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中华医学杂志(英文版) 2025年第03期

作者： xiao chaoyue Feng Xiang Zhao Tiantian Ding Gouping Gao Yawen Department of Oncology The Second Xiangya Hospital Central South University Changsha Hunan China

Immunometabolism:a new dimension in immunotherapy resistance

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Frontiers of Medicine 2023年第4期17卷 585-616页

作者： chaoyue xiao Wei Xiong Yiting Xu Ji’an Zou Yue Zeng Junqi Liu Yurong Peng Chunhong Hu Fang Wu Department of Oncology The Second Xiangya HospitalCentral South UniversityChangsha 410011China NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research InstituteCentral South UniversityChangsha 410078China Xiangya School of Medicine Central South UniversityChangsha 410013China Hunan Cancer Mega-Data Intelligent Application and Engineering Research Centre Changsha 410011China Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer The Second Xiangya HospitalCentral South UniversityChangsha 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011China

Immune checkpoint inhibitors(ICIs)have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment,while substantial patients remain unresponsive or develop resistance to ICIs as a single agent,which is traceable to cellular metabolic *** dysregulated metabolism has long been adjudged as a hallmark of tumor,it is now increasingly accepted that metabolic reprogramming is not exclusive to tumor cells but is also characteristic of ***,people used to pay more attention to the effect of tumor cell metabolism on immunocytes,but in practice immunocytes interact intimately with their own metabolic function in a way that has never been realized before during their activation and differentiation,which opens up a whole new frontier called *** metabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistance and ameliorate existing ICI immunotherapy,whose crux might be to ascertain synergistic combinations of metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune ***,we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimension of metabolic reprogramming in diverse tumor-infiltrating immunocytes,and related metabolic intervention in the hope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance.

关键词： immune cell immunometabolism metabolic reprogramming immunotherapy resistance tumor microenvironment immune checkpoint inhibitor

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先天性巨结肠细胞能量代谢的酶学研究

中华小儿外科杂志 1996年第1期17卷 6-8页

作者：李戎王果肖超跃同济医科大学附属同济医院小儿外科广东省中山市人民医院儿科深圳市儿童医院筹建办公室

为了解先天性巨结肠（ＨＤ）病变肠段细胞能量代谢的状况。通过酶组织化学方法对２０例ＨＤ患儿正常段、狭窄段全层组织，进行了五种酶的定性、定量及计数分析：①ＡＴＰ（ａｓｅ）（腺苷三磷酸酶），②ＳＤＨ（琥珀酸脱氢酶），③ＭＡ... 详细信息

为了解先天性巨结肠（ＨＤ）病变肠段细胞能量代谢的状况。通过酶组织化学方法对２０例ＨＤ患儿正常段、狭窄段全层组织，进行了五种酶的定性、定量及计数分析：①ＡＴＰ（ａｓｅ）（腺苷三磷酸酶），②ＳＤＨ（琥珀酸脱氢酶），③ＭＡＯ（单胺氧化酶），④ＣｈＥ（胆碱脂酶），⑤ＣｈＥ－Ａｇ（胆碱脂酶＋镀银）。发现狭窄段有如下变化：ＡＴＰ（ａｓｅ）、ＳＤＨ和ＣｈＥ活性显著升高（Ｐ＜０．０１）；ＭＡＯ活性显著降低（Ｐ＜０．０１）；粘膜下和肌间神经丛（ＣｈＥ＋Ａｇ）减少１／３，神经节细胞数（ＳＤＨ）减少４／５（Ｐ＜０．０１）。说明ＨＤ狭窄段细胞能量代谢是旺盛的，检测ＡＴＰ（ａｓｅ）、ＳＤＨ、ＭＡＯ可作为诊断ＨＤ新的参考。

关键词：先天性巨结肠细胞生物化学能量代谢酶学

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儿童哮喘严重度与体质指数的相关性研究

医学研究杂志 2010年第8期39卷 86-87页

作者：肖超跃陈娟娟侯金花龙琦深圳市第二人民医院儿科 518035

目的研究儿童哮喘严重度与体质指数的相关性。方法两组122例儿童,其中哮喘患儿62例,对照组60例,计算体质指数(BMI)值,BMI=体重(kg)/身高(m2)。BMI≥同年龄、同性别的95百分位数或BMI>30者诊断为肥胖。结果 25.8%哮喘组患儿肥胖,而对照组... 详细信息

目的研究儿童哮喘严重度与体质指数的相关性。方法两组122例儿童,其中哮喘患儿62例,对照组60例,计算体质指数(BMI)值,BMI=体重(kg)/身高(m2)。BMI≥同年龄、同性别的95百分位数或BMI>30者诊断为肥胖。结果 25.8%哮喘组患儿肥胖,而对照组5%,两组比较,差别有显著性。哮喘严重度与体质指数相关性比较,轻度哮喘肥胖儿为25%,中度哮喘肥胖儿37.5%,重度哮喘肥胖儿50%,组间比较差别有显著性。结论儿童肥胖是哮喘发病的因素。哮喘的严重度与体质指数呈正相关性。

