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Lessons from “real life experience” of rifaximin use in the management of recurrent hepatic encephalopathy

World Journal of Hepatology 2020年第1期12卷 10-20页

作者： Fiona Chautant Maeva Guillaume Marie-Angèle Robic Jean-François Cadranel Jean-Marie Peron Hortensia Lison charlène cool Christophe Bureau Véronique Duhalde Service Pharmacie Centre Hospitalier Universitaire de ToulouseHôpital Paule de ViguierToulouse 31059France Department of Hepato-Gastroenterology University HospitalToulouse 31059France Department of Hepato-Gastroenterology Laennec HospitalCreil 60109France Department of Pharmacy and UMR INSERM 1027 University HospitalToulouse 31059France Department of Pharmacy University Hospital ToulouseToulouse 31059France

BACKGROUND Hepatic encephalopathy(HE)is a major complication of cirrhosis with independent prognostic *** current management of HE is mainly based on *** has been shown to decrease the risk of HE recurrence in patients with episodic *** can also be ***,there is no drug support recommendation for rifaximin use in this *** To assess the effectiveness of rifaximin in the management of recurrent episodes of HE and recurrent acute exacerbations on persistent HE,in“real life conditions”.METHODS In this retrospective study,using a within-subjects design,we collected data of patients treated with rifaximin for HE in two liver diseases centers,during the six-month period before and during the six-month period after the initiation of *** primary effectiveness endpoint was the total number of HE events involving *** Rifaximin was introduced for prevention of recurrent HE episodes in 29 out of 62 patients with normal mental status between episodes and for prevention of recurrent acute exacerbations on persistent HE in 33 out of 62 *** the“prevention of recurrent HE episodes”group,fewer HE events(0.79 vs 1.78;P=0.013)were reported during the period of time when rifaximin was *** the“prevention of recurrent acute exacerbations on persistent HE”group,there was no significant difference in the number of HE-events(1.48 vs 1.77;P=0.582).CONCLUSION In this real-life experience,the effectiveness of rifaximin was confirmed in the prevention of HE episodes recurrence but was not proved in the prevention of acute exacerbations recurrence on persistent HE.

关键词： Rifaximin Hepatic encephalopathy Cirrhosis Liver disease Hospitalization

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Treatment, residual chlorine and season as factors affecting variability of trihalomethanes in small drinking water systems

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 171-179页

作者： Roberta DYCK Genevieve cool Manuel RODRIGUEZ Rehan SADIQ School of Engineering University of British Columbia Okanagan Kelowna V1V 1V7 Canada Ecole superieure d'amenagement du territoire Universite Laval Quebec G1V 0A6 Canada

Seasonal variability in source water can lead to challenges for drinking water providers related to operational optimization and process control in treatment facilities. The objective of this study is to investigate seasonal variability of water quality in municipal small water systems （〈 3000 residents） supplied by surface waters. Residual chlorine and trihalomethanes （THM） were measured over seven years （2003-2009）. Comparisons are made within each system over time, as well as between systems according to the type of their treatment technologies. THM concentrations are generally higher in the summer and autumn. The seasonal variability was generally more pronounced in systems using chlorination plus additional treatment. Chloroform, total THM （TTHM） and residual chlorine concentrations were generally lower in systems using chlorination plus additional treatment. Conversely, brominated THM concentrations were higher in systems using additional treatment. Residual chlorine was highest in the winter and lowest in the spring and summer. Seasonal variations were most pronounced for residual chlorine in systems with additional treatment. There was generally poor correlation between THM concentrations and concentrations of residual chlorine. Further study with these data will be beneficial in finding determinants and indicators for both quantity and variability of disinfection byproducts and other water quality parameters.

关键词： drinking water residual chlorine seasonal variability small municipal systems treatment technologies trihalomethanes

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Clinical outcome of open ankle fractures in patients above 70 years of age

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World Journal of Orthopedics 2023年第7期14卷 554-561页

作者： Wajiha Zahra Mina Seifo Paul cool David Ford Tosan Okoro Department of Trauma and Orthopedics Royal Shrewsbury HospitalShrewsbury SY38XQUnited Kingdom Department of Trauma and Orthopedics Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom Department of Trauma and Orthopedics Keele UniversityStafford ST55BGUnited Kingdom

