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Performance of Gas-Steam Combined Cycle Cogeneration Units Influenced by Heating Network Terminal Steam Parameters

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Energy Engineering 2024年第6期121卷 1495-1519页

作者： Guanglu xie Zhimin Xue Bo Xiong Yaowen Huang chaoming Chen Qing Liao Cheng Yang Xiaoqian Ma Zhongshan Jiaming Electric Power Co. Ltd.CNOOC Gas&Power GroupZhongshan528403China School of Electric Power South China University of TechnologyGuangzhou510640China

The determination of source-side extracted heating parameters is of great significance to the economic operation of cogeneration systems.This paper investigated the coupling performance of a cogeneration heating and power system multidimensionally based on the operating characteristics of the cogeneration units,the hydraulic and thermodynamic characteristics of the heating network,and the energy loads.Taking a steam network supported by a gas-steam combined cycle cogeneration system as the research case,the interaction effect among the source-side prime movers,the heating networks,and the terminal demand thermal parameters were investigated based on the designed values,the plant testing data,and the validated simulation.The operating maps of the gas-steam combined cycle cogeneration units were obtained using THERMOFLEX,and the minimum source-side steam parameters of the steam network were solved using an inverse solution procedure based on the hydro-thermodynamic coupling model.The cogeneration operating maps indicate that the available operating domain considerably narrows with the rise of the extraction steam pressure and flow rate.The heating network inverse solution demonstrates that the source-side steam pressure and temperature can be optimized from the originally designed 1.11 MPa and 238.8°C to 1.074 MPa and 191.15°C,respectively.Under the operating strategy with the minimum source-side heating parameters,the power peak regulation depth remarkably increases to 18.30%whereas the comprehensive thermal efficiency decreases.The operation under the minimum source-side heating steam parameters can be superior to the originally designed one in the economy at a higher price of the heating steam.At a fuel price of$0.38/kg and the power to fuel price of 0.18 kg/(kW·h),the critical price ratio of heating steam to fuel is 119.1 kg/t.The influence of the power-fuel price ratio on the economic deviation appears relatively weak.

关键词： Gas-steam combined cycle cogeneration of heating and power steam network inverse problem operating performance

Preparation of metal‐organic frameworks and their derivatives for supercapacitors

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Biosurface and Biotribology 2022年第3期8卷 151-164页

作者： Youjian Li Donglin Gan Xu Deng Lili Jiang chaoming xie Xiong Lu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‐functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjingJiangsuChina Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengduChina Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science and EngineeringXihua UniversityChengduChina

To satisfy the requirements of social power development,it is urgently necessary to develop innovative and sustainable new energy storage devices.Supercapacitors have attracted considerable attention as a new type of energy storage device,owing to their high energy density,high power density,fast charging and discharging speeds,and long cycle life.The electrode material is an important factor in determining the electrochemical performance of supercapacitors.In recent years,researchers explored the application of metal‐organic frameworks(MOFs)and their derivatives as electrode materials for supercapacitors.In this paper,the preparation of monometallic,bimetallic,and conductive MOFs,and their derivatives for application in supercapacitors are reviewed.In addition,challenges facing MOFs in the field of supercapacitors and their future development prospects are discussed.

关键词： bimetallic MOFs conductive MOFs derivatives monometallic MOFs supercapacitors

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming xie Xing Zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiotherapy Dongguan Institute of Clinical Cancer Research Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors Affiliated Dongguan Hospital Southern Medical University The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen University Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen University Department of Oncology Maoming People's Hospital Department of Radiation Oncology Kecheng District People's Hospital Chinese Academy of Sciences Department of Radiation Oncology State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co. Ltd Department of Radiation Oncology The Second Affiliated Hospital of Soochow University Department of Radiation Oncology Yuebei People's Hospital Affiliated to the Medical College of Shantou University Chinese Academy of Sciences Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical University Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical University Chinese Academy of Sciences State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co. Ltd Department of Radiation Oncology The Affiliated Huai'an First People's Hospital of Nanjing Medical University Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang University

