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Effect of Air Plasma Processing on the Adsorption Behaviour of Bovine Serum Albumin on Spin-Coated PMMA Surfaces

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Journal of Bionic Engineering 2008年第3期5卷 204-214页

作者： chaozong liu Brian J. Meenan Advanced Materials and Biomaterials Research Centre School of Engineering The Robert Gordon University Aberdeen ABIO 1FR UK Northern ireland Bioengineering Centre University of Ulster Newtownabbey BT37 OQB Northern Ireland UK

This paper reports the adsorption of Bovine Serum Albumin （BSA） onto Dielectric Barrier Discharge （DBD） processed Poly（methyl methacrylate）（PMMA） surfaces by a Quartz Crystal Microbalance with Dissipation monitoring （QCM-D） technique. The purpose is to study the influence of DBD processing on the nature and scale of BSA adsorption on PMMA surface in vitro. It was observed that DBD processing improves the surface wettability of PMMA film, a fact attributable to the changes in surface chemistry and topography. Exposure of the PMMA to Phosphate Buffed Saline （PBS） solution in the QCM-D system resulted in surface adsorption which reaches an equilibrium after about 30 minutes for pristine PMMA, and 90 minutes for processed PMMA surface. Subsequent injection of BSA in PBS indicated that the protein is immediately adsorbed onto the PMMA surface. It was revealed that adsorption behaviour of BSA on pristine PMMA differs from that on processed PMMA surface. A slower adsorption kinetics was observed for pristine PMMA surface, whilst a quick adsorption kinetics for processed PMMA. Moreover, the dissipation shift of protein adsorption suggested that BSA forms a more rigid structure on pristine PMMA surface that on processed surface. These data suggest that changes in wettability and attendant chemical properties and surface texture of the PMMA surface may play a significant role in BSA adsorption process.

关键词： in vitro test protein adsorption surface modification polymethylmethacrylate QCM-D

Osteochondral tissue repair in osteoarthritic joints： clinical challenges and opportunities in tissue engineering

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Bio-Design and Manufacturing 2018年第2期1卷 101-114页

作者： Maryam Tamaddon Ling Wang Ziyu liu chaozong liu Institute of Orthopaedic and Musculoskeletal Science Division of Surgery and Interventional Science University College London Royal National Orthopaedic Hospital Stanmore HA7 4LP UK School of Mechanical Engineering Xi'an Jiaotong University Xi'an 710049 People's Republic of China

Osteoarthritis （OA）, identified as one of the priorities for the Bone and Joint Decade, is one of the most prevalent joint diseases, which causes pain and disability of joints in the adult population. Secondary OA usually stems from repetitive overloading to the osteochondral （OC） unit, which could result in cartilage damage and changes in the subchondral bone, leading to mechanical instability of the joint and loss of joint function. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bone in the early stages of OA and have shown potential in restoring the joint＇s function. In this approach, the use of three-dimensional scaffolds （with or without cells） provides support for tissue growth. Commercially available OC scaffolds have been studied in OA patients for repair and regeneration of OC defects. However, none of these scaffolds has shown satisfactory clinical results. This article reviews the OC tissue structure and the design, manufacturing and performance of current OC scaffolds in treatment of OA. The findings demonstrate the importance of biological and biomechanical fixations of OC scaffolds to the host tissue in achieving an improved cartilage fill and a hyaline-like tissue formation. Achieving a strong and stable subchondral bone support that helps the regeneration of overlying cartilage seems to be still a grand challenge for the early treatment of OA.

