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Fracture of Extensively Porous-Coated Cylindrical Femoral Stem Following Revision Total Hip Arthroplasty

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Chinese Medical Journal 2016年第11期129卷 1374-1376页

作者： chao-fan zhang Chun Hoi Yan Fu Yuen Ng Ping Keung Chan Kwong Yuen Chiu Department of Orthopaedics and Traumatelogy The University of Hong Kong Queen Mary Hospital Hong Kong SAR China Department of Orthopaedics The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350004 China Department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen Hospital Shenzhen Guangdong 518053 China

Total hip arthroplasty （THA） is one of the most clinically successful surgeries. Despite the prevalence of THA, the number of revisions for septic or aseptic reasons continues to increase.

关键词： Extensively Porous-coated Stem Femoral Stem Fracture Revision Total Hip Arthroplasty

New SNP variants of MARVELD2(DFNB49) associated with non-syndromic hearing loss in Chinese population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第2期20卷 164-169页

作者： Jing ZHENG Wen-fang MENG chao-fan zhang Han-qing LIU Juan YAO Hui WANG Ye CHEN Min-xin GUAN Division of Medical Genetics and Genomics the Children's HospitalZhejiang University School of Medicine Institute of Genetics Zhejiang University Attardi Institute of Mitochondrial Biomedicine School of Laboratory Medicine and Life SciencesWenzhou Medical University

Non-syndromic hearing loss(NSHL)is a common defect in *** of MARVELD2 at the DFNB49 locus have been shown to cause bilateral,moderate to profound ***,the role of MARVELD2 in NSHL susceptibility in the Chinese population has not been *** we conducted a case-control study in an eastern Chinese population to profile the spectrum and frequency of MARVELD2 variants,as well as the association of MARVELD2 gene variants with *** results showed that variants identified in the Chinese population are significantly different from those reported in Slovak,Hungarian,and Czech Roma,as well as Pakistani *** identified 11 variants in a cohort of 283 NSHL cases.

关键词： MARVELD2 Non-syndromic hearing loss(NSHL) non-syndromic hearing

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-chao zhang Wu Ning Hai-Bin Liu Hua Yang chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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基于多元时间序列融合的飞行动作识别方法

空军工程大学学报（自然科学版） 2017年第4期18卷 34-39页

作者：周超樊蓉张戈黄震宇空军工程大学航空航天工程学院西安710038

针对飞行动作数据随机性强与长度不一致的问题,提出通过减小动态时间规整(DTW)算法的搜索空间,并定义不同特征参数贡献度的概念,实现对飞行数据的多元时间序列融合,从而完成对战术机动动作的识别。通过引入预分类和细分类结合的方式,对... 详细信息

针对飞行动作数据随机性强与长度不一致的问题,提出通过减小动态时间规整(DTW)算法的搜索空间,并定义不同特征参数贡献度的概念,实现对飞行数据的多元时间序列融合,从而完成对战术机动动作的识别。通过引入预分类和细分类结合的方式,对动作数据进行预处理,然后根据改进的动态时间规整(WDTW)算法对待测数据进行识别。仿真实验表明,相比传统DTW算法,WDTW算法通过降低算法复杂度,识别计算时间变化明显;对核密度与精准度系数的分析表明识别准确率亦有所提高。实验结果验证了所提方法的准确性。

关键词：动作识别动态时间规整多元时间序列数据融合

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang chao Wang Yunhong zhang Hong Liu Yu zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： chao Tan Junling Lü Chunchi zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper chao Li Li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin Li Xin zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

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一种有效带宽模型化估计方法

同济大学学报（自然科学版） 2002年第10期30卷 1262-1266页

作者：范超张大方蔡丽湖南大学计算机与通信学院湖南长沙410082

网络路径的有效带宽是计算机网络性能评价与流量工程中QoS验证中重要的度量参数 ,可广泛应用于根据网络条件进行视频分层传输、区分服务中的带宽分配、服务器选址和拥塞控制中 .但由于有效带宽不仅与路径的链路带宽有关 ,而且随背景流... 详细信息

网络路径的有效带宽是计算机网络性能评价与流量工程中QoS验证中重要的度量参数 ,可广泛应用于根据网络条件进行视频分层传输、区分服务中的带宽分配、服务器选址和拥塞控制中 .但由于有效带宽不仅与路径的链路带宽有关 ,而且随背景流量改变而动态变化 ,这使得端到端有效带宽的测量相当困难 .从Cruz流量模型出发 ,提出有效带宽的估计可以通过对流量进行延时分析实现 ,给出了有效带宽估计的边界 ,并分析了实际测量中可能遇到的问题和解决办法 .

关键词：模型化估计有效带宽端到端测量流量模型突发性约束单向延时计算机网络网络性能