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Food Science and Human Wellness 2024年第4期13卷 2068-2078页

作者： Hongxuan Li Shasha Cheng Yuhong Wang Yilin Sun Jiaxin Zhang Mingshuang Sun chaoxin man Yu Zhang Yujun Jiang Key Laboratory of Dairy Science Ministry of EducationCollege of Food Science and EngineeringNortheast Agricultural UniversityHarbin 150030China

Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem *** acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver *** plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic *** study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of *** J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating *** results showed that pre-intake of *** J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver *** addition,pre-intake *** J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.

关键词： Alcoholic liver disease Probiotics Nuclear factor E2-related factor 2(Nrf2) Oxidative stress Short-chain fatty acids

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Desiccation and osmotic resistance mechanism of Cronobacter spp. isolated from powdered infant formula

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Food Science and Human Wellness 2024年

作者： Shiqian Fu Danliangmin Song Xue Qin Lihan Wang Qianyu Zhao chaoxin man Xinyan Yang Yujun Jiang Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition College of Food and Pharmaceutical Sciences Ningbo University Key Laboratory of Dairy Science Ministry of Education Department of Food Science Northeast Agricultural University

Cronobacter spp. has strong resistance to desiccation and high permeability in Enterobacteriaceae， and powdered infant formula (PIF) is one of the main contamination routes. In recent years， the contamination of Cronobacter spp. in PIF incidents occur from time to time， causing infant serious diseases or death. In this investigation， matrix-assisted laser desorption/ionization time of flight mass spectrometry was used to identify the phenotypes of 35 Cronobacter strains isolated from PIF and its processing environment. Subsequently， the isolates were evaluated for drying and osmotic pressure tolerance. The results showed that the deactivation rate of the strains ranged from 9.01% to 77.57%， and the highest osmotic pressure condition the strains could tolerate was 6% NaCl. In addition， there was a positive correlation between biofilm formation ability and desiccation resistance. Combined with transcriptomics， Cronobacter spp. can activate biofilm synthesis， produce more trehalose， accumulate betaine and electrolytes to stabilize intracellular structure under the two treatment conditions. 31 and 43 genes were found related to desiccation and permeability resistance， respectively. And some genes (cysM， thuF， ycjO， et al) were found to be associated with two tolerances for the first time.

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Heat-killed Lactobacillus paracasei JY56 can relieve ovalbumin-induced food allergy via regulating immuno-inflammatory responses and gut microbiota

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Food Science and Human Wellness 2024年

作者： Miao Zheng Ming Ma Ruxue Fang Yilin Sun Xinyan Yang chaoxin man Qianyu Zhao Yujun Jiang Key Lab of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University

Food allergy (FA) is an aberrant immune response triggered by the ingestion of a food antigen. Ovalbumin (OVA)-sensitized and challenged BALB/c mice were orally administered heat-killed (HK)-L. paracasei JY56. In this work， HK-L. paracasei JY56 alleviated the FA-induced decrease in body weight and rectal temperature and reduced the allergy score. Serum analysis showed that HK-L. paracasei JY56 reduced the levels of specific antibodies (OVA-sIgE and OVA-sIgG) and allergic mediators (histamine and mast cell protease) in FA mice. In addition， HK-L. paracasei JY56 also could alleviate OVA-induced FA by suppressing Th2 and Th17-type immune responses， which was evidenced by the regulation of splenic lymphocyte subpopulations and associated cytokine secretion. Moreover， jejunal histological analysis and intestinal barrier function related gene expression measurement were performed to verify the intestinal barrier repair of HK-L. paracasei JY56. Meanwhile， the TLR4/NF-κB inflammatory pathway activation was inhibited by HK-L. paracasei JY56 at gene and protein levels. Finally， HK-L. paracasei JY56 was performed to modulate the gut microbiota structure and increase the levels of short-chain fatty acids. In conclusion， HK-L. paracasei JY56 could alleviate OVA-induced FA in multiple ways， and this study provides a theoretical basis for the application of inactivated probiotics in functional foods for FA.

