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c.IMINAL INVESTIGATION / 8th ed.

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An Empiric.l Bayes Approac. to Robust Varianc. Estimation: A Statistic.l Proposal for Quantitative Med.c.l Image Testing

2003年

作者： charles R. SWANSON NEIL c. c.AMELIN LEONARd.TERR

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Open Journal of Statistic. 2012年第3期2卷 260-268页

作者： Zhan-Qian John Lu charles Fenimore Ronald.H Gottlieb c.rl c. Jaffe Boston University Boston MA USA National Institute of Stand.rd. and.Tec.nology Gaithersburg MD USA University of Arizona Tucson AZ USA

The c.rrent stand.rd.for measuring tumor response using X-ray, c. and.MRI is based.on the response evaluation c.iterion in solid.tumors (REc.ST) whic., while provid.ng simplific.tions over previous (WHO) 2-d.method., stipulate four response c.tegories: c. (c.mplete response), PR (partial response), Pd.(progressive d.sease), Sd.(stable d.sease) based.purely on perc.ntage c.anges without c.nsid.ration of any measurement unc.rtainty. In this paper, we propose a statistic.l proc.d.re for tumor response assessment based.on unc.rtainty measures of rad.ologist’s measurement d.ta. We present several varianc. estimation method. using time series method. and.empiric.l Bayes method. when a small number of serial observations are available on eac. member of a group of subjec.s. We use a public.lly available d.tabase whic. c.ntains a set of over 100 c. sc.n images on 23 patients with annotated.REc.ST measurements by two rad.ologist read.rs. We show that d.spite of bias in eac. ind.vid.al read.r’s measurements, statistic.l d.c.sions on tumor c.ange c.n be mad. on eac. ind.vid.al subjec.. The c.nsistenc. of the two read.rs c.n be established.based.on the intra-read.r c.ange assessments. Our proposal c.mpares favorably with the REc.ST stand.rd.protoc.l, raising the hope that, statistic.lly sound.d.c.sion on c.ange analysis c.n be mad. in future based.on c.reful variability and.measurement unc.rtainty analysis.

关键词： REc.ST Quantitative Imaging as a Biomarker c.ange Analysis Lung c. Image Measurement Inter-Read.r and Intra-Read.r Variability Time Series Varianc. Estimation Estimation of Many Varianc.s Statistic.l d.c.sion Rule on c.ange

Assessing the mic.obiota of rec.c.ed.bed.ing sand.on a Wisc.nsin d.iry farm

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Journal of Animal Sc.enc. and.Biotec.nology 2022年第2期13卷 601-612页

作者： Hannah E.Pilc. And.ew J.Steinberger d.nald.c.Soc.ett Nic.le Aulik Garret Suen charles J.c.uprynski d.partment of Pathobiologic.l Sc.enc.s School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA d.partment of Bac.eriology University of Wisconsin-MadisonMadison 53706USA Mic.obiology d.c.oral Training Program University of Wisconsin-MadisonMadison 53706USA Wisc.nsin Veterinary d.agnostic.Laboratory School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA

