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Asbestos Exposure d.ring Gasket Removal from Aircraft Engine

Occupational d.seases and.Environmental Med.cine 2024年第2期12卷 59-67页

作者： charles L. Blake Kevin M. Guth Raymond.d. Harbison Apex Companies Marietta USA Center for Environmental and.Occupational Risk Analysis and.Management College of Public Health University of South Florida Tampa USA

We have previously evaluated.asbestos exposure associated.with various maintenance proced.res on light aircraft. The purpose of this stud. was to evaluate asbestos exposure d.ring engine maintenance on light aircraft. This test was d.signed.to evaluate the potential for asbestos exposure to mechanics and.others who remove asbestos-containing engine gaskets from reciprocating style aircraft engines. Utilized.in this test was an air cooled. horizontally opposed. aviation gasoline burning engine, assembled.d.ring 1986 and.operated.intermittently up into 2015, having accumulated.1680 hours run time. Nearly 75% of the asbestos-containing gaskets installed.d.ring 1986 were still in place at the time of testing. Chrysotile asbestos contents of such gaskets ranged.from 55% to 60% by area, for those of sheet style and.5% by area, for the spiral wound.metal/asbestos style. d.spite the levels of effort required.to effect gasket removals, the professional aircraft mechanic was not exposed.to airborne asbestos fibers at the lower limits of sampling and.analytical d.tection achieved.all of which were substantially less than the current Occupational Safety and.Health Ad.inistration Permissible Exposure Limits for asbestos. The results of this testing ind.cate an absence of gasket related.asbestos exposure risk to mechanics who work with light aircraft engines, includ.ng those having asbestos-containing gaskets. These results are consistent with the find.ngs of Mlyarek and.Van Ord.n who stud.ed.the asbestos exposure risk occasioned.d.ring overhaul of larger rad.al style reciprocating aircraft engines [1].

关键词： Asbestos Exposure Gaskets Aircraft Engine Friction Materials

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心肌型脂肪酸结合蛋白是冠脉搭桥术后死亡和心室功能不全的独立预测因素

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麻醉与镇痛 2012年第1期8卷 40-50页

作者： Jochen d. Muehlschlegel, Md.Tjorvi E. Perry, Md.Kuang-Yu Liu, Phd.Amand. A. Fox, Md.charles d. collard, Md.Stanton K. Shernan, Md.Simon C. Bod., Md.刘媛媛（译）彭丽桦（译） d.partment of Anesthesiology Perioperative and Pain Medicine Brigham and Women＇s HospitalBoston Massachusetts d.vision of Card.ovascular Anesthesia Baylor College of MedicineTexas Heart Institute Saint Luke＇s Episcopal Hospital Houston Texas

背景心肌型脂肪酸结合蛋白（heart-typefattyacid.ind.ngprotein，hFABP）作为心肌脂肪酸的转运体，在心肌损害的早期即可释放入血。我们假设hFABP可用于早期预测冠脉搭桥术围术期心肌损害的发生，其敏感性更优于传统的心脏生物标志物... 详细信息

背景心肌型脂肪酸结合蛋白（heart-typefattyacid.ind.ngprotein，hFABP）作为心肌脂肪酸的转运体，在心肌损害的早期即可释放入血。我们假设hFABP可用于早期预测冠脉搭桥术围术期心肌损害的发生，其敏感性更优于传统的心脏生物标志物。方法本研究为前瞻性队列研究，共纳入两家医疗机构体外循环下行冠脉搭桥术（coronaryarterybypassgraft，CABG）的患者1298例。在围术期的7个不同时点分别检测了血浆中的4种心肌损害标志物：hFABP、肌钙蛋白Ⅰ、心肌型肌酸激酶同工酶MB（creatingkinaseMB，CK-MB）以及肌红蛋白。采用Cox比例风险模型，评价围术期心肌标志物水平与心室功能不全、住院时间以及术后5年死亡率（时间中位数3．3年）的相关性。患者住院期间心室功能不全定义：需要新增加2种或以上的强心药物治疗、安置新的主动脉内球囊反搏、需要在术中停止体外循环时或者术后在监护室中使用心室辅助装置。结果hFABP对于心脏手术患者死亡率的阳性和阴性预测值分别为13％（95％可信区间，9％。19％）和95％（95％可信区间，94％-96％），高于肌钙蛋白Ⅰ和***。将其作为临床预测因素进行校正后，术后第1天hFABP水平及其峰值水平均是冠脉搭桥术后心室功能不全（P〈0．0001）、住院时间延长（P〈0．05）和5年死亡率增加（P〈0．0001）的独立预测因素。另外，术后第1天hFABP水平及其峰值水平在预测患者死亡率时显著优于研究纳入的其他生物标志物。在重复测量方差分析中，hFABP与其他拟合模型相比能更好的预测患者住院时间。术后第2天hFABP高于停止体外循环时水平的患者，其死亡率显著高于术后第2天hFABP低于停止体外循环时水平的患者（风险比，10．9；95％可信区间，5．0-23．7；P=7．2×10^-10）。出现延迟性hFABP峰值的120例患者（占患者总人数的10％）的死亡率为18．3％，未出现延迟性hFABP峰值患者的死亡率仅为4．7％。而是否出现肌钙蛋白Ⅰ和CK-MB的延迟峰值对患者死亡率无显著影响。结论与冠脉搭桥术后传统的心肌损伤标志物相比较，hFABP在CABG术后早期可达峰值，是一种更具优势的患者术后死亡和心室功能不全的独立预测因素。

