检索结果-南通市图书馆

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

引用

Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

引用

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

引用

Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stability of Delayed Switched Systems With State-Dependent Switching

引用

IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 872-881页

作者： chao liu Zheng yang Xiaoyang liu Xianying Huang School of Computer Science and Engineering Chongqing University of TechnologyChongqing 400054China Hubei Key Laboratory of Applied Mathematics(Hubei University) Wuhan 430062China

This paper investigates the stability of switched systems with time-varying delay and all unstable subsystems. According to the stable convex combination, we design a state-dependent switching rule. By employing Wirtinger integral inequality and Leibniz-Newton formula, the stability results of nonlinear delayed switched systems whose nonlinear terms satisfy Lipschitz condition under the designed state-dependent switching rule are established for different assumptions on time delay. Moreover,some new stability results for linear delayed switched systems are also presented. The effectiveness of the proposed results is validated by three typical numerical examples.

关键词： Stability statedependent switching switched system time delay

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution of Microstructures of a Low Carbon Bainitic Steel Held at High Service Temperature

引用

Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 436-443页

作者： chao Sun Shanwu yang Guoliang liu School of Materials Science and Engineering University of Science and Technology Beijing

Low carbon bainitic steel derives the high strength mainly from high density of dislocations rather than carbon and alloy element content, so it tends to evolve into equilibrium microstructure with low density of dislocations under thermal disturbance. In the present investigation, granular bainite and lath-like bainitic ferrite were produced respectively in Mo-free low-carbon steels by changing cooling rate;. It has been found that granular bainite possesses a lower strength at room temperature than bainitic ferrite, but it exhibits a slower decrease of strength with temperature increasing. Dislocation density in both granular bainite and bainitic ferrite decreases via recovery and recrystallization at high temperature. However, when reheating of bainite is carded out at temperature below 600 ℃, a long time will be needed for incubation of recrystallization, during which the hardness of bainite maintains stable. The property makes bainite, especially granular bainite, become a potential microstructure for matrix of high strength fire-resistant steel.

关键词： Low carbon bainitic steel High temperature strength Microstructure evolution Recrystallization Bainite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

生物材料异物反应的调控策略

引用

中国组织工程研究 2025年第16期29卷 3513-3520页

作者：叶超刘晓红海军军医大学附属长海医院心血管外科上海市200433

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰... 详细信息

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰的策略,同时探讨了这些方法的优势和局限性。方法:应用计算机在PubMed、Wiley、EBSCOhost、ScienceDirect和Elsevier数据库检索2000年1月至2024年3月期间的相关文献,以“biological materials,foreign body reaction,fibrosis,macrophage,myofibroblasts,inflammation,regulation,tissue repair”为检索词,最终纳入69篇文献进行分析。结果与结论:通过调整生物材料的表面特性(例如尺寸、形状、粗糙度、表面电荷、亲水性以及机械刚度等)能够减轻其对免疫系统的刺激,进而降低发生异物反应的风险;通过可控量的药物刺激产生持久的化学反应,结合使用可控降解的载体材料,可以减轻异物反应;生物材料仿生表面修饰(如两性离子涂层、蛋白质分子涂层等生物活性分子涂层)在短期能有效减轻异物反应。由于植入物和组织再生的免疫反应具有复杂性,在设计和制造植入物时也应考虑异物反应和组织再生之间的整体平衡。

关键词：生物材料异物反应纤维化巨噬细胞肌成纤维细胞炎症调控组织修复

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

引用

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

注重实践,鼓励创新,促进医院全面发展——我院课堂教学与实习教学的回顾

引用

山西医科大学学报（基础医学教育版） 2003年第1期5卷 94-96页

作者：李海潮杨柳山西医科大学附属大同市第三人民医院

作者把教学就是服务的观点应用于教学管理的实际工作中,坚持理论与实践相结合的办学理念,采取了加强领导,健全组织管理,狠抓管理人员的素质教育和带教教师及授课教师的角色转换,严格管理过程,精心带教和授课,严格考核制度,健全档案管理... 详细信息

作者把教学就是服务的观点应用于教学管理的实际工作中,坚持理论与实践相结合的办学理念,采取了加强领导,健全组织管理,狠抓管理人员的素质教育和带教教师及授课教师的角色转换,严格管理过程,精心带教和授课,严格考核制度,健全档案管理等切合实际的管理措施,取得了一定的效果,为临床实习生的教学开辟了新的途径.

关键词：办学理念教学管理素质教育课堂教学实习教学医学教育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

引用

World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan yang Jian-Qin liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydroclimatic anomalies in China during the post-Laki years and the role ofconcurring El Nino

引用

Advances in Climate Change Research 2021年第2期12卷 187-198页

作者： GAO chao-chao yang Lin-Shan liu Fei Department of Environmental Science Zhejiang UniversityHangzhou310058China Key Laboratory of Tropical Atmosphere‒Ocean System Ministry of Education School of Atmospheric SciencesSun Yat-sen UniversityZhuhai519082China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai519082China

Arctic is warming at an alarming speed causing accelerated melting of Greenland and rising of sea level,and geoengineering by injectingaerosol into stratosphere(SAI)has been proposed as a backup approach to mitigate ***,studies suggest that SAI implementationmay have adverse impacts on global especially monsoon precipitation,and Northern Hemisphere high-latitude injections may have dis-proportionally high effects than tropical *** 1783e1784 CE Laki eruption in Iceland provides an analogy to study the climatic andthe subsequent socioecological responses to Arctic SAI,and China possesses a rich legacy of documents recording climatic disasters anddescribing their direct impacts on agriculture and *** the most recent summer precipitation reconstructions and the documentary data,this study presents a systemic analysis of the hydroclimatic anomalies as well as the societal and ecological consequences in China following the1783e1784 CE Laki *** results from multi-proxies show severe drought conditions in eastern China during the post-Laki years,accompanied by large scale locust breakout,famine and human *** drought and associated disasters first emerged in the North ChinaPlain in 1784 CE,intensified and expanded to the middle and lower reaches of the yangtze River in 1785 *** drought and famine stresses inChina are part of the very unsettled climate conditions experienced across the Northern Hemispheric world during the *** isolating theENSO-induced precipitation from the reconstructed summer precipitation changes,our results indicate that the Laki eruption did cause severedrought in monsoon China during the next three *** drought responses in the 1783e1784 were largely counter-balanced by the wettinginduced by the concurring strong El Ni~no *** results help to enhance our understanding of the hydroclimate consequence of NH highlatitude volcanic eruption in China,and the potential role climate interna

关键词： 1783‒1784 CE Laki eruption Hydroclimatic anomalies China El Nino Proxy reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：