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From blood to brain:amoeboid microglial cell,a nascent macrophage and its functions in developing brain

Acta Pharmacologica Sinica 2007年第8期28卷 1087-1096页

作者： charanjit kaur S Thameem DHEEN Eng-ang LING Department of Anatomy Yong Loo Lin School of Medicine National University of Singapore117597Singapore

Amoeboid microglial cells(AMC)in the developing brain are active *** macrophagic nature of these cells has been demonstrated by many methods,such as the localization of various hydrolytic enzymes and the presence of comple-ment type 3 surface receptors in *** importantly is the direct visualizationof these cells engaged in the phagocytosis of degenerating cells at the ultrastruc-tural *** evidence of them being active macrophages is the avid inter-nalization of tracers administered by the intravenous or intraperitoneal routes indeveloping *** potential involvement of AMC in immune functions is sup-ported by the induced expression of major histocompatibility complex class I andII antigens on them when challenged by lipopolysaccharide or interferon-γ.Im-munosuppressive drugs,such as glucocorticoids and immune function-enhanc-ing drugs like melatonin,affect the expression of surface receptors and antigensand the release of cytokines by *** studies in our laboratory haveshown the expression of insulin-like growth factors,endothelins,2',3'-cyclic nucle-otide 3'-phosphodiesterase,and N-methyl-D-asparate *** along withthe release of chemokines,such as stromal derived factor-la and monocytechemoattractant protein-1,suggests multiple functional roles of AMC in earlybrain development.

关键词： developing brain amoeboid microglial cells functions

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Modelling fertility:an application of count regression models

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Chinese Journal of Population,Resources and Environment 2015年第4期13卷 349-357页

作者： Ranjita Pandey charanjit kaur Department of Statistics University of Delhi

Often the lifecycle data occur as count of the vital events and are recorded as *** purpose of this article is to model the fertility behavior based on religious,educational,economic,and occupational *** responses of classified groups according to these determinants are examined for significant influence on fertility using Poisson regression model(PRM) based on the National Family Health Survey-3 *** observed and predicted probabilities under PRM indicate modal value of two children for the Poisson distribution modeled *** of dominance of two child in the data motivates the authors to adopt multinomial regression model(MRM) in order to link fertility with various socioeconomic indicators responsible for fertility *** of the explanatory factors is limited to the availability of *** and patterns of preference for birth counts suggest that religion,caste,wealth,female education,and occupation are the dominant factors shaping the observed birth *** analysis suggests that both the models used in the study perform similarly on the sample ***,fitting of MRM by taking birth count of two as comparison category shows improved Akaike information criterion and consistent Akaike information criterion *** work contributes to the existing literature as it attempts to provide more insight into the determinants of Indian fertility using Poisson and MRM.

关键词： count data fertility Poisson model multinomial regression models

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Hypoxia and the developing brain： factors underlying cell damage

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解剖学杂志 2009年第3期32卷 281-285页

作者： charanjit kaur Ling Eng Ang Department of Anatomy Yong Loo Lin School of Medicine Blk MDIO 4 Medical DriveNational University of Singapore Singapore 117597

Structural and functional integrity of brain function depends on a regular oxygen supply. The developing brain is extremely sensitive to oxygen deprivation or hypoxia which affects the normal development and maturatio... 详细信息

关键词：组织缺氧大脑细胞损害外科医学

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