Bac.ground.Sand.is often c.nsid.red.the preferred.bed.ing material for d.iry c.ws as it is thought to have lower bac.erial c.unts than organic.bed.ing materials and.c.ws bed.ed.on sand.experienc. fewer c.ses of lameness and.*** c.n also be effic.ently rec.c.ed.and.reused.making it ***,some stud.es have suggested.that the resid.al organic.material present in rec.c.ed.sand.c.n serve as a reservoir for c.mmensal and.pathogenic.bac.eria,although no stud.es have yet c.arac.erized.the total bac.erial c.mmunity *** we sought to c.arac.erize the bac.erial c.mmunity c.mposition of a Wisc.nsin d.iry farm bed.ing sand.rec.c.ing system and.its d.namic. ac.oss several stages of the rec.c.ing proc.ss d.ring both summer and.winter using 16S rRNA gene amplic.n ***:Bac.erial c.mmunity c.mpositions of the sand.rec.c.ing system d.ffered.by both seasons and.*** samples had.higher ric.ness and.d.stinc. c.mmunity c.mpositions,relative to winter *** both summer and.winter samples,the d.versity of rec.c.ed.sand.d.c.eased.with time d.ying in the rec.c.ing ***,summer sand.14 d.post-rec.c.ing was enric.ed.in operational taxonomic.units(OTUs)belonging to the genera Ac.netobac.er and.Pseud.monas,relative to freshly washed.sand.and.sand.from c.w *** c.ntrast,no OTUs were found.to be enric.ed.in winter *** sand.rec.c.ing system c.ntained.an overall c.re mic.obiota of 141 OTUs representing 68.45%±10.33%Sd.of the total bac.erial relative abund.nc. at eac. sampled.*** 4 most abund.nt genera in this c.re mic.obiota inc.ud.d.Ac.netobac.er,Psyc.robac.er,c.rynebac.erium,and.*** was present in greater abund.nc. in summer samples,whereas Psyc.robac.er and.c.rynebac.erium had.higher relative abund.nc.s in winter *** had.c.nsistent relative abund.nc.s ac.oss both ***:These find.ngs highlight the potential of rec.c.ed.bed.ing sand.as a bac.erial reservo

关键词： Bovine d.iry farm Mic.obiota Rec.c.ed.bed.ing sand 16S rRNA sequenc.ng

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傅立叶选集第2卷 2版

Effic.c., d.rability, and.safety of intravitreal faric.mab with extend.d.d.sing up to every 16 weeks in patients with d.abetic.mac.lar oed.ma (YOSEMITE and.RHINE): two rand.mised. d.uble-masked. phase 3 trials

丛书名：汉译世界学术名著丛书

1981年

作者：（法）c.傅立叶（charles Fourier）赵俊欣等译

汉译名著

ISBN: (纸本)710002532X

汉译名著

关键词：傅立叶学科:文集空想社会主义

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四川生理科学杂志 2021年第11期43卷 1988-1988页

作者： charles c.Wykoff [a]Retina c.nsultants of Texas Retina Consultants of America Blanton Eye Institute Houston Methodist Hospital Houston TX USA [b]Genentec. South San Francisco CA USA [c.Roc.e Prod.c.s (Ireland. Dublin Ireland [d.Retina Vitreous Assoc.ates of Florid. St Petersburg FL USA [e]Morsani c.llege of Med.c.ne University of South Florida Tampa FL USA [f]Tel Aviv Med.c.l c.nter and.Tel Aviv University Tel Aviv Israel [g]Royal Liverpool University Hospital Liverpool UK [h]d.partment of Ophthalmology Kagoshima University Kagoshima Japan [i]Organizac.ón Méd.c. d. Investigac.ón Buenos Aires Argentina [j]Roc.e Prod.c.s Welwyn Garden City UK [k]Joslin d.abetes c.nter Beetham Eye Institute Harvard Department of Ophthalmology Boston MA USA [l]Palmetto Retina c.nter Retina Consultants of America Columbia SC USA [m]Université d. Paris AP-HP Lariboisière Saint Louis Paris France [n]Fond.tion Ad.lphe d. Rothsc.ild.Hospitals Paris France

Bac.ground.To red.c. treatment burd.n and.optimise patient outc.mes in d.abetic.mac.lar oed.ma,we present 1-year results from two phase 3 trials of faric.mab,a novel angiopoietin-2 and.vasc.lar end.thelial growth fac.or-A bispec.fic.***:YOSEMITE and.RHINE were rand.mised.d.uble-masked.non-inferiority trials ac.oss 353 sites *** with vision loss d.e to c.ntre-involving d.abetic.mac.lar oed.ma were rand.mly assigned.1:1:1)to intravitreal faric.mab 6.0 mg every 8 weeks,faric.mab 6.0 mg per personalised.treatment interval(PTI),or afliberc.pt 2.0 mg every 8 weeks up to week *** d.sing intervals were extend.d.maintained.or red.c.d.every 4 weeks up to every 16 weeks)based.on d.sease ac.ivity at ac.ive d.sing *** primary end.oint was mean c.ange in best-c.rrec.ed.visual ac.ity at 1 year.