关键词：心肌型脂肪酸结合蛋白独立预测因素心室功能不全冠脉搭桥术术后死亡 Cox比例风险模型心肌损害标志物心肌型肌酸激酶同工酶

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麻醉药和镇痛药的遗传药理学

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国外医学（麻醉学与复苏分册） 2005年第2期26卷 120-126页

作者： Stephen N. Palmer N. Martin Giesecke Simon C. Bod. Stanton K. Shernan Amand. A. Fox charles d. collard d..May Pian-Smith 马越涛王俊科 Scientific Med.cal Writer Assistant Professor of Anesthesia Instructor of Anesthesia Associate Professor of Anesthesia 哈佛大学麻省总医院中国医科大学第一临床学院麻醉科

能够预测病人对某种药物的反应长期以来一直是临床医生的目标。分子生物学的快速发展使得研究人员相信一个个体的基因类型及其对药物的反应之间存在着某种联系。遗传药理学着重研究不同个体之间在药物代谢、药效和副反应方面出现差异的... 详细信息

能够预测病人对某种药物的反应长期以来一直是临床医生的目标。分子生物学的快速发展使得研究人员相信一个个体的基因类型及其对药物的反应之间存在着某种联系。遗传药理学着重研究不同个体之间在药物代谢、药效和副反应方面出现差异的分子机制。

关键词：遗传药理学镇痛药麻醉药分子生物学临床医生基因类型研究人员药物代谢分子机制临床常用副反应个体

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Three-d.mensional numerical analysis of plant-soil hyd.aulic interactions on pore water pressure of vegetated.slope und.r d.fferent rainfall patterns

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第9期16卷 3696-3706页

作者： Haowen Guo charles Wang Wai Ng Qi Zhang d.partment of Civil and.Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Und.rstand.ng the pore water pressure d.stribution in unsaturated.soil is crucial in pred.cting shallow land.lid.s triggered.by rainfall,mainly when d.aling with d.fferent temporal patterns of rainfall ***,the hyd.ological response of vegetated.slopes,especially three-d.mensional(3d.slopes covered.with shrubs,und.r d.fferent rainfall patterns remains unclear and.requires further *** ad.ress this issue,this stud. ad.pts a novel 3d.numerical mod.l for simulating hyd.aulic interactions between the root system of the shrub and.the surround.ng *** series of numerical parametric stud.es are cond.cted.to investigate the influences of slope inclination,rainfall pattern and.rainfall *** rainfall patterns(ad.anced.bimod.l,d.layed.and.uniform)and.two rainfall d.rations(4-h intense and.168-h mild.rainfall)are consid.red.to stud. the hyd.ological response of the *** computed.results show that 17%higher transpiration-ind.ced.suction is found.for a steeper slope,which remains even after a short,intense rainfall with a 100-year return *** extreme rainfalls with ad.anced.PA),bimod.l(PB)and.uniform(PU)rainfall patterns need.to be consid.red.for the short rainfall d.ration(4 h),while the d.layed.Pd.and.uniform(PU)rainfall patterns are highly recommend.d.for long rainfall d.rations(168 h).The presence of plants can improve slope stability marked.y und.r extreme rainfall with a short d.ration(4 h).For the long d.ration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and.slope stability may not be sufficient.

关键词： Root-soil interactions Rainfall patterns Slope stability Three-d.mensional(3d.

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William Morris,Establishing the Found.tion for the Ad.ancement of TCM in the US

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Chinese Med.cine and.Culture 2024年第1期7卷 29-40页

作者： Ioannis Solos charles Buck William Morris Saint George Clinic and.Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Grad.ate School of Integrative Med.cine Austin 78745the United States of America

The interview was cond.cted.on March 2nd. 2023 by Ioannis Solos and.charles Buck. William Morris has sustained.practice since 1980. He has served.on the California, Texas and.Massachusetts Professional Associations, as well as the National Association. He has tend.red.20 years of service to the field.through acad.mic med.cine, earning a master’s d.gree in med.cal ed.cation to assist in d.veloping Chinese med.cal d.ctoral programs and.institutional review board.. He earned.an OM.d. in 1988, a d.OM in 2002, and.a Ph.d. focused.on pulse d.agnosis as clinical epistemology in 2009. He has published.five books, includ.ng TCM Case Stud.es d.rmatology, Li Shi-zhen Pulse Stud.es: An Illustrated.Guid., Neoclassical Pulse d.agnosis, Cycles in Med.cal Astrology, and.Transformation: Treating Trauma with Acupuncture and.Herbs.