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降尿酸乳酸菌菌株的筛选及其全基因组分析

中国食品学报 2024年第7期24卷 88-99页

作者：苗超张宇杨鑫焱姜毓君满朝新赵倩玉东北农业大学食品学院乳品科学教育部重点实验室哈尔滨150030

高尿酸血症是痛风发病的生化基础,严重威胁人体健康。通过测定35株乳酸菌对鸟苷和肌苷的降解能力,筛选出4株具有较高降解能力的乳酸菌,对这4株菌的菌悬液、细胞内容物及代谢物进行黄嘌呤氧化酶活性抑制试验,选取其中抑制能力最强的菌株... 详细信息

高尿酸血症是痛风发病的生化基础,严重威胁人体健康。通过测定35株乳酸菌对鸟苷和肌苷的降解能力,筛选出4株具有较高降解能力的乳酸菌,对这4株菌的菌悬液、细胞内容物及代谢物进行黄嘌呤氧化酶活性抑制试验,选取其中抑制能力最强的菌株进行全基因组测序和安全性验证。结果表明,鼠李糖乳酪杆菌JY027对鸟苷和肌苷的降解率分别达80.27%和87.33%,且该菌株的菌悬液、细胞内容物及代谢物对黄嘌呤氧化酶的抑制率分别为85.71%,78.34%,84.05%,说明其具有较强的降尿酸能力。此外,通过对鼠李糖乳酪杆菌JY027的全基因组编码基因的预测,发现该菌株具有次黄嘌呤磷酸核糖基转移酶、次黄嘌呤核苷酸脱氢酶等多个尿酸代谢相关基因。经过吲哚、溶血等试验验证了该菌株的安全性。本研究为鼠李糖乳酪杆菌JY027用于缓解高尿酸血症提供了理论基础。

关键词：乳酸菌高尿酸血症鼠李糖乳酪杆菌全基因组安全性

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复配菌株对发酵乳品质与功能特性的改善作用研究进展

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食品工业科技 2024年第11期45卷 372-380页

作者：王烨侯保朝洪维錬何剑李宝磊满朝新姜毓君张宇东北农业大学食品学院乳品科学教育部重点实验室黑龙江哈尔滨150030 国家乳业技术创新中心上海201111

发酵乳具有悠久的历史,是经乳酸菌发酵而成的,富含蛋白质、矿物质和维生素等多种营养成分。随着人们对生活品质追求的提高,发酵乳受到消费者越来越多的关注。目前市面上的发酵乳多数是以单菌株或传统乳酸菌(嗜热链球菌和保加利亚乳杆菌... 详细信息

发酵乳具有悠久的历史,是经乳酸菌发酵而成的,富含蛋白质、矿物质和维生素等多种营养成分。随着人们对生活品质追求的提高,发酵乳受到消费者越来越多的关注。目前市面上的发酵乳多数是以单菌株或传统乳酸菌(嗜热链球菌和保加利亚乳杆菌)作为发酵剂制备而成的,但是以此生产发酵乳会有发酵时间过长、口感略差和稳定性不佳等问题。近年来,复配菌株作为发酵乳的发酵剂成为发酵乳制备方向的研究热点,利用不同菌株间的互作协同作用,可以有效提高代谢产物的含量和丰富度,进而改善发酵乳的品质及功能特性,弥补传统发酵乳在产品形态以及感官体验等方面的不足。本文综述了复配菌株能够加快发酵乳pH下降速度,丰富产品感官以及改善其流变特性和持水能力,同时还可以增强发酵乳在降血脂、抗炎、抗氧化、抑菌等功能方面的能力。最后展望了发酵乳在未来可以进行创新的研究方向,为今后发酵乳的多元化、功能化、精准化生产提供指导。

关键词：菌株发酵乳理化特性功能特性

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植物乳植杆菌J26组合物对高脂饮食诱导肥胖小鼠的减肥作用研究

