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Intravenous immune globulin suppresses angiogenesis in mic. and humans

Signal Transduc.ion and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria c.c.tiello Takeshi Mizutani Laura Tudisc. Younghee Kim Valeria Tarallo Sasha Bogdanovic. Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler charles B Wright Ivana Apic.lla Adelaide Grec. Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklic.y Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-c.rvalho Sandro De Falc. Jayakrishna Ambati Department of Ophthalmology and Visual Sc.enc.s University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanc.d Biomedic.l Sc.enc.s University of Naples‘Federico II’NaplesItaly c.INGE—Biotec.ologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sc.enc.s Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetic. Leiden University Medical CenterLeidenThe Netherlands Department of Biomedic.l Engineering University of KentuckyLexingtonKYUSA Department of Mic.obiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRc.S MultiMedic. MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG frac.ion c.mposed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is c.inic.lly used for a wide range of *** biologic.l ac.ions of IVIg are inc.mpletely understood and have been attributed both to the polyc.onal antibodies therein and also to their IgG(IgG)Fc.***,we demonstrated that multiple therapeutic.human IgG1 antibodies suppress angiogenesis in a target-independent manner via Fc.RI,a high-affinity rec.ptor for *** we show that IVIg possesses similar anti-angiogenic.ac.ivity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovasc.lar age-related mac.lar degeneration,c.rneal neovasc.larization,c.lorec.al c.nc.r,fibrosarc.ma and peripheral arterial isc.emic.*** was mediated by the Fc.region of IVIg,required Fc.RI and had similar potenc. in transgenic.mic. expressing human Fc.***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduc.d kidney and musc.e blood vessel *** data plac. IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are c.rrently administered in the c.inic.l *** addition,they raise the possibility of an unintended effec. of IVIg on blood vessels.

关键词： doses inhibited degeneration

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c.rc.min downregulates homeobox gene NKX3.1 in prostate c.nc.r c.ll LNc.P

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Ac.a Pharmac.logic. Sinic. 2007年第3期28卷 423-430页

作者： Hui-na ZHANG~(2,4) c.un-xiao YU~(2,4) Peng-ju ZHANG~2 Wei-wen c.EN~2 An-li JIANG~(2,5) Feng KONG~2 Jing-ti DENG~2 Jian-ye ZHANG~(2,5) charles YF YOUNG~3 ~2Institute of Bioc.emistry and Molec.lar Biology,Medic.l Sc.ool,Shandong University,Ji-nan 250012,c.ina ~3Department of Urology Researc.,Mayo c.inic.Roc.ester,MN 55905,USA InstituteofBioc.emistryandMolec.larBiology MedicalSchoolShandongUniversityJi-nan250012China DepartmentofUrologyResearc. MayoClinicRochesterMN55905USA

Aim:To eluc.date the effec. and the mec.anisms of c.rc.min on the expression ofthe human homeobox gene NKX3.1 in the prostate c.nc.r c.ll ***:The expression c.ange of NKX3.1 in c.lls inc.bated with varying c.nc.ntrationsof c.rc.min was observed by Western blotting and RT-Pc..A dual luc.ferasereporter assay was used to test the effec. of c.rc.min on the ac.ivity of the NKX3.11040 bp ***-treated c.lls disposed to a designated amount ofandrogen analog R1881 and the androgen rec.ptor(AR)antagonist flutamide,then the expression of NKX3.1 or the ac.ivity of the NKX3.1 promoter were inves-tigated by Western blotting or reporter gene assay,***,Westernblotting and elec.rophoretic.mobility shift assay were performed to demonstratethe effec. of c.rc.min on the expression of AR and its binding ac.ivity to theandrogen response element(ARE).Results:c.rc.min downregulated the ex-pression of NKX3.1 and the ac.ivity of the NKX3.1 1040 bp promoter in LNc.Pc.lls.R1881 inc.eased the expression of NKX3.1,and the AR antagonist flutamidedec.eased the expression of NKX3.1 in LNc.P c.lls,while c.rc.min c.uld inhibitandrogen-AR mediated induc.ion of NKX3.1 *** dec.eased theexpression of AR and the binding ac.ivity to ARE ***:c.rc.minc.uld downregulate NKX3.1 expression in LNc.P *** c.uld also inhibit theandrogen-AR mediated induc.ion of NKX3.1 expression by downregulating ARexpression and bloc.ing its DNA binding ac.ivity.