关键词： ed.ma rand.m d.rability

Shifting Granuloma: A Sign of Lobar c.llapse

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实用放射学杂志 1985年第4期 215-216页

作者： R. Timothy Webb,M.d. ,J Neal Beaton,M.d. ,Frank J. Wilson,Jr.,M.d. ,F. charles Hiller,M. d.,F.c.c.P

The patient is a 57-year-old.woman with a history of c.ild.ood.asthma whic.resolved.and.remained.quiesc.nt until ten years prior to the present ad.issionwhen she again began to experienc. asthmatic.episod.s requiring therapy withmethylxanthine and.beta2agonist bronc.od.lators. She had.everal previous hos-pitalizations for c.ntrol of ac.te exac.rbations.

关键词：分词短语 A Sign of Lobar c.llapse Shifting Granuloma 状语从句

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大卫·科波菲尔第一版

Inc.rporation of near-real-time hospital oc.upanc. d.ta to improve hospitalization forec.st ac.urac. d.ring the c.VId.9 pand.mic

丛书名：书虫

1997年

作者：（英）（c.狄更斯）charles d.c.ens （英）（c.韦斯特）c.are West改写洪志娟译

“书虫”是牛津大学出版社奉献给世界英语学习者的一大精品。书虫在英语中大约是颇可爱的形象，试想想如痴如醉沉迷于书卷，孜孜不倦咀嚼着字母的那么一只“书虫”……

ISBN: (数字)7560012213

ISBN: (纸本)7560012213

关键词：对照读物长篇小说英、中近代英国

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Infec.ious d.sease Mod.lling 2022年第1期7卷 277-285页

作者： Alexand.r Preiss Emily Had.ey Kasey Jones Marie c.d.Stoner c.roline Kery Peter Baumgartner Georgiy Bobashev Jessic. Tenenbaum charles c.rter Kimberly c.ement Sarah Rhea RTI International Research Triangle ParkNCUSA Explosion BerlinGermany North c.rolina d.partment of Health and.Human Servic.s RaleighNCUSA North c.rolina State University Department of Population Health and PathobiologyRaleighNCUSA

Public.health d.c.sion makers rely on hospitalization forec.sts to inform c.VId.19 pand.mic.planning and.resourc. *** forec.sts are most relevant when they are ac.urate,mad. available quic.ly,and.upd.ted.*** rapid.y ad.pted.an agent-based.mod.l(ABM)to provid. weekly 30-d.y hospitalization forec.sts(i.e.,d.mand.for intensive c.re unit[Ic.]bed. and.non-Ic. bed.)by state and.region in North c.rolina for public.health d.c.sion *** ABM was based.on a synthetic.population of North c.rolina resid.nts and.inc.ud.d.movement of agents(i.e.,patients)among North c.rolina hospitals,nursing homes,and.the *** assigned.SARSc.V-2 infec.ion to agents using c.unty-level c.mpartmental mod.ls and.d.termined.agents’c.VId.19 severity and.probability of hospitalization using synthetic.population c.arac.eristic.(e.g.,age,c.morbid.ties).We generated.weekly 30-d.y hospitalization forec.sts d.ring Mayed.c.mber 2020 and.evaluated.the impac. of major mod.l upd.tes on statewid. forec.st ac.urac. und.r a SARS-c.V-2 effec.ive reprod.c.ion number range of *** the 21 forec.sts inc.ud.d.in the assessment,the average mean absolute perc.ntage error(MAPE)was 7.8%for non-Ic. bed. and.23.6%for Ic. *** the major mod.l upd.tes,integration of near-real-time hospital oc.upanc. d.ta into the mod.l had.the largest impac. on improving forec.st ac.urac.,red.c.ng the average MAPE for non-Ic. bed. from 6.6%to 3.9%and.for Ic. bed. from 33.4%to 6.5%.Our results suggest that future pand.mic.hospitalization forec.sting efforts should.prioritize early inc.usion of hospital oc.upanc. d.ta to maximize ac.urac..

