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Laparoscopic intracorporeal anastomosis vs open anastomosis for ileostomy reversal in Crohn's disease:A single center retrospective study

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 105-113页

作者： Wei-Hang liu Mao Xiong Guo-Qing Chen Zhui Long chao Xu li Zhu Jing-Song Wu Department of General Surgery Chongqing General HospitalChongqing 401120China

BACKGROUND There is an increased maturation of laparoscopic intracorporeal anastomosis ***,research on its application for small bowel stoma reversal in patients with Crohn's disease(CD)is ***,in this study,we compared the perioperative outcomes between laparoscopic intracorporeal ileostomy reversal(liIR)and open ileostomy reversal(OIR).AIM To compare the safety,feasibility,bowel function recovery,and short-and longterm liIR and OIR outcomes in patients with *** This study included patients who underwent ileal reversal for CD between January 2021 and January 2023 at our *** baseline data,postoperative recovery,and complication indicators were retrospectively *** regression analysis was conducted to explore factors that significantly influenced the development of enteral nutrition intolerance-related *** Notably,15 of the 45 patients in this study underwent OIR,and the remaining 30 received ***,no statistically significant differences were found between the two groups regarding clinical baseline characteristics,operation time,intraoperative hemorrhage,anastomotic site,enterolysis range,first postoperative flatus,postoperative complications,reoperation rate,or incidence of postoperative enteral nutrition *** with the OIR group,the liIR group had a shorter postoperative hospital stay(P=0.045),lower incidence of enteral nutrition intolerance symptoms(P=0.019),and earlier postoperative total enteral nutrition initiation(P=0.033);however,it incurred higher total hospital costs(P=0.038).Furthermore,multivariate logistic regression analysis revealed that the duration of surgery and anastomotic technique were independent risk factors for postoperative symptoms of enteral nutrition intolerance(P<0.05).CONCLUSION Laparoscopic intracorporeal anastomosis for ileostomy reversal is safe and *** who underwent this technique demonstrated improved tolerance to postoperat

关键词： Crohn’s disease Ileostomy reversal Laparoscopic intracorporeal anastomosis Enteral nutrition intolerance Total enteral nutrition

Inter3D:Capture of TAD Reorganization Endows Variant Patterns of Gene Transcription

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 69-84页

作者： Tianyi Ding Shaliu Fu Xiaoyu Zhang fan Yang Jixing Zhang Haowen Xu Jiaqi Yang chaoqun Chen Yibing Shi Yiran Bai Wannian li Xindi Chang Shanjin Wang chao Zhang Qi liu He Zhang State Key Laboratory of Cardiology and Medical Innovation Center Institute for Regenerative MedicineShanghai East HospitalFrontier Science Research Center for Stem CellsSchool of Life Science and TechnologyTongji UniversityShanghai 200092China Jiangxi Province Key Laboratory of Organ Development and Epigenetics Clinical Medical Research CenterAffiliated Hospital of Jinggangshan UniversityMedical Department of Jinggangshan UniversityJi'an 343009China School of life Science Jinggangshan UniversityJi'an 343009China

Topologically associating domain(TAD)reorganization commonly occurs in the cell nucleus and contributes to gene activation and inhibition through the separation or fusion of adjacent ***,functional genes impacted by TAD alteration and the underlying mechanism of TAD reorganization regulating gene transcription remain to be fully ***,we first developed a novel approach termed Inter3D to specifically identify genes regulated by TAD *** study revealed that the segregation of TADs led to the disruption of intrachromosomal looping at the myosin light chain 12B(MYL12B)locus,via the meticulous reorganization of TADs mediating epigenomic landscapes within tumor cells,thereby exhibiting a significant correlation with the down-regulation of its transcriptional ***,the fusion of TADs facilitated intrachromosomal interactions,suggesting a potential association with the activation of cytochrome P450 family 27 subfamily B member 1(CYP27B1).Our study provides comprehensive insight into the capture of TAD rearrangement-mediated gene loci and moves toward understanding the functional role of TAD reorganization in gene *** Inter3D pipeline developed in this study is freely available at https://***/bm2-lab/inter3D and https://***/biocode/tool/BT7399.

