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Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism

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World Journal of Gastroenterology 2012年第25期18卷 3282-3287页

作者： Shu Zhao Hong Sha Zhang-Yong Li, chao-shi ren Institute of BiomedicalEngineering Chinese Academy of Medical Sciences and PekingUnion Medical College Tianjin 300192 China College of Bioinformation Chongqing Univer-sity of Posts and Telecommunications Chongqing 400065 China

AIM： To introduce a bioimpedance gastric motility mea- surement method based on an electrical-mechanical composite concept and a preliminary clinical application. METHODS： A noninvasive gastric motility measure- ment method combining electrogastrograrn （EGG） and impedance gastric motility （IGM） test was used. Prelim- inary clinical application studies of patients with func- tional dyspepsia （FD） and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients （mean age 40.9±9.7 years） and 40 healthy volun- teers （mean age 30.9±7.9 years） were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients （mean age 50.5±13.0 years） and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after ***： There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency （PNF） 70.8±25.5 in healthy subjects and 28.3 =t= 16.9 in FD patients, P 〈 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not im- proved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups （PNF 70.4：1：25.5 for healthy subjects and 36.1 4- 21.8 for gastritis patients, P 〈 0.05）. The EGG rhythm of the gastritis patients returned to normal （frequency insta- bility coefficient 2.22±0.43 before treatment and 1.77 ：t： 0.19 one wk after treatment, P 〈 0.05） after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tenden- cy toward improvement but had not reached statistical si

关键词： Gastric motility Electrical bioimpedance Electrical-mechanical composite Electrogastrogram

Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 983-989页

作者： Zhang-yong LI chao-shi ren Shu ZHAO Hong SHA Juan DENG College of Bioinformation Chongqing University of Posts and Telecommunications Chongqing 400065 China nstitute of Biomedical Engineering Chinese Academy of Medical Sciences ＆ Peking Union Medical College Tianjin 300192 China

For some time now,the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine,exocrine secretion,and gastric *** this paper,a noninvasive method to study gastric motility was developed,taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography(EGG).This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity(basic electric rhythm) and the mechanical gastric ***,preliminary clinical studies of healthy subjects and subjects with functional dyspepsia(FD) and gastritis were carried *** impedance gastric motility(IGM) measurements of the healthy and FD subjects were compared,along with the studies of the FD subjects before treatment and after one week and three weeks of *** also compared IGM measurements of healthy subjects and subjects with erosive gastritis,along with the studies of the subjects with erosive gastritis before treatment and after one week of *** show that FD subjects have poor gastric motility(Prence of IGM parameters between the gastritis and healthy subjects(Prend to improvement(P>0.05),These results suggest the possibility of clinic application of the proposed method.

关键词： Gastric motility Electrical bioimpedance Electrogastrography Functional dyspepsia Gastritis

CLE25 peptide regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex

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Journal of Integrative Plant Biology 2019年第10期61卷 1043-1061页

作者： shi-chao ren Xiu-Fen Song Wen-Qiang Chen Ran Lu William J. Lucas Chun-Ming Liu Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Nanxincun 20 Fragrant Hill Beiing 100093 China University of Chinese Academy of Sciences Beiing 100049 China Department of Plant Biology College of Biological Sciences University of California Davis CA 95616 USA Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beiing 100081 China

The phloem, located within the vascular system, is critical for delivery of nutrients and signaling molecules throughout the plant body. Although the morphological process and several factors regulating phloem differentiation have been reported, the molecular mechanism underlying its initiation remains largely unknown. Here, we report that the small peptide-coding gene, CLAVATA 3 (CLV3)/EMBEYO SURROUNDING REGION 25 (CLE25), the expression of which begins in provascular initial cells of 64-cell-staged embryos, and continues in sieve element-procambium stem cells and phloem lineage cells, during postembryonic root development, facilitates phloem initiation in Arabidopsis. Knockout of CLE25 led to delayed protophloem formation, and in situ expression of an antagonistic CLE25G6T peptide compromised the fate-determining periclinal division of the sieve element precursor cell and the continuity of the phloem in roots. In stems of CLE25G6T plants the phloem formation was also compromised, and procambial cells were over-accumulated. Genetic and biochemical analyses indicated that a complex, consisting of the CLE-RESISTANT RECEPTOR KINASE (CLERK) leucinerich repeat (LRR) receptor kinase and the CLV2 LRR receptor- like protein, is involved in perceiving the CLE25 peptide. Similar to CLE25, CLERK was also expressed during early embryogenesis. Taken together, our findings suggest that CLE25 regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex.