Objective: Glioblastomas are highly vascularized malignant tumors. We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor, anlotinib, for a newly diagnosed glioblastoma.Methods: This multicenter, single-arm trial（NCT04119674） enrolled 33 treatment-na?ve patients with histologically proven glioblastomas between March 2019 and November 2020. Patients underwent treatment with the standard STUPP regimen [fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w × 6 w（total = 54-60 Gy）] or radiotherapy plus continuous daily temozolomide（TMZ）(75 mg/m2of body surface area/d, 7 d/w from the first to the last day of radiotherapy), followed by 6 cycles of adjuvant TMZ（150±200 mg/m2× 5 d during each 28-d cycle） plus anlotinib(8 mg/d on d 1±14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy, 8 maximal cycles as adjuvant therapy, followed by maintenance at 8 mg/d. The primary endpoint was progression-free survival（PFS）. Secondary endpoints included overall survival（OS） and adverse events（AEs）.Results: Thirty-three patients received the planned treatment. The median PFS was 10.9 months（95% CI, 9.9±18.7 months） and the 12-month PFS rate was 48.5%. The median OS was 17.4 months（95% CI, 14.5±21.1 months） and the 12-month OS rate was 81.8%. The most common AEs included hypertriglyceridemia [58%（n = 19）], hypoalbuminemia [46%（n = 15）], and hypercholesterolemia [46%（n = 15）] during concurrent chemoradiotherapy and leukopenia [73%（n = 24）], hypertriglyceridemia [67%（n = 22）], and neutropenia [52%（n = 17）] during adjuvant therapy. Five patients discontinued treatment due to AEs. HEG1（HR, 5.6; 95% CI, 1.3±23.7; P = 0.021） and RP1L1 alterations（HR, 11.1; 95% CI, 2.2±57.2; P = 0.004） were associated with a significantly shorter PFS.Conclusions: Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable toxicity. HEG1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anlotinib anti-angiogenesis multi-kinase inhibitor progression-free survival temozolomide

Bio-inspired nanofunctionalisation of biomaterial surfaces:a review

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Biosurface and Biotribology 2019年第3期5卷 83-92页

作者： chaoming xie Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031People's Republic of China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengduSichuan 61031People's Republic of China

The surfaces of biomaterials determine their efficacy and hence,have an important role in clinical applications.Through bio-inspired surface nanofunctionalisation,the surface properties of biomaterials such as physical morphologyand chemical composition can be tailored using biomimicry.It is a powerful tool for improving the interactions betweenthe physiological environment and biomaterial surfaces.Therefore,research on bio-inspired nanofunctionalised surfaceshas attracted much attention in recent years.This review focus on the recent bio-inspired strategies based on the structureof the extracellular matrix(ECM)and composition of mussel-inspired polydopamine(PDA).The design,preparation,andproperties of ECM and PDA-inspired nanofunctionalised biomaterial surfaces are reviewed.l have also highlighted theeffects of these bio-inspired nanofunctionalised biomaterial surfaces on bone regeneration,cartilage repair,andantibacterial activities.

关键词： functional biomaterials surfaces

Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

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Bioactive Materials 2022年第12期7卷 213-227页

作者： Yazhen Li Lu Yang Yue Hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao chaoming xie Xiong Lu State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan610031China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Lab for Aging Research and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan610041China

Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge.Here,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanoparticle(PHA)-incorporated conductive alginate/gelatin(AG)scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory microenvironment.PHA confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the scaffold.The conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+channels.Moreover,the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species(ROS)-scavenging ability and anti-inflammatory activity.It also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in macrophages.The scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive,ROS-scavenging,anti-inflammatory,and immunomodulatory abilities.This study provides fundamental insights into the synergistical effects of conductivity,osteoinductivity,and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration.

关键词： Polydopamine Graphene oxide Conductive scaffold ROS-Scavenging Macrophage polarization

Corrigendum to“Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics”[Bioact.Mater.6(2021)2676-2687/452]

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生物活性材料(英文) 2023年第5期23卷 524-525页

作者： Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan chaoming xie Xiong Lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhenGuangdong518055China College of Life Science and Biotechnology Mianyang Teachers’CollegeMianyang621006China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing100101China Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China

The authors regret 详细信息

The authors regret

关键词： Figure catalyzed correction

Engineering multifunctional bioadhesive powders through dynamic metal-ligand coordination

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Science China Chemistry 2022年第11期65卷 2260-2273页

