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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson fariba Roshanzamir Anders Hagnestål sagar M.Patel Oseeyi I.Daudu Donald f.Becker Jonathan L.Robinson Jens Nielsen Department of Life sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

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16th Annual Meeting of the World Chinese Urological society:Reunion and sharing of global Chinese urological advances

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UroPrecision 2024年第2期2卷 62-64页

作者： Guiting Lin Run Wang Tom f.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology MD Anderson Cancer CenterHoustonTexasUSA Department of surgery Division of UrologyUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

1|*** few years without in-person meeting during the American Urological Association(AUA)due to COVID-19 pandemic,the world's brightest Chinese urologists and urological researchers gathered *** May 3,2024,the 16th Annual Meeting of the World Chinese Urological society(WCUs)was successfully held in san Antonio,*** conference attracted Chinese experts and scholars from the field of urology around the world to discuss and share the latest academic achievements and research *** significant event provided an important academic exchange platform for Chinese urology experts globally.

关键词： union globally World

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Physical properties and maximum allowable mass-radius relation of complexity-free compact stellar objects within modified f(R,T)gravity formalism

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Chinese Physics C 2024年第7期48卷 273-288页

作者： M.K.Jasim s.K.Maurya Abdelghani Errehymy Ali Khalid Jassim Kottakkaran sooppy Nisar Abdel-Haleem Abdel-Aty Department of Mathematical and Physical sciences College of Arts and SciencesUniversity of NizwaNizwa 616Sultanate of Oman Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa Electrical Engineering Department College of EngineeringMustansiriyah UniversityBaghdadIraq Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia Department of Physics College of SciencesUniversity of BishaP.O.Box 344Bisha 61922Saudi Arabia

This paper investigates the physical properties and predicted radii of compact stars generated by the Tolman-IV complexity-free model within the background of modified gravity theory,particularly the f(R,T)-gravity theory,under complexity formalism for a spherically symmetric spacetime proposed by ***[Phys Rev D 97:044010,2018].By solving the resulting set of differential equations,we obtain the explicit forms of the energy-momentum(EM)tensor components,including the density,radial pressure,and tangential *** influence of the parameterχon various physical properties of the star is thoroughly *** model undergoes a series of rigorous tests to determine its physical *** findings indicate that the model exhibits regularity,stability,and a surface with vanishing *** boundary of this surface is determined by carefully selecting the parameter *** complexity method employed in f(R,T)gravity offers an interesting approach for developing astrophysical models that are consistent with observable events as demonstrated by recent *** this regard,we use observational data from the GW190814 event,detected by the LIGO and Virgo observatories,to investigate the validity of the Tolman-IV model in f(R,T)*** analysis includes comparing the model's predictions with the observed characteristics of the compact object involved in the *** addition,data from two-millisecond pulsars,PsR J1614-2230 and PsR J0952-0607,are incorporated to further constrain the theoretical ***,we present a diagram depicting the relationship between the total mass and radius of the compact object candidates for different values ofχ.

关键词： complexity modified gravity compact stars

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影响青藏高原植被生产力的极端气候阈值

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中国科学：地球科学 2024年第6期54卷 1996-2007页

作者：朴正刚李湘怡徐浩王锴汤舒畅阚飞洪松柏北京大学城市与环境学院北京100871

多种与水分和热量相关的极端气候事件对青藏高原植被生长造成了不利影响.然而,目前尚不清楚多大程度的极端气候胁迫水平会导致植被生长出现强烈响应.为了填补这一知识空白,我们综合利用水文气象数据和卫星遥感获取的植被指数,检测了2001... 详细信息

多种与水分和热量相关的极端气候事件对青藏高原植被生长造成了不利影响.然而,目前尚不清楚多大程度的极端气候胁迫水平会导致植被生长出现强烈响应.为了填补这一知识空白,我们综合利用水文气象数据和卫星遥感获取的植被指数,检测了2001~2018年间影响植被生产力对干旱、极端高温和极端低温响应的两个关键气候阈值(反映植被生产力响应发生突变和对植被损害达到最大).结果表明,当土壤湿度下降到正常水平的(-1.41±0.6)个标准差(σ)以下时,植被生产力对干旱事件的响应频率会迅速增加;当土壤湿度低于(-2.98±0.9)σ时,干旱对植被生产力造成的损害达到最大.区域上极端低温的阈值平均值为(-1.44±0.5)σ和(-2.53±0.8)σ,而极端高温的阈值平均值为(1.34±0.4)σ和(2.31±0.4)σ.这表明,极端高温比极端低温更易引发植被生产力的强烈响应.此外,我们发现极端温度事件中土壤水分亏缺的复合效应降低了极端低温和极端高温的阈值.基于地球系统模式预测,到2100年,青藏高原的西南部和东北部的部分地区将有极高的风险受到超过阈值的极端气候事件影响.本研究基于极端气候阈值识别了青藏高原地区具有高影响力的极端气候事件,提高了对不同极端气候事件植被生长响应的认识,为评估极端气候事件对区域生态系统的影响提供了研究范例.