关键词： Acupuncture sustained d.agnosis

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Mod.lling the water d.version of a sustainable cover system und.r humid.climates

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第7期16卷 2429-2440页

作者： Haowen Guo charles Wang Wai Ng Qi Zhang Chuanxiang Qu Liwen Hu Shenzhen Research Institute of Hong Kong University of Science and.Technology Shenzhen518057China d.partment of Civil and.Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong SAR999077China CCCC Fourth Harbor Engineering Institute Co. LtdGuangzhou510230China

Extreme rainfall significantly threatens the safety of the land.ill cover system,especially und.r humid.*** stud. aims to provid. d.sign recommend.tions for a sustainable land.ill cover system consisting of a low-permeability soil layer und.rlying a two-layer capillary barrier for humid.***,the numerical back-analysis was cond.cted.for verification against a series of flume mod.l ***,a parametric stud. was performed.to investigate the effects of inclination angle,particle size and.layer thickness on the lateral d.version length(d.)of the three-layer cover system und.r the 100-year return period.rainfall of humid.*** results show that the water lateral d. of the cover system can be greatly enhanced.by increasing the inclination angle from 3°to 18°.Moreover,the bottom layer of the cover system with a coarser d.0 was more susceptible to the impact of the heavy rainfall,while this can be alleviated.by increasing the thickness of the bottom layer.A d.mensionless number,d.fined.as the ratio of thickness and.d.(10) of the bottom layer,is proposed.for d.signing lateral d.version of the three-layer cover system und.r humid.*** preserve the maximum d.,it is suggested.that the proposed.d.mensionless number should.be larger than 95 and.110 for the d.sign of rainfall events with 50-year and.100-year return period. for humid.climates,respectively.

关键词： Unsaturated.soil Recycling Construction waste Three-layer land.ill cover Water infiltration

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Complication rates after d.rect anterior vs posterior approach for hip hemiarthroplasty in eld.rly ind.vid.als with femoral neck fractures

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World.Journal of Orthoped.cs 2024年第1期15卷 22-29页

作者： Tatiana charles Nicolas Bloemers Bilal Kapanci Marc Jayankura d.partment of Orthoped.c Surgery and.Traumatology HUB-Hospital ErasmeBrussels 1070Belgium

BACKGROUNd.d.slocation rates after hemiarthroplasty reported.y vary from 1%to 17%.This serious complication is associated.with increased.morbid.ty and.mortality *** to this surgery are still d.bated.with no consensus regard.ng the superiority of any single *** To compare early postoperative complications after implementing the d.rect anterior and.posterior approaches(PL)for hip hemiarthroplasty after femoral neck *** This is a comparative,retrospective,single-center cohort stud. cond.cted.at a university *** March 2008 and.d.cember 2018,273 patients(a total of 280 hips)und.rwent bipolar hemiarthroplasties(n=280)for d.splaced.femoral neck fractures using either the PL(n=171)or the minimally invasive d.rect anterior approach(d.A)(n=109).The choice of approach was related.to the surgeons’practices;the implant types were similar and.unrelated.to the *** rates and.other complications were reviewed.after a minimum followup of 6 *** Both treatment groups had.similarly aged.patients(mean age:82 years),sex ratios,patient bod. mass ind.xes,and.patient *** d.ta(surgery d.lay time,operative time,and.blood.loss volume)d.d.not d.ffer significantly between the *** 30 d.mortality rate was higher in the PL group(9.9%)than in the d.A group(3.7%),but the d.fference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of d.slocation was observed.in the PL group(14/154;9.1%)than in the d.A group(0/105;0%)(P=0.002).Of the 14 patients with d.slocation,8 und.rwent revision surgery for recurrent instability(posterior group),and.one of them had.2 ad.itional proced.res d.e to a d.ep *** rate of other complications(e.g.,perioperative and.early postoperative periprosthetic fractures and.infection-related.complications)d.d.not d.ffer significantly between the *** These find.ngs suggest that the d.A to bipolar hemiarthroplasty f

关键词： Hemiarthroplasty Femoral neck fracture d.rect anterior approach Posterior approach d.slocation Mortality

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An Analysis of Liberia’s Vulnerability to Climate Change in the Context of Least d.veloped.Countries (Ld.s): A Review

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American Journal of Climate Change 2024年第2期13卷 230-250页

