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Day surgery model: a new path for hospital high-quality development

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Clinical Research Communications 2024年第2期7卷 1-3页

作者： chao-liang tang Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China.

In the current healthcare system,the day surgery model is increasingly valued and has become an important driving force for the high-quality development of *** day surgery model refers to a medical model where patient... 详细信息

关键词： surgery driving hospital

Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

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Neural Regeneration Research 2020年第10期15卷 1807-1813页

作者： Jun-Mou Hong Yi-Da Hu Xiao-Qing Chai chao-liang tang Department of Vascular Surgery Zhongshan HospitalXiamen UniversityXiamenFujian ProvinceChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor ***1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic vascular *** pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular ***,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous *** studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral *** this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular *** review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

关键词： activin receptor-like kinase 1 aneurysm atherosclerotic plaque endoglin extracellular matrix protein intracranial arteriovenous malformation matrix metalloproteinase pericyte transforming growth factor beta 1 pathway vascular development

Mechanisms and status of research on the protective effects of traditional Chinese medicine against ischemic brain injury

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Traditional Medicine Research 2022年第1期7卷 35-43页

作者： Zhe-Tao Zhang Cheng-Yun Hu Fei-Biao Dai Fei tang chao-liang tang Department of Pharmacy The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China Department of Anesthesiology Anhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of Anesthesiology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Ischemic brain injury occurs when the metabolic needs of brain tissue cannot be met due to insufficient blood supply to the *** is one of the main causes of death and adult disability *** recurrence rate of ischemic brain injury is *** places a heavy economic burden on families and society,and seriously affects human health and quality of *** traditional Chinese medicine,ischemic stroke belongs to the category of“stroke”.The use of traditional Chinese medicine to treat stroke has a long *** years of experimental research,a large amount of theoretical knowledge and practical experience have been *** blood circulation and removing blood stasis is the basis of traditional Chinese medicine theory on the treatment of ischemic *** used single Chinese medicines include Chuangxiong(Ligusticum chuanxiong hort),Danggui(Angelica sinensis),Danshen(Salvia miltiorrhiza Bunge),Honghua(Carthamus tinctorius L.),Mudanpi(Moutan Cortex),and Huangqi(Astragali Radix).Buyang Huanwu decoction,Xinglou Chengqi decoction,Taohong Siwu decoction,and other traditional Chinese medicine prescriptions are believed to have a protective effect against brain damage caused by ischemic *** the development of modern medical technology,the mechanism of traditional Chinese medicine treatments for ischemic brain injury has gradually been *** article reviews the mechanisms of traditional Chinese medicine’s protection against ischemic brain injury and its current clinical application.

关键词： traditional Chinese medicine ischemic brain injury stroke brain protection clinical application

Circularly polarized light emission and detection by chiral inorganic semiconductors

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Frontiers of Optoelectronics 2024年第2期17卷 43-49页

作者： Zha Li Wancai Li Dehui Li Wei tang Huageng liang Huaibing Song chao Chen liang Gao Jiang tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Health Care Center National Center for Global Health and MedicineTokyo 162‑8655Japan Hepato‑Biliary‑Pancreatic Surgery Division Department of SurgeryThe University of Tokyo HospitalTokyo 113‑8655Japan Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China

Chiral inorganic semiconductors with high dissymmetric factor are highly desirable,but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and *** this study,we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr_(3) film and PbS quantum dots(QDs)for circularly polarized light(CPL)emission and detection,*** prepared CsPbBr_(3)/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm,featuring high dissymmetric factor up to around *** electron transition based mechanism is responsible for chirality transfer.

关键词： High dissymmetric factor Circularly polarized light emission Semiconductor Hard template,Chirality

Neuroprotective effect of bispectral index-guided fast-track anesthesia using sevoflurane combined with dexmedetomidine for intracranial aneurysm embolization

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Neural Regeneration Research 2018年第2期13卷 280-288页

作者： chao-liang tang Juan Li Zhe-tao Zhang Bo Zhao Shu-dong Wang Hua-ming Zhang Si Shi Yang Zhang Zhong-yuan Xia Department of Anesthesiology Renmin Hospital of Wuhan University Department of Anesthesiology Anhui Provincial Hospital of Anhui Medical University Department of Pharmacy Anhui Provincial Hospital of Anhui Medical University Department of Neurosurgery Anhui Provincial Hospital of Anhui Medical University

Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//***. cn/）（registration number： ChiCTR-IPR- 16008113）.

