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Artemisia argyi extract subfraction exerts an antifungal effect against dermatophytes by disrupting mitochondrial morphology and function

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Chinese Journal of Natural Medicines 2024年第1期22卷 47-61页

作者： CHEN Le ZHU Yunyun guo chaowei guo Yujie ZHAO Lu MIAO Yuhuan DU Hongzhi LIU Dahui College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Artemisia argyi(A.argyi),a plant with a longstanding history as a raw material for traditional medicine and functional diets in Asia,has been used traditionally to bathe and soak feet for its disinfectant and itch-relieving properties.Despite its widespread use,scientific evidence validating the antifungal efficacy of A.argyi water extract(AAWE)against dermatophytes,particularly Trichophyton rubrum,Trichophyton mentagrophytes,and Microsporum gypseum,remains limited.This study aimed to substantiate the scientific basis of the folkloric use of A.argyi by evaluating the antifungal effects and the underlying molecular mechanisms of its active subfraction against dermatophytes.The results indicated that AAWE exhibited excellent antifungal effects against the three aforementioned dermatophyte species.The subfraction AAWE6,isolated using D101 macroporous resin,emerged as the most potent subfraction.The minimum inhibitory concentrations(MICs)of AAWE6 against T.rubrum,M.gypseum,and T.mentagrophytes were 312.5,312.5,and 625μg·mL−1,respectively.Transmission electron microscopy(TEM)results and assays of enzymes linked to cell wall integrity and cell membrane function indicated that AAWE6 could penetrate the external protective barrier of T.rubrum,creating breaches(“small holes”),and disrupt the internal mitochondrial structure(“granary”).Furthermore,transcriptome data,quantitative real-time PCR(RT-qPCR),and biochemical assays corroborated the severe disruption of mitochondrial function,evidenced by inhibited tricarboxylic acid(TCA)cycle and energy metabolism.Additionally,chemical characterization and molecular docking analyses identified flavonoids,primarily eupatilin(131.16±4.52 mg·g^(−1))and jaceosidin(4.17±0.18 mg·g^(−1)),as the active components of AAWE6.In conclusion,the subfraction AAWE6 from A.argyi exerts antifungal effects against dermatophytes by disrupting mitochondrial morphology and function.This research validates the traditional use of A.argyi and provides scientific support for its antidermatophytic applicati

关键词： Artemisia argyi Dermatophyte Antifungal activity Mitochondrial structure Mitochondrial function Transcriptome analysis

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Micro/nano-mechanical behaviors of individual FCC,BCC and FCC/BCC interphase in a high-entropy alloy

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Journal of Materials Science & Technology 2022年第19期114卷 102-110页

作者： Wei Zhang Zhichao Ma Chaofan Li chaowei guo Dongni Liu Hongwei Zhao Luquan Ren School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China Key Laboratory of CNC Equipment Reliability Ministry of EducationJilin UniversityChangchun 130025China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Bionic Engineering Ministry of Education Jilin UniversityChangchun 130025China Weihai Institute for Bionics Jilin UniversityWeihai 264207China

Here,a systematic investigation was made on the interphase strengthening effects induced superior me-chanical performances of multiphase high-entropy alloys(HEAs)at micro/nano-scale,compared with sin-gle phase HEAs.A pillar compression test under a scanning electron microscope(SEM)was performed on the individual face centered cubic(FCC),body centered cubic(BCC),and mixed-phases with different di-ameters in a Fe_(24)Co_(25)Ni_(24)Cr_(23)Al_(4)HEA using focused ion beam(FIB)milling and a nanoindenter equipped with a flat punch.The stress-strain response of pillar underneath the indenter was selected to explore the diameter/phase-dependent size effect,the periodically fluctuation of local stress,and strain hardening.It was revealed that the pillars at the interphase exhibited significantly higher strength,compared with the FCC and BCC pillars.An experiment also verified the coincident mechanical size effects independent with the type of phases.The stress responses in the mixed-phase pillars manifested as a distinct transition from the dramatic drop to the minor fluctuation during the post-yield stages with the increasing strain,indicating the propagation of Al-Ni enriched solid solution phase(BCC1)under compression.Except the BCC1 phase,numerous dislocations were observed in the post-deformed pillars,particularly serving as the major source to enhance the strain hardening of BCC pillars.

