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Correlation between Late Cord Clamping and Phototherapy and Other Neonatal Unfavorable Outcomes: A Randomized Clinical Trial

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Open Journal of Obstetrics and Gynecology 2022年第3期12卷 193-200页

作者： Janete Vettorazzi Gabriela Françoes Rostirolla Maria Alexandrina Zanatta Edimárlei Gonsales Valério charles francisco ferreira Jose Geraldo Lopes Ramos Postgraduation Program in Health Sciences: Gynecology and Obstetrics Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine Universidade de Caxias do Sul (UCS)

Background: Recently, late umbilical cord clamping is generally recommended, which decreases neonatal anemia;however, it may also increase neonatal jaundice and some other poor outcomes. Objectives: We here attempted to determine whether late clamping actually increases the incidence of phototherapy for jaundice and other poor outcomes of the term “low-risk newborns”. Methods: With the approval of the Brazilian Registry of Clinical Trials (REBEC), a total of 357 low-risk newborns (singleton, uncomplicated pregnancy/delivery, in a Brazilian public institution) were randomized into two groups: group I (n = 114): cord clamping 1 minute (early clamping) or group II (n = 243): cord clamping between 1 - 3 minutes (late clamping). Statistics were used appropriately (i.e., measures of central tendency, dispersion for continuous variables, Shapiro-Wilk, Mann-Whitney test, or Chi-square test). Results: Phototherapy was performed in 5.3% in both groups. Also, there were no statistical differences in the occurrence of secondary outcomes, such as sepsis, neonatal ICU admission, and transient tachypnea of the newborns: i.e., 0.9%, 15.8%, and 3.5%, respectively for group I versus 1.2%, 15.6%, and 5.8%, respectively for group II. Conclusion: Late umbilical cord clamping does not increase the need for phototherapy in low-risk neonates. This result corroborates the current recommendation of late cord clamping, whenever appropriate.

关键词： Phototherapy Neonatal Anemia Neonatal Jaundice Late Cord Clamping

Impact of Selective vs Routine Midline Episiotomy and Lacerations of the Anal Sphincter

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 794-810页

作者： Samanta Schneider Amanda Vilaverde Perez Nadine Morais da Silva charles francisco ferreira Fernanda Santos Grossi Mariana Sbaraini Sérgio H. Martins-Costa Janete Vettorazzi Edimárlei Gonsales Valério PostgraduationProgram in Health Sciences Gynecology and Obstetrics Faculty of Medicine (FAMED Universida de Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brasil School of Medicine (FAMED) Universidade Federal do Rio Grande do Sul Porto Alegre Brasil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) Universida de Federal do Rio Grande do Sul Porto Alegre Brasil

Introduction: Obstetric anal sphincter tear (OAST) is associated with anal incontinence. Episiotomy was proposed as a form of protection of the anal sphincter at delivery;however, several studies have shown that routine use of episiotomy does not reduce the risk of OAST. Objective: This study aims to analyse whether the reduction in the rate of episiotomy in a school hospital in Brazil was associated with an increase in the incidence of obstetric lacerations of the anal sphincter, in addition to associated factors. Methods: Observational, cross-sectional and retrospective study. We included all vaginal deliveries of single pregnancies, cephalic presentation, from 34 weeks of gestational age, performed in 2011-2012 (liberal episiotomy) and 2015-2016 (restricted episiotomy), and compared in relation to the rate of mediolateral episiotomy and OAST. Results: 4268 births were analysed (2043 in 2011-2012 and 2225 in 2015-2016). The episiotomy rate decreased from 59.4% to 44.2% (p ≤ 0.0001). In 2011-2012, there were 10 obstetric anal sphincter lacerations in 2043 births (0.48%), while in the period 2015-2016 there were 31 lacerations in 2225 births (1.39%). There was interaction when comparing the two periods in relation to the episiotomy and the occurrence of OAST (p ≤ 0.0001). Factors associated with OAST were labor induction and shoulder dystocia. Conclusion: There was an increase in the rate of lacerations of the anal sphincter with use of restrictive episiotomy. However, this increase occurred both in deliveries with and in deliveries without episiotomy.

