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Numerical Study of a Confined Axisymmetric Jet Impingement Heat Transfer with Nanofluids

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Engineering（科研） 2013年第1期5卷 69-74页

作者： Jun-Bo Huang Jiin-yuh Jang Department of Mechanical Engineering National Cheng-Kung University Tainan Taiwan 70101

A numerical simulation on confined impinging circular jet working with a mixture of water and Al2O3 nanoparticles is investigated. The flow is turbulent and a constant heat flux is applied on the heated plate. A two-phase mixture model approach has been adopted. Different nozzle-to-plate distance, nanoparticle volume concentrations and Reynolds number have been considered to study the thermal performances of the system in terms of local, average and stagnation point Nusselt number. The local Nusselt number profiles show that the highest values within the stagnation point region, and the lowest at the end of the heated plate. It is observed that the average Nusselt number increases for increasing nanoparticle concentrations, moreover, the highest values are observed for H/D=5, and a maximum increase of 10% is obtained at a concentration equal to 5%.

关键词： Nanofluid Confined Jet Turbulent flow

Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress

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World Journal of Cardiology 2010年第12期2卷 421-427页

作者： yuh Fen Pung William M Chilian Department of Integrative Medical Sciences Northeastern Ohio Universities College of Medicine and Pharmacy

The myocardium adapts to ischemic insults in a variety of *** adaptation is the phenomenon of acute preconditioning,which can greatly ameliorate ischemic ***,this effect wanes within a few hours and does not confer chronic protection.A more chronic adaptation is the so-called second window of preconditioning,which enables protection for a few *** most potent adaptation invoked by the myocardium to minimize the effects of ischemia is the growth of blood vessels in the heart,angiogenesis and arteriogenesis (collateral growth),which prevent the development of ischemia by enabling flow to a jeopardized region of the *** brief review examines the mechanisms underlying angiogenesis and arteriogenesis in the *** concept of a redox window,which is an optimal redox state for vascular growth,is discussed along with signaling mechanisms invoked by reactive oxygen species that are stimulated during ***,the review discusses of some of the pathologies,especially the metabolic syndrome,that negatively affect collateral growth through the corruption of redox signaling processes.

关键词： Angiogenesis Arteriogenesis Redox-dependent signaling Mitochondria

Comment on: Bibliometric analysis of glaucoma-related literature based on SCIE database: a 10-year literature analysis from 2009 to 2018

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1356-1356页

作者： yuh-Shan Ho Trend Research Centre Asia UniversityWufengTaichung 41354TaiwanChina

Dear Editor,Sun et al[1]recently published a bibliometric paper in the International Journal of Ophthalmology entitled“Bibliometric analysis of glaucoma-related literature based on SCIE database:a 10-year literature analysis from 2009 to 2018”.The authors mentioned in section MATERIALS AND METHODS that“SCIE database established by Institute for Scientific Information(ISI)was used for the purpose of this study.”and“The search strategy was as follows:theme=(glaucoma OR ocular hypertension),and the‘theme’field contains:title,abstract,author keywords,and keywords *** type=(article),and other types of articles,such as case reports,reviews,letters to the editors,and so on,were *** time period of publications was focused on the latest 10y from 2009 to *** the search date was 2019-3-29.”

关键词： SCIE database analysis

Control of dendrite morphogenesis

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Control of dendrite morphogenesis

Comment on “Selective adsorption of tannins onto hide collagen fibres”

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： yuh-Nung Jan HHM UCSF

＜正＞For the past 10 years,we have been trying to uncover the rules and the mechanisms that control dendrite morphogenesis by using a group of Drosophila larval sensory neurons known as dendritic arborization（da） neurons. We have gained some insights into dendrite development including how axons and dendrites are made differently, how a neuron acquires its neuronal type specific morphology,how the dendrites of different neurons are organized, how the size of a dendritic arbor is controlled,and how the pruning and remodeling of dendrites are regulated during *** have also begun to study the relationship between neuronal function and dendritic morphology by using those da *** order to study another important aspect of dendrite morphogeneis,namely,the potential role of sensory stimulation dependent dendritic plasticity in neuronal circuit wiring,we have recently started using as an assay system,another group of Drosophila larval neuron known as larval ventral lateral neurons（LNv’s）,which are part of larval light sensing circuits required for the entrainment to environmental light dark cycles and for larval light avoidance *** found that the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the LNV’s and concomitant changes of their physiological ***,our genetic analyses have begun to identify critical molecular components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.

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Science China Chemistry 2005年第2期48卷 176-176页

作者： yuh-Shan Ho School of Public Health Taipei Medical University 250 Wu-Hsing Street Taipei 11014 China

In a recent publication by Liao et al.[1], the section 1.3 Modeling of adsorption kinetics, authors mentioned a pseudo- second-order model from eq. (3) to eq. (5). In fact, the second order kinetic expression for the adsorption systems of divalent metal ions using sphagnum moss peat has been reported by Ho[2]. In order to distinguish the kinetics equation based on adsorption capacity of solid from concentration of solution, Ho's second order rate expression has been named pseudo-second order[2-5]. The most frequently cited papers were published in Chemical Engineering Journal[3], Process Biochemistry[4] and Water Research[5].

