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Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island,Shanghai

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Infectious Diseases of Poverty 2022年第5期11卷 50-62页

作者： Chao Lv Jun Shang Wengang Zhang Bingqing Sun Min Li chaoyi guo Nan Zhou Xiaokui guo Shixin Huang Yongzhang Zhu Department of Animal Health and Food Safety School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghai 200025China Shanghai Center for Animal Disease Prevention and Control Shanghai Institute for Veterinary Drugs and Feeds ControlShanghai 201103China

Background:Antimicrobial resistance(AMR)is one of the greatest threats to animal and public health.Here,we conducted a dynamic surveillance of Escherichia coli on Chongming Island in Shanghai during 2009-2021 to identify the characteristics and trends of Chongming’s AMR pandemic.Methods:Rectal(cloaca)swabs from four poultry and nine swine farms(Chongming Island,2009-2021)were collected for E.coli strains acquisition.The micro-broth dilution method was used to test antimicrobial susceptibility of E.coli isolates against 10 antimicrobial classes including 15 antimicrobials.Utilizing generalized linear mixed models(GLMMs)and co-occurrence analyses,we further explored the multiple-drug-resistance(MDR)combinations and dynamic patterns of E.coli over 10 years in two food animals.Results:Total of 863 MDR isolates were found among 945 collected E.coli isolates,337 from poultry and 608 from swine.Both isolates exhibited high resistant rates(>70%)to tetracyclines,phenicols,sulfonamides,penicillins,and aminoglycosides(only in swine).The resistant rates of swine isolates to penicillins,aminoglycosides,tetracyclines,phenicols,and polymyxins were significantly higher than those of poultry isolates,whereas resistance to fluoroquinolones was reversed.Resistance to polymyxins decreased similarly in swine(42.4%in 2009 to 0.0%in 2021)and poultry isolates(from 16.5%to 0.0%).However,resistance to other seven antimicrobial classes(excluding carbapenems and penicillins)declined dramatically in swine isolates,particularly fluoroquinolones(from 80.5%to 14.4%),and tendencies of resistance to the seven classes showed markedly divergent patterns in poultry isolates.Using Poisson GLMMs,the AMR carriage since 2016 was significantly lower than that of 2009(odds ratio<1),indicating a decline in the risk of MDR emergence.Furthermore,despite the highly diverse MDR profiles,co-occurrence analysis identified two prominent MDR clusters of penicillins-phenicols-fluoroquinolones in poultry and aminoglycosides-tetracyclines-sulfonamides-phenicols in sw

关键词： Antimicrobial resistance Escherichia coli Food animal Longitudinal trend analysis Chongming Island Shanghai

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Evaluating cost and benefit of air pollution control policies in China:A systematic review

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Journal of Environmental Sciences 2023年第1期123卷 140-155页

作者： Xinyuan Liu chaoyi guo Yazhen Wu Chen Huang Keding Lu Yuanhang Zhang Lei Duan Miaomiao Cheng Fahe Chai Fengqiao Mei Hancheng Dai Laboratory of Energy&Environmental Economics and Policy College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China School of Environment Tsinghua UniversityBeijing 100084China Chinese Research Academy of Environmental Sciences Beijing 100012China

China has put great efforts into air pollution control over the past years and recently committed to its most ambitious climate target.Cost and benefit analysis has been widely used to evaluate the control policies in terms of past performance,future reduction potential,and direct and indirect impacts.To understand the cost and benefit analysis for air pollution control in China,we conducted a bibliometric review of more than 100 studies published over the past two decades,including the current research progress,most commonly adopted methods,and core findings.The control target in cost and benefit analysis has shifted in three stages,from individual and primary pollution control,moving to joint prevention of multiple and secondary pollutants,and then towards synergistic control of air pollution and carbon.With the expansion of the research scope,the integrated assessment model has gradually demonstrated the necessity for long-term ex-anti policy simulation,especially for dealing with complex factors.To ensure long-term air quality,climate,public health,and sustainable economic development,substantial evidence from published studies has suggested that China needs to continue its efforts in the upstream adjustment of the energy system and industrial structure with multi-regional and-sector collaboration.This cost and benefit review paper provides decision-makers with the fundamental information and knowledge gaps in air pollution control strategies in China,and direction for facing future challenges.

