检索结果-南通市图书馆

Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate

Journal of Animal Science and Biotechnology 2021年第2期12卷 569-578页

作者： Joshua A.Jackman Astghik Hakobyan Hovakim Zakaryan charles c.elrod School of chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Group of Antiviral Defense Mechanisms Institute of Molecular Biology of NASYerevanArmenia Natural Biologics Inc. NewfieldNY 14867USA. Department of Animal Science Cornell UniversityIthacaNY 14853USA

Background:The ongoing African swine fever virus(ASFv)epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high *** has been recently identified that feed and feed ingredients,along with drinking water,can serve as transmission vehicles and might facilitate transboundary spread of ***,it is important to test the antiviral activity of regulatory compatible,antiviral feed additives that might inhibit ASFv infectivity in *** promising group of feed additive candidates includes medium-chain fatty acids(McFA)and monoglyceride derivatives,which are known to disrupt the lipid membrane surrounding certain enveloped viruses and ***:The antiviral activities of selected McFA,namely caprylic,capric,and lauric acids,and a related monoglyceride,glycerol monolaurate(GML),to inhibit ASFv in liquid and feed conditions were investigated and suitable compounds and inclusion rates were identified that might be useful for mitigating ASFv in feed *** assays showed that all tested McFA and GML inhibit *** was more potent than McFA because it worked at a lower concentration and inhibited ASFv due to direct virucidal activity along with one or more other antiviral ***-dependent feed experiments further showed that sufficiently high GML doses can significantly reduce ASFv infectivity in feed in a linear manner in periods as short as 30 min,as determined by infectious viral titer ***-linked immunosorbent assay(ELISA)experiments revealed that GML treatment also hinders antibody recognition of the membrane-associated ASFv p72 structural protein,which likely relates to protein conformational changes arising from viral membrane ***:Together,the findings in this study indicate that McFA and GML inhibit ASFv in liquid conditions and that GML is also able to reduce ASFv infectivity in feed,which may help to curb disease tr

关键词： African swine fever virus Antiviral Feed pathogen mitigation McFA Medium-chain fatty acids Monoglycerides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medium-chain fatty acids and monoglycerides as feed additives for pig production:towards gut health improvement and feed pathogen mitigation

引用

Journal of Animal Science and Biotechnology 2020年第3期11卷 611-625页

作者： Joshua A.Jackman RDean Boyd charles c.elrod School of chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Hanor company FranklinKY 42134USA North carolina State University RaleighNC 27695USA Natural Biologics Inc. NewfieldNY 14867USA Department of Animal Science Cornell UniversityIthacaNY 14853USA.

Ongoing challenges in the swine industry,such as reduced access to antibiotics and virus outbreaks(e.g.,porcine epidemic diarrhea virus,African swine fever virus),have prompted calls for innovative feed additives to support pig ***-chain fatty acids(McFAs)and monoglycerides have emerged as a potential option due to key molecular features and versatile functions,including inhibitory activity against viral and bacterial *** this review,we summarize recent studies examining the potential of McFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed *** molecular properties and biological functions of McFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig *** latest progress in testing McFAs and monoglycerides as feed additives in pig diets is then presented,and their effects on a wide range of production issues,such as growth performance,pathogenic infections,and gut health,are *** utilization of McFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described,along with advances in molecular encapsulation and delivery ***,we discuss how McFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease *** forward,we envision that McFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

关键词： Antibiotics Feed pathogen mitigation Growth promotion Gut health Immune enhancement McFA Medium-chain fatty acids Monoglycerides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NRF2 signaling cascade in amyotrophic lateral sclerosis:bridging the gap between promise and reality

引用

Neural Regeneration Research 2024年第5期19卷 1006-1012页

作者： Pauline Tarot christelle Lasbleiz Jean-charles Liévens MMDN Univ MontpellierEPHEINSERMMontpellierFrance cNRS ParisFranceEPHEINSERMMontpellierFrance

Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor *** include muscle weakness and atrophy,spasticity,and progressive ***,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral *** only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial *** difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis *** mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious *** the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and *** here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis c9orf72 NRF2 oxidative defense oxidative stress sulforaphane superoxide dismutase 1 TDP43

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

引用

Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar Rana Hum Kala Rana Jacob BLandis Tianhui Kuang Juntong chen Hengchang Wang Tao Deng charles c.Davis Hang Sun cAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI computational Biology center Boyce Thompson InstituteIthacaNew York 14853USA cAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest china comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

引用

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Modified Transitional Korteweg-De Vries Equation: Posed in the Quarter Plane

引用

Journal of Applied Mathematics and Physics 2024年第7期12卷 2691-2701页

作者： charles Bu Department of Mathematics Wellesley College Wellesley MA USA

This paper is concerned with a modified transitional Korteweg-de Vries equation ut+f(t)u2ux+uxxx=0, (x,t)∈R+×R+with initial value u(x,0)=g(x)∈H4(R+)and inhomogeneous boundary value u(0,t)=Q(t)∈c2([ 0,∞ )). Under the conditions either 1) f(t)≤0, f′(t)≥0or 2) f(t)≤−αwhere α>0, we prove the existence of a unique global classical solution.