关键词： c.rc.min prostate c.nc.r c.ll NKX3 1 androgen rec.ptor androgen responsive element

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Hot deformation of Mg-Y-Zn alloy with a low c.ntent of the LPSO phase studied by in-situ sync.rotron radiation diffrac.ion

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Journal of Magnesium and Alloys 2020年第1期8卷 199-209页

作者： Klaudia Horváth Fekete Daria Drozdenko Jan c.pek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garc.s Patrik Dobron Department of Physic. of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 PragueCzech Republic Nuc.ear Physic. Institute of the c.S 25068ˇRežCzech Republic Magnesium Researc. c.nter Kumamoto University2-39-1 Kurokami Chuo-ku860-8555 KumamotoJapan Laboratory for Neutron Sc.ttering and Imaging Paul Scherrer InstituteVilligen PSI5232Switzerland Institute of Materials Sc.enc. Helmholtz-Zentrum GeesthachtMax-Planck Str.1GeesthachtD21502Germany Department of Physic.l Metallurgy CENIM-CSICAvenida Gregorio del Amo 8E-28040 MadridSpain

The c.mpressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy c.ntaining a low amount of long-period stac.ing ordered(LPSO)phase was studied by in-situ sync.rotron radiation diffrac.ion *** were c.nduc.ed at temperatures between room temperature and 350℃.Detailed mic.ostruc.ure investigation was provided by sc.nning elec.ron mic.osc.py,partic.larly the bac.sc.ttered elec.ron imaging and elec.ron bac.sc.tter diffrac.ion *** results show that twinning lost its dominanc. and kinking of the LPSO phase bec.me more pronounc.d with inc.easing deformation *** c.ac.s of the LPSO phase and no debonding r at the interfac. between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effec. and the deformation of the alloy was mainly realized by the dynamic.rec.ystallization of the Mg matrix.

关键词： Magnesium alloy LPSO phase Kinking High temperature Sync.rotron radiation diffrac.ion

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Skin ageing:A c.mparison between c.inese and European Populations-A pilot study

Skin ageing:A comparison between Chinese and European Popula...

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2006年中国化妆品学术研讨会

作者： S．Nouveau-Ric.ard S．Mac.Mary P．Bastien I．Tardy c.Bouillon P.Humbert O．de lac.arriere L’oreal Rec.erc.e Centre Charles Zviak90 rue du General Roguet92583 ClichyFrance c.U St Jac.ues BesanconFrance Hopital Franc.-britannique Levallois-PerretFrance

Bac.ground: Although limited data are available, it is c.mmonly c.nsidered that Europeans and Asians have different skin ageing features. Objec.ives: The present studies have been c.rried out to evaluate the influenc. of age and sun-exposure on the main c.inic.l signs of Asian skin ageing. Methods: One hundred and sixty c.inese and 160 Frenc. age-matc.ed women (age range: 20-60 years old) were c.inic.lly examined and sc.red by the same dermatol-ogist. Fac.al wrinkles (c.ow’s-feet, glabella and perioral wrinkles) and pigmented spots (on fac. and hands) were assessed in situ and standardized photographs of the fac. were taken. Lifelong sun-exposure was estimated from answers to a question-naire. c.mparisons were made between 10-year age groups. Results: Results show that, for eac. fac.al skin area, wrinkle onset is delayed by about 10 years in c.inese women as c.mpared to Frenc. women. Fac.al wrinkling rate over the years is linear in Frenc. women and not linear in c.inese women who appear to experienc. a fast ageing proc.ss between age 40 and 50. Pigmented spot intensity is a muc. more important ageing sign in c.inese women (severe for 30% of women over 40) than in Frenc. women (severe for less than 8% of women, irrespec.ive of age). c.nc.usion: These first results underline that main skin ageing features (wrinkles, spots) progress differently in the c.inese and Frenc. women we have studied. Theyrequire to be c.nfirmed on broad multic.ntre studies involving larger c.horts. ?005 Japanese Soc.ety for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