关键词： Topologically associating domain Inter3D Chromosomal loop Gene transcription Cancer

Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice

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Current Medical Science 2024年第1期44卷 110-120页

作者： Chang-zhi ZHOU Xiong XIONG Wei-jun TAN Ya-fei WANG Zhen YANG Xue-ying li Xiu-wen YANG Xiao-fan liU Sun-feng YU liang-chao WANG Shuang GENG Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Objective The function of Bcl-6 in T follicular helper(Tfh)cell maturation is indispensable,and Tfh cells play a pivotal role in *** study investigated the impact of Bcl-6 on asthmatic *** The microscopic pathological alterations,airway resistance(AR),and lung compliance(LC)were determined in asthmatic mice and Bcl-6 interference *** surface molecular markers of Tfh cells and the Bcl-6 mRNA and protein expression were determined by flow cytometry,RT-qPCR,and Western blotting,*** relationships between the Tfh cell ratio and the IgE and IgG1 concentrations in peripheral blood mononuclear cells(PBMCs)and bronchoalveolar lavage fluid(BALF)were *** Asthmatic inflammatory changes were observed in the lung tissue and were attenuated by Bcl-6 siRNA and dexamethasone(DXM).Asthmatic mice exhibited an increased AR and a decreased LC,while Bcl-6 siRNA or DXM mitigated these *** percentages of Tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after Bcl-6 inhibition or DXM ***-qPCR and Western blotting analyses revealed that the Bcl-6 expression level in PBMCs was significantly higher in asthmatic mice,and it decreased following Bcl-6 inhibition or DXM *** IgE expression in the serum and BALF and the B cell expression in PBMCs exhibited a similar *** asthmatic mice,the ratio of Tfh cells in the peripheral blood showed a strong positive correlation with the IgE levels in the serum and BALF,but not with the IgG1 *** The amelioration of airway inflammation and airway hyper-responsiveness is achieved through Bcl-6 suppression,which effectively hinders Tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： Bcl-6 Tfh asthma airway hyper-responsiveness mouse model

Intervention Strategies for the National Project of Workplace Health Promotion in China

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Biomedical and Environmental Sciences 2015年第5期28卷 396-400页

作者： li Shuang li Tao li chao lin WANG chao National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and Prevention

The World Health Organization＇s （WHO） definition of health is：‘A state of complete physical, mental, and social well-being, and not merely the absence of disease＇. This definition has changed the perception of ＇no disease is healthy＇ and given the public a new way to think about health and its influencing factors. The public＇s perception has changed from receiving health education passively to promoting their health actively by improving their own capacity, health perception, and performance.

关键词：工作场所基因健康促进健康教育世界卫生组织一氧化氮胰岛素中国

抽水蓄能电站电缆敷设中三维设计软件运用探析

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电力设备管理 2025年第2期 204-206页

作者：孙帆石爽李希哲姜继鼎于滨张明中国电建集团西北勘测设计研究院有限公司北京博超时代软件有限公司

本文针对电站电缆敷设中三维设计软件的运用问题展开探讨,总结了三维设计软件在电缆敷设过程中的应用优势和流程,对多种三维设计软件进行分析,并基于电缆施工管理系统(CCM)软件,提出了三维设计软件在电缆敷设过程中的具体应用对策,包括... 详细信息

本文针对电站电缆敷设中三维设计软件的运用问题展开探讨,总结了三维设计软件在电缆敷设过程中的应用优势和流程,对多种三维设计软件进行分析,并基于电缆施工管理系统(CCM)软件,提出了三维设计软件在电缆敷设过程中的具体应用对策,包括建模优化、敷设方案的设计等多个方面,实现了对于电站电缆敷设的合理设计。

关键词：抽水蓄能电站电缆敷设三维设计软件

Influence of oxide scales on the corrosion behaviors of B510L hot-rolled steel strips

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International Journal of Minerals,Metallurgy and Materials 2016年第7期23卷 769-778页

作者： Cheng Man chao-fang Dong Hui-bin Xue Kui Xiao Xiao-gang li Hui-bin Qi Key Laboratory for Corrosion and Protection(MOE) University of Science and Technology BeijingBeijing 100083China Ningbo Institute of Material Technology and Engineering Chinese Academy of SciencesNingbo 315201China BaoSteel Group Technological Center Shanghai 201900China

The influence of oxide scales on the corrosion behaviors of B510 L hot-rolled steel strips was investigated in this study. Focused ion beams and scanning electron microscopy were used to observe the morphologies of oxide scales on the surface and cross sections of the hot-rolled steel. Raman spectroscopy and X-ray diffraction were used for the phase analysis of the oxide scales and corrosion products. The corrosion potential and impedance were measured by anodic polarization and electrochemical impedance spectroscopy. According to the results, oxide scales on the hot-rolled strips mainly comprise iron and iron oxides. The correlation between mass gain and test time follows a power exponential rule in the damp-heat test. The corrosion products are found to be mainly composed of γ-Fe OOH, Fe3O4, ？-Fe OOH, and γ-Fe2O3. The contents of the corrosion products are different on the surfaces of the steels with and without oxide scales. The steel with oxide scales is found to show a higher corrosion resistance and lower corrosion rate.