关键词： Osteochondral tissue engineering Osteoarthritis Osteochondral scaffold Cartilage and subchondral bone Clinical scaffolds

Surface Wettability and Chemistry of Ozone Perfusion Processed Porous Collagen Scaffold

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Journal of Bionic Engineering 2011年第3期8卷 223-233页

作者： chaozong liu Shirley Z. Shen 乙hiwu Han School of Mechanical and Systems Engineering University of Newcastle Newcastle upon Tyne NEI 7R U UK Polymer Composite & Nanomaterials CSIRO Manufacturing & Infrastructure Technology Highett Vic 3190 Australia Key Laboratory of Bionic Engineering (Ministry of Education China) Jilin University Changchun 130022 P. R. China

Crosslinking treatment of collagen has often been used to improve the biological stability and mechanical properties of 3D porous collagen scaffolds. However, accompanying these improvements, the collagen fibril surface becomes hydrophobic nature resulting in a reduced surface wettability. The wetting of the collagen fibril by culture medium is reduced and it is difficult for the medium to diffuse into the 3D structure of a porous collagen scaffold. This paper reports a ＂perfusion processing＂ strategy using ozone to improve the surface wettability of chemical crosslinked collagen scaffolds. Surface wettability, surface composition and biological stability were analyzed to evaluate the effectiveness of this surface processing strategy. It was observed that ozone perfusion processing improved surface wettability for both exterior and interior surfaces of the porous 3D collagen scaffold. The improvement in wettability is attributed to the incorporation of oxygen-containing functional groups onto the surface of the collagen fibrils, as confirmed by X-ray Photoelectron Spectroscopy （XPS） analysis. This leads to a significant improvement in water taking capability without compromising the bulk biological stability and mechanical properties, and confirms that ozone perfusion processing is an effective tool to modify the wettability both for interior and exterior surfaces throughout the scaffold.

关键词： scaffold collagen surface modification hydrophilicity ozone perfusion

The balance of contradictory factors in the selection of biodiesel and jet biofuels on algae fixation of flue gas

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Energy and AI 2022年第3期9卷 1-11页

作者： Ziyu liu chaozong liu Shujun Han Xiaoyi Yang School of Energy and Power Engineering Energy and Environment International CentreBeihang UniversityChina Centre for Materials Research University College LondonUK School of Aeronautic Science and Engineering Beihang UniversityChina

The purpose would discover the impacts of the contradictory factors in application of algae in CO_(2) sequestration with sustainable biofuel benefit. Based on LCA approach, the quantitively AI assessment model and approach have been established coupling upstream CO_(2) source and downstream algal product at the uniform algae level of Nannochloropsis oceanica, which would benefit for algae biofuel deliverables choice. The AI model investigated the effects of interaction factors on the energy consumption, including transportation distances with purification modes coupling with CO_(2) concentration in flue gas, lipid content with specific productivity coupling the nutrient supply, refining process with final products. Computational framework of AI model is classified into three submodels, including CO_(2) capture and purification model, algae cultivation and harvesting model, refining process and biofuel product model. According to uncertainty analysis by AI model, the positive energy gains have been conducted at a wide range of lipid contents despite of jet biofuel or biodiesel coupling solar energy utilization and by-product of bioactive nutrients effects. Biodieselwet and HTL-HRJ jet biofuel performed the priorities in energy consumption in three pathways of jet biofuel and three pathways of biodiesels. The allocation analysis confirmed that algae biofuel will be promising in the direction of cultivating appropriate algae for the target biofuel product requirement and enhancing by-product recovery. The results would enhance the interests in both LCA and CO_(2) sequestration with sustainable biofuel benefit.

关键词： CO_(2)sequestration Uncertainty analysis Jet biofuel Biodiesel Algae LCA

Growth of TiO2 Nanotube on Titanium Substrate to Enhance its Biotribological Performance and Biocorrosion Resistance

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Journal of Bionic Engineering 2019年第6期16卷 1039-1051页

作者： Jiajun Luo Bianhong Li Sara Ajami Shuanhong Ma Feng Zhou chaozong liu Institute of Orthopaedic&Musculoskeletal Science Division of Surgery&Interventional ScienceUniversity College LondonRoyal National Orthopaedic HospitalStanmoreHA14LPUnited Kingdom School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Solid L ubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

