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Large Waterway-crossing Immersed Tunnel for Highway and Railway Transportation ： Dongping Tunnel in Foshan, China

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隧道建设（中英文） 2018年第2期38卷 329-336页

作者： HE Weiguo LYU Yang SONG chaoye China Railway Tunnel Surveyand Design Institute Co. Ltd.Tianjin 300133China

1 Significance of Dongping TunnelDongping Tunnel is an important passage in the Pearl River Delta Region. It not only enables fast collection and distribution of passenger flow and material flow,but also drives development of the central cities in the whole Pearl River Delta Economic Zone and enhances the region′s ability for economic agglomeration. Thus, it allows the strategic southward expansion of Guangzhou City.

关键词：隧道建设中国水道

Closely packed Si@C and Sn@C nano-particles anchored by reduced graphene oxide sheet boosting anode performance of lithium ion batteries

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Journal of Materials Science & Technology 2021年第28期87卷 18-28页

作者： chaoye Zhu Yao Zhang Ziqiang Wu Zhihong Ma Xinli Guo Fuyi Guo Jiakun Zhang Yushu Li School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing211189China School of Materials Science and Engineering Baise UniversityBaise533000China

Both silicon and tin are promising anodes for new generation lithium ion batteries due to high lithium storage capacities(theoretically 4200 mA h g^(-1) and 992 mA h g^(-1),respectively).However,their large volumetric expansions(both are above 300%)usually lead to poor cycling *** this case,we synthesized closely packed Si@C and Sn@C nano-particles anchored by reduced graphene oxide(denoted as Si@C/Sn@C/rGO)by the way of solution impregnation and subsequent hydrogenation *** particles with a diameter of 100 nm are coated by carbon and surrounded by Si@C particles around 40 nm in average diameter through the high-resolution transmission electron *** of Si and Sn are alleviated by carbon shells,and reduced graphene oxide sheets accommodate their volume *** prepared Si@C/Sn@C/rGO electrode delivers an enhanced initial coulombic efficiency(78%),rate capability and greatly improved cycle stability(a high reversible capacity of nearly 1000 mA h g^(-1) is achieved after 300 cycles at a current density of 1000 mA g^(-1)).It can be believed that packing Sn@C nano-particles with Si@C relieves the volume expansion of both and releases the expansion ***@C particles enhance anode process kinetics by reducing charge transfer resistance and increasing lithium ion diffusion *** present work provides a viable strategy for facilely synthesizing silicon-tin-carbon composite anode with long life.

关键词： Sn-Si-C nano-composites Anode Lithium ion batteries

VSOLassoBag:a variable-selection oriented LASSO bagging algorithm for biomarker discovery in omic-based translational research

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Journal of Genetics and Genomics 2023年第3期50卷 151-162页

作者： Jiaqi Liang chaoye Wang Di Zhang Yubin Xie Yanru Zeng Tianqin Li Zhixiang Zuo Jian Ren Qi Zhao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Coloproctology Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangdong Institute of GastroenterologyThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510060China Computer Science Department School of Computer ScienceCarnegie Mellon UniversityPittsburghPA 15213United States

Screening biomolecular markers from high-dimensional biological data is one of the long-standing tasks for biomedical translational *** its advantages in both feature shrinkage and biological interpretability,Least Absolute Shrinkage and Selection Operator(LASSO)algorithm is one of the most popular methods for the scenarios of clinical biomarker ***,in practice,applying LASSO on omics-based data with high dimensions and low-sample size may usually result in an excess number of predictive variables,leading to the overfitting of the ***,we present VSOLassoBag,a wrapped LASSO approach by integrating an ensemble learning strategy to help select efficient and stable variables with high confidence from omics-based *** a bagging strategy in combination with a parametric method or inflection point search method,VSOLassoBag can integrate and vote variables generated from multiple LASSO models to determine the optimal *** application of VSOLassoBag on both simulation datasets and real-world datasets shows that the algorithm can effectively identify markers for either case-control binary classification or prognosis *** addition,by comparing with multiple existing algorithms,VSOLassoBag shows a comparable performance under different scenarios while resulting in fewer features than *** summary,VSOLassoBag,which is available at https://***/VSOLassoBag/under the GPL v3 license,provides an alternative strategy for selecting reliable biomarkers from high-dimensional omics *** user’s convenience,we implement VSOLassoBag as an R package that provides multithreading computing configurations.

关键词： Feature selection LASSO bagging algorithm Biomarker discovery Omics data

Chinese Longest Sea-crossing Metro Tunnel:Wuyuan Bay Station-Liuwudian Station Section of Xiamen Metro Line#3

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隧道建设（中英文） 2018年第3期38卷 501-505页

作者： HE Weiguo SONG chaoye DU Baoyi China Railway Tunnel Survey and Design Institute Co. Ltd.Tianjin 300133China

Project significance Xiamen metro Line#3 runs from Xiamen Railway Station to Xiangran *** is the southwest-northeast trunk line that connects the main island and the subcentre in the eastern regions(Xiangran District).The Wuliu Section(the sea-crossing section from Wuyuan Bay Station to Liuwudian Station)is the main engineering feat of the metro line due to its high construction difficulty and tight *** one of the earliest sea-crossing metro tunnels constructed in China,this project represents significant engineering achievements and *** plane view of Wuliu Section is shown in Fig.1.2 Brief introduction of the project 2.1 Design overview The Wuliu Section of Xiamen Metro Line#3 crosses the Xiamen east sea area and connects the main island with Xiangran Dis *** is to the northwest of the Xiangran subsea *** total length the section is 4.95 km,including about 3.6 km of sea-crossing *** maximum water depth is 25 m and the maximum buried depth of the tunnel is 69 *** adopts a single-line,dual-bore section and uses the combined M mining method-shield method"construction *** are one inclined construction shaft,one air shaft,ten service channels,three wastewater pump houses and one power *** plane view of the tunnel is shown in Fig.2.