关键词： nerve regeneration dexmedetomidine sevoflurane bispectral index fast-track anesthesia embolization of intracranial aneurysm stress response neuroprotection neural regeneration

Dynamic Scene Graph Generation of Point Clouds with Structural Representation Learning

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Tsinghua Science and Technology 2024年第1期29卷 232-243页

作者： chao Qi Jianqin Yin Zhicheng Zhang Jin tang School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China Standard and Metrology Research Institute China Academy of Railway Sciences Corporation LimitedBeijing 100081China

Scene graphs of point clouds help to understand object-level relationships in the 3D *** graph generation methods work on 2D structured data,which cannot be used for the 3D unstructured point cloud *** point-cloud-based methods generate the scene graph with an additional graph structure that needs labor-intensive manual *** address these problems,we explore a method to convert the point clouds into structured data and generate graphs without given ***,we cluster points with similar augmented features into groups and establish their relationships,resulting in an initial structural representation of the point ***,we propose a Dynamic Graph Generation Network(DGGN)to judge the semantic labels of targets of different *** dynamically splits and merges point groups,resulting in a scene graph with high *** show that our methods outperform other baseline *** output reliable graphs describing the object-level relationships without additional manual labeled data.

关键词： scene graph generation structural representation point cloud

Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of Materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei tang chao Hou Hao Lu Zhi Zhao Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were *** on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been *** study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

Structural uncertainty quantification of Reynolds-Averaged Navier–Stokes closures for various shock-wave/boundary layer interaction flows

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Chinese Journal of Aeronautics 2024年第3期37卷 34-48页

作者： Fanzhi ZENG Tianxin ZHANG Denggao tang Jinping LI chao YAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China School of Aeronautical Engineering Air Force Engineering UniversityXi’an 710038China

Accurate prediction of Shock-Wave/Boundary Layer Interaction(SWBLI)flows has been a persistent challenge for linear eddy viscosity models.A major limitation lies in the isotropic representation of the Reynolds stress,as assumed under the Boussinesq *** studies have shown promise in improving the prediction capability for incompressible separation flows by perturbing the Reynolds-stress anisotropy ***,it remains uncertain whether this approach is effective for SWBLI flows,which involve compressibility and *** address this issue,this study systematically quantifies the structural uncertainty of the anisotropy for oblique SWBLI *** eigenspace perturbation method is applied to perturb the anisotropy tensor predicted by the Menter Shear–Stress Transport(SST)model and reveal the impacts of anisotropy on the prediction of quantities of interest,such as separation and reattachment positions,wall static pressure,skin friction,and heat *** results demonstrate the potential and reveal the challenges of eigenspace perturbation in improving the SST ***,a detailed analysis of turbulent characteristics is performed to identify the source of *** findings indicate that eigenspace perturbation primarily affects turbulent shear stress,while the prediction error of the SST model is more related to turbulent kinetic energy.

关键词： Shock-wave/boundary layer interaction(SWBLI) Turbulence models Uncertainty analysis Eigenspace perturbation Anisotropy

Neuroprotective Effects of Dexmedetomidine Preconditioning on Oxygen-glucose Deprivation-reoxygenation Injury in PC12 Cells via Regulation of Ca^2+-STIM1/Orail Signaling

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Current Medical Science 2020年第4期40卷 699-707页

作者： Yi-da HU chao-liang tang Jia-zhen JIANG Hai-yan LV Yuan-bo WU Xiu-de QIN Si SHI Bo ZHAO Xiao-nan ZHU Zhong-yuan XIA Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060China Deparment of Anesihesiology the Firsi Affiliated Hospital of University of Science and Technology of ChinaDivision of LifeSciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Emergency Huashan Hospital NorthFudan UniversiryShanghai 201907China Department of Neurology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 201620China Department of Neurology the First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Neurology Shenzhen Traditional Chinese Medicine Hospitalthe Fourth Clinical Medical College of GuangzhouUniversity of Chinese MedicineShenzhen 518033.China Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Summary:Dexmedetomidine(DEX),a potent and highly selective agonist for a2-adrenergic receptors(a2AR),exerts neuroprotective effects by reducing apoptosis through decreased neuronal Ca^2+***,the exact action mechanism of DEX and its effects on oxygen-glucose deprivation-reoxygenation(OGD/R)injury in vitro are *** demonstrate that DEX pretreatment reduced OGD/R injury in PC12 cells,as evidenced by decreased oxidative stress,autophagy,and neuronal ***,DEX pretreatment decreased the expression levels of stromal interaction molecule 1(STIM1)and calcium release-activated calcium channel protein 1(Orail),and reduced the concentration of intracellular calcium *** addition,variations in cytosolic calcium concentration altered apoptosis rate of PC12 cells after exposure to hypoxic conditions,which were modulated through STIM 1/Orail ***,DEX pretreatment decreased the expression levels of Beclin-1 and microtubule-associated protein 1A/1B-light chain 3(LC3),hallmark markers of autophagy,and the formation of *** conclusion,these results suggested that DEX exerts neuroprotective effects against oxidative stress,autophagy,and neuronal apoptosis afier OGD/R injury via modulation of Caf-STIM1/Orai1 *** results offer insights into the molecular mechanisms of DEX in protecting against neuronal ischemia-reperfusion injury.

关键词： dexmedetomidine neuroprotection Ca^2+ STIM1/Orai 1 autophagy PC12 cells neuronal apoptosis