检索结果-南通市图书馆

Non-exercise estimated cardiorespiratory fitness and cancer incidence:The NIH-AARP diet and health study

Journal of Sport and Health Science 2023年第6期12卷 739-746页

作者： Baruch Vainshelboim Jonathan Myers charles EMatthews Center for Tobacco Research Division of Medical OncologyDepartment of Internal MedicineThe Ohio State UniversityColumbusOH 43214USA Cardiology Division Veterans Affairs Palo Alto Health Care System/Stanford UniversityPalo AltoCA 94304USA Metabolic Epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is *** study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and *** The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline(1995–1996)(men(n=238,835)and women(n=163,713))and were followed until December 31,*** exposure variable was NEE-CRF expressed in metabolic ***-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline *** outcomes were total cancer incidence and incidence of prostate,breast,lung,and colorectal *** proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk *** During 13.7±3.2 years of follow-up(mean±SD),64,344 men and 31,315 women developed a new *** every 1-metabolic equivalent higher NEE-CRF,the hazard ratios and 95%confidence intervals(95%CIs)were 0.96(95%CI:0.94–0.97)and 0.88(95%CI:0.84–0.92)of total and colorectal cancer incidence among men,and 0.95(95%CI:0.93–0.97)and 0.94(95%CI:0.91–0.97)of total and breast cancer incidence among women,respectively(all p<0.001).NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in *** These results suggest that higher CRF levels,as assessed by the applied non-exercise estimated method,may provide preventive benefits against the development of cancer,while low CRF could potentially serve as a modifiable cancer risk *** NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complemen

关键词： Aerobic capacity Breast cancer Cancer risk Colorectal cancer VO_(2max)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line

引用

Chinese Journal of Cancer Research 2013年第2期25卷 134-142页

作者： Lianna Li charles F. Bellows Department of Surgery Tulane University University of Mississippi Cancer Institute

Objective： Colon cancer stem cells （CSCs） are implicated in colorectal cancer carcinogenesis, metastasis, and therapeutic resistance. The identification of these cells could help to develop novel therapeutic strategies. Doublecortin-like kinase 1 （DCLK1） has been viewed as a marker for gastrointestinal stem cells that fuel the self-renewal process, however others view them as a marker of Tuft cells or as an enteroendocrine subtype. The purpose of this study was to use a colon cancer cell line to identify and characterize the stem-like characteristics of the DCLKI＋ cell population. Methods： To enrich stem-like cells, HCT116 cells （derived from colon adenocarcinomas） were cultured using serum-free media to form spheres under both normal oxygen and hypoxia condition. DCLK1 transcript expression in the adherent parental cells and spheroids was quantified using quantitative real time reverse transcription- polymerase chain reaction [（q）RT-PCR]. DCLK1 protein expression was determined using flow cytometry. Self-renewal capability from adherent parental cells and spheroids was determined using extreme limiting dilution analysis （ELDA）. Results： Under both normal oxygen and hypoxia condition, the adherent parental cells were composed of cells that express low levels of DCLK1. However, spheroids exhibited an increased frequency of cells expressing DCLK1 on both mRNA and protein levels. Cells derived from spheroids also possess stronger self-renewal capability. Conclusions： The higher fraction of DCLK1 ＋ cells exhibited by spheroids and hypoxia reflects the stem- like characteristics of these cells. DCLK1 may represent an ideal marker to study and develop effective strategies to overcome chemo-resistance and relapse of colon cancer.

关键词： Doublecortin-like kinase 1 (DCLK1) colorectal cancer cancer stem cells stem cell marker spheroids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Uniform Asymptotic Expansion of the Voltage Potential in the Presence of Thin Inhomogeneities with Arbitrary Conductivity

引用

Chinese Annals of Mathematics,Series B 2017年第1期38卷 293-344页

作者： charles DAPOGNY Michael S.VOGELIUS Laboratoire Jean Kuntzmann CNRSUniversité Grenoble-Alpes Department of Mathematics Rutgers University