关键词： Air pollution control policy Cost and benefit analysis Climate policy Health co-benefit Economic impact

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Global antimicrobial resistance:a system-wide comprehensive investigation using the Global One Health Index

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Infectious Diseases of Poverty 2022年第4期11卷 94-95页

作者： Nan Zhou Zile Cheng Xiaoxi Zhang Chao Lv chaoyi guo Haodong Liu Ke Dong Yan Zhang Chang Liu Yunfu Chang Sheng Chen Xiaokui guo Xiao-Nong Zhou Min Li Yongzhang Zhu Department of Animal Health and Food Safety School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China 不详

Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of"ESKAPE pathogens"in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparities

关键词： Global antimicrobial resistance Global One Health Index Antimicrobial resistance surveillance networks

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ESKAPE耐药菌文献计量分析

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上海预防医学 2024年第2期36卷 207-215页

作者：郭超一李敏朱泳璋郭晓奎上海交通大学医学院国家热带病研究中心全球健康学院上海200025 上海交通大学-爱丁堡大学全健康研究中心上海200025

【目的】基于全健康理念对近10年国内外屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属(ESKAPE)6类多重耐药菌相关研究进行文献计量可视化分析,了解该领域的研究现状及未来可能的研究方向。【方法】在... 详细信息

【目的】基于全健康理念对近10年国内外屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属(ESKAPE)6类多重耐药菌相关研究进行文献计量可视化分析,了解该领域的研究现状及未来可能的研究方向。【方法】在中国知网数据库(CNKI)和Web of Science(WoS)上分别检索ESKAPE耐药菌研究相关文献,检索时间范围为2013年1月1日—2022年12月31日,通过CiteSpace 6.1.R6软件对所获得文献的作者、来源机构、国家、关键词等进行计量可视化分析。【结果】研究共纳入中文文献2991篇,英文文献24497篇。虽然英文文献发文量及增速均高于中文文献,但中国学者的英文文献发文量呈显著上升趋势。中文文献的作者和机构之间合作程度弱于英文文献的作者和机构之间合作程度。总体上发文量最多的国家是美国(6623篇),其次为中国(3776篇),但2022年年发文量中国(851篇)超越美国(600篇);全球国际合作关系良好,虽然中国已同全球25个国家存在合作关系,但国际合作程度仍稍弱于美国。中文文献高频关键词主要是耐药性、医院感染和抗菌药物等,英文文献高频关键词是金黄色葡萄球菌、肺炎克雷伯菌和耐甲氧西林等。【结论】耐碳青霉烯肺炎克雷伯菌、耐碳青霉烯肠杆菌科和全健康等是研究热点,未来应深化跨部门、多地域协作,加强重要耐药菌感染控制,优化感染治疗策略。

关键词： ESKAPE 全健康文献计量学 CiteSpace 可视化分析

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Impacts of climate change mitigation on agriculture water use:A provincial analysis in China

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Geography and Sustainability 2020年第3期1卷 189-199页

作者： chaoyi guo Hancheng Dai Xiaorui Liu Yazhen Wu Xiaoyu Liu Yong Liu College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China State Environmental Protection Key Laboratory of All Materials Flux in Rivers Beijing 100871China

Agriculture consumes huge amounts of water in China and is profoundly affected by climate change.This study projects the agricultural water use towards 2030 under the climate change mitigation target at the provincial level in China by linking a computable general equilibrium(CGE)model and a regression model.By solving the endogeneities amongst agricultural water use,output and climate factors,we explore how these variables affect water use and further predict future trends through soft-link with the IMED|CGE model.It is found that sunshine duration has a slightly positive impact on water use.Furthermore,agricultural output will significantly drive agricultural water use based on historical data of the past 16 years.Results also show that carbon reduction would have a trade-offor co-benefit effect on water use due to regional disparity.Provinces with increasing agricultural exports,such as Xinjiang and Ningxia,would anticipate considerable growth in agricultural water use induced by carbon reduction.The soft-link method proposed by this study could be applied for future studies that aim to incorporate natural and geographical factors into human activities,and vice versa,for assessing sustainable development policies in an integrated way.

