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Clinical characteristics,diagnosis,and treatment of COVID-19:A case report

World Journal of Clinical Cases 2020年第11期8卷 2325-2331页

作者： Yan-Fei He Shi-Jie Lian yu-chao dong Cadre Health Care Department The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Respiratory and Critical Care Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China

BACKGROUND Since December 2019,many cases of pneumonia caused by novel coronavirus have been discovered in Wuhan,China,and such cases have spread nationwide *** present,coronavirus disease 2019(COVID-19)is a worldwide *** are the clinical features of this disease?What is the clinical diagnosis and how should such patients be treated?As a clinician,mastery of the clinical characteristics,basic diagnosis,and treatment methods of COVID-19 are required to provide help to *** SUMMARY A 42-year-old male patient with a cough lasting 6 d without obvious cause,as well as fever and fatigue for 1 d,was admitted to Hankou Hospital on January 22,2020 and transferred to Huoshenshan Hospital on February *** main clinical symptoms were dry cough,fatigue,and *** was diagnosed with *** the 4th d of admission,the patient’s condition gradually worsened,with increased respiratory rate and body *** blood lymphocytes decreased *** the 8th d of admission,the patient’s highest temperature was 40.7°C,and oxygen saturation was 83%despite high-flow oxygen *** computed tomography results showed that the virus progressed *** number of lesions significantly increased with expanded scope and increased *** distribution of lesions advanced from peripheral to *** addition to nasal catheter oxygen inhalation and symptomatic support,antiviral drugs were used throughout the *** January 22,oseltamivir phosphate capsules were given orally(75 mg,twice daily)for 6 *** January 24,three tablets of lopinavir and ritonavir were added orally(twice daily).After 6 d,this was changed to 0.2 g(two tablets)arbidol,taken orally(three times daily)for 5 *** the severe stage,methylprednisolone was given(40 mg)once every 12 h,immunoglobulin(20 g)was administered by intravenous drip infusion once daily,and thymosin(1.6 mg)was injected subcutaneously once daily combined with *** Februar

关键词： COVID-19 SARS-CoV-2 Clinical characteristics Diagnosis and treatment Young adults Case report

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Randomized trial on the application of biofragmentable anastomosis ring in intestinal anastomosis

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Chinese Medical Journal 2009年第15期122卷 1755-1758页

作者： CHEN Shuang YANG Bin HE Jia-hui ZHANG yu-chao LAI dong-ming Department of Gastrointestinal Surgery Second Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background The biofragmentable anastomosis ring （BAR） is a simple alternative device to create intestinal anastomosis. Our study was designed to evaluate the clinical value of BAR in intestinal anastomosis. Methods A total of 167 patients performed intestinal anastomosis from January 2002 to February 2006 were randomized to BAR group （n=82） and manual suture group （n=-85） as control. They were equally allocated to the two groups regarding sex, age, site of anastomosis, emergent or elective surgery and contaminant diseases. The results of postoperative complications and recovery were recorded in each group. Results Eighty-seven intraperitoneal BAR anastomoses were completed in 82 patients. Two and one postoperative deaths were recorded in BAR and suture group, respectively, no deaths were directly related to anastomotic technique. In suture group, anastomotic leakage and early bleeding both occurred in two patients respectively, no anastomotic bleeding occurred in BAR group, one patient in BAR group developed enterocutaneous fistulae. Perioperative bleeding, operation time and length of hospitalization were similar in two groups （P 〉0.05）. Time for return of bowel function was significantly shortened in BAR group than that in suture group （P 〈0.05）. Conclusion The BAR appears to be a standard, easy, safe and effective alternative either in elective or emergent intraperitoneal intestinal anastomotic surgery.

关键词： biofragmentable anastomosis ring intestinal anastomosis complications

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Citation Classics in Asthma Research： The 100 Top-Cited Articles During 1960-2014

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Chinese Medical Journal 2018年第9期131卷 1115-1116页

作者： Sha Li Cheng-Jie Zhu yu-Lan Qu yu-chao dong Yan Shang Chong Bai Department of Respiratory and Critical Care Medicine Changhai HospitalSecond Military Medical University Shanghai 200433China Section of Health No. 94804 Unit of People's Liberation Army Shanghai 200434 China Department of Respiratory Medicine Haining People's Hospital of Zhejiang Province Haining Zhejiang 314400 China

To the Editor：Asthma poses a serious health problem *** of all ages can be affected by this chronic airway disorder that,when uncontrolled,may place severe limits on daily life and is sometimes *** prevalence of asthma is increasing in most countries throughout the world,especially among children.[1]During the past decades,many scientific advances have been made to improve our understanding of asthma and our ability to manage and control it *** advances are mainly reflected by related scientific articles,particularly by those most influential papers.

