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RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2

Science China Life Sciences 2024年

作者： Lili Zhi chaoqun chen Ge Zhang Tian Huang Wenxia He Jinrui Zhang Dan chen Jiayi Liu Jinyao Zhao Yangfan Qi Guiying Wang Wenjing Zhang Yang Wang Sino-US Research Center for Cancer Translational Medicine of the Second Affiliated Hospital of Dalian Medical University&Institute of Cancer Stem Cell Dalian Medical University Department of Immunology College of Basic Medical SciencesDalian Medical University Institute of Cancer Stem Cell Dalian Medical University Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian Medical University Department of General Surgery the Second Hospital of Hebei Medical University The Second Department of General Surgery the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma

Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis;however,their specific involvement in colon cancer remains largely *** we report that the splicing factor RBM25 is overexpressed in colon cancer,and this increased expression correlates with a poor prognosis of patients with colon ***,RBM25 ablation suppresses the growth of colon cancer cells both in vitro and in ***,our transcriptome-wide analysis of splicing events revealed that RBM25regulates a large number of cancer-related alternative splicing events across the human genome in colon ***,RBM25regulates the splicing of MNK2 by interacting with the poly G rich region in exon 14a,thereby inhibiting the selection of the proximal 3′splice site (ss),resulting in the production of the oncogenic short isoform,*** of RBM25 leads to an increase in the MNK2a isoform and a decrease in the MNK2b ***,re-expression of MNK2b or blocking the 3′ss of the alternative exon 14a with ASO partially reverses the RBM25 knockdown mediated tumor ***,MNK2b levels were significantly increased in colon cancer tissues,which is positively correlated with the expression level of ***,our findings uncover the critical role of RBM25 as a key splicing factor in colon cancer,suggesting its potential as a prognostic marker and therapeutic target.

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Cu-Mn-Si催化剂的制备及其在仲丁醇脱氢反应中的应用

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石油炼制与化工 2024年第3期55卷 21-26页

作者：陈超群张莹张丽沈阳化工大学化学工程学院沈阳110142

分别采用共沉淀法和溶胶凝胶法制备Cu-Mn-Si催化剂,考察其在仲丁醇脱氢制甲乙酮反应中的催化性能。通过X射线衍射、程序升温还原、N_(2)吸附-脱附和程序升温氧化对两种方法制备的催化剂进行表征。结果表明,不同方法制备的催化剂,其中的... 详细信息

分别采用共沉淀法和溶胶凝胶法制备Cu-Mn-Si催化剂,考察其在仲丁醇脱氢制甲乙酮反应中的催化性能。通过X射线衍射、程序升温还原、N_(2)吸附-脱附和程序升温氧化对两种方法制备的催化剂进行表征。结果表明,不同方法制备的催化剂,其中的铜锰络合物(CuMn_(2)O_(4))晶相结构不同。共沉淀法、溶胶凝胶法制备的催化剂中CuMn_(2)O_(4)晶相分别归属于JCPDS 71-1142和JCPDS 34-1400。溶胶凝胶法制备的催化剂晶粒小、分散性好、比表面积大,因而活性较高,Mn的加入没有提高催化剂的性能。Mn的加入可以降低共沉淀法制备的催化剂的还原温度,提高催化剂中Cu组分的分散程度,因而提高了催化剂的性能。溶胶凝胶法所制备的催化剂中,Cu SiO_(2)催化剂具有最高的仲丁醇转化率、甲乙酮选择性和甲乙酮收率,分别达99.26%,99.19%,98.45%;共沉淀法制备的催化剂,当n(Cu)∶n(Mn)∶n(Si)=0.8∶0.2∶1.0时,具有最高的仲丁醇转化率,可达94.92%,其甲乙酮选择性略低于Cu SiO_(2)催化剂,为98.53%,甲乙酮收率为93.52%。

关键词：共沉淀法溶胶凝胶法 Cu-Mn-Si催化剂仲丁醇甲乙酮脱氢

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Dynamic Accuracy Analysis of a 5PSS/UPU Parallel Mechanism Based on Rigid-Flexible Coupled Modeling

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 77-90页

作者： Yanbiao Li Zesheng Wang chaoqun chen Taotao Xu Bo chen College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of E&M Ministry of Education&Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310023China

In order to improve the low output accuracy caused by the elastic deformations of the branch chains,a finite element-based dynamic accuracy analysis method for parallel mechanisms is proposed in this ***,taking a 5-prismatic-spherical-spherical(PSS)/universal-prismatic-universal(UPU)parallel mechanism as an example,the error model is established by a closed vector chain method,while its influence on the dynamic accuracy of the parallel mechanism is analyzed through numerical *** to the structural and error characteristics of the parallel mechanism,a vector calibration algorithm is proposed to reduce the position and pose errors along the whole motion ***,considering the elastic deformation of the rod,the rigid-flexible coupling dynamic equations of each component are established by combining the finite element method with the Lagrange *** elastodynamic model of the whole machine is obtained based on the constraint condition of each moving part,and the correctness of the model is verified by ***,the effect of component flexibility on the dimensionless root mean square error of the displacement,velocity and acceleration of the moving platform is investigated by using a Newmark method,and the mapping relationship of these dimensionless root mean square errors to dynamic accuracy is further *** research work provides a theoretical basis for the design of the parameter size of the prototype.