关键词： strip steel hot rolling focused ion beams Raman spectroscopy oxide scale corrosion

An Attribute-Based Ring Signature Scheme in Lattice

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Wuhan University Journal of Natural Sciences 2012年第4期17卷 297-301页

作者： li Wei fan Mingyu JIA Zhenhong School of Computer Science and Engineering Universityof Electronic Science and Technology of China Chengdu 610054Sichuan China School of Information Science and Engineering XinjiangUniversity Urumqi 830046 Xinjiang China

An attribute-based ring signature scheme in lattice was proposed in this paper. In this signature scheme, an entity’s attributes correspond to the columns of a lattice matrix, and the signature was generated by using a subset of these attributes. The entities possessing these attributes form a ring. The scheme is computationally efficient than the schemes based on the integer factor problem and discrete logarithm problem, furthermore it is still secure in quantum computing environment.

关键词： ring signature attribute Bonsai tree model lattice

Kinetic Monte Carlo code development and application on the formation of hydrogen-vacancy clusters in tungsten

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Science China(Physics,Mechanics & Astronomy) 2019年第1期62卷 83-89页

作者： chao Meng JianNan Hao Ke Xu li-fang Wang Xiaolin Shu Shuo Jin Guang-Hong Lu Department of Physics Beihang University Beijing Key Laboratory of Advanced Nuclear Materials & Physics Beihang University

We have developed an object kinetic Monte Carlo(OKMC)code and simulated hydrogen-vacancy clustering behavior and dependence on temperature and hydrogen-vacancy ratio in *** each of the temperatures we simulated from 300 K to1000 K,H_nV clusters with smaller n form before those with larger *** elevating temperature leads to a decrease in hydrogen vacancies:H_(10)V and H_9V clusters dominate at 300 K and 600 K,whereas H_5V,H_6V,and H_7V clusters dominate when the temperature reaches 1000 ***,only H_nV clusters with smaller n formed when a lower hydrogen-vacancy ratio was used due to insufficient availability of hydrogen atoms to occupy *** results suggest hydrogen emission occurs very rarely at lower temperatures,while higher temperatures facilitate the dissociation of hydrogen from H_nV clusters.

关键词： tungsten hydrogen vacancy KMC

Numerical study of the mechanical process of long-distance replacement of the definitive lining in severely damaged highway tunnels

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Underground Space 2023年第2期9卷 200-217页

作者： Xinrong liu Yang Zhuang Xiaohan Zhou chao li BinBin lin Ninghui liang Zuliang Zhong Zhiyun Deng School of Civil Engineering Chongqing UniversityChongqing 400045China National Joint Engineering Research Center of Geohazards Prevention in The Reservoir Areas Chongqing 400045China College of Civil Engineering Guizhou UniversityGuizhou 550025China Department of Hydraulic Engineering Tsinghua UniversityBeijing 100084China

Mountain road tunnels are prone to water leakage and lining corrosion under the complex geological conditions and corrosive envi-ronments,which will reduce the strength of the lining structure until it loses its load-bearing capacity;eventually,the definitive lining will need to be *** this paper,a highway tunnel in a mountainous area in Southwest China is taken as an *** investi-gation found that the tunnel was seriously corroded by sulfate,the strength of the definitive lining decreased,and large-scale cracks and spalling appeared on the surface,so the operator decided to replace the definitive lining by the method of interval *** on the data obtained from drilling and coring,a numerical model of long-distance replacement of the definitive lining of the damaged tunnel is ***,the back analysis of the calculation parameters is carried out,and the modified calculation results are com-pared with the field monitoring results for ***,the deformation trend of the tunnel and the development of the plastic zone during the process of long-distance replacement of the definitive lining are ***,the construction scheme is ***-ical analysis results show that the replacement of the definitive lining of the tunnel mainly leads to the settlement of the arch crown and the uplift of the inverted *** deformation of the tunnel shows two rapid growth stages and two stable stages during the replace-ment process;after replacement,the deformation of the arch crown and the inverted arch is divided into two buffer zones and one stable *** the progress of the replacement of the definitive lining,the plastic zone does not *** the reinforcement measures,with the increase in the grouting range,the grouting efficiency decreases,and the effect of the temporary steel arch on controlling the overall deformation is not *** length of the replacement of the single section should be determin

关键词： Deteriorated tunnel Long-distance replacement of the definitive lining Back analysis Reinforcement measures Numerical simulation