关键词： Restrictive Episiotomy Third-Degree Perineal Laceration Fourth-Degree Perineal Laceration Obstetric Anal Sphincter Tear

Measurement of Anomalous Radon Gas Emanation Across the Yammouneh Fault in Southern Lebanon: A Possible Approach to Earthquake Prediction

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International Journal of Disaster Risk Science 2015年第3期6卷 250-266页

作者： Mohammed A.Kobeissi francisco Gomez charles Tabet Lebanese Atomic Energy Commission Lebanese National Council for Scientific Research Department of Geological Sciences University of Missouri Lebanese National Council for Scientific Research BeirutLebanon

The eastern Mediterranean region is an active tectonic setting that includes the Dead Sea Transform Fault, which forms the boundary between the African and the Arabian Plates and crosses Lebanon from south to north, striking in a restraining bend around 25–30°NE. The major structural feature in Lebanon is the Yammouneh Fault, which reaches to Syria and southern Turkey in a north–south direction. Measurements of radon gas concentration and exhalation rates in two locations along the southern segment of the Yammouneh Fault in south Lebanon were performed. Two profiles in the El-Khiam basin and Blat pull-apart basin and perpendicular to the Yammouneh Fault trace were analyzed. An approximate fault width 25–30 m wide was determined in the El-Khiam study area. Temporal increase of radon concentration was measured and correlated with stress/strain tectonic activity and stress drops along the studied fault segment *** variable radon concentrations were detected during one of the measurements where an earthquake occurred in the region of Tiberias Lake in northern Palestine along the Yammouneh Fault in the study area. Measurements of radon concentration along a station’s profile in Blat village did not show any radon anomalous variation due to the discontinuity along the fault(pull-apart), and possible absence of stress and energy accumulation along the Yammouneh Fault line in that location.

关键词： CR-39 Detector Earthquake prediction Exhalation rate Lebanon Radon Stress/strain

Bias-Free Solar-to-Hydrogen Conversion in a BiVO_(4)/PM6:Y6 Compact Tandem with Optically Balanced Light Absorption

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Energy & Environmental Materials 2024年第4期7卷 231-238页

作者： Catarina G.ferreira Constanza Sansierra francisco Bernal-Texca Mingyu Zhang Carles Ros Jordi Martorell ICFO-Institut de CiAencies FotAoniques The Barcelona Institute of Science and TechnologyCastelldefels 08860BarcelonaSpain Departament de FAısica Universitat PolitAecnica de CatalunyaTerrassa 08222Spain

The high voltage required to overcome the thermodynamic threshold and the complicated kinetics of the water splitting reaction limit the efficiency of single semiconductor-based photoelectrochemistry.A semiconductor/solar cell tandem structure has been theoretically demonstrated as a viable path to achieve an efficient direct transformation of sunlight into chemical ***,compact designs exhibiting the indispensable optimally balanced light absorption have not been *** the current work,we design and implement a compact tandem providing the complementary absorption of a highly transparent BiVO_(4)photoanode and a PM6:Y6 solar *** bandgap combination approaches the optimal to reach the solar-to-hydrogen(STH)conversion upper limit for tandem photoelectrochemical cells(PECs).We demonstrate that,by using a photonic multilayer structure to adequately balance sunlight absorption among both tandem materials,a 25%increase in the bias-free STH conversion can be achieved,setting a clear path to take compact tandem PECs to the theoretical limit performance.