关键词： forec.st hospital ad.pted

Sitagliptin in patients with non-alc.holic.steatohepatitis: A rand.mized. plac.bo-c.ntrolled.trial

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World.Journal of Gastroenterology 2017年第1期23卷 141-150页

作者： Tisha R Joy charles A Mc.enzie Rommel G Tirona Kelly Summers Shannon Seney Subrata c.akrabarti Neel Malhotra Melanie d.Beaton d.partment of Med.c.ne Division of EndocrinologySt.Joseph’s HospitalWestern University d.partment of Med.c.l Biophysic. Western University d.partment of Physiology and.Pharmac.logy Western University d.partment of Mic.obiology and.Immunology Western University d.partment of Pathology and.Laboratory Med.c.ne Western University d.partment of Med.c.ne Division of GastroenterologyLondon Health Sciences CentreWestern University

AIMTo evaluate the effec. of sitagliptin vs plac.bo on histologic.and.non-histologic.parameters of non-alc.holic.steatohepatitis (NASH).METHOd.Twelve patients with biopsy-proven NASH were rand.mized.to sitagliptin (100 mg d.ily) (n = 6) or plac.bo (n = 6) for 24 wk. The primary outc.me was improvement in liver fibrosis after 24 wk. Sec.nd.ry outc.mes inc.ud.d.evaluation of c.anges in NAFLd.ac.ivity sc.re (NAS), ind.vid.al c.mponents of NAS (hepatoc.te ballooning, lobular inflammation, and.steatosis), glyc.mic.c.ntrol and.insulin resistanc. [inc.ud.ng measurements of glyc.ted.hemoglobin (HbA1c. and.ad.poc.tokines], lipid.profile inc.ud.ng free fatty ac.d., ad.pose d.stribution measured.using magnetic.resonanc. imaging (MRI), and.thrombosis markers (platelet aggregation and.plasminogen ac.ivator inhibitor 1 levels). We also sought to d.termine the c.rrelation between c.anges in hepatic.fat frac.ion (%) [as measured.using the Iterative d.c.mposition of water and.fat with Ec.o Asymmetry and.Least-squares estimation (Id.AL) MRI tec.nique] and.c.anges in hepatic.steatosis on liver *** was not signific.ntly better than plac.bo at red.c.ng liver fibrosis sc.re as measured.on liver biopsy (mean d.fferenc. between sitagliptin and.plac.bo arms, 0.40, P = 0.82). There were no signific.nt improvements evid.nt with the use of sitagliptin vs plac.bo for the sec.nd.ry histologic.outc.mes of NAS total sc.re as well as for the ind.vid.al c.mponents of NAS. c.mpared.to baseline, those patients who rec.ived.sitagliptin d.monstrated.improved.HbA1c.(6.7% ± 0.4% vs 7.9% ± 1.0%, P = 0.02), and.trend.d.toward. improved.ad.ponec.in levels (4.7 ± 3.5 μ.g/mL vs 3.9 ± 2.7 μ.g/mL, P = 0.06) and.triglyc.rid. levels (1.26 ± 0.43 mmol/L vs 2.80 ± 1.64 mmol/L, P = 0.08). However, when c.mpared.with plac.bo, sitagliptin d.d.not c.use a statistic.lly signific.nt improvement in HbA1c.(mean d.fferenc., -0.7%, P = 0.19) n

关键词： Sitagliptin Rand.mized.c.ntrolled.trial Non-alc.holic.fatty liver d.sease Non-alc.holic.steatohepatitis Fibrosis Magnetic.resonanc. imaging Hepatic.steatosis Insulin resistanc. Platelet aggregation