BACKGROUND Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and ***,data on the clinical outcomes of open ankle fracture management in patients older than 70 is *** To evaluate the clinical outcomes following open ankle fracture management in patients older than *** secondary aim is to look at predictors of poor *** Following local research and audit department registration,22 years of prospectively collated data from an electronic database in a district general hospital were *** patients older than 70 years of age with an open ankle fracture requiring surgical intervention were *** information,the nature,and the number of surgical interventions were ***,including surgical site infection(SSI),venous thromboembolic events(VTEs)during hospital stay,and mortality rate,were *** A total of 37 patients were identified(median age:84 years,range:70-98);n=30 females median age:84 years,range:70-97);n=7 males median age:74 years,range:71-98))who underwent surgical intervention after an open ankle *** patients developed SSIs(43%).Superficial SSIs(n=8)were managed without surgical intervention and treated with antibiotics and regular dressing *** SSIs(n=8;20%)required a median of 3(range:2-9)surgical interventions,with four patients requiring multiple washouts and one patient having metalwork *** incidence was 5%during the hospital *** patients died within 30 d,and mortality at one year was 19%.The 10-year mortality rate was 57%.The presence of a history of stroke,cancer,or prolonged inpatient stay was found to be predictive of lower survivorship in this population(log-rank test:cancer P=0.008,stroke P=0.001,length of stay>33 d P=0.015).The presence of a cardiac history was predictive of wound complications(logistic regression,P=0.045).Age,number of operations,and di

关键词： Fragility fracture Open fracture Clinical outcome Mortality Infection Survival

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cool！用手机玩网游

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大众硬件 2005年第12期 105-106页

作者： cool 江苏

很多朋友都喜欢用手机玩游戏,不在乎游戏本身,只因为那份随意。午休时办公室里、下班后公交车上,甚至暖洋洋的被窝里,何时何地,只要愿意, 运动拇指,想玩就玩。笔者就是一个手机游戏迷,曾兴奋地用手机玩贪吃蛇类的单机游戏,也曾尖叫着... 详细信息

很多朋友都喜欢用手机玩游戏,不在乎游戏本身,只因为那份随意。午休时办公室里、下班后公交车上,甚至暖洋洋的被窝里,何时何地,只要愿意, 运动拇指,想玩就玩。笔者就是一个手机游戏迷,曾兴奋地用手机玩贪吃蛇类的单机游戏,也曾尖叫着用手机和朋友的手机互连游戏,现在却迷上了用手机玩网络游戏。下文将“手机+网游”这个cool玩法介绍给你。

关键词： cool 手机办公室公交车游戏

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我最冷cool

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课堂内外（小学版） 2014年第11期 32-37页

作者：小cool龙

现在几乎每个家庭里都住着一个冷冰冰的家伙,它就是电冰箱。我们可以把剩菜剩饭装进它的肚子里,也可以把雪糕饮料暂时存放其中,当然还少不了把蔬菜瓜果关在里面＂存活＂更久……它真是一名非常重要的家庭成员。这一期就让这个冷冷的家... 详细信息

现在几乎每个家庭里都住着一个冷冰冰的家伙,它就是电冰箱。我们可以把剩菜剩饭装进它的肚子里,也可以把雪糕饮料暂时存放其中,当然还少不了把蔬菜瓜果关在里面＂存活＂更久……它真是一名非常重要的家庭成员。这一期就让这个冷冷的家伙说说它的故事吧。

关键词： cool 蔬菜瓜果冷冻食品家庭成员制冷压缩机家用冰箱制冷效果就这样古巴比伦人工制冷

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Dietary zinc and metallothionein on small intestinal disaccharidases activity in mice

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World Journal of Gastroenterology 2011年第3期17卷 354-360页

作者： Cuong D Tran Johanna cool Cory J Xian Gastroenterology Unit ChildrenYouth and Women's Health Service Discipline of Physiology School of Medical SciencesThe University of Adelaide Discipline of Agricultural and Animal Science School of AgricultureFood and Wine The University of Adelaide Adelaide Sansom Institute for Health Research School of Pharmacy and Medical SciencesUniversity of South Australia