关键词： bismuth vanadate compact tandem organic solar cells photonic multilayers solar-to-hydrogen conversion

Novel preoperative strategies to improve hepatocellular carcinoma resectability

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 140-141页

作者： francisco Tustumi Fabricio ferreira Coelho Paulo Herman Department of Gastroenterology Universidade de São PauloSao PauloBrazil Department of Surgery Hospital Israelita Albert EinsteinSao PauloBrazil

Peng et al.(1)performed a pretty interesting article,reporting the proposal of a new strategy to improve resectability for hepatocellular carcinoma(HCC).Their findings are *** strategies to improve liver resection are methods for promoting future liver remnant(FLR)growth in a timely manner before cancer *** main strategies are portal vein embolization(PVE)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).

关键词： hepatocellular liver

Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo Joao francisco Coelho dos Santos Jr Wagner Jose Barbosa Corradi francisco ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

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Bioactive Materials 2024年第4期34卷 311-325页

作者： Emanuel Quartin Susana Rosa Sara Gonzalez-Anton Laura Mosteo Lopez Vitor francisco Delfim Duarte Cristina Lo Celso Ricardo Pires das Neves Lino ferreira CNC-Center for Neuroscience and Cell Biology CIBB-Centre for Innovative Biomedicine and BiotechnologyUniversity of Coimbra3004-517CoimbraPortugal IIIUC-Institute of Interdisciplinary Research University of Coimbra3004-517CoimbraPortugal Faculty of Medicine University of Coimbra3004-517CoimbraPortugal Department of Life Sciences Imperial College LondonSouth Kensington CampusThe Francis Crick InstituteLondonUK Haematopoietic Stem Cell Laboratory The Francis Crick InstituteLondonUK Instituto de Investigação e Inovação em Saúde(i3S) University of PortoPortoPortugal Department of Biomedicine Faculdade de Medicina da Universidade do Porto(FMUP)PortoPortugal Department of Onco-Hematology Instituto Português de Oncologia(IPO)-PortoPortoPortugal

More effective approaches are needed in the treatment of blood cancers,in particular acute myeloid leukemia(AML),that are able to eliminate resistant leukemia stem cells(LSCs)at the bone marrow(BM),after a chemotherapy session,and then enhance hematopoietic stem cell(HSC)engraftment for the re-establishment of the HSC ***,we investigate whether light-activatable nanoparticles(NPs)encapsulating all-trans-retinoic acid(RA^(+)NPs)could solve both *** in vitro results show that mouse AML cells transfected with RA^(+)NPs differentiate towards antitumoral M1 macrophages through RIG.1 and OASL gene *** in vivo results further show that mouse AML cells transfected with RA^(+)NPs home at the BM after transplantation in an AML mouse *** photo-disassembly of the NPs within the grafted cells by a blue laser enables their differentiation towards a macrophage *** macrophage activation seems to have systemic anti-leukemic effect within the BM,with a significant reduction of leukemic cells in all BM compartments,of animals treated with RA^(+)NPs,when compared with animals treated with empty *** a separate group of experiments,we show for the first time that normal HSCs transfected with RA^(+)NPs show superior engraftment at the BM niche than cells without treatment or treated with empty *** is the first time that the activity of RA is tested in terms of long-term hematopoietic reconstitution after transplant using an in situ activation approach without any exogenous priming or genetic conditioning of the transplanted ***,the approach documented here has the potential to improve consolidation therapy in AML since it allows a dual intervention in the BM niche:to tackle resistant leukemia and improve HSC engraftment at the same time.

关键词： Light Nanoparticles Retinoic acid Leukemia M1 macrophages Drug delivery

Soil texture prediction through stratification of a regional soil spectral library

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Pedosphere 2022年第2期32卷 294-306页

作者： José Janderson ferreira COSTA élvio GIASSON Elisangela Benedet DA SILVA Tales TIECHER Antonny francisco Sampaio DE SENA Ryshardson Geovane Pereira de Oliveira E SILVA Department of Soil Science Faculty of AgronomyUniversity of Rio Grande do SulBento Gonçalves Avenue 7712Porto Alegre 91540-000Brazil Agricultural Research and Rural Extension Corporation of Santa Catarina Rodovia Admar Gonzaga 1347FlorianópolisSanta Catarina 88034-901Brazil