关键词： Size effect Stress fluctuation Compression Interphase High-entropy alloys

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Synthesis of nearly spherical AlN particles by an in-situ nitriding combustion route

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Journal of Advanced Ceramics 2021年第2期10卷 291-300页

作者： Zhilei Wei Kang Li Bangzhi Ge chaowei guo Hongyan Xia Yajie guo Zhongqi Shi State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China Engineering Research Center of Transportation Materials of Ministry of Education School of Materials Science and EngineeringChang’an UniversityXi’an710064China

Spherical AlN powders with micrometer size have attracted great attention owing to their good fluidity and dispersity. However, the industrial preparation methods usually require high temperature and long soaking time, which lead to the high cost and limit the wide application of the products. Herein, nearly spherical AlN particles with the average size of 2.5 μm were successfully synthesized via an in-situ combustion synthesis method. The effect of N_(2) pressure, NH_(4)Cl content, and Al particle size on the combustion reaction procedure, phase composition, and microstructure of the products was systematically investigated. The results showed that the decreased N_(2) pressure, increased NH_(4)Cl content, and Al particle size led to the decreasing of combustion temperature and speed, which further affected the morphology of the products. As a result, low N_(2) pressure(0.2 MPa), a small amount of NH4Cl(0.5 wt%), and fine Al particles(~2.5 μm) contributed to a moderate combustion temperature and facilitated the formation of nearly spherical AlN particles. In addition, based on the gas-releasing assisted quenching experiments and thermo-kinetic analysis, a two-step growth mechanism for the nearly spherical AlN particles was rationally proposed. The present method shows the advantages of low cost and high efficiency for preparing nearly spherical AlN particles, which can be used as raw materials for electronic substrates and fillers for packaging materials.

关键词： combustion synthesis AlN microstructure growth mechanism

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A wireless-communication-based measurement of gas pressure with capsule-slime sealing device

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International Journal of Mining Science and Technology 2019年第6期29卷 917-923页

作者： Zhengyan Wu Deqiang Fan Shuguang Jiang Hao Shao Kai Wang Weiqing Zhang chaowei guo Key Laboratory of Coal Methane and Fire Control Ministry of EducationChina University of Mining&TechnologyXuzhou 221116China National Professional Laboratory for Fundamental Research of Mine Gas and Dust Control Technology Xuzhou 221116China School of Safety Engineering China University of Mining&TechnologyXuzhou 221116China State Key Laboratory of Coal Resources and Safe Mining China University of Mining&TechnologyXuzhou 221116China

To solve the existing problems of imperfect sealing and the inaccurate measurement of gas pressure in traditional sealing,the present study builds a new model of capsule-slime sealing device based on wireless pressure gauge.The new sealing device is mainly composed of two sets of capsules,a capsule connecting piece and a slime part,measures the pressure through the wireless communication technology,and seals through chemical reaction in the capsule,which generates gas to expand the capsule and extrude the pre-stored slime.Two methods of extruding pre-stored slime are proposed:in the first method,transverse force is generated by the expansion of the capsules at both ends,pushing the capsules toward the middle through the chute and squeezing the pre-stored slime out;in the second,high-pressure gas generated in the capsules is led into the expansion tube,which is inserted into the storage tube,squeezing it and letting the slime out to complete the sealing process.Then the research studies the effect of sealing under the condition of drilling with the structure of slime storage tube.The results indicate that the maximum standing time of slime wrapped in metal net is 2 h,instead of the expected 10 d,failing to meet the sealing requirements.When the slime viscosity is 1200–3000 m Paás in the structure of slime storage tube,the best viscosity of slime is achieved and can simulate sealing the drilling hole(5–4,4–2.36,2.36–1.18,1.18–0.15 mm in diameter),as well as the gap caused by mixed sand accumulation.

关键词： Wireless pressure gauge Capsule-slime Hole sealing device Simulated sealing

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综合防尘措施在成庄矿井下综掘工作面的应用

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能源与节能 2024年第1期 225-229页

作者：郭朝伟晋能控股装备制造集团成庄矿山西晋城048000

煤矿井下生产过程中会产生大量粉尘,不仅对作业环境、机电设备造成严重影响,也时刻威胁着井下安全生产和作业人员身体健康。结合煤矿综掘工作面粉尘的产生机理及运动规律,探讨了多层级综合防尘措施在成庄矿井下综掘工作面的实际应用。... 详细信息

煤矿井下生产过程中会产生大量粉尘,不仅对作业环境、机电设备造成严重影响,也时刻威胁着井下安全生产和作业人员身体健康。结合煤矿综掘工作面粉尘的产生机理及运动规律,探讨了多层级综合防尘措施在成庄矿井下综掘工作面的实际应用。综合防尘措施的应用,对综掘工作面粉尘形成了有效拦截,进一步提升了降尘率,既优化了工作面的作业环境,又保障了安全生产。

关键词：综合防尘降尘率作业环境安全生产

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NR4A1在食管癌中的表达及其临床预后意义

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食管疾病 2024年第2期6卷 134-140页

作者：李淑娜郭超韡张雅怡李新阳河南科技大学临床医学院河南科技大学第一附属医院中国洛阳471003 河南科技大学护理学院河南洛阳471023

目的研究核受体NR4A1在食管癌(esophageal cancer,EC)中表达、临床意义和对EC细胞增殖的影响。方法基于在线数据库分析NR4A1在EC中的表达水平、临床特征相关性、预后影响及免疫细胞浸润情况,通过CCK-8和克隆形成实验探索NR4A1对EC细胞... 详细信息

