卷 31-46页

作者： William j. Barnes charles T. Anderson Department of Biology Center for Ugnocellulose Structure and Formation The Pennsylvania State University University Park PA 16802 USA

Plant cell walls contain elaborate polysaccharide networks and regulate plant growth, development, mechanics, cell-cell communication and adhesion, and defense. Despite conferring rigidity to support plant structures, the cell wall is a dynamic extracellular matrix that is modified, reorganized, and degraded to tightly control its properties during growth and development. Far from being a terminal carbon sink, many wall polymers can be degraded and recycled by plant cells, either via direct re-incorporation by trans- glycosylation or via internalization and metabolic salvage of wall-derived sugars to produce new precur- sors for wall synthesis. However, the physiological and metabolic contributions of wall recycling to plant growth and development are largely undefined. In this review, we discuss long-standing and recent evi- dence supporting the occurrence of cell-wall recycling in plants, make predictions regarding the develop- mental processes to which wall recycling might contribute, and identify outstanding questions and emerging experimental tools that might be used to address these questions and enhance our understanding of this poorly characterized aspect of wall dynamics and metabolism.

关键词： Plant cell walls wall degradation wall recycling wall biosynthesis

Is analysis of lower esophageal sphincter vector volumes of value in diagnosing gastroesophageal reflux disease?

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World j.urnal of Gastroenterology 2003年第1期9卷 174-178页

作者： Robert E.Marsh Christopher L.Perdue Ziad T.Awad Patrice Watson Mohamed Selima Richard E.Davis charles j.filipi Department of Surgery Creighton University School of MedicineOmaha Nebraska USA Department of Preventive Medicine Creighton University School of MedicineOmaha Nebraska USA

AIM:With successful surgical treatment of gastroesophageal reflux disease(GERD),there is interest in understanding the anti-reflux barrier and its mechanisms of *** date, the potential use of vector volumes to predict the DeMeester score has not been adequately explored. METHODS:627 patients in the referral database received esophageal manometry and ambulatory 24-hour pH *** data included LES resting pressure(LESP), overall LES length(OL)and abdominal length(AL),total vector volume(TVV)and intrabdominal vector volume(IVV). RESULTS:In cases where LESP,TVV or IVV were all below normal,there was an 81.4%probability of a positive DeMeester *** cases where all three were normal, there was an 86.9%probability that the DeMeester score would be ***-operating characteristics(ROC) for LESP,TVV and IVV were nearly identical and indicated no useful cut-off *** regression demonstrated that LESP and IVV had the strongest association with a positive DeMeester score;however,the regression formula was only 76.1%accurate. CONCLUSION:While the indices based on TVV,IVV and LESP are more sensitive and specific,respectively,than any single measurement,the measurement of vector volumes does not add significantly to the diagnosis of GERD.

关键词： Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Esophagogastric j.nction Female Gastroesophageal Reflux Humans Hydrogen-Ion Concentration Male Manometry Middle Aged ROC Curve Regression Analysis

Thermodynamic Foundation for High Temperature Electrochemistry

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Chemical Research in Chinese Universities 2004年第4期20卷 494-500页

作者： ZHANG W. E. A. charles j. Congleton Corrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne NE1 7RU UK NE1 7RU UKNE1 7RU UK

Thermodynamic concepts required for the thermodynamic calculation of the potentials of electrodes for high temperature applications are briefly reviewed. A thermodynamic approach to the calculation of half cell potentials and the standard chemical potential of an electron at high temperatures which are related to the Standard Hydrogen Electrode(SHE) is discussed. As examples, an external Ag/AgCl reference electrode and a YSZ(Ag|O_2) pH sensor for high temperature applications are analyzed by using the thermodynamic approach to derive a high temperature pH measurement equation. The two electrodes are employed to measure high temperature pH and the measured pH was compared with the calculated pH by using a solution chemistry method. Concepts and principles for electrode kinetics are also briefly introduced and a modification to the Tafel equations is suggested.

关键词： High temperature potential Half cell potential External Ag/AgCl reference electrode Standard chemical potential of an electron High temperature pH sensor.

Roles of the main olfactory and vomeronasal systems in the detection of androstenone in inbred strains of mice

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Current Zoology 2010年第6期56卷 813-818页

作者： Vera V. VOZNESSENSKAYA Maria A. KLYUCHNIKOVA charles j. WYSOCKI A.N. Severtzov Institute of Ecology & Evolution RAS Monell Chemical Senses Center