TiO2 nanotubes(NTs)have a great potential in improving the osetointegration of titanium(Ti)-based *** efforts have been made to evaluate the biological performance of the TiO2 nanotube in regulating protein adsorption and cells *** often used in orthopaedic applications,although biotribological performance and biocorrosion are important issues in these applications,few researches have been reported on the biotribological perfonnance of NT *** paper reports the preparation of a structure-optimised TiO2 NT(SO-NT)material via a multi-step oxidation strategy,as well as its biotribological and biocorrosion *** this procedure,an interfacial bonding layer of approximately 120 nm=150 nm was first formed on the titanium substrate,which was then joined to the NT *** mechanical testing with respect to impact,bending,and biotribological perfbnnance have demonstrated the resultant SO-NT layer possess improved mechanical stability compared to conventional *** uniform hyperfine interfacial bonding layer with nano-sized grains exhibited a strong bonding to NT layer and Ti *** was observed that the layer not only effectively dissipates external impacts and shear stress but also acts as a good corrosion resistance barrier to prevent the Ti substrate from *** models were proposed to analyze and predict the shear performance and corrosion-resistance mechanisms of the resultant *** obtained results demonstrated that the SO-NT material has great potential in orthopaedic applications.

关键词： TiO2 nanotubes tribology titanium implant surface modification biomaterials

Thermodynamic and kinetics of hydrogen photoproduction enhancement by concentrated sunlight with CO_(2) photoreduction by heterojunction photocatalysts

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Energy and AI 2021年第4期6卷 14-20页

作者： Ziyu liu Teng Yi Chenxu Huang Kwang-Leong Choy chaozong liu School of Medical Science and Engineering Beihang UniversityChina Centre for Materials Research University College LondonUK National Institude of Defense Science and Technology China Northwest Institute of Mechanical&Electrical Engineering China

For achieving water splitting into hydrogen under sunlight for practical applications,the high efficiencies of the photoreduction of CO_(2) over TiO_(2)/Fe3O4 photocatalysts combined with hydrogenation of water splitting over Pt/TiO_(2) were investigated by practical concentrated solar energy compared with Hg lamp and Xe *** on AI analysis on the influence factors,the key parameters for TOC concentration were photocatalysts,Na2CO3 concentration and radiation intensity while the key parameters for hydrogen production were photocatalysts,radiation intensity,and TOC ***,the mechanism of concentrated sunlight effects has been discussed from the view of thermodynamics and *** concentrated sunlight provides a simultaneous supply of sufficient electron–hole pairs and thermal *** to hydrogen and CO_(2) reduction are both enhanced in concentrated sunlight due to endothermal *** changes the internal electric field of p-n junction of in different possible ways,and thus composite photocatalysts with favorable formation of p-n junctions would enhance the charge separation by internal electric ***,photocatalysts are beneficial for providing more excited electrons at a time for achieving CO_(2) photoreduction at the surface region of the particles with higher density of radiation by concentrated solar ***,products from CO_(2) photoreduction,acting as sacrificial electron donors,improved hydrogen evolution in solar-mediated water splitting for prohibiting reverse reactions.

关键词： Concentrated sunlight Hydrogen evolution CO_(2)photoreduction p-n junction Thermodynamics and kinetics

Oxygen and Glucose Transportation and Distribution on 3D Osteochondral Scaffold in Silico Model

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Journal of Bionic Engineering 2022年第4期19卷 1100-1108页

作者： Ziyu liu Hao Huang Jingying Yang Maryam Tamaddon Haoyu Wang Yingying Gu Zhenyun Shi chaozong liu Division of Surgery and Interventional Science Royal National Orthopaedic HospitalUniversity College LondonStanmoreLondon HA74LPUK Beijing Advanced Innovation Centre for Biomedical Engineering School of Engineering MedicineBeihang UniversityBeijing 100083China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

Nutrients supply especially like nutrients and oxygen play vital role in tissue engineering *** is found that tissue could not grow very well in the middle of the scaffold because few nutrients could transport to the *** limitations would reduce cell proliferation and *** that case,there is urgent need to understand the nutrient distribution for both in vitro and in vivo study,as no technology is able for researchers to observe the nutrients transport during those *** this paper,a numerical model coupling with VOF(volume of fluid)model and species transport model together for predicting the distribution of oxygen and glucose in the scaffold after implantation in to the site is *** with our previous in vivo tests,the regenerated tissue distribution has a similar trend as oxygen distribution rather than *** reported scaffold manufactured by additive manufacturing provided a good interconnected structure which facilitated the nutrient transportation in the *** nutrient transportation,this numerical model could be used in better understanding the nutrients transportation in the scaffold,and leading to a better understanding of tissue formation in the scaffold.