目的研究核受体NR4A1在食管癌(esophageal cancer,EC)中表达、临床意义和对EC细胞增殖的影响。方法基于在线数据库分析NR4A1在EC中的表达水平、临床特征相关性、预后影响及免疫细胞浸润情况,通过CCK-8和克隆形成实验探索NR4A1对EC细胞增殖的影响。结果NR4A1在EC组织中高表达且与病理分型、临床分期、肿瘤分级、淋巴结转移情况、差OS显著相关(P<0.05),免疫浸润分析提示EC中NR4A1表达与CD4^(+)T细胞、CD8^(+)T细胞、B细胞、巨噬细胞和自然杀伤细胞的富集相关(P<0.05),且下调NR4A1的表达可显著抑制细胞增殖(P<0.05)。结论NR4A1在EC中表达升高,且高表达患者预后较差,抑制NR4A1表达可阻止EC细胞增殖。

关键词：食管癌 NR4A1 表达预后细胞增殖

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Portrait and Classification of Individual Haze Particulates

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Journal of Environmental Protection 2016年第10期7卷 1355-1379页

作者： Clara Yuan Li Mingshuai Ding Yang Yang Pengcheng Zhang Yao Li Yuecun Wang Longchao Huang Pingjiong Yang Ming Wang Xiao Sha Yameng Xu chaowei guo Zhiwei Shan Weston High School Weston MA USA Center for Advancing Materials Performance from the Nanoscale (CAMP-Nano) & Hysitron Applied Research Center in China (HARCC) State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong University Xi’an China

Haze (known as “Mai” 霾 in Chinese) threatens the health of billions of people across the globe. To begin solving this problem without severely slowing down the economy, one has to mechanistically and geographically pinpoint the sources of these pollutants, the key of which is to thoroughly characterize and fingerprint the particulates. Here we present a broad survey and classification of thousands of individual airborne particu-lates by using the Scanning Electron Microscope (SEM) to measure their diverse mor-phologies and chemistries, which could eventually be organized into a “haze finger-print database”. For instance, one collection in Xi’an City, China during March-April 2014 yielded 494 airborne particulates that settled on silicon wafers placed outside the window of a 3rd floor office. These 494 particulates were manually imaged with high resolution (down to 2 nm), elementally mapped using Energy-dispersive X-ray Spec-troscopy (EDS), and were identified and categorized into presumed source classes such as construction activities (Ca, Al, Si-O), coal burning (sulfates), biologic (pollen, bac-teria), automotive, mining, steel making, and etc. About 20% of the particulates have mysterious origins, as it is still unclear how they were formed, and a fraction of them contained clearly hazardous elements such as lead and chromium. For future work, we propose using unmanned aerial vehicles with a special “rolling film” substrate that can autonomously collect airborne particulates, a customized SEM auto-imaging system, and machine learning software to establish an online open-access database. The end goal would be to monitor and analyze the particulate pollutants that are pumped into our atmosphere every day, and precisely track down their sources so we can better model and police the quality of the air around us.

关键词： PM2.5 PM10 Air Pollution Fingerprint Robot

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成庄矿井上下立体递进式瓦斯抽采技术研究

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能源与节能 2023年第12期 157-160,205页

作者：郭朝伟韩兵晋城蓝焰煤业集团股份有限公司成庄矿山西泽州048021 中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122

为平衡高瓦斯矿井瓦斯抽采工程与煤矿采掘生产之间的关系,成庄矿形成了井上下立体递进式瓦斯抽采技术体系。在规划区,采用地面直井、U型井、定向井、卸压井等对煤体预抽5~15 a,降低煤层瓦斯含量至8~14 m^(3)/t;在准备区,在井下采用定向... 详细信息

为平衡高瓦斯矿井瓦斯抽采工程与煤矿采掘生产之间的关系,成庄矿形成了井上下立体递进式瓦斯抽采技术体系。在规划区,采用地面直井、U型井、定向井、卸压井等对煤体预抽5~15 a,降低煤层瓦斯含量至8~14 m^(3)/t;在准备区,在井下采用定向长钻孔区域递进式模块抽采+条带区域抽采+密集钻孔抽采技术,对煤层瓦斯进行递进式、持续性、大范围的预抽;在回采区及采空区,采用“高位定向长钻孔高体积分数小流量+低位采空区横川埋管低体积分数大流量”的抽采方法,改变采空区的风流方向及瓦斯分布状态,降低了上隅角的瓦斯体积分数。综合抽采治理后,成庄矿工作面风排瓦斯量降低到17.86 m^(3)/min,回风巷瓦斯体积分数保持在0.2%~0.4%,工作面上隅角瓦斯体积分数低于0.63%。