关键词： Wuyuan Bay Station Xiangran Airport

BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong Bao Lin Tang chaoye Wang Chunlei Liu Yukai Wang Yuyan Teng Mohan Zheng Weiping Mu Zhixiang Zuo Yubin Xie Xiaotong Luo Jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

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Protein & Cell 2024年第8期15卷 594-611页

作者： Jian Wu chaoye Wang Shuhui Sun Tianmin Ren Lijie Pan hongyi Liu Simeng Hou Shen Wu Xuejing Yan Jingxue Zhang Xiaofang Zhao Weihai Liu Sirui Zhu Shuwen Wei Chi Zhang Xu Jia Qi Zhang Ziyu Yu Yehong Zhuo Qi Zhao Chenlong Yang Ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer Center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12 cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

氯化物环境暗挖海底隧道支护结构的耐久性设计

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现代隧道技术 2016年第2期53卷 165-172页

作者：宋超业贺维国中铁隧道勘测设计院有限公司天津300133

海底隧道长期受海水氯化物环境的影响,而隧道的设计使用年限为100年甚至更长,这就要求设计中对于其耐久性要比常规隧道做出更多的研究。目前海底隧道耐久性研究主要集中在钢筋混凝土结构的材料选择和配合比设计。文章针对氯化物环境下... 详细信息

海底隧道长期受海水氯化物环境的影响,而隧道的设计使用年限为100年甚至更长,这就要求设计中对于其耐久性要比常规隧道做出更多的研究。目前海底隧道耐久性研究主要集中在钢筋混凝土结构的材料选择和配合比设计。文章针对氯化物环境下的矿山法海底隧道,对其环境条件、规范要求和耐久性设计原则等进行了详细分析,提出了耐久性设计应与结构承载力设计并重、预留空间满足后期可修复要求的理念。隧道衬砌结构应采用高强高性能混凝土,提高其密实性抵抗海水侵蚀;矿山法隧道采用限量排放地下水处理,保证排水系统通畅可靠。

关键词：海底隧道氯化物耐久性衬砌结构

上软下硬岩质地层大跨隧道叠合承载拱结构设计分析

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现代隧道技术 2018年第1期55卷 17-26页

作者：宋超业贺维国中铁隧道勘测设计院有限公司、天津市隧道设计及安全评估企业重点实验室天津300133

在上软下硬岩质地层中修建浅埋暗挖大跨地铁车站隧道的工程实例较少,选择合理的车站结构型式和施工方法所参照的经验也十分有限。文章以大连地铁兴工街站为背景,通过对上软下硬岩质地层大跨隧道围岩松动特性进行分析和类似工程介绍,提... 详细信息

在上软下硬岩质地层中修建浅埋暗挖大跨地铁车站隧道的工程实例较少,选择合理的车站结构型式和施工方法所参照的经验也十分有限。文章以大连地铁兴工街站为背景,通过对上软下硬岩质地层大跨隧道围岩松动特性进行分析和类似工程介绍,提出了一种叠合承载拱新型车站结构型式和相应施工方法,实现单拱大跨车站结构,其结构跨度可达20 m以上,并对该结构的初期支护和二次衬砌设计方法和受力特征进行了介绍。实际应用效果表明,叠合承载拱结构依靠拱部叠合初期支护拱结构承受施工期间全部荷载,在其保护下施工下部结构,可有效控制地层变形,同时适合岩质地层快速机械化施工。

关键词：岩质地层大跨隧道叠合承载拱上软下硬单拱车站

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浅析瓷砖整体隆起

陶瓷 2022年第4期 16-19页

作者：孙朝晔中国建筑第六工程局建设发展有限公司天津300300

在标准层装修施工中,地砖施工多为楼层整体施工,即单一楼层、单一施工队、同一批工人和同一批施工建材。在同一建筑、不同楼层、不同施工队伍、相同施工建材的前提下,对瓷砖整体隆起的产生原因和预防整治措施进行浅析。结合相关理论和... 详细信息

在标准层装修施工中,地砖施工多为楼层整体施工,即单一楼层、单一施工队、同一批工人和同一批施工建材。在同一建筑、不同楼层、不同施工队伍、相同施工建材的前提下,对瓷砖整体隆起的产生原因和预防整治措施进行浅析。结合相关理论和施工经验,从垫层含水率、建材线性膨胀系数、楼板不均匀沉降、房间应力扩散和预应力张拉回弹等多方面进行讨论,以加强细节把控和交底,减小不必要的返工,节省项目成本。

关键词：垫层含水率线性膨胀系数不均匀沉降应力扩散预应力张拉

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