关键词：哮喘肥胖体质指数

基于GPSSA算法的复杂地形多无人机航迹规划

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北京航空航天大学学报 2025年第1期51卷 303-313页

作者：闫少强杨萍刘卫东李新其雷剑赵超跃火箭军工程大学基础部西安710025

针对多无人机协同航迹规划求解时间要求高、收敛难等问题,提出了一种基于博弈夺食机制和自毁机制的改进麻雀搜索算法(GPSSA)的多无人机协同航迹规划方法。利用分层规划思想分别建立单无人机航迹规划模型和多无人机协同航迹规划模型,将... 详细信息

针对多无人机协同航迹规划求解时间要求高、收敛难等问题,提出了一种基于博弈夺食机制和自毁机制的改进麻雀搜索算法(GPSSA)的多无人机协同航迹规划方法。利用分层规划思想分别建立单无人机航迹规划模型和多无人机协同航迹规划模型,将其转化为优化问题。提出博弈夺食机制和自毁机制用以改进麻雀算法,防止其快速丢失种群多样性,增强原算法逃脱局部极值吸引的能力,使得算法搜索方式更加灵活。利用改进麻雀算法对模型进行求解,仿真结果表明,GPSSA算法能够快速完成满足约束的航迹规划,且具有更好的收敛速度、寻优精度和算法鲁棒性。

关键词：多无人机协同航迹规划麻雀搜索算法博弈夺食机制自毁机制

A general alternate loading technique and its applications in the inverse designs of centrifugal and mixed-flow pump impellers

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Science China(Technological Sciences) 2021年第4期64卷 898-918页

作者： WANG chaoyue WANG FuJun AN DongSen YAO ZhiFeng xiao RuoFu LU Li HE ChengLian ZOU ZhiChao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing 100083China China Institute of Water Resources and Hydropower Research Beijing 100038China China Water Resources Beifang Investigation Design and Research Co.Ltd.Tianjin 300222China

For the inverse designs of centrifugal and mixed-flow pump impellers,clarifying the generation process of secondary flows and putting forward corresponding suppression measures is an important approach to improve the impeller *** this paper,to provide a better qualitative insight into the generation mechanism of secondary flows in the impeller,a simple kinematic equation is derived based on the ideal assumptions,which indicates that the potential rothalpy gradient(PRG)is the most important dynamic source that actively induces secondary vortical *** by the natural adverse PRG on the S1 and S2 stream surfaces,two typical secondary flows,H-S and P-S secondary flows,are clearly *** specially suppress these typical secondary flows,a general alternate loading technique(GALT)is proposed,aiming to adjust the real blade loadingδp to control the PRG *** the blade fore part,theδp on the hub streamline should be slowly increased to avoid breakneck growth of the potential rothalpy to reduce adverse streamwise PRG on the S2 *** the blade middle part,theδp should be moderately decreased to reduce adverse streamwise PRG on the S1 *** the blade aft part,the difference in theδp between the shroud and hub streamlines should be decreased faster to control the exit *** applying the GALT to the impeller designs of three typical pump types in hydraulic engineering,the organizational effect of the PRG on fundamental flow structures is *** GALT can effectively control the PRG distributions and suppress the secondary flows,thereby widening the pump’s high-efficiency zone,improving flow uniformity and suppressing pressure *** with the current Z-G method and the ALT,the GALT can meet the requirements of"de-experience"better,thereby enabling the designers to obtain good products explicitly and quickly.

关键词： alternate loading technique inverse design centrifugal pump mixed-flow pump impeller potential rothalpy gradient

基于无应力状态法的运营期混凝土斜拉桥调索关键技术研究

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公路交通技术 2025年第1期41卷 84-90+98页

作者：陈浩蒋超越招商局重庆交通科研设计院有限公司

由于早期斜拉桥设计理论不完善，施工控制水平较低，较多运营期斜拉桥现有结构状态与原设计状态存在差异，为解决运营期斜拉桥索力异常、内力状态不佳的问题，采用基于无应力状态法的调索方法，先通过各种实测方法及索力精确识别方法对... 详细信息