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中国乳品工业 2024年第3期52卷 5-13,64页

作者：郑亚平郝占西姜毓君满朝新张宇东北农业大学食品学院乳品科学教育部重点实验室哈尔滨150030 均瑶润盈生物科技(上海)有限公司上海201799 国家乳业工程技术研究中心润盈(上海)实验室上海201799

胞外多糖是一类来源广泛的生物活性分子,具有调节肠道菌群的潜力。文章利用单因素及响应面优化实验确定副干酪乳酪杆菌(副干酪乳杆菌)JY56胞外多糖的最优发酵条件:发酵温度为30℃,发酵时间为26 h,发酵pH为6.0。进一步制备了植物乳植杆菌... 详细信息

胞外多糖是一类来源广泛的生物活性分子,具有调节肠道菌群的潜力。文章利用单因素及响应面优化实验确定副干酪乳酪杆菌(副干酪乳杆菌)JY56胞外多糖的最优发酵条件:发酵温度为30℃,发酵时间为26 h,发酵pH为6.0。进一步制备了植物乳植杆菌J26与副干酪乳酪杆菌JY56胞外多糖组合物(J26&JY56 Exopolysaccharide Composition, JEC)。为了研究组合物JEC对肥胖的影响,采用高脂饮食诱导建立肥胖小鼠模型。经饮食干预10周后,结果表明,组合物JEC减缓体重增加的效果显著(P<0.05),缓解了由于长期摄入高脂饮食造成的肝脏脂肪堆积,基本恢复到正常水平。其中,JEC组小鼠血清中的TNF-α(301.77±9.87) ng/L、IL-6(225.39±10.09) ng/L、IL-1β(21.92±1.58) ng/L和IFN-γ(180.90±8.52)ng/L含量明显低于高脂饮食诱导的肥胖模型小鼠组(HFD)(P<0.05)。此外,JEC组的肝细胞中未观察到明显的脂滴空泡和坏死细胞,以及炎症细胞浸润现象。植物乳植杆菌J26与副干酪乳酪杆菌JY56胞外多糖组合物JEC具有对高脂饮食诱导的肥胖小鼠的减肥作用。

关键词：植物乳植杆菌J26 副干酪乳酪杆菌JY56胞外多糖组合物合生素肥胖

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后生元的功能及其应用

中国食品学报 2024年第2期24卷 373-381页

作者：李誉张竞文郑亚平汪玲娥张惠琳叶亚明张宇张微满朝新姜毓君东北农业大学食品学院、乳品科学教育部重点实验室哈尔滨150030 均瑶大健康饮品股份有限公司湖北宜昌443199

随着人们生活质量的提高,对疾病及健康的关注度也随之提高。人们不再将关注点放于治疗疾病的相关医疗器械与药物成分,而是逐渐对起着预防、改善或辅助性缓解作用的新兴物质、成分或加工产品进行着重了解。这类物质对机体的作用更加侧重... 详细信息

随着人们生活质量的提高,对疾病及健康的关注度也随之提高。人们不再将关注点放于治疗疾病的相关医疗器械与药物成分,而是逐渐对起着预防、改善或辅助性缓解作用的新兴物质、成分或加工产品进行着重了解。这类物质对机体的作用更加侧重于通过定期的外部摄入来维持生理功能的运转或或促进健康。可外部摄入且有益于机体的物质最基本的要求是食用安全,而无副作用、多种类、多元化将、高效方便将是人们未来关注的新标签。定期摄入具有安全认证的益生菌产品,被认为是改善人体健康状况以及缓解疾病的一种较为安全且普遍的方法,而益生菌存活率低,发挥作用要求较高,使得其在大规模制备、长时间运输储存并保证其作用特性上存在一定的困难。到目前为止,各种保证益生菌高活性的制备、储存方法也在被不断地研究。近年来,伴随人们对益生菌研究的深入,已发现由益生菌通过不同制备方法所得的后生元也可对机体产生积极影响,并具备益生菌产品所不具有的稳定且储运方便等特点,或将成为未来改善机体状况或增强机体功能的新方向。本文综述后生元对机体的各种功能,其相关产品在各领域的应用情况。

