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采用β受体阻滞剂和噻嗪类利尿剂作为高血压单药治疗和联合治疗时,血浆肾素活性对血压反应的预测

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中华高血压杂志 2010年第12期18卷 1198-1198页

作者： Turner ST Schwartz GL chapman ab Beitelshees AL Gums JG Cooper-DeHoff RM Boerwinkle E Johnson JA Bailey KR 黄晓斌

年龄和种族类别或肾素水平已被推荐作为使用8受体阻滞剂或噻嗪类利尿剂进行单药治疗预测血压反应的指标。然而使用B受体阻滞剂或噻嗪类利尿剂与其他抗高血压药物进行联合治疗，上述特征，或其他特征指标的预测作用还不明确。

关键词：噻嗪类利尿剂 β受体阻滞剂血浆肾素活性抗高血压药物预测作用联合治疗单药治疗血压反应

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Nanoparticle Targeting with Antibodies in the Central Nervous System

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Biomedical Engineering Frontiers 2023年第1期4卷 159-176页

作者： Ju Hyun Lee Dana V.chapman W.Mark Saltzman Department of Biomedical Engineering Yale UniversityNew HavenCTUSA

Treatments for disease in the central nervous system(CNS)are limited because of difficulties in agent penetration through the blood-brain barrier,achieving optimal dosing,and mitigating off-target *** prospect of precision medicine in CNS treatment suggests an opportunity for therapeutic nanotechnology,which offers tunability and adaptability to address specific diseases as well as targetability when combined with antibodies(abs).Here,we review the strategies to attach abs to nanoparticles(NPs),including conventional approaches of chemisorption and physisorption as well as attempts to combine irreversible ab immobilization with controlled *** also summarize trends that have been observed through studies of systemically delivered ab–NP conjugates in ***,we discuss the future outlook for ab–NPs to deliver therapeutics into the CNS.

关键词： agent irreversible particle

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全基因组和基于基因的荟萃分析识别影响氢氯噻嗪血压反应的新型基因位点

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中华高血压杂志 2016年第11期24卷 1007-1007页

作者：刘莉叶鹏 Salvi E Wang Z Rizzi F Gong Y McDonough CW Padmanabhan S Hiltunen TP Lanzani C Zaninello R Chittani M Bailey KR Sarin AP Barcella M Melander O chapman ab Manunta P Kontula KK Glorioso N Cusi D Dominiczak AF Johnson JA Barlassina C Boerwinkle E Cooper-DeHoff RM Turner ST

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反... 详细信息

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反应、血压调节或高血压易感性的候选基因进行了基于基因的分析。

关键词：血压调节基因位点荟萃分析抗高血压药物基因组研究抗高血压治疗缝隙连接蛋白叉头 junction 候选基因

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fficient and universal characterization of atomic structures through a topological graph order parameter

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npj Computational Materials 2022年第1期 334-345页

作者： James chapman Nir Goldman Brandon C.Wood Physical and Life Sciences Directorate Lawrence Livermore National LaboratoryLivermoreCAUSA Department of Chemical Engineering University of CaliforniaDavisCaliforniaCA95616United States

A graph-based order parameter,based on the topology of the graph itself,is introduced for the characterization of atomistic *** order parameter is universal to any material/chemical system and is transferable to all structural *** sets of data are used to validate both the generalizability and accuracy of the algorithm:(1)liquid lithium configurations spanning up to 300 GPa,(2)condensed phases of carbon along with nanotubes and buckyballs at ambient and high temperature,(3)a diverse set of aluminum configurations including surfaces,compressed and expanded lattices,point defects,grain boundaries,liquids,nanoparticles,all at nonzero temperatures,and(4)eleven niobium oxide crystal phases generated with ab initio molecular *** compare our proposed method to existing,state-of-the-art methods for the cases of aluminum and niobium *** order parameter uniquely classifies every configuration and outperforms all studied existing methods,opening the door for its use in a multitude of complex application spaces that can require fine structure-level characterization of atomistic graphs.

关键词： parameter configuration uniquely

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Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

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