关键词： Comment on Selective adsorption of tannins onto hide collagen fibres Ho

Biomarkers in Acute Kidney Injury

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Open Journal of Nephrology 2013年第1期3卷 51-60页

作者： Cai-Mei Zheng Min-Tser Liao Mei-Yu Lin Lan Lo Chia-chao Wu Yung-Ho Hsu yuh-Feng Lin Kuo-Cheng Lu Department of Medicine Cardinal Tien Hospital School of Medicine Fu Jen Catholic University New Taipei City Chinese Taipei Department of Pediatrics Taoyuan Armed Forces General Hospital Chinese Taipei Division of Nephrology Department of Medicine Taipei Medical University-Shuang Ho Hospital Taipei Medical University Chinese Taipei Division of Nephrology Department of Medicine Tri-Service General Hospital National Defense Medical Center Chinese Taipei

Acute kidney injury (AKI) is one of the popular topics of discussions due to increasing development of biomarkers recently. The disease progression and prognosis may be determined by these biomarkers detected in blood and urine specimens. Since acute kidney injury is associated with a broad spectrum of disease conditions, prevention and early detection of AKI becomes very important in those clinical settings. Early measurements of AKI biomarkers predict subsequent development of intrinsic AKI, dialysis requirement, duration of intensive care unit stay and finally affect mortality. We, here, discuss the acute kidney injury in different clinical situations and associated natures of biomarkers, which may help us guide to prevent and treat AKI more effectively.

关键词： Acute Kidney Injury Critical Care Centers Biomarkers Renal Replacement Therapy

Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants

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Molecular Plant 2015年第7期8卷 1011-1023页

作者： Zhaosheng Kong Motohide Ioki Siobhan Braybrook Shundai Li Zheng-Hua Ye yuh-Ru Julie Lee Takashi Hotta Anny Chang Juan Tian Guangda Wang Bo Liu Department of Plant Biology University of California Davis CA 95616 USA State Key Laboratory of Plant Genomics Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Sainsbury Laboratory Cambridge University of Cambridge Cambridge CB2 1LR UK Department of Biochemistry and Molecular Biology Pennsylvania State University State College PA 16802 USA Department of Plant Biology University of Georgia Athens GA 30602 USA Present address: Center for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies Onogawa 16-2 Tsukuba Ibaraki305-8506 Japan Present address: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5 Takayama Ikoma Nara 630-0192 Japan

In plants, anisotropic cell expansion depends on cortical microtubules that serve as tracks along which macromolecules and vesicles are transported by the motor kinesins of unknown identities. We used cotton （Gossypium hirsutum） fibers that underwent robust elongation to discover kinesins that are involved in cell elongation and found Gh KINESIN-4A expressed abundantly. The motor was detected by immunofluores- cence on vesicle-like structures that were associated with cortical microtubules. In Arabidopsis thaliana, the orthologous motor At KINESIN-4A/FRA1, previously implicated in cellulose deposition during second- ary growth in fiber cells, was examined by live-cell imaging in cells expressing the fluorescently tagged functional protein. The motor decorated vesicle-like particles that exhibit a linear movement along cortical microtubules with an average velocity of 0.89 l^m/min, which was significantly different from those linked to cellulose biosynthesis. We also discovered that At KINESIN-4A/FRA1 and the related At KINESIN-4C play redundant roles in cell wall mechanics, cell elongation, and the axial growth of various vegetative and reproductive organs, as the loss of At KINESIN-4C greatly enhanced the defects caused by a null mutation at the KINESIN-4A/FRA 1 locus. The double mutant displayed a lack of cell wall softening at normal stages of rapid cell elongation. Furthermore, enhanced deposition of arabinose-containing carbohydrate was detected in the kinesin-4 mutants. Our findings established a connection between the Kinesin-4-based transport of cargoes containing non-cellulosic components along cortical microtubules and cell wall mechanics and cell elongation in flowering plants.

关键词： cytoskeleton cytoskeleton-cell wall interactions leaf/vegetative development Arabidopsis cotton

Identification of TM9SF2 as a Candidate of the Cell Surface Marker Common to Breast Carcinoma Cells

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Chinese Journal of Clinical Oncology 2009年第1期6卷 1-9页

作者： Samah Abou-Sharieha yuh Sugii Tuoya Dongwei Yu Ling Chen Heizou Tokutaka Masaharu Seno Department of Medical and BioengineeringScience Graduate School of Natural Science and Technology Okayama UniversityOkayama 700-8530 Japan. SOM Japan Inc. Tottori 680-0941 Japan.

OBJECTIVE We aimed identification of cell surface molecules, which might serve as diagnostic biomarkers or useful targets for therapies, in breast cancer. METHODS We developed unique DNA microarray coupled with spherical self-organizing map （sSOM） analysis to characterize cells and tissues by the cell surface markers. In the microarray 1,797 probes for human genes coding membrane bound proteins were spotted. With this microarray the gene expression profiles of eight breast carcinoma cell lines were compared to identify the genes that were commonly expressed in breast carcinomas but not in normal cells. RESULTS The gene expression profiles of sSOM from the eight breast carcinoma cell lines were successfully distinguished from that of normal breast tissue derived cells suggesting the presence of genes of interest, sSOMon the data extensively filtered revealed several candidate genes, of which expression was significant in carcinoma cells but low in normal cells. Finally, TM9SF2 was nominated through validations of PCR procedures together with CD24 and ErbB3, which are known breast carcinoma markers. TMgSF2 expression was further confirmed by immunological staining. Interestingly, TMgSF2 was found to be expressed in all the cell lines evaluated while CD24 and ErbB3 were not in all of the carcinoma cells, supporting their relationship in sSOM. Although physiological significance of TMgSF2 is unknown yet, siRNA treatment significantly inhibited the growth of MDA- MB-231 cells. CONCLUSION We propose TM9SF2 as a novel and useful diagnostic marker as well as a potential molecular target specific to breast carcinoma cells covering wide range of breast cancer.

关键词： breast carcinoma cell surface marker spherical self-organizing map DNA microarray TM9SF2.

The newly identified augmin complex is required in the assembly of the acentrosomal microtubule assay in higher plants

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The newly identified augmin complex is required in the assem...