AIM: To examine the effect of increasing dietary zinc (Zn) intake and the lack of metallothionein (MT) expression on activity of small intestinal disaccharidases. METHODS: MT-Ⅰ and Ⅱ knockout (MT-/-) and wild-type (MT+/+) female mice at 3.5 wk of age were randomly fed with a diet containing 2 (2 Zn), 15 (15 Zn) or 50 (50 Zn) mg Zn/kg (n = 8/group/genotype) for 5 wk. Small intestinal segments (duodenum, jejunum and ileum) were collected and either fixed in 10% formalin for histological analysis or snap frozen in liquid nitrogen for sucrase, lactase and maltase activity ***: Plasma Zn was significantly (P < 0.05) lower (33%) in MT-/- compared with MT+/+ mice fed the 2 Zn diet. Villus height and crypt depth were increased by approximately 15% in MT+/+ mice compared with MT-/- mice. Duodenal disaccharidase activities were significantly higher in MT+/+ compared with MT-/- mice particularly in those fed the 2 Zn diet. For the 50 Zn diet, jejunal sucrase and lactase activities were significantly higher in MT-/- (13 313 ± 2314; 4107 ± 364 μmol glucose/well/min/g tissue, respectively) compared with MT+/+ mice (7054 ± 608; 1818 ± 174). Similarly, ileal lactase activities were higher in MT-/- (1480 ± 192) compared with MT+/+ (629 ± 353) mice particularly those fed the 2 Zn diet. CONCLUSION: Increasing dietary Zn has little effect on disaccharidases activity in MT wild-type mice. The presence of MT may enhance morphological and functional development of the gut.

关键词： Lactase Maltase Sucrase Metallothionein Diet Zinc

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Ball,Ball!

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课堂内外（小学版） 2018年第1期 98-101页

作者：乐乐姐姐小cool龙

大家好,我们是重庆市人民小学棒球队!棒球是什么？可可豆们肯定知道。棒球怎么玩？……嗯,可能大部分可可豆就不清楚了,那么,请跟我们一起来玩棒球吧!

关键词：课堂内外小学

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清凉一夏——保持电脑的凉爽

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电子制作．电脑维护与应用 2004年第6期 34-35页

作者： cool

想像一下，假如你在闷热的沙漠中，穿着一件皮制大衣．跑了一整天，将是什么样的情况？此刻可能想要一个凉爽的风扇．一杯冰茶．你的电脑也是如此．电脑每天运行就犹如痛苦的马拉松赛跑．而且只是依赖于风扇．散热片等来保持各部件的凉... 详细信息

想像一下，假如你在闷热的沙漠中，穿着一件皮制大衣．跑了一整天，将是什么样的情况？此刻可能想要一个凉爽的风扇．一杯冰茶．你的电脑也是如此．电脑每天运行就犹如痛苦的马拉松赛跑．而且只是依赖于风扇．散热片等来保持各部件的凉爽．现在电脑的电路元器件在不断地缩小．但它所散发的热量却在不断地提高．

关键词：电脑散热片机箱风扇噪音机箱温度 CPU风扇显卡风扇液体降温

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你所不知道的市售非公版显卡分析

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微型计算机 2011年第21期31卷 131-133页

作者： cool

一直以来，相比公版显卡，非公版显卡是市场中的绝对主流产品。但比较遗憾的是，部分非公版显卡为了节约成本，在用料和设计上并不能令人满意。不过这种情况在DirectX 11显卡时代来临后，得到了很大的改善。一些具有个性化和实用性的非... 详细信息

一直以来，相比公版显卡，非公版显卡是市场中的绝对主流产品。但比较遗憾的是，部分非公版显卡为了节约成本，在用料和设计上并不能令人满意。不过这种情况在DirectX 11显卡时代来临后，得到了很大的改善。一些具有个性化和实用性的非公版显卡层出不穷，成为市场的亮点。那么如今的非公版显卡市场究竟有哪些变化，非公版显卡都有哪些特别的设计呢？

关键词：显卡市场 DirectX 市售节约成本个性化设计

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笔记本电脑选购四大误区

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数码先锋 2009年第12期 76-77页

作者： cool

随着笔记本的价格越来越平民化，越来越多非IT专业人员选购笔记本电脑用于娱乐、工作。然而由于对硬件缺乏深入了解，在选购中很容易走进一些误区，不但花了更多钱，而且也不见得购到的笔记本电脑满足自己的使用需求。在这篇文章中，我... 详细信息

随着笔记本的价格越来越平民化，越来越多非IT专业人员选购笔记本电脑用于娱乐、工作。然而由于对硬件缺乏深入了解，在选购中很容易走进一些误区，不但花了更多钱，而且也不见得购到的笔记本电脑满足自己的使用需求。在这篇文章中，我们把选本时容易进入的误区、以及其他购机时需要注意的地方汇总起来。希望能够对大家选购笔记本电脑有所帮助。

关键词：笔记本电脑电脑选购误区 IT专业使用需求平民化硬件购机

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