关键词： Parallel mechanism Geometric error Calibration algorithm Elastodynamic model Dynamic accuracy

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基于动态嵌套网格技术的载荷出舱过程研究

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航天返回与遥感 2024年第2期45卷 29-40页

作者：陈超群张红英陈建平童明波曾建江南京航空航天大学航空学院南京210016

针对内装载荷在空中分离出舱过程中存在的安全性和姿态稳定性问题,文章采用动态嵌套网格结合罚函数的研究方法对载荷在考虑适配器碰撞下的出舱分离过程进行了数值模拟。相较于以往的研究,该方法将分离过程中的气动特性由离散的稳态计算... 详细信息

针对内装载荷在空中分离出舱过程中存在的安全性和姿态稳定性问题,文章采用动态嵌套网格结合罚函数的研究方法对载荷在考虑适配器碰撞下的出舱分离过程进行了数值模拟。相较于以往的研究,该方法将分离过程中的气动特性由离散的稳态计算转变为连续的瞬态计算,将适配器碰撞由特征点法估算转变为节点-面法精细计算,实现了非定常流场与多体碰撞的耦合求解,拥有更好的保真性。文章首先通过与美国空军Arnolds工程发展中心风洞实验室的标模试验进行对比,验证了所采用的数值方法的准确性;随后建立了载荷出舱系统仿真模型并分析了标准工况下的出舱特性以及初始速度、初始攻角对载荷在牵引伞作用下出舱过程的影响。结果表明:标准工况下载荷能够安全平稳出舱;初始速度越低,分离过程越平稳,适配器受压缩程度越低,马赫数Ma=0.5时运载器与载荷的最小间距相较于Ma=0.8时增大了1 mm;初始攻角较大对分离时的安全性和稳定性有不利影响,攻角ɑ=15°时适配器摩擦力是ɑ=5°时的2.67倍。该方法适用于采用适配器作为安全保护措施的载荷出舱系统的数值模拟研究,所得结论可为研究载荷出舱系统分离过程提供一定参考。

关键词：多体系统空中分离动态嵌套网格罚函数计算流体力学适配器牵引伞

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嘎木珠尔的临床应用研究概况

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中国蒙医药（蒙） 2024年第2期19卷 82-85页

作者：陈超群韩额尔德木图不详

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新形势下MDT监管模式在清廉医院建设中的实践

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现代医院 2024年第5期24卷 670-673页

作者：王雪飞陈超群王晓莹浙江大学医学院附属儿童医院浙江杭州310057

在全国范围内开展医药领域腐败问题集中整治工作的新形势下,浙江大学医学院附属儿童医院纪检监察室借鉴多学科行政管理模式,创建了以清廉科室、行风查房为抓手的MDT监管模式,推进落实党风廉政建设党委主体责任和纪委的监督责任,通过查... 详细信息

在全国范围内开展医药领域腐败问题集中整治工作的新形势下,浙江大学医学院附属儿童医院纪检监察室借鉴多学科行政管理模式,创建了以清廉科室、行风查房为抓手的MDT监管模式,推进落实党风廉政建设党委主体责任和纪委的监督责任,通过查摆问题、督促整改、完善制度等方式实现全流程闭环管理。在强化责任体系建设、廉洁风险防控、强化行风建设、精准廉政宣教等方面取得良好成效。

关键词： MDT监管模式纪检监察清廉科室行风查房医院党建

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Hollow ZIF-67-derived Co@N-doped carbon nanotubes boosting the hydrogenation of phenolic compounds to alcohols

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Chinese Journal of Chemical Engineering 2024年第2期66卷 157-166页

作者： Zhihao Guo Jiuxuan Zhang Lanlan chen chaoqun Fan Hong Jiang Rizhi chen State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 211816China

The selective hydrogenation of highly toxic phenolic compounds to generate alcohols with thermal stability,environmental friendliness,and non-toxicity is of great ***,a series of Co-based catalysts,named Co@NCNTs,were designed and constructed by direct pyrolysis of hollow ZIF-67(HZIF-67)under H_(2)/Ar *** evolution of the catalyst surface from the shell layer assembled by ZIF-67-derived particles to the in situ-grown hollow nitrogen-doped carbon nanotubes(NCNTs)with certain length and density is achieved by adjusting the pyrolysis atmosphere and *** to the synergistic effects of in situ-formed hollow NCNTs,well-dispersed Co nanoparticles,and intact carbon matrix,the as-prepared Co@NCNTs-0.10-450 catalyst exhibits superior catalytic performance in the hydrogenation of phenolic compounds to *** turnover frequency value of Co@NCNTs-0.10-450is 3.52 h^(-1),5.9 times higher than that of Co@NCNTs-0.40-450 and 4.5 times higher than that of Co@NCNTs-0.10-550,exceeding most previously reported non-noble metal *** findings provide new insights into the development of non-precious metal,efficient,and cost-effective metal-organic framework-derived catalysts for the hydrogenation of phenolic compounds to alcohols.