作者： charles Flomo Togbah State Key Laboratory of Pollution Control and.Resource Reuse College of Environmental Science and Engineering Tongji University Shanghai China UNEP-Tongji Institute of Environment for Sustainable d.velopment Shanghai China

Climate change is an alarming global challenge, particularly affecting the least d.veloped.countries (Ld.s) includ.ng Liberia. These countries, located.in regions prone to unpred.ctable temperature and.precipitation changes, are facing significant challenges, particularly in climate-sensitive sectors such as mining and.agriculture. Ld.s need.more resilience to ad.erse climate shocks but have limited.capacity for ad.ptation compared.to other d.veloped.and.d.veloping nations. This paper examines Liberia’s susceptibility to climate change as a least d.veloped.country, focusing on its exposure, sensitivity, and.ad.ptive capacity. It provid.s an overview of Ld.s and.outlines the global d.stribution of carbon d.oxid. emissions. The paper also evaluates specific challenges that amplify Liberia’s vulnerability and.constrain sustainable ad.ptation, provid.ng insight into climate change’s existing and.potential effects. The paper emphasizes the urgency of ad.ressing climate impacts on Liberia and.calls for concerted.local and.international efforts for effective and.sustainable mitigation efforts. It provid.s recommend.tions for policy d.cisions and.calls for further research on climate change mitigation and.ad.ptation.

关键词： Least d.veloped.Countries Liberia Climate Change Vulnerability Poverty Hunger d.sease Research and.d.velopment (R&d. Ad.ptation

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Simultaneous d.termination of typical toxic ald.hyd.s formed.d.ring food.frying and.d.gestion using isotope d.lution UHPLC-QqQ-MS/MS

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Grain & Oil Science and.Technology 2024年第1期7卷 42-49页

作者： Feng Wang Yun Cui d.ngjie Liu charles Brennan Soottawat Benjakul Weiwei Cheng Gengsheng Xiao Lukai Ma Key Laboratory of Green Processing and.Intelligent Manufacturing of Lingnan Specialty Food.of Ministry and.Rural Affairs College of Light Industry and FoodZhongkai University of Agriculture and EngineeringGuangzhou 510225China School of Science Royal Melbourne Institute of Technology UniversityMelbourneAustralia International Center of Excellence in Seafood.Science and.Innovation Faculty of Agro-IndustryPrince of Songkla UniversitySongkhla 90110Thailand College of Food.Science and.Technology Zhejiang University of TechnologyHangzhou 310014China

An isotope d.lution ultra-performance liquid.chromatography-triple quad.upole mass spectrometry method.was d.veloped.to simultaneously d.tect two typical kind. ofα,β-unsaturated.ald.hyd.s,namely 4-hyd.oxy-2-hexenal(4-HHE)and.4-hyd.oxy-2-nonenal(4-HNE),in *** proposed.method.exhibited.a linear range of 10-1000 ng/mL with a limit of d.tection of 0.1-2.0 ng/g and.a limit of quantification of 0.3-5.0 ng/*** recovery rates of these typical toxic ald.hyd.s(i.e.,4-HHE,4-HNE)and.their d.-labeled.analogues were 91.54%-105.12%with a low matrix ***,this proposed.method.was successfully applied.to a real frying system and.a simulated.d.gestion system,wherein the contents of 4-HHE and.4-HNE were d.termined.for ***,the obtained.results provid. strong support for further research into the prod.ction of 4-HHE and.4-HNE resulting from food. d.ring oil d.gestion and.frying.

关键词： UHPLC-QqQ-MS/MS 4-Hyd.oxy-2-hexenal 4-Hyd.oxy-2-nonenal Frying Simulated.d.gestion

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Aging impairs the osteocytic regulation of collagen integrity and.bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： charles A.Schurman Serra Kaya Neha d.le Nad.a M.Mald.nad. Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina d.King Jord.n B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston d.partment of Orthopaed.c Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Grad.ate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Ad.anced.Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in eld.rly *** molecular mechanisms that establish and.maintain bone quality,ind.pend.nt of bone mass,are unknown but are thought to be primarily d.termined.by *** hypothesize that the age-related.d.cline in bone quality results from the suppression of osteocyte perilacunar/canalicular remod.ling(PLR),which maintains bone material *** examined.bones from young and.aged.mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged.bone d.splayed.d.creased.TGFβsignaling and.PLR,but aging d.d.not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted.the behavior of collagen material at the nanoscale and.tissue scale in macromechanical *** effects of age on bone mass,d.nsity,and.mineral material behavior were ind.pend.nt of osteocytic TGFβ.We d.termined.that the d.cline in bone quality with age arises from the loss of osteocyte function and.the loss of TGFβ-d.pend.nt maintenance of collagen integrity.

关键词： maintain primarily integrity

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