关键词： CLE25 peptide CLERK-CLV2 receptor complex

Contributions of Individual Amino Acid Residues to the Endogenous CLV3 Function in Shoot Apical Meristem Maintenance in Arabidopsis

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Molecular Plant 2012年第2期5卷 515-523页

作者： Xiu-Fen Song Da-Li Yu Ting-Ting Xu shi-chao ren Peng Guo Chun-Ming Liu Key Laboratory of Plant Molecular Physiology institute of BotanyChinese Academy of SciencesNanxincun 20Fragrant HillBeijing 100093China Graduate School of Chinese Academy of Sciences Beijing 100049China

As a peptide hormone, CLV3 restricts the stem cell number in shoot apical meristem （SAM） by interacting with CLV1/CLV2/CRN/RPK2 receptor complexes. To elucidate how the function of the CLV3 peptide in SAM maintenance is established at the amino acid （AA） level, alanine substitutions were performed by introducing point mutations to individual residues in the peptide-coding region of CLV3 and its flanking sequences. Constructs carrying such substitutions, expressed under the control of CLV3 regulatory elements, were transformed to the clv3-2 null mutant to evaluate their efficiencies in complementing its defects in SAMs in vivo. These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance. In contrast, substitutions of flanking residues did not impose much damage on CLV3. Complementation of different alanine-substituted constructs was confirmed by measurements of the sizes of SAMs and the WUS expression levels in transgenic plants. These studies established a complete contribution map of individual residues in the peptide-coding region of CLV3 for its function in SAM, which may help to understand peptide hormones in general.

关键词： CLV3 peptide stem cell maintenance amino acid residue contribution.

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电阻抗断层成像与胃排空和胃动力检测

世界华人消化杂志 2008年第8期16卷 799-805页

作者：任超世王妍赵舒中国医学科学院中国协和医科大学生物医学工程研究所天津市300192

电阻抗断层成像(EIT)是继形态、结构成像之后,于近20余年发展,出现的新一代医学成像技术,具有功能成像,无损伤和医学图像监护三大突出优势.其在胃肠领域的最多应用是评价通过胃部的食物流动以替代临床仍然视为胃排空测量金标准的核素法... 详细信息

电阻抗断层成像(EIT)是继形态、结构成像之后,于近20余年发展,出现的新一代医学成像技术,具有功能成像,无损伤和医学图像监护三大突出优势.其在胃肠领域的最多应用是评价通过胃部的食物流动以替代临床仍然视为胃排空测量金标准的核素法.在离体的模型实验中EIT可精确测量玻璃棒/气囊的容积变化.在体实验条件下,EIT能精确测量胃容积(气囊)的变化.EIT胃排空测量与染料稀释法、胃存留法、核素法等有较好的相关性.EIT胃动力测量以置于体表的电极阵列实现无损检测,以实时图像方式直接显示体内胃体的收缩和运动状况,将是胃动力检测与评价手段的重大进步,显示了诱人的应用前景.

关键词：电阻抗断层成像胃排空胃动力生物电阻抗

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生物电阻抗胃动力检测与评价

世界华人消化杂志 2010年第1期18卷 1-8页

作者：任超世李章勇赵舒重庆邮电大学生物信息学院重庆市400065 中国医学科学院北京协和医学院生物医学工程研究所天津市300192

生物电阻抗技术是一种利用组织与器官的电特性及其变化规律提取与人体生理、病理状况相联系的生物医学信息的检测技术,具有无创、廉价、方便和功能信息丰富等特点.采用生物阻抗方法,依据胃组织和胃内食物的电特性及其在消化过程中的变... 详细信息

生物电阻抗技术是一种利用组织与器官的电特性及其变化规律提取与人体生理、病理状况相联系的生物医学信息的检测技术,具有无创、廉价、方便和功能信息丰富等特点.采用生物阻抗方法,依据胃组织和胃内食物的电特性及其在消化过程中的变化规律,可提取与胃动力学状况相对应的生理、病理信息,研究胃的收缩、蠕动、传导及排空过程,实现胃动力功能的无创检测与胃运动状况的评价.本文回顾了生物电阻抗胃动力检测方法的发展,总结了阻抗胃动力信号的特征,从胃动力电-机复合机制的认识高度介绍了阻抗胃动力检测方法,综述了阻抗胃动力方法在胃动力基础实验、功能性消化不良患者胃动力检测、胃炎患者的胃动力评价,以及胃癌检测与普查等方面的应用研究,提出了阻抗胃动力方法今后的发展方向.

关键词：胃动力生物电阻抗无创检测电-机复合机制临床应用

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

Intelligent optimization methods of phase-modulation waveform

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Journal of Systems Engineering and Electronics 2022年第4期33卷 916-923页

作者： SUN Jianwei WANG chao shi Qingzhan ren Wenbo YAO Zekun YUAN Naichang College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System National University of Defense TechnologyChangsha 410073China

With the continuous improvement of radar intelligence, it is difficult for traditional countermeasures to achieve ideal results. In order to deal with complex, changeable, and unknown threat signals in the complex electromagnetic environment, a waveform intelligent optimization model based on intelligent optimization algorithm is proposed. By virtue of the universality and fast running speed of the intelligent optimization algorithm, the model can optimize the parameters used to synthesize the countermeasure waveform according to different external signals, so as to improve the countermeasure *** algorithm(GA) and particle swarm optimization(PSO)are used to simulate the intelligent optimization of interruptedsampling and phase-modulation repeater waveform. The experimental results under different radar signal conditions show that the scheme is feasible. The performance comparison between the algorithms and some problems in the experimental results also provide a certain reference for the follow-up work.

关键词： waveform optimization intelligent optimization phase-modulation genetic algorithm(GA) particle swarm optimization(PSO)