关键词：井上下联合抽采递进式模块预抽高体积分数小流量低体积分数大流量

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不同氮肥施用量对二年生射干生长、产量和品质的影响

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中国实验方剂学杂志 2022年第23期28卷 135-141页

作者：郭超伟刘雨李金鑫杨雅雯苗玉焕刘大会湖北中医药大学药学院武汉430065

目的:探究不同氮肥施用量对射干生长、产量和品质的影响,为射干提质增效栽培提供合理施氮依据。方法:在施用磷肥、钾肥120 kg·hm^(-2)的基础上,设置0(N_(0))、60(N_(60))、120(N_(120))、180(N_(180))、240(N_(240))kg·hm^(-2)共5个... 详细信息

目的:探究不同氮肥施用量对射干生长、产量和品质的影响,为射干提质增效栽培提供合理施氮依据。方法:在施用磷肥、钾肥120 kg·hm^(-2)的基础上,设置0(N_(0))、60(N_(60))、120(N_(120))、180(N_(180))、240(N_(240))kg·hm^(-2)共5个氮肥施用水平,研究不同氮肥施用量对射干农艺性状、产量、矿质元素积累量、黄酮类成分含量的影响。结果:施用氮肥有利于射干各器官的干物质积累,显著提高射干药材产量,射干产量增加48.75%~86.62%。当氮肥施入量为60~180 kg·hm^(-2)时能提高根茎中射干苷、野鸢尾苷、次野鸢尾黄素等活性成分含量,但不利于鸢尾黄素和野鸢尾黄素的积累;锰、铁元素分别在氮肥施用量为120、60 kg·hm^(-2)时最高。结合活性成分含量进行主成分分析,综合得分排名为N_(180)>N_(120)>N_(60)>N_(240)>N_(0)。相关性分析结果表明,射干苷含量与射干体内氮元素积累呈正相关、与钙元素呈负相关;鸢尾黄素含量与氮呈负相关、与钙呈正相关;野鸢尾黄素与钙、锌呈正相关。结论:氮肥120~180 kg·hm^(-2)的施用量可提高射干药材产量及根茎中射干苷、野鸢尾苷和次野鸢尾黄素等含量,提升药材的产量和品质。

关键词：射干氮肥产量黄酮类成分矿质元素

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射干养分需求规律分析

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中国实验方剂学杂志 2022年第23期28卷 128-134页

作者：李金鑫刘雨郭超伟杨雅雯苗玉焕刘大会湖北中医药大学药学院武汉430065

目的:研究射干干物质积累、矿质元素吸收及药用成分积累变化规律,为射干规范化种植中的合理施肥提供理论依据。方法:以二年生射干为研究对象,自播种90 d后开始取样,每隔30 d采集样品一次,分别测定各器官干物质积累量、矿质元素含量及根... 详细信息

目的:研究射干干物质积累、矿质元素吸收及药用成分积累变化规律,为射干规范化种植中的合理施肥提供理论依据。方法:以二年生射干为研究对象,自播种90 d后开始取样,每隔30 d采集样品一次,分别测定各器官干物质积累量、矿质元素含量及根茎中黄酮类成分含量。结果:根据不同时期各器官干物质累积情况,将二年生射干生育期划分为7个阶段,幼苗期(第1年7月前)、第1年营养生长期(第1年8—10月)、第1年生长后期(第1年11月—第2年1月)、返青期(第2年2—3月)、第2年营养生长期(第2年4—5月)、生殖生长期(第2年6—10月)、第2年生长后期(第2年11—第3年1月)。在全生育期内,每年的生长后期为射干根茎膨大期,全株干物质积累量则在生殖生长期后最高。根茎中的黄酮类成分含量在不同阶段差异较大,其中芒果苷、鸢尾黄素、野鸢尾黄素在第2年营养生长期含量较高;射干苷、野鸢尾苷在第1年生长后期和第2年生长后期积累量较高;次野鸢尾黄素在第2年营养生长期和第2年生长后期含量高于其他阶段;第2年营养生长期(次年4月)6种黄酮类成分总量达到整个生育期的峰值。相关性分析结果显示,9种矿质元素与与鸢尾黄素、野鸢尾黄素、次野鸢尾黄素存在不同程度的正相关。结论:射干第1年干物质积累量较为缓慢、需肥量较少,可减少基肥的施入。第2年尤其是进入生殖生长期后对肥料需求量较大,故在此之前应尽早补充氮磷钾肥及其他微肥。此外,射干根茎第1年10—11月及第2年11—12月在年底存在膨大期,此时应保证根茎氮、钾供应,或增加有益元素的施入提高射干质量。

关键词：射干干物质矿质元素黄酮

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