关键词： Climate change Agricultural water use Soft link IMED|CGE Regression model Co-benefit Trade-off

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森林火灾与中压配电线路故障的发生时序研究

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重庆理工大学学报（自然科学） 2024年第4期38卷 237-242页

作者：李天友郭伯森黄超艺苏俊王连辉陈石川厦门理工学院电气工程与自动化学院福建厦门361024 厦门市高端电力装备及智能控制重点实验室福建厦门361024 国网福建省电力有限公司福州350003

电力线路穿过林区,线路故障的电火花可能引发森林火灾,同时森林火灾也有可能造成穿过林区的电力线路故障,两者的发生顺序(即发生时序)对火灾事故责任划分有着重要意义,但在工程实践中判断发生时序十分困难。为此,选择中压配电线路作为... 详细信息

电力线路穿过林区,线路故障的电火花可能引发森林火灾,同时森林火灾也有可能造成穿过林区的电力线路故障,两者的发生顺序(即发生时序)对火灾事故责任划分有着重要意义,但在工程实践中判断发生时序十分困难。为此,选择中压配电线路作为研究对象,建立树线故障模拟实验平台,研究线路触树发生单相接地故障和火灾下诱使线路发生故障这2种情况下的零序电压变化情况,并通过对零序电压进行Hilbert变换绘制包络线进行故障场景的初步筛分;再通过THD、近似熵、相关系数对波形进行相似度判断,将3种相似度特征量使用模糊C聚类进行分析,总结提出森林火灾与中压配电线路故障发生时序的判别方法。研究结果显示:该研究能够为森林火灾与电力线路故障的发生时序判别提供技术方法,具有相应的工程应用价值,对事故责任划分提供技术参考。

关键词：配电线路模拟实验平台导线痕迹森林火灾发生时序判别

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安宁疗护患者远程居家照护方案的构建及初步应用

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中华护理杂志 2024年第5期59卷 517-525页

作者：郭俊晨许湘华刘超毅王英刘君清照谌永毅朱丽辉肖亚洲刘阳湖南省肿瘤医院肿瘤护理教研室长沙市410013 湖南省肿瘤医院护理部长沙市410013 湖南省肿瘤医院信息科长沙市410013 湖南省肿瘤医院安宁疗护病房长沙市410013 湖南省肿瘤医院办公室长沙市410013 南华大学护理学院

目的构建安宁疗护患者远程居家照护方案并进行初步应用,为开展安宁疗护远程居家照护实践提供参考。方法以支持性照护模型为理论指导,在文献研究的基础上结合质性访谈初步拟订安宁疗护患者远程居家照护方案。2023年3月进行2轮函询,征询... 详细信息