由于早期斜拉桥设计理论不完善，施工控制水平较低，较多运营期斜拉桥现有结构状态与原设计状态存在差异，为解决运营期斜拉桥索力异常、内力状态不佳的问题，采用基于无应力状态法的调索方法，先通过各种实测方法及索力精确识别方法对桥梁结构现状进行精确识别，再基于原设计成桥目标状态求得索力调整目标状态，最后采用无应力状态法对斜拉桥调索过程控制。结果表明：采用无应力状态法进行斜拉桥索力调整，能精确控制调索后的斜拉索索力，以达到主梁内力状态的优化目标，保障桥梁结构安全，可供运营期斜拉桥索力调整参考。

关键词：无应力状态法运营期斜拉桥索力调整

Assessment and Application of Beach Quality Based on Analytic Hierarchy Process in Yangkou Beach, Qingdao

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Journal of Ocean University of China 2023年第1期22卷 151-160页

作者： LI Haimeng WANG Jingyi ZHU chaoyue International School Beijing University of Posts and TelecommunicationsBeijing 100876China College of Marine Geoscience Ocean University of ChinaQingdao 266100China

The whole-beach quality assessment is the basis of building and preserving beautiful *** beach quality assessment index system and assessment standard have been established based on the attributes of beaches(including the width,slope,landform,and types),sorting coefficient,and softness degree of surface *** assessment weight of each index for quality evaluation was analyzed using the analytic hierarchy process,and comprehensive scores of selected beach profiles were calculated in accordance with the light assessment standard.A beach quality evaluation model based on index weight and scores was established in this *** factors of 12 profiles of Yangkou Beach in Qingdao City were surveyed to carry out a quality assessment,and the comprehensive scores of each profile were calculated in accordance with the evaluation *** results showed that the quality of Yangkou Beach can be divided into four ratings:excellent,good,medium,and *** excellent-quality area includes a wide and flat dry beach zone and soft,flat,and clean intertidal and subtidal zones covered with well-sorted fine sand,and leisure sports,such as volleyball,running,and swimming,are suitable for *** good-quality area features a slightly narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered with fine sand and a small tidal gully,and a small amount of foreign matter;leisure sports,such as walking and running,are suitable for *** study recommends the building of fixed drainage ditches or underground culverts to reduce the tidal *** medium-quality area consisted of a narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered by poorly sorted medium sand,a tide ditch,and a small amount of foreign *** this area,walking is suitable for *** should be supplemented in the intertidal *** poor-quality area contained a very narrow and dry beach zone covered with poor-sorted grav

关键词： Yangkou Beach assessment index analytic hierarchy process weight quality zoning

Coburn Type Operators and Compact Perturbations

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Chinese Annals of Mathematics,Series B 2021年第5期42卷 677-692页

作者： Tingting ZHOU Bin LIANG chaoyue WANG Department of Mathematics Jilin UniversityChangchun 130012China College of Science Beijing Forestry UniversityBeijing 100083China School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024China

A bounded linear operator T acting on a Hilbert space is called Coburn operator if ker(T-λ) = {0} or ker(T-λ)*= {0} for each λ∈ C. In this paper, the authors define other Coburn type properties for Hilbert space operators and investigate the compact perturbations of operators with Coburn type properties. They characterize those operators for which has arbitrarily small compact perturbation to have some fixed Coburn ***, they study the stability of these properties under small compact perturbations.

关键词： Coburn type properties Compact perturbations

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全自动碘分析仪测定水碘与尿碘的试验研究

济南大学学报(自然科学版) 2025年第1期39卷 112-116页

作者：樊晓翠段朝悦王丹宇满曼于海容崔震尹硝山东省计量科学研究院山东济南250014 济南大学生物科学与技术学院山东济南250022 北京宝德仪器有限公司北京102206

为了建立测定水碘和尿碘的全自动碘分析仪的仪器检测方法,并验证该方法可替代手工法进行水碘和尿碘的检测,采用砷铈催化分光光度法(简称手工法)和全自动碘分析仪测定法(简称仪器法)测定水碘和尿碘的标准液梯度曲线、冻干人尿中碘成分分... 详细信息

为了建立测定水碘和尿碘的全自动碘分析仪的仪器检测方法,并验证该方法可替代手工法进行水碘和尿碘的检测,采用砷铈催化分光光度法(简称手工法)和全自动碘分析仪测定法(简称仪器法)测定水碘和尿碘的标准液梯度曲线、冻干人尿中碘成分分析标准物质以及实际样品的碘含量,从标准曲线线性相关系数r、冻干人尿中碘成分分析标准物质、实际样品检测结果,实验条件等多个方面进行比对分析。结果表明:手工法和仪器法所测水碘和尿碘的线性相关系数r均大于0.9990,所测冻干人尿中碘成分分析标准物质中碘离子的质量浓度与标准值一致,所测实际样品中碘的质量浓度结果经过t检验,p值大于0.05,不存在显著性差异,全自动碘分析仪所测数据更准确可靠。

关键词：水碘尿碘分光光度法全自动碘分析仪

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