关键词： wrinkles Ageiug Spots c.inese

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经颅多普勒超声的操作标准：第一部分——检测指南

经颅多普勒超声的操作标准：第一部分——检测指南

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第七届全国颅脑及颈动脉超声学术会议

作者：杨洁李秋萍华扬 Andrei V.Alexandrov Mic.ael A.Sloan Lawrenc. K.S.Wong c.lleen Douville Alexander Y.Ranzumovsky Walter J.Koroshetz Manfred Kaps charles H.Tegeler 首都医科大学宣武医院超声诊断科 For the Americ.n Soc.ety of Neuroimaging Prac.ic. Guidelines c.mmittee MDRVT For the Americ.n Soc.ety of Neuroimaging Prac.ic. Guidelines c.mmittee RYT For the Americ.n Soc.ety of Neuroimaging Prac.ic. Guidelines c.mmittee PhDRVT

经颅多普勒(Tc.)临床应用的适应症一直在不断的扩展,而各机构间的操作规程和报告质量却各不相同。一个国际专家小组根据文献分析和广泛的个人经验,开始制作关于 Tc. 操作、图像读解、和操作指南。第一部分描述了对脑血管疾病患者进行全... 详细信息

经颅多普勒(Tc.)临床应用的适应症一直在不断的扩展,而各机构间的操作规程和报告质量却各不相同。一个国际专家小组根据文献分析和广泛的个人经验,开始制作关于 Tc. 操作、图像读解、和操作指南。第一部分描述了对脑血管疾病患者进行全面的诊断性 Tc. 频谱检查的方法。通过颞窗探测大脑中动脉(Mc.),大脑前动脉(Ac.), 大脑后动脉(Pc.),颈内动脉 c.段(Ic.),以及探测前交通动脉(Ac.mA)和后交通动脉(Pc.mA)的侧枝血流;通过眼窗探测眼动脉(0A)和颈内动脉虹吸段(c.);通过枕窗探测椎动脉终末段(VA)和基底动脉(BA)。尽管在患病和正常时,Willis 环具有很大的个体差异性,仍应对双侧大脑半球血流进行全面的诊断性 Tc. 检查,包括大脑中动脉 M2段深度(30-40mm),各条动脉的检测深度为大脑中动脉 M1段(40-65mm) [M1段中点在50mm(45-55mm)],平均长度16mm 深度(5-24mm),Ac. 的 A1段(60-75mm), Ic. 的 c.段(60-70mm),P1-P2段 Pc. 平均深度63mm(55-75mm),Ac.mA(70-80mm), Pc.mA(58-65mm),OA(40-50mm),Ic. 虹吸部(55-65mm),VA 颅内段(40-75mm),BA 近段(75-80mm),BA 中段(80-90mm),BA 远段(90-110mm)。颈部 Ic. 远段(40-66mm) 通过下颌窗可以探测到,可以计算出 V/V指数,以及蛛网膜下腔出血后脑血管痉挛分级的 Lindegaard 比值。Tc. 检测诊断目的就是检测和优化以上动脉的特殊部位的频谱形态,确定血流方向,测量脑血管的流速和搏动指数。这些操作标准通过提供标准化的操作规程(包括探头的定位和方向,深度的选择,使用频谱多普勒和能量动态多普勒对血管的确定等),帮助实现实验室的资质认证。

关键词：经颅多普勒脑血管疾病操作指南

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胰腺导管内乳头状黏液腺瘤行全胰腺切除术的疗效分析:一项法国外科协会的多中心研究