Knowing the spatial distribution of soil texture,which is a physical property,is essential to support agricultural and environmental decision *** texture can be estimated using visible,near infrared,and shortwave infrared(Vis-NIR-SWIR)***,the performance of spectroscopic models is variable because of soil ***,few studies address the effects of soil sample variability on the performance of the models,especially for larger spectral libraries that include soils that are more ***,the objectives of this study were to:i)apply Vis-based color parameters on the stratification of a regional soil spectral library;ii)evaluate the performance of the predictive models generated from the spectral library stratification;iii)compare the performance of stratified models(SMs)and the model without stratification(WSM),and iv)explain possible changes in prediction accuracy based on the ***,a regional soil spectral library with 1535 samples from the State of Santa Catarina,Brazil was *** reflectance data were obtained by Vis-NIR-SWIR spectroscopy in the laboratory using a spectroradiometer covering the 350–2500 nm spectral ***,silt,and clay fractions were determined using the pipette ***-two components of color parameters were derived from the Vis spectrum using the colorimetric models.A cubist regression algorithm was used to assess the accuracy of the applicability of the initial models(SMs and WSM)and of the validation between the *** order derivatives(FODs)at 0.5,1.5,and 2 intervals were used to explain possible changes in the performance of the *** SMs with higher contents of clay and iron oxides obtained the highest accuracy,and the most important spectral bands were identified,mainly in the 480–550 and 850–900 nm ranges and the 1400,1900,and 2200 nm ***,stratification of soil spectral libraries is a good strategy to improve regional assessments of soil resou

关键词： color parameters cubist regression fractional order derivatives soil spectroscopy spectroscopic model stratified model Vis-NIR-SWIR

Monitoring of Ultrafine Particles in the Surrounding Urban Area of In-Land Passenger Ferries

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Journal of Environmental Protection 2019年第6期10卷 838-860页

作者： Margarida Lopes Ana Russo Célia Gouveia francisco ferreira Department of Sciences and Environmental Engineering NOVA School of Science and Technology NOVA University of Lisbon Caparica Portugal Instituto Dom Luiz (IDL) Faculdade de Ciências da Universidade de Lisboa Lisboa Portugal Portuguese Institute for Sea and Atmosphere Lisbon Portugal Centre for Environmental and Sustainability Research (CENSE) NOVA School of Science and Technology NOVA University of Lisbon Caparica Portugal

Maritime transportation, widely used both in international transport of goods and touristic purposes, has been identified as a significant source of ultrafine particles (UFP). In-land passenger ferry is a source of UFP far less addressed;however, in locations with relatively high frequency of this transportation mode, it is expected that they contribute to an increase of their concentration. Moreover, the negative effects of UFP on human health and environment are known and therefore, monitoring UFP produced by ferries is vital to assess the degree of exposure of who work or live close to ferries’ terminals or downwind to their cruising path. This work aims to study the influence of in-land ferries activities on UFP in the urban/suburban areas near ferries’ terminals and downwind across the cruising path. The UFP monitoring campaign was carried out from September to December 2018 for 19 non-consecutive periods. The sampling sites were chosen in order to maximize measurements under downwind conditions and allow the association between ferry operation and UFP concentration response. Based on data collected, correlation analysis was performed between ferry’s traffic and particle number counting (PNC) of UFP, and also with meteorological variables. Results show an increase in PNC ranging from 25 to 197% during the third minute around a ferry movement and are moderate to positive significant correlations between PNC values and the number of ferry operations (r = 0.79 to r = 0.94), showing that UFP emitted by in-land ferries contributes to PNC increase. Moreover, negative correlations (r = -0.85 to r = -0.93) between PNC and wind intensity were also found.

关键词： Air Pollution PNC In-Land Passenger Ferries Monitoring Campaign Health