作者： Junchang Guo Yue Hou Liansong Ye Junnan Chen Hong Wang Li Yang Jinbo Jiang Qiangqiang Sun chaoming xie Bing Hu Jiaxi Cui Xu Deng Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China West China Hospitcal Sichuan UniversityChengdu 610041China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Bioadhesive gels with robust adhesion on wet and irregular tissue surfaces are desirable for clinical applications.Assembly of bioadhesive powders is an effective strategy for obtaining gels that adhere to wet and irregular tissue surfaces by absorbing interfacial water.However,current bioadhesive powders lack positive biological functions and are prone to postoperative adhesion.Here,we present a powder strategy based on metal-ligand coordination to create a series of bioadhesive polyacrylic acid(PAA)gels.In the gel network,metal ions(M^(n+))are used to coordinate with the carboxy ligands of PAA to form dynamic noncovalent crosslinks.The powders can absorb interfacial water and assemble into gels on wet and irregular tissue surfaces within a few seconds,forming an initial adhesion layer by electrostatic interactions.Furthermore,the polymers can diffuse into the tissue matrix,and metal-ligand coordination is reconstructed to enhance the adhesion.Moreover,with a cationic shield layer,the bioadhesive powders can effectively avoid postoperative adhesion.Importantly,M^(n+) ions endow the gel with customized biological functions.We demonstrate that the hemostatic,antibacterial,peroxidase-like catalytic,and photodetachment abilities of the gels by incorporating different M^(n+) ions.These advantages make the bioadhesive powder a promising platform for diverse tissue repair applications.

关键词： bioadhesive powders adhesive gel water-triggered gelation metal-ligand coordination functional gel

Injectable hydrogels for anti-tumour treatment:a review

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Biosurface and Biotribology 2020年第3期6卷 59-74页

作者： Huan He chaoming xie Xiong Lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong University610031 ChengduSichuanPeople’s Republic of China

Injectable hydrogels have become the material of choice for the treatment of solid tumours based on their advantages in loading anti-tumour materials.This study reviews the main scientific research achievements on antitumour injectable hydrogels in recent years.The gel-forming mechanism of anti-tumour injectable hydrogels was listed,and the advantages and difficulties of each gel-forming mechanism were summarised.In addition,several current anti-tumour methods based on injectable hydrogels were discussed,including chemotherapy,hyperthermiabased therapy,catalytic therapy and immune therapy,as well as the integration of diagnosis and treatment to monitor the progress of cancer treatment.The anti-tumour mechanism and the advantages and disadvantages of various tumour treatments were analysed.Finally,the future development trend of injectable hydrogels for anti-tumour therapy was discussed.

关键词： treatment. treatment mechanism

^(40)Ar/^(39)Ar Thermochronology Constraints on Jurassic Tectonothermal Event of Nyainrong Microcontinent

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Journal of Earth Science 2014年第1期25卷 98-108页

作者： chaoming xie Cai Li Yanwang Wu Ming Wang Peiyuan Hu College of Earth Science Jilin University

To reveal the Jurassic tectonothermal event occurring to the Nyainrong microcontinent which is gripped among the Bangong-Nujiang suture zone,^40Ar/^39Ar dating was carried out on the basement orthogneiss and Jurassic granitc gneiss in the microcontinent. In the heating stage, four sam- pies exhibited a flat plateau age, with the value Tp concentrated in the range of 166-176 Ma; isochron age Ti was concentrated in the range of 165-175 Ma, and their corresponding ages were the consistent within allowable range. The ages should be representative of the era of the final deformation of the Amdo gneiss and cooling emplacement of the magmatic rock in the Jurassic. The geochronological studies have shown that the final deformation of microcontinent crystalline basement and the cooling of the Mesozoic large-scale tectonothermal events occurred in late Middle Jurassic. In Middle Jurassic, Nyainrong microcontinent experienced strong tectonic movement. Combining with the geochronologi- cal with isotope geochemistry for the microcontinent, the cause of the tectonothermal event should be attributed to the collision between the Nyainrong microcontinent and South Qiangtang Block following the northward subduction of Bangong-Nujiang oceanic crust.

关键词： Tibet Plateau Nyainrong microcontinent Jurassic tectonothermal event, ^40Ar/^39Ar thermochronology.