We investigated the role of the main olfactory and accessory olfactory systems （MOS and AOS respectively） in the detection of androstenone. We used the following experimental approaches： behavioral, surgical removal of the vomeronasal organ （VNX） followed by histochemical verification and Fos immunohistochemistry. Using a Y-maze paradigm we estimated sensitivity of NZB/B1Nj.and CBA/j.mice to androstenone. CBA mice were 2,000-fold more sensitive to androstenone than NZB mice. VNX caused a 4-tol6-fold decrease in sensitivity to androstenone in highly-sensitive CBA mice, but did not affect thresholds in NZB mice. Results indicate the involvement of the MOS and AOS in the detection of androstenone. We observed a specific pattern of Fos-positive cells in the main olfactory bulb of CBA mice but not in NZB mice subsequent to exposure of mice to androstenone; the compound activated cells in the accessory olfactory bulb in both strains of mice, indicating the involvement of the vomeronasal organ. Patterns of Fos-positive cells in the vomeronasal organ were recorded subsequent to exposure to androstenone. Fos-positive receptor cells in the vomeronasal organ of CBA and NZB mice were different, in CBA mice Fos-positive cells were noted in both the basal and apical zones, however, in NZB mice activation was observed only in the apical zone [Current Zoology 56 （6）： 813-818, 2010].

关键词： Olfaction Vomeronasal organ Chemosensory receptors Olfactory behavior Immunohistochemistry

The evolution of Hessian fly from the Old World to the New World： Evidence from molecular markers

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Insect Science 2015年第6期22卷 768-784页

作者： Brandon j. Schemerhom Yan Ma Crane charles F. Crane USDA-ARS Department of Entomology Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907USA

Eighteen polymorphic microsatellite loci and 11 single-nucleotide polymor- phisms were genotyped in 1 095 individual Hessian fly specimens representing 23 popula- tions from North America, southern Europe, and southwest Asia. The genotypes were used to assess genetic diversity and interrelationship of Hessian fly populations. While phyloge- netic analysis indicates that the American populations most similar to Eurasian populations come from the east coast of the United States, genetic distance is least between （Alabama and California） and （Kazakhstan and Spain）. Allelic diversity and frequency vary across North America, but they are not correlated with distance from the historically documented point of introduction in New York City or with temperature or precipitation. Instead, the greatest allelic diversity mostly occurs in areas with Mediterranean climates. The mi- crosatellite data indicate a general deficiency for heterozygotes in Hessian fly. The North American population structure is consistent with multiple introductions, isolation by dis- tance, and human-abetted dispersal by bulk transport of puparia in infested straw or on harvesting equipment.

关键词： allele frequency Hessian fly microsatellite population structure SNP SSR

Balancing Frequencies and Fault Detection in the In-Parameter-Order Algorithm

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j.urnal of Computer Science & Technology 2015年第5期30卷 957-968页

作者：高世伟吕江花杜冰磊 charles j. Colbourn 马世龙 State Key Laboratory of Software Development Environment Beihang University Beijing 100191 China School of Computing Informaties and Decision Systems Engineering Arizona State University Tempe AZ 85287-8809 U.S.A.

The In-Parameter-Order （IPO） algorithm is a widely used strategy for the construction of software test suites for combinatorial testing （CT） whose goal is to reveal faults triggered by interactions among parameters. Variants of IPO have been shown to produce test suites within reasonable amounts of time that are often not much larger than the smallest test suites known. When an entire test suite is executed, all faults that arise from t-way interactions for some fixed t are surely found. However, when tests are executed one at a time, it is desirable to detect a fault as early as possible so that it can be repaired. The basic IPO strategies of horizontal and vertical growth address test suite size, but not the early detection of faults. In this paper, the growth strategies in IPO are modified to attempt to evenly distribute the values of each parameter across the tests. Together with a reordering strategy that we add, this modification to IPO improves the rate of fault detection dramatically （improved by 31% on average）. Moreover, our modifications always reduce generation time （2 times faster on average） and in some eases also reduce test suite size.

关键词： combinatorial testing IPO test suite generation expected time to fault detection software under test

One hundred years of population ecology:Successes,failures and the road ahead

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Integrative Zoology 2015年第3期10卷 233-240页

作者： charles j.KREBS Department of Zoology University of British ColumbiaVancouverCanada and Institute for Applied EcologyUniversity of CanberraCanberraAustralia

Population ecology is the most mature of the three subdisciplines of ecology partly because it has a solid mathematical foundation and partly because it can address the primary questions of distribution and abundance with experimental *** there is much left to do to integrate our population knowledge into community and ecosystem ecology to help address the global issues of food security and the conservation of *** different approaches are now being developed to bring about this integration and much more research will be necessary to decide which if any will be most useful in achieving our goals of explaining the changes we see in the distribution and abundance of animals and *** web ecology would appear to be the best approach at present because it uses the detailed information of the population ecology of particular species in combination with data on consumer-resource interactions to apply to the applied problems of biodiversity conservation,food security,pest management and disease *** we can use our understanding of population ecology to address the practical problems of our time in a creative way,we will benefit both the human population and the Earth’s *** remains to be done.

关键词： abundance geographic distributions history of ecology population models