关键词： Modified Transitional KdV Equation Initial-Boundary Value Problem Semi-Group Local and Global Existence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst:A laparoscopic deroofing approach

引用

UroPrecision 2024年第1期2卷 36-39页

作者： Alain M.Mukendi Emelia K.c.de Heer-Menlah Phaladi charles E.Mathye Department of Surgery Division of UrologyHelen Joseph HospitalUniversity of the WitwatersrandJohannesburgSouth Africa

Background:Renal cysts are common in clinical practice,but some may harbor rare pathological entities such as mixed epithelial and stromal tumors(MEST).Imaging studies are crucial for accurate *** laparoscopic deroofing is an established approach for symptomatic renal cysts,encountering MEST within a cyst is *** Presentation:We present the case of a 37-year-old female who presented with persistent left flank *** revealed a large renal cyst in the lower pole of the left kidney,classified as Bosniak *** analgesia,the patient's symptoms persisted,leading to a laparoscopic deroofing *** examination postprocedure revealed a *** patient reported complete resolution of symptoms at the 3-month ***:This unique case presents the successful identification and surgical management of a MEST masquerading as a lower pole renal cyst through laparoscopic *** also contributes to the existing literature by highlighting the importance of considering rare pathological entities in the evaluation of renal cysts and the value of laparoscopic techniques in their management.

关键词： laparoscopic deroofing mixed epithelial and stromal tumor renal cyst renal tumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Otolaryngology residency program factors associated with female resident representation

引用

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 7-11页

作者： Julia E.canick James c.campbell charles R.Woodard Lars J.Grimm Alissa M.collins Duke University School of Medicine DurhamNorth CarolinaUSA Department of Head and Neck Surgery&communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Department of Radiology Duke University School of MedicineDurhamNorth CarolinaUSA

Objective:Female representation in the field of otolaryngology is *** is the first point at which medical school graduates specialize in a chosen field and thus represents an opportunity to recruit and train more female *** study sought to identify program factors associated with greater female representation among resident ***:Departmental websites of all 124 otolaryngology residency programs in the United States and Puerto Rico were examined for a list of *** programs with a resident roster available,the genders of residents,faculty,program directors,and chairpersons were *** and city population for each program was also recorded,as was female resident *** were compared using Pearson chi‐squared univariate ***:1,632 residents and 2,605 faculty were included in the analysis of 109 *** median female resident representation was 40%.Programs with larger faculty sizes,more female faculty,and urban location were associated with an above‐median female resident *** with a larger residency cohort approached significance regarding above‐median female resident *** female faculty representation,program director gender,chairperson gender,and US region were not associated with variation in female resident ***:Greater female otolaryngology residency representation was associated with programs having an urban location and greater numbers of female and total *** was also likely that a larger resident cohort size may affect female resident *** proportions of female faculty,program director,and chairperson gender,as well as the US region,were not associated with variation in female resident gender representation.

关键词： gender program director recruitment residency training

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

引用

Stroke & Vascular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier Lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel Laurent catherine Vergely Yannick Bejot charles Guenancia cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEc 2 Universitéde BourgogneDijonFrance cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(Ac)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3cm/m^(2)is currently tested in the ARcADIA(AtRial cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of Ac as defined in the ARcADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the Ac criteria(79 NT-proBNP,47 PTFV1,4 LADI).In the multivariate logistic regression,c reactive protein>3mg/L(OR(95%cI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%cI)1.07(1.04 to 1.10),pciated with *** 6 months of follow-up,AFDAS was detected in 33%of Ac patients and in 14%of the remaining ones(p=0.003).However,Ac was not independently associated with AFDAS,contrary to left atrial volume index(>34mL/m^(2),OR 2.35(cI 1.09 to 5.06)p=0029).conclusion Ac as defined in ARcADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,Ac was not independently associated with AFDAS at *** ARcADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with Ac markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Post Episiotomy Morbidity among Parturient in Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State

引用

Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1144-1160页

作者： John chinedu Obasi Ayodele Adegbite Olaleye Boniface N. Ejikeme John O. Egede charles Nwambeke Edene Enemma christian Enemma Victor Onuchukwu Emmanuel Onyekelu Nathan c. Ekpe Wendy Oliobi Emmanuel c. Uwakwe Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital AbakalikiNigeria

Background: Episiotomy is a very common obstetric surgery, and it could be associated with serious complications. However, these complications largely are not noticed due to the shift of attention from mother to baby, after a successful delivery. Objective: To identify the morbidities associated with episiotomies and factors associated with such morbidities. Method: This was a questionnaire based cross sectional descriptive study among women who attended the Obstetric Department of Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State, between 1st July and 31st Nov, 2023. The study population consisted of parturients who had episiotomies in their previous confinements, attending either the antenatal clinic or the postnatal clinic at Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State. Results: Macrosomia was the most common indication of episiotomy at a rate of 31.6%. The majority of episiotomies were performed on the parturients in their first confinement at a rate of 64.5% and the majority of repairs were performed by the Registrar at a rate of 65.0%. Informed consent was obtained from 45.79% of parturients while 54.21% were not informed before the episiotomy was administered. Only 55.3% of the parturient received analgesia before episiotomy was administered. The majority of the parturients had their episiotomy repaired between 10 - 15 minutes at a rate of 40.3%. Postoperative pain at the rate of 44.5% was the most common complication and dyspareunia as a form of sexual complication was the commonest at a rate of 31.3%. conclusion: The parturient needs to be properly counselled before administration of episiotomy and adequate analgesia should be given, as episiotomy is a surgical procedure. Proper training of health workers on both the technique of administering and repairing episiotomy is important. Restrictive use of routine episiotomy in primigravidae is advised to reduce the rate of episiotomy.

关键词： Episiotomy Vulva Pains Primigravidae Morbidities Analgesia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：