关键词：青藏高原极端气候阈值植被生产力

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Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes s.Y.Leung Chit Chow siaw shi Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David shu Cheong Hui Paul Kay sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORf7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

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Elastic, thermodynamic, electronic, and optical properties of recently discovered superconducting transition metal boride NbRuB:An ab-initio investigation

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Chinese Physics B 2017年第10期26卷 339-347页

作者： f Parvin s H Naqib Department of Physics University of Rajshahi

The elastic, thermodynamic, electronic, and optical properties of recently discovered and potentially technologically important transition metal boride NbRuB, are investigated using the density functional formalism. Both generalized gradient approximation （GGA） and local density approximation （LDA） are used for optimizing the geometry and for estimating various elastic moduli and constants. The optical properties of NbRuB are studied for the first time with different photon polarizations. The frequency （energy） dependence of various optical constants complement quite well the essential features of the electronic band structure calculations. Debye temperature of NbRuB is estimated from the thermodynamical study. All these theoretical estimates are compared with published results, where available, and discussed in detail. Both electronic band structure and optical conductivity reveal robust metallic characteristics. The NbRuB possesses significant elastic anisotropy. Electronic features, on the other hand, are almost isotropic in nature. The effects of electronic band structure and Debye temperature on the emergence of superconductivity are also analyzed.

关键词： hard materials ternary borides DfT calculations electronic band structure optical properties superconductivity

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni f.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.f.Cao N.Cao s.A.Cetin J.f.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen s.K.Choi X.Chu G.Cibinetto f.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis f.De Mori B.fang s.s.fang W.X.fang Y.fang Y.Q.fang R.farinelli L.fava f.feldbauer G.felici C.Q.feng J.H.feng Y.T.feng K.fischer M.fritsch C.D.fu J.L.fu Y.W.fu H.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du Z.H.Duan P.Egorov Y.H.fan J.fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao f.A.Harris K.K.He K.L.He f.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.f.Hu T.Hu Y.Hu G.s.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain f.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson s.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang X.s.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson s.Kabana N.Kalantar-Nayestanaki X.L.Kang X.s.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li f.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan fudan University Shanghai 200433China GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INfN Laboratori Nazionali di frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INfN Laboratori Nazionali di frascati INFN Sezione di PerugiaI-06100PerugiaItaly INfN Laboratori Nazionali di frascati University of PerugiaI-06100PerugiaItaly INfN sezione di ferrara INFN Sezione di FerraraI-44122FerraraItaly INfN sezione di ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BEsIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(s)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BEsIII D^(0)meson decays amplitude analysis CP-even fraction

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Thermodynamic Analysis and Optimization of flat Plate solar Collector Using TiO_(2)/Water Nanofluid

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Journal of Harbin Institute of Technology(New series) 2024年第4期31卷 61-73页

作者： firas f.Qader falah Z.Mohammed Barhm Mohamad Technical Engineering College-Kirkuk Northern Technical UniversityKirkuk 36001Iraq Medical Device Technology Engineering AL-Qalam University CollegeKirkuk 36001Iraq Department of Petroleum Technology Koya Technical InstituteErbil Polytechnic UniversityErbil 44001Iraq

To research solar energy's efficiency and environmental benefits,the thermal efficiency,exergy,and entropy of solar collectors were *** experiment involved two glass-topped collectors,fluid transfer tubes,and aluminum heat-absorbing *** wool insulation minimized heat loss.A 0.5% TiO_(2)/Water nanofluid was created using a mechanical and ultrasonic *** showed that solar radiation increased thermal efficiency until midday,reaching 48.48% for water and 51.23% for the *** increasing mass flow rates from 0.0045 kg/s to 0.02 kg/s,thermal efficiency improved from 16.26% to 47.37% for water and from 20.65% to 48.76% for the *** water provided 380 W and 395 W of energy in March and April,while the nanofluid increased it to 395 W and 415 W during these *** flow generated energy,and the Reynolds number raised *** noon exergy efficiency for nanofluids was 50%-55%,compared to 30% for *** noon,the broken exergy measured 877.53 W for the nanofluid and 880.12 W for *** Kirkuk,Iraq,the 0.5% TiO_(2)/Water nanofluid outperformed water in solar collectors.

关键词： energy exergy entropy generation nanofluid flat plate solar collector

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Nonlinear continuous bi-inductance electrical line with dissipative elements:Dynamics of the low frequency modulated waves

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Chinese Physics B 2020年第4期29卷 179-189页

作者： s M Ngounou f B Pelap Unite de Recherche de Mecanique et de Modelisation des systèmes Physiques(UR-2 MsP) Faculte des SciencesUniversite de DschangBP 69 DschangCameroun Unite de Recherche de Matiere Condensee d'Electronique et de Traitement du signal(UR-MACETs) Faculte des SciencesUniversite de DschangBP 67 DschangCameroun

The dynamics of modulated waves in a nonlinear bi-inductance transmission line with dissipative elements are *** show the existence of two frequency modes and carry out intensive investigations on the low frequency *** to the multiple scales method,the behavior of these waves is investigated and the dissipative effects are *** appears that the dissipation coefficient increases with the carrier wave *** the continuous approximation,we derive that the propagation of these waves is governed by the complex Ginzburg-Landau equation instead of the Korteweg-de-Vries equation as previously *** studies of the dynamics of plane waves in the line reveal the existence of three additional regions in the dispersion curve where the modulational phenomenon is *** the low frequency mode,we demonstrate that the network allows the propagation of dark and bright *** findings are in perfect agreement with the analytical predictions.

关键词： dissipative bi-inductance network low frequency mode continuous approximation complex Ginzburg-Landau equation

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz s.A.Pikuz W.Yan T.M.Jeong s.singh P.Hadjisolomou O.finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa Y.fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.sasorov s.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo s.V.Bulanov T.Kawachi A.s.Pirozhkov ELI Beamlines facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon science(KPsI) QSTKyotoJapan Central Laser facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IfsA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AsCR PragueCzech Republic fZU-Institute of Physics AsCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine IsTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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