关键词：后生元功能应用研究益生菌

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乳品安全控制溯源技术研究进展

中国乳品工业 2024年第7期52卷 42-46页

作者：祁雪鹤宋丹靓敏苏群超黄燕贾嫒杨鑫焱满朝新姜毓君东北农业大学食品学院乳品科学教育部重点实验室哈尔滨150030

为保障乳品质量与安全,近年来不断开发高效乳品安全溯源技术。文章介绍了乳品安全溯源技术现状,对原料乳收集及加工过程中可能存在的风险和乳品掺假问题进行分析,并阐述无线射频识别(RFID)及电子产品码技术、指纹技术和区域链技术及其... 详细信息

为保障乳品质量与安全,近年来不断开发高效乳品安全溯源技术。文章介绍了乳品安全溯源技术现状,对原料乳收集及加工过程中可能存在的风险和乳品掺假问题进行分析,并阐述无线射频识别(RFID)及电子产品码技术、指纹技术和区域链技术及其在乳品安全溯源方面的国内外实例,为乳品安全溯源问题提供思路,便于出现问题时及时追溯源头,促进乳品行业稳步发展。

关键词：乳品安全溯源技术供应链

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发酵乳后酸化的影响因素及其控制措施

食品研究与开发 2024年第4期45卷 200-208页

作者：朱曼李宝磊侯保朝洪维錬何剑张宇姜毓君满朝新东北农业大学食品学院乳品科学教育部重点实验室黑龙江哈尔滨150030 国家乳业技术创新中心上海201111

发酵乳因其独特的口感及较高的营养价值备受消费者的青睐,但由于微生物残余的代谢活性导致发酵乳出现后酸化现象,使其在冷链运输、储存及销售过程中品质急剧下降,菌株稳定性显著降低,严重影响消费者对产品的接受度,并且缩短产品的货架... 详细信息

发酵乳因其独特的口感及较高的营养价值备受消费者的青睐,但由于微生物残余的代谢活性导致发酵乳出现后酸化现象,使其在冷链运输、储存及销售过程中品质急剧下降,菌株稳定性显著降低,严重影响消费者对产品的接受度,并且缩短产品的货架期。因此,该文探讨影响发酵乳后酸化的因素(包括发酵剂的类型、乳的成分、加工参数、益生菌和益生元),对发酵乳后酸化的产生机制进行讨论,并从物理、化学和生物方面综述控制发酵乳后酸化的措施,讨论相关技术的局限性,以期为减弱发酵乳的后酸化程度,改善发酵乳的货架期品质提供参考途径。

关键词：发酵乳酸奶后酸化影响因素产生机制控制措施

Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway

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Food Science and Human Wellness 2023年

作者： Jiaxin Zhang Jinjing Zhong Zhengying Cui Yu Shen Yaping Zheng Yu Zhang chaoxin man Yanmei Hou Qianyu Zhao Yujun Jiang Hyproca Nutrition Co. Ltd. Key Laboratory of Dairy Science Ministry of Education Department of Food Science Northeast Agricultural University

Branched-chain fatty acids (BCFAs) are new bioactive fatty acids with anti-inflammatory properties. However， the role of BCFAs in alleviating ulcerative colitis has not been clarified. Herein， we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate and explore the corresponding mechanism. These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice， and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response. These data also show that BCFAs can down-regulate the gene and protein expression of the Toll-like receptor 4 (TLR4)/ nuclear factor kappa-B p65 (NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway， and at the same time significantly reduce the expression of pro-inflammatory factors Tumor Necrosis Factor Alpha (TNF-α)， Interleukin 1β (IL-1β)， and Interleukin 18 (IL-18) in colon tissue， and significantly increase the expression of the anti-inflammatory factor Interleukin 10 (IL-10). In conclusion， these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate dextran sodium sulfate (DSS)-induced ulcerative colitis. This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.

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