Asymptotic expansions of the voltage potential in terms of the "radius" of a diametrically small(or several diametrically small) material inhomogeneity(ies) are by now quite well-known. Such asymptotic expansions for diametrically small inhomogeneities are uniform with respect to the conductivity of the *** contrast, thin inhomogeneities, whose limit set is a smooth, codimension 1 manifold,σ, are examples of inhomogeneities for which the convergence to the background potential,or the standard expansion cannot be valid uniformly with respect to the conductivity, a, of the inhomogeneity. Indeed, by taking a close to 0 or to infinity, one obtains either a nearly homogeneous Neumann condition or nearly constant Dirichlet condition at the boundary of the inhomogeneity, and this difference in boundary condition is retained in the *** purpose of this paper is to find a "simple" replacement for the background potential, with the following properties:(1) This replacement may be(simply) calculated from the limiting domain Ω\σ, the boundary data on the boundary of Ω, and the right-hand side.(2) This replacement depends on the thickness of the inhomogeneity and the conductivity,a, through its boundary conditions on σ.(3) The difference between this replacement and the true voltage potential converges to 0 uniformly in a, as the inhomogeneity thickness tends to 0.

关键词： Uniform asymptotic expansions Conductivity problem Thin inhomogeneities

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Brief Overview of Low CO_2 Emission Technologies forIron and Steel Making

引用

Journal of Iron and Steel Research International 2010年第3期17卷 1-7页

作者： Chunbao (charles) XU CANG Da-qiang Department of Chemical Engineering Lakehead'.University Ontario P7B 5El Canada School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083 China

The global steel production has been growing for the last 50 years, from 200 Mt in 1950s to 1 240 Mt in 2006. Iron and steel making industry is one of the most energy-intensive industries, with an annual energy consumption of about 24 EJ, 5% of the world＇s total energy consumption. The steel industry accounts for 3%-4% of totat world greenhouse gas emissions. Enhancing energy efficiency and employing energy saving/recovering technologies such as coke dry quechning （CDQ） and top pressure recovery turbine （TRT） can be short-term approaches to the steel industry to reduce greenhouse gas emission. The long-term approaches to achieving a significant reduction in CO2 emissions from the steel industry would be through developing and applying CO2 breakthrough technologies for iron and steel making, and：through increasing use of renewable energy for iron and steel making. Thus, an overview of new CO2 breakthrough technologies for iron and steel making was made.

关键词： greenhouse gas emission CO2 reduction technology ironmaking steelrnaking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A high incidence of non-cavity nesting in an introduced population of House Sparrows suggests that the species should not be constrained by cavity-nest site availability

引用

Avian Research 2017年第4期8卷 202-209页

作者： Elizabeth Louise Sheldon Simon charles Griffith Department of Biological Sciences Macquarie UniversitySydneyNSW 2109Australia

Background: The House Sparrow(Passer domesticus) has undergone dramatic population declines in many parts of *** has been widely hypothesised that a lack of cavity nest sites has contributed to this *** the idea of the House Sparrow being nest site limited is somewhat incompatible with the long history of nest site plasticity in the ***: The nest-site selection in a population of non-native House Sparrows introduced to Australia from Europe just over 150 years ago was *** prevalence of non-cavity nesting was quantified,and nest-site selection in terms of landscape and nesting structure were ***: Flexible nesting behaviors were reported over a range of different landscapes and a surprisingly high rate of nesting in vegetation(43%) was *** nests found in vegetation were not in cavities,but were woven into the foliage and supported by branches and ***: The high rate of vegetation nesting indicates that in this introduced population,the House Sparrow is unlikely to be constrained by cavity-nest site *** high degree of nest site plasticity in the Australian population may suggest that European House Sparrows have the potential to shift away from their proclivity for cavity *** work in Europe should examine the incidence of non-cavity nesting in House Sparrows more closely,and perhaps reconsider the idea that House Sparrows are nest-site constrained.

关键词： Passer domesticus Cavity nests House Sparrow decline Nesting plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases

引用

World Journal of Gastroenterology 2009年第2期15卷 192-197页

作者： charles H Knowles Joanne E Martin Neurogastroenterology Group Centres for Academic Surgery and Pathology Institute of Cellular and Molecular Science Barts and the London Queen Mary's School of Medicine and Dentistry Whitechapel London United Kingdom

Gastrointestinal neuromuscular diseases are a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular (including interstitial cell of Cajal) dysfunction. Common to most of these diseases are symptoms of impaired motor activity which manifest as slowed or obstructed transit with or without evidence of transient or persistent radiological visceral dilatation. A variety of histopathological techniques and allied investigations are being increasingly applied to tissue biopsies from such patients. This review outlines some of the more recent advances in this fi eld, particularly in the most contentious area of small bowel disease manifesting as intestinal pseudo-obstruction.