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Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-Qian Wang Yin Zhang Wei-Wei Wang Mei-Qian Fu Hong-Bing Mo Wei-dong yu chao Liu Jun Yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

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Apoptosis of Lewis Lung Carcinoma Cells Induced by Microwave via p53 and Proapoptotic Proteins In vivo

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Chinese Medical Journal 2017年第1期130卷 15-22页

作者： Kou-dong Zhang Lin-Rong Tong Shui-Ming Wang Rui-yun Peng Hai-dong Huang yu-chao dong Xing-Xing Zhang Qiang Li Chong Bai Department of Respiratory and Critical Care Medicine Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Respiratory Medicine Yancheng First People's Hospital Yancheng Jiangsu 224000 China Department of Respiratory Medicine Chenggong Hospital Xiamen University Xiamen Fujian 361000 China Institute of Radiation Medicine The Academy of Military Medical Sciences Beijing 100850 China

Background： Microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. However, its therapeutic application in non-small-cell lung cancer and the underlying mechanism remains to be investigated. This study aimed to investigate its effect on Lewis lung carcinoma （LLC） tumor in vivo. Methods： Fifty LLC tumor-bearing C57BL/6 mice were adopted to assess the effect of microwave radiation on the growth and apoptosis of LLC tumor in vivo. These mice were randomly assigned to 10 groups with 5 mice in each group. Five groups were treated by single pulse microwave at different doses for different time, and the other five groups were radiated by multiple-pulse treatment of a single dose. Apoptosis of cancer cells was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Western blotting was applied to detect the expression of proteins. Results： Single pulse of microwave radiation for 5 min had little effect on the mice. Only 15-min microwave radiation at 30 mW/cm2 significantly increased the mice body temperature （2.20 ± 0.82）℃ as compared with the other groups （0.78 ± 0.29 ℃, 1.24 ± 0.52 ℃, 0.78 ± 0.42 ℃, respectively）, but it did not affect the apoptosis of LLC tumor cells significantly. Continous microwave radiation exposure, single dose microwave radiation once per day for up to seven days, inhibited cell division and induced apoptosis of LLC tumor cells in a dose- and duration-dependent manner. It upregulated the protein levels of p53, Caspase 3, Bax and downregulated Bcl-2 protein. Conclusions： Multiple exposures of LLC-bearing mice to microwave radiation effectively induced tumor cell apoptosis at least partly by upregulating proapoptotic proteins and downregulating antiapoptotic proteins. Continuous radiation at low microwave intensity Ibr a short time per day is promising in treating non-small-cell lung cancer.

关键词： Apoptosis Lewis Lung Carcinoma Cells Microwave Radiation Non-small-cell Lung Cancer

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： chao Tan Junling Lü Chunchi Zhang dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Study on Influence of Farmers' Relational Network on Their Undertaking Process

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Asian Agricultural Research 2012年第3期4卷 41-45页

作者： LI chao-dong,yu Tong-tao College of Sociology and Political Science,Anhui University,Hefei 230601,China

We elaborate relevant theories of farmers' relational network,including the Differential Model of Association,the Strength of Weak Tie,Strength of Strong Tie and Favor and *** farmers' relational network in the Differential Model of Association can be divided into three layers:strong tie,weak tie and irrelative relationship according to Granovetter *** three layers have deep influence on opportunity selection during the undertaking,financing and enterprise *** rational knowledge of these layers,farmers may exploit undertaking *** the basis of these,we made detailed analysis on farmers' selection of relations in the opportunity selection,financing and enterprise development stages.

关键词： Relational network Farmer’s undertaking Differenti

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Neuropeptide S attenuates defensive and risk assessment behaviors induced by alarm pheromones through activation of cognate receptor-expressing neurons in the posterior medial amygdala

Neuropeptide S attenuates defensive and risk assessment beha...

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中国神经科学学会第十二届全国学术会议

作者： yu-Feng SHAO Can WANG Jun-Fan XIE chao-yu CONG Le XIN Guang-Fu CUI Lin-Xin WANG yu-Nong CHEN chao-yu dong Jing LI Yi-Ping HOU Departments of Neuroscience Anatomy Histology and Embryology Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou University

Objective Our previous studies have demonstrated that neuropeptide S(NPS) respectively facilitates olfactory function and ameliorates olfactory spatial memory impairment through selective activation of the neurons bearing NPS receptor(NPSR) in the olfactory cortex and the subiculum complex. High level expression of NPSR m RNA in the posterior medial amygdala suggests that NPS-NPSR system might be involved in the regulation of defensive and risk assessment behaviors induced by alarm pheromones(APs). The present study was undertaken to investigate that the effect of intracerebroventricular(i.c.v.) injection of NPS or co-injection of NPSR antagonist on APs-induced defensive and risk assessment behaviors, and the NPS-induced activated neurons in the posterodorsal medial amygdaloid nuclei(MePD) and posteroventral medial amygdaloid nuclei(Me PV) in mice, respectively. Methods APs was harvested by electrical stimulation of the donor mouse’s perianal region, and control was collected by electrical stimulation of the neck skin. A modified open field chamber was used to detect the defensive and risk assessment behaviors. The potential neuronal targets of NPS in the Me PV and MePD were identified with c-Fos immunohistochemistry, and the coexpression of NPSR in the NPS-induced activated neurons was examined with dualimmunofluorescence. Results(1) APs significantly reduced the outside duration(p < 0.01) and walking distance(p < 0.01), meanwhile increased the conceal duration(p < 0.01) and headout duration(p < 0.01) compared to control.(2) Central administration of a range dose(0.1, 0.5 and 1 nmol) of NPS attenuated the APs-induced defensive and risk assessment behaviors. The dose of 0.5 nmol NPS showed the most effective.(3) [D-Val] NPS, a selective antagonist of NPSR, dosed at 20 and 40 nmol(i.c.v.) significantly dosedependently antagonized the inhibitory effects of NPS(0.5 nmol) on APs-induced defensive and risk assessment behaviors.(4) In comparison with vehicle, NPS signific

关键词： neuropeptide S neuropeptide S receptor defensive and risk assessment behaviors posterior medial amygdala alarm pheromones

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi yu-Xin Yang Bao-Xia dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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