关键词： Nutrient transport Scaffold Nutrient distribution Computational fluid dynamic Discrete phase model

Improving the fretting biocorrosion of Ti6Al4V alloy bone screw by decorating structure optimised TiO2 nanotubes layer

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Journal of Materials Science & Technology 2020年第14期47卷 47-55页

作者： Jiajun Luo Maryam Tamaddon Changyou Yan Shuanhong Ma Xiaolong Wang Feng Zhou chaozong liu Institute of Orthopaedic&Musculoskeletal Science Division of Surgery&Interventional ScienceUniversity College LondonRoyal National Orthopaedic HospitalStanmoreHA74LPUnited Kingdom State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and ***,the fretting biocorrosion is the main concern that limited its successfully application in orthopaedic *** this study,a structure optimised thin TiO2 nanotube(SONT)layer was successfully created on Ti6Al4V bone screw,and its fretting corrosion performance was investigated and compared to the pristine Ti6Al4V bone screws and NT decorated screw in a bone-screw fretting simulation *** results have shown that the debonding TiO2 nanotube from the bone screw reduced significantly,as a result of structure *** SONT layer also exhibited enhanced bio-corrosion resistance compared pristine bone screw and conventionally NT modified bone *** is postulated that interfacial layer between TiO2 nanotube and Ti6Al4V substrate,generated during structure optimisation process,enhanced bonding of TiO2 nanotube layer to the Ti6Al4V bone screws that leading to the improvement in fretting corrosion *** results highlighted the potential SONT in orthopaedic application as bone fracture fixation devices.

关键词： Bone implant interface Bone screws Biomedical materials TiO2 nanotubes Fretting corrosion

Effects of bionic mechanical stimulation on the properties of engineered cartilage tissue

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Bio-Design and Manufacturing 2021年第1期4卷 33-43页

作者： Zhiyan Hao Sen Wang Jichang Nie Dichen Li Ao Fang Jianfeng Kang chaozong liu Ling Wang State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710054ShaanxiChina School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710054ShaanxiChina Jihua Laboratory Foshan 528200GuangdongChina Institute of Orthopaedic and Musculoskeletal Science Division of Surgery and Interventional ScienceRoyal National Orthopaedic HospitalUniversity College LondonStanmore HA74LPUK

Tissue-engineered cartilage(TEC)remains a potential alternative for the repair of articular cartilage ***,there has been a significant different between the properties of TEC and those of natural *** have shown that mechanical stimulation such as compressive load can help regulate matrix remodelling in TEC,thus affecting its biomechanical ***,the influences of shear induced from the tissue fluid phase have not been well studied and may play an important role in tissue regeneration especially when integrated with the compressive ***,the aim of this study was to quantitatively investigate the effects of combined loading mechanisms on TEC in vitro.A bespoke biosimulator was built to incorporate the coupled motion of compression,friction and *** specimens,encapsulating freshly isolated rabbit chondrocytes in a hydrogel,were cultured within the biosimulator under various mechanical stimulations for 4 weeks,and the tissue activity,matrix contents and the mechanical properties were *** groups were categorized according to different mechanical stimulation combinations,including strain(5-20%at 5%intervals)and frequency(0.25 Hz,0.5 Hz,1 Hz),and the effects on tissue behaviour were *** the dynamic culture process,a combined load was applied to simulate the combined effects of compression,friction and shear on articular cartilage during human *** results indicated that a larger strain and higher frequency were more favourable for the specimen in terms of the cell proliferation and extracellular matrix ***,the combined mechanical stimulation was more beneficial to matrix remodelling than the single loading ***,the contribution of the combined mechanical stimulation to the engineered cartilaginous tissue matrix was not sufficient to impede biodegradation of the tissue with culture time.

关键词： Bionic mechanical stimulation Tissue-engineered cartilage Biosimulator Shear