关键词： Phenolic compounds Hollow ZIF-67 pyrolysis Nitrogen-doped carbon nanotubes Reduction Multiphase reaction Catalysis

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BS_(0.5)BNT-based relaxor ferroelectric ceramic/glass-ceramic composites for energy storage

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Journal of Advanced Ceramics 2023年第4期12卷 695-710页

作者： Xuhai Shi Kai Li Zong-Yang Shen Junqi Liu chaoqun chen Xiaojun Zeng Bo Zhang Fusheng Song Wenqin Luo Zhumei Wang Yueming Li China National Light Industry Key Laboratory of Functional Ceramic Materials Energy Storage and Conversion Ceramic Materials Engineering Laboratory of Jiangxi ProvinceAdvanced Ceramic Materials Research InstituteSchool of Materials Science and EngineeringJingdezhen Ceramic UniversityJingdezhen 333403China

Relaxor ferroelectric ceramics have very high dielectric constant(e)but relatively low electrical breakdown strength(Eb),while glass-ceramics exhibit higher E,due to the more uniformly dispersed amorphous phases and submicrocrystals/nanocrystals *** to effectively combine the advantages of both relaxor ferroelectric ceramics and glass-ceramics is of great significance for the development of new dielectric materials with high energy storage *** this work,we firstly prepared BaO-SrO-Bi_(2)O_(3)-Na_(2)0-TiO_(2)-Al_(2)O_(3)-SiO_(2)(abbreviated as GS)glass powders,and then fabricated(Ba_(0.3)Sr_(0.7))_(0.5)(Bi_(0.5)Na_(0.5))_(0.5)TiO_(3)+x wt%GS ceramic composites(abbreviated as ***-xGS,x=0,2,6,10,14,16,and 18).Submicrocrystals/nanocrystals with a similar composition to *** were crystalized from the glass,ensuring the formation of uniform core-shell structure in ***-xGS relaxor ferroelectric ceramic/glass-ceramic *** the addition amount of GS was 14 wt%,the composite possessed both high&r(>3200 at 1 kHz)and high E,(~170 kV/cm)at room temperature,and their recoverable energy storage density and efficiency were Wrec=2.1 J/cm’and n=65.2%,*** ***-14GS composite also had several attractive properties such as good temperature,frequency,cycle stability,and fast charge-discharge *** work provides insights into the relaxor ceramic/glass-ceramic composites for pulsed power capacitors and sheds light on the utilization of the hybrid systems.

关键词： relaxor ferroelectrics energy storage ceramics glass-ceramics Bi_(0.5)Na_(0.5)TiO_(3)(BNT) Ba_(0.3)Sr_(0.7)TiO_(3)(BST)

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Evolution of Unsteady Flow near Rotor Tip during Stall Inception

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Journal of Thermal Science 2011年第4期20卷 294-303页

作者： Shaojuan Geng Feng Lin Jingyi chen chaoqun Nie Institute of Engineering Thermophysics Chinese Academy of Sciences RO. Box 2706 Beijing 100190 China

Previously the features of circumferential propagation of self-induced tip leakage flow unsteadiness for a low speed isolated axial compressor rotor in the authors' laboratory were discovered and investigated via numerical simulation,which only occurs below a critical stable flow point that is close to but not yet at the stall *** in this paper,the detailed investigation on evolution of tip leakage flow during the throttling process into spike rotating stall was conducted by adopting the valve-throttling *** this process,the development of the circumferential propagation of tip leakage flow unsteadiness was especially focused *** to the unsteady characteristics of pressure signals,the evolvement of compressor flow field can be classified into four *** compressor throttled,the oscillation frequency of self-induced unsteady tip leakage flow decreased gradually,and thus resulted in the decrease of its circumferential propagation *** circumferential propagation of self-induced tip leakage flow unsteadiness is closely related with rotating *** the forward spillage of tip leakage flow at the leading edge occurred,the spike type rotating stall was *** flow struc-tures were given in the paper.

关键词：旋转失速非定常流动演变转子轴流压缩机传播速度节流过程流场结构

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RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2363-2383页

作者： Lei chen Wenjing Zhang Dan chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang chaoqun chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi Institute of Cancer Stem Cells and the Second Affiliated Hospital of Dalian Medical University Dalian Medical UniversityDalian116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Department of Oncology the Second Affiliated Hospital of Dalian Medical UniversityDalian116023China Department of Thoracic Surgery the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Research Center the Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct ***,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely *** we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer *** level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant ***4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR ***,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in ***,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine ***,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high *** RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics.

关键词： LKB1 ESCC protective

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