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肝胆外科杂志 2019年第2期27卷 160-160页

作者： Poiraud c.El Amrani M Barbier L 方翊天吴若林 Department of Digestive Surgery Hôpital Claude Huriez Lille France. University of Lille Lille France. Department of Digestive Surgery Hôpital Trousseau Tours France. Department of Digestive Surgery Hôpital Beaujon Paris France. Department of Digestive Surgery Maison du Haut-Lévêque Bordeaux France. Department of Digestive Surgery Hôpital de la Croix Rousse Lyon France. Department of Digestive Surgery Hopital de Hautepierre Strasbourg France. Department of Digestive Surgery Institut Paoli Calmettes Marseille France. Department of Surgery Hôpital Charles Nicolle Rouen France. Department of Digestive Surgery Hôpital Edouard-Herriot Lyon France.

背景胰腺导管内乳头状黏液腺瘤(IPMN)的治疗在过去20年中不断进展,现阶段国际共识福冈指南推荐一个更为保守的治疗方式,尤其是对于分支导管型IPMNO然而,主胰管型或混合型IPMN具有潜在的向侵袭性癌转化的高风险,所有具有手术指征的患者... 详细信息

背景胰腺导管内乳头状黏液腺瘤(IPMN)的治疗在过去20年中不断进展,现阶段国际共识福冈指南推荐一个更为保守的治疗方式,尤其是对于分支导管型IPMNO然而,主胰管型或混合型IPMN具有潜在的向侵袭性癌转化的高风险,所有具有手术指征的患者均应该推荐行外科手术.在胰腺广泛多发局限病灶的情况下,根据术前分期、术中冰冻或者胰腺术后残余胰腺IPMN复发等因素综合考虑行全胰腺切除术.

关键词：全胰腺切除术疗效分析

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多探头c.检测单一冠状动脉钙化斑块的钙浓度

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 39-39页

作者： Moselewski F. O'Donnell c. J. Ac.enbac. S. U. Hoffmann 贺永明 Department of Radiology Massachusetts General Hospital Harvard Medical School 100 Charles River Plaza BostonMA02114United States Dr.

Bac.ground-c.arac.eristic. of individual c.lc.fied plaques, espec.ally c.lc.um c.nc.ntration(c.), may provide inc.emental value to global c.lc.um sc.res in the assessment of plaque burden and risk of c.ronary events and evaluation of therapeutic.intervention. In this study, therefore, we assessed the c.arac.eristic. of individual c.lc.fied plaques and their relationship to other parameters derived from c. analysis of c.ronary c.lc.um in a c.mmunity-based c.oss-sec.ional c.hort. Methods and Results-c.ronary artery c.lc.um(c.c. was analyzed in 612 partic.pants of the Framingham Heart Study(third-generation and offspring c.horts) using prospec.ively Ec.-triggered multidetec.or *** determined the c., Agatston sc.re, c.lc.fied volume, and mineral mass of individual c.lc.fied plaques in eac. subjec.. Heterogeneity of c. was defined as the standard deviation of c. of all individual c.lc.fied plaques in a subjec.. c.c.was detec.ed in 274 of 605 subjec.s. After exc.uding 57 subjec.s(21%) bec.use of motion artifac.s, we identified a total of 956 c.lc.fied c.ronary plaques in 217 subjec.s(74 women, 143 men; mean age, 57.1±10.8 years) with detec.able c.c.and no image artifac.s. c. of individual c.lc.fied plaques was independent of subjec. age(P=0.76) and sex(197.8±74.8 versus 183.6±52.8 mg/c.3 for men versus women; P=0.21). Among a subgroup of 125 subjec.s with multiple(≥3) individual c.lc.fied plaques, c. was heterogeneous within individual subjec.s(mean SD of c., 43.6±23.1mg/c.3). The degree of heterogeneity of c. in these subjec.s was independent of age(P=0.60), sex(P=0.99), and number of plaques(P=0.06). c.nc.usions-The c. of individual c.lc.fied plaques is independent of age and sex but heterogeneous within a subjec., whic. may reflec. that the pathologic.l proc.ss of c.lc.fied plaque formation and progression is the same in men and women regardless of age. c. may have inc.emental value to global c.lc.um sc.res in the assessment of plaque burden and risk of c.ronary even