目的构建安宁疗护患者远程居家照护方案并进行初步应用,为开展安宁疗护远程居家照护实践提供参考。方法以支持性照护模型为理论指导,在文献研究的基础上结合质性访谈初步拟订安宁疗护患者远程居家照护方案。2023年3月进行2轮函询,征询专家意见并修订方案,形成终稿。2023年4月,采用便利抽样法选取湖南省长沙市某三级甲等肿瘤专科医院安宁疗护病房即将出院的10例患者初步应用该方案,采用不良事件发生例数、远程照护满意度评价方案应用效果。结果共16名专家完成2轮函询,其权威系数为0.928。2轮函询的有效问卷回收率分别为94.12%、100%,专家意见提出率分别为100%、25.00%,条目评分的变异系数分别为0.05~0.18、0~0.16,肯德尔和谐系数分别为0.093、0.210(P<0.001)。最终构建的方案包括症状管理、生活照护、心理及精神照护、社会信息支持4个维度,疼痛管理、呼吸困难管理、胃肠道症状管理、咳嗽/咳痰管理等17个模块,涵盖37项具体实施内容。方案应用期间脱落1例患者,最终纳入9例。患者均未发生不良事件,其远程照护满意度问卷得分为(60.22±7.41)分,处于高满意度水平。结论该研究构建的方案具有较强的科学性、针对性及可行性,可为医护人员开展安宁疗护远程居家照护实践提供指导。

关键词：安宁疗护远程护理家庭护理德尔菲技术

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Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3849-3861页

作者： Li He Ruiqi Liu Honghua Yue Xiaoxin Zhang Xiaohui Pan Yutao Sun Jun Shi guonian Zhu chaoyi Qin Yingqiang guo Department of Cardiovascular Surgery and Cardiovascular Surgery Research Laboratory West China HospitalSichuan UniversityChengdu 610041 SichuanChina Department of Plastic and Burn Surgery West China HospitalSichuan UniversityChengduChina West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest China HospitalSichuan UniversityChengduChina Department of Endocrinology&Metabolism West China HospitalSichuan UniversityChengduChina Department of Pulmonary and Critical Care Medicine and Institute of Respiratory Health West China HospitalSichuan UniversityChengduChina

Atrial fibrillation(AF)is a frequent arrhythmia associated with cardiovascular morbidity and mortality.Neutrophil extracellular traps(NETs)are DNA fragments with cytoplasm proteins released from neutrophils,which are involved in various cardiovascular diseases.To elucidate the role of NETs in AF,we investigated the effect of NETs on AF progression and the secretion of NETs in AF.Results showed that:NETs induced the autophagic apoptosis of cardiomyocytes,and NETs also led to mitochondrial injury by promoting mitochondrial depolarization and ROS production.Ongoing tachy-pacing led to the structural loss of cardiomyocytes and provided potent stimuli to induce NETs secretion from neutrophils.In the meanwhile,increased Ang II in AF facilitated NETs formation through the upregulation of AKT phosphorylation,while it could not directly initiate NETosis as the autophagy was not induced.In vivo,DNase I was administrated to abrogate NETs formation,and AF-related fibrosis was ameliorated as expected.Correspondingly,the duration of the induced AF was reduced.Our study addresses the formation mechanism of NETs in AF and demonstrates the lethal effects of NETs on cardiomyocytes through the induction of mitochondrial injury and autophagic cell death,which comprehensively describes the positive feedback comprised of NETs and stimuli secreted by cardiomyocytes that sustains the progression of AF and AF related fibrosis.

关键词： cardiomyocytes fibrillation cardiovascular

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Effects of Three Nitrification Inhibitors on the Nitrogen Conversion in Purple Soil and Its Effect on the Nitrogen Uptake of Citrus Seedlings

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Agricultural Sciences 2018年第6期9卷 655-669页

作者： Wenli Li Zhenzhen Zhang Danping Li chaoyi guo Yujiang Li Min Yang Xiaojun Shi Yueqiang Zhang College of Resources and Environment Southwest University Chongqing China Academy of Agricultural Sciences Southwest University Chongqing China National Monitoring Station of Soil Fertility and Fertilizer Efficiency on Purple Soils Chongqing China