关键词： Enteric myopathy Enteric neuropathy Interstitial cells of Cajal Intestinal pseudo-obstruction,Visceral pain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

引用

Chinese Chemical Letters 2015年第4期26卷 485-490页

作者： Shuai Wei charles L.Brooks Ⅲ Department of Chemistry University of Michigan Department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitochondrial quality control in amyotrophic lateral sclerosis：towards a common pathway？

引用

Neural Regeneration Research 2017年第7期12卷 1052-1061页

作者： Bilal Khalil Jean-charles Liévens Department of Neuroscience Mayo Clinic Florida Jacksonville FL USA MMDN Université de Montpellier EPHE INSERM U1198 Montpellier France

Amyotrophic lateral sclerosis（ALS）is a devastating neurodegenerative disorder characterized by loss of upper and lower motor *** mechanisms contribute to the disease initiation and progression,including mitochondrial dysfunction which has been proposed to be a central determinant in ALS ***,while mitochondrial defects have been mainly described in ALS-linked SOD1 mutants,it is now well established that mitochondria become also dysfunctional in other ALS *** such context,the mitochondrial quality control system allows to restore normal functioning of mitochondria and to prevent cell death,by both eliminating and replacing damaged mitochondrial components or by degrading the entire organelle through *** evidence shows that ALS-related genes interfere with the mitochondrial quality control *** review highlights how ineffective mitochondrial quality control may render motor neurons defenseless towards the accumulating mitochondrial damage in ALS.

关键词： C9orf72 FUS SOD1 Optineurin Parkin PGC-1α PINK1 TDP-43 proteinopathies TBK1 VCP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The nature of friction: A critical assessment

引用

Friction 2014年第1期2卷 1-26页

作者： Stephen HSU charles YING Fei ZHAO George Washington University Washington DCUSA National Science Foundation ArlingtonVAUSA

Friction is an essential part of human *** need traction to walk,stand,work,and *** the same time,we need energy to overcome the resistance to motion,hence,too much friction costs excess energy to perform work,introducing *** the 21st century,we are facing the dual challenges of energy shortage and global warming from burning fossil ***,the ability to control friction has become a top priority in our world *** our understanding of the fundamental nature of friction is still *** has always been a subject of *** study of the origin of friction began in the 16th century,after the pioneering work by Leonardo da *** progress in understanding the nature of friction has been slow,hampered by the lack of instrument to measure friction *** experiments performed by Amontons,Coulomb,and others have yielded important insights to build the foundation of our *** in the late 1800s and early 1900s,the advent of steam engines,locomotives,followed by the automobiles airplanes,and space exploration demands a clear understanding of friction and the ability to control it for the machinery to *** progress on how to apply and control friction in engineering friction was made through trial and *** the beginning of the 21st century,a new dimension of nanoscale friction came into the picture in conjunction with the arrival of *** understanding of atomic and molecular friction has been expanding ***,integration of the new found knowledge of nanofriction into engineering practices has been ***?What is the scaling relationship between atomic friction and macro-friction?Is it possible to predict friction at the macro-level from nanoscale results?Why nanofriction values often do not agree with the macrofriction values given the same materials pair?Could it be there is a length scale dependent characteristic friction value?In eng

关键词： friction scaling laws molecular friction length scale dominant friction values

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sigma-1 receptor: culprit and rescuer in motor neuron diseases

引用

Neural Regeneration Research 2021年第1期16卷 106-107页

作者： Jean-charles Liévens Tangui Maurice MMDN Univ MontpellierINSERMEPHEMontpellierFrance

Initially,the Sigma-1 receptor(S1R)was incorrectly categorized as one of the opioid *** it has since become clear that S1R is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1R is a 223 amino-acid long protein that shares no clear homology with any other known mammalian proteins,its closest homolog being the fungal ERG2 sterol *** its pharmacological counterpart,the Sigma-2 receptor that was only recently cloned,is genetically distinct.S1R is more likely considered as an atypical ligand-modulated chaperone protein.S1R is widely expressed in many organs including brain where its function has mainly been explored.

关键词： organs opioid Sigma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：