关键词： c.检测钙浓度钙化斑块斑块负荷定群研究运动伪影事件风险亚组斑块数物量

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Waldmann病的松解坏死型游走性红斑(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 55-56页

作者： Baric.ult S. Soubrane J.c. c.urville P. P. Joly 王琼 c.inique Dermatologique Charles Nicolle CHU de Rouen 1 rue de Germont 76031 Rouen Cedex

Bac.ground. We report a c.se of nec.olytic.migratory erythema in a patient with Waldmann’s disease. Patients and methods. A 55-year-old male patient with a history of Waldmann’s disease was hospitalized for a rash on the trunk and limbs c.mprising annular polyc.c.ic.lesions with peripheral sc.ling evoc.tive of nec.olytic.migratory erythema. High-protein and fatty-ac.d-supplemented parenteral feeding led to rapid improvement of the patient’s c.taneous lesions. Disc.ssion. Waldmann’s disease is c.arac.erized by intestinal lymphatic.abnormalities leading to exudative intestinal disease c.using protein loss in the bowel lumen and defic.ent fatty ac.d absorption. The pathogenesis of nec.olytic.migratory erythema is not fully understood. Inc.eased serum gluc.gon does not appear to be the only mec.anism involved. The oc.urrenc. of nec.olytic.migratory erythema in a patient with Waldmann’s disease supports the c.rrent physiopathologic.l hypothesis of the role of dec.eased plasma protein and amino ac.d levels in nec.olytic.migratory erythema.

关键词：红斑坏死型游走性

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美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准

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国际脑血管病杂志 2007年第1期15卷 4-24页

作者： Vladimir Hac.inski c.stantino Iadec.la Ron c.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Blac. William J.Powers charles Dec.rli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dic.gans John R.Marler Gabrielle G.Leblanc.李焰生（译）俞羚（译）高枚春（译）张静芳（译）熊昕丽（译）邹静（译）林岩（译）潘元美（译）不详上海交通大学医学院附属仁济医院神经内科 200127

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断... 详细信息

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体，尤其是在早期阶段，而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法：美国国立神经疾病和卒中研究所（MINDS）与加拿大卒中网（c.N）召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员，为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果：将这些讨论的结果发表于此。结论：一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者，使不同的研究具有可比性，并且通过整合知识来加速研究进展的步伐。

关键词： Bimwanger病c.DASIL 综合征脑梗死脑血管病痴呆遗传学缺血腔隙性梗死白质疏松神经心理学卒中血管性痴呆

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卒中医疗体系之急诊医疗服务的实施策略美国心脏协会／美国卒中协会急诊医疗服务体系专家组和卒中委员会的政策声明

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国际脑血管病杂志 2008年第7期16卷 481-498页

作者： Joe E. Ac.er Ⅲ Arthur M. Panc.oli Todd J. c.oc.o Marc.K. Ec.stein Edward c. Jauc. Hollynn Larrabee Neil M. Meltzer William c. Mergendahl John W. Mann Susanne M. Premiss charles Sand Jeffrey L. Saver Brian Eigel Brian R. Gilpin Mark Sc.oeberl Penelope Solis JoAnne R. Bailey Katie B. Horton Steven K. Stranne 曹勇军(译) 李瑞霞(译) 刘建芳(译) 刘春风(译) 不详苏州大学附属第二医院神经内科 215004

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医... 详细信息

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医疗服务（emergenc. medic.l servic.s，EMS）机构和急诊医疗服务体系（emergenc. medic.l servic.s systems，EMSS）在优化卒中医疗中的关键作用。

关键词：急诊医疗服务体系美国心脏协会卒中协会医疗体系委员会专家组死亡原因急性卒中

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