Experiments were carried out to study the effects of nitrification inhibitors (NI) on the transformation of soil nitrogen (N) in purple soil and the effects on the N accumulation in different organs of citrus seedlings. In incubation and pot experiments, the rate of nitrification inhibitors 2-chloro-6-trichloro-methyl pyridine (Nitrapyrin), 3,4-dimethylpyrazole phosphate (DMPP) and dicyandiamide (DCD) was 2.4%, 1.0% and 5.0% of N rate, respectively. The trend of different nitrification inhibitors on ammonium nitrogen ( NH+4-N ), nitrate nitrogen ( NO-3-N ) content and pH was compared in incubation experiment;and the effect of different NI on the dry matter quality, N uptake of citrus seedling was studied in pot experiment. The results showed that NI could significantly inhibit soil nitrification in the early culture period (p DMPP > En (calculated as nitrogen application rate). Application of NI increased the height and dry matter accumulation, N accumulation of citrus seedling grown in pot experiment. Thus, application of NI would be helpful for improving N use efficiency in purple soil which is one of major soil types for citrus production in China.

关键词： Citrus Nitrification Inhibitors Soil Nitrogen

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骨碎补总黄酮调控H型血管影响大鼠股骨Masquelet诱导膜模型的骨重建

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中国组织工程研究 2024年第32期28卷 5130-5135页

作者：曾志奎熊伟梁卫东钱国文梁超轶潘斌郭灵魏文强邱勋祥邓文芳袁灵梅江西中医药大学附属医院江西省南昌市330006 江西中医药大学中药固体制剂制造技术国家工程研究中心江西省南昌市330004 江西中医药大学江西省南昌市330004 江西理工大学江西省南昌市330013

背景:多项研究发现,骨碎补总黄酮可促进诱导膜中血管新生、改善诱导膜生物性能、加速诱导膜技术骨重建,但相关分子机制仍需进一步探究。目的:观察骨碎补总黄酮通过调控H型血管对大鼠股骨Masquelet诱导膜模型骨重建的影响。方法:将36只雄... 详细信息

背景:多项研究发现,骨碎补总黄酮可促进诱导膜中血管新生、改善诱导膜生物性能、加速诱导膜技术骨重建,但相关分子机制仍需进一步探究。目的:观察骨碎补总黄酮通过调控H型血管对大鼠股骨Masquelet诱导膜模型骨重建的影响。方法:将36只雄性SD大鼠按体质量分层后随机分为空白组、模型组、中药组,每组12只,3组均建立4 mm右后肢股骨骨缺损模型,模型组与中药组骨缺损处充填聚甲基丙烯酸甲酯骨水泥;造模后6周,空白组骨缺损处填充大鼠自体尾骨,模型组与中药组取出诱导膜内的骨水泥后植入大鼠自体尾骨。植骨第3天开始,中药组灌胃给予骨碎补总黄酮157.5 mg/(kg·d),其余两组灌胃给予生理盐水,连续给药至植骨后8周。植骨后8周取材进行相关检测。结果与结论:①X射线片显示,空白组缺损区骨折线清晰,仅有少量骨痂形成;模型组缺损区可见不连续皮质骨,骨缺损区仍存在;中药组缺损区充满新生骨组织,骨髓腔与部分皮质骨形成,骨折线消失。②Micro-CT扫描显示,空白组缺损区新生骨量较少,模型组缺损区骨小梁数量明显增多,中药组大量新生骨组织填充于骨缺损区。③苏木精-伊红染色显示,空白组缺损区仅见少量新骨形成,成骨质量较差;模型组缺损区有较多的新骨形成,但骨组织内夹杂有部分纤维结缔组织;中药组缺损区可见大量新骨形成,成骨质量最佳。④CD31/Emcn免疫荧光双标染色显示,空白组骨缺损区新生骨组织内H型血管数量稀少、分布稀疏;相比空白组,模型组骨缺损区骨组织内含更多H型血管,血管呈相对规则的条状分布;中药组骨缺损区H型血管数量最多,并且血管分布密集。⑤结果表明,骨碎补总黄酮可通过上调H型血管表达增强成血管-成骨作用,提高大鼠股骨Masquelet诱导膜模型成骨效能、促进骨重建。

关键词： Masquelet技术骨碎补总黄酮 H型血管诱导膜骨缺损骨重建

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