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Relationship Between Microcystin in Drinking Water and Colorectal Cancer

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Biomedical and Environmental Sciences 2002年第2期15卷 166-171页

作者： ZhouL yuh 等 CancerInstitute ZhejiangUniversity SchoolofMedicine ZhejiangUniversity

Objective To investigate the association of microcystin (MC) in drinking water with the incidence of colorectal cancer. Methods The study was designed as a retrospective cohort. Eight townships or towns were randomly selected as the study sites in Haining City of Zhejiang Province, China. 408 cases of colon and rectum carcinomas diagnosed from 1977 to 1996 in the study sites were included, and a survey on types of drinking water of these patients was conducted. Samples of different water sources (well, tap, river and pond) were collected separately and microcystin concentrations were determined by indirect competitive ELISA method. Results The incidence rate of colorectal cancer was significantly higher in population who drank river and pond water than those who drank well and tap water. Compared to well water, the relative risk (RR) for colorectal cancer was 1.88 (tap), 7.94 (river) and 7.70 (pond) respectively. The positive rate (>50 pg/mL) of microcystin in samples of well, tap, river and pond water was 0, 0, 36.23% and 17.14% respectively. The concentration of microcystin in river and pond water was significantly higher than that in well and tap water (P<0.01). Spearman rank correlation analysis showed that in the study sites, the microcystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs= 0.881, P<0.01). Conclusions The types of drinking water are positively associated with the incidence of colorectal cancer in the study sites, and this may be related to microcystin contamination of drinking water. Further biological study is needed to support the possible causative role of mycrocystin in carcinogenesis of colon and rectum.

关键词： Drinking water Microcystin Colorectal cancer

Comment on “Removal of heavy metals from aqueous solution by carbon nanotubes: adsorption equilibrium and kinetics” by Li, Y.H., Di, Z.C., Luan, Z.K., Ding, J., Zuo, H., Wu, X.Q., Xu, C.L. and Wu, D.H.

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Journal of Environmental Sciences 2005年第1期17卷 175-176页

作者： yuh-ShanHo SchoolofPublicHealth TaipeiMedicalUniversity250Wu-HsingStreetTaipei11014TaiwanChina

No abstract available

关键词： Comment on "Removal of heavy metals from aqueous solution by carbon nanotubes:adsorption adsorption equilibrium "

α-Siphons of a Suboptimal Control Model of a Subclass of Petri Nets

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Intelligent Control and Automation 2011年第1期2卷 24-30页

作者： Daniel yuh chao 不详

It has been a hot research topic to synthesize maximally permissive controllers with fewest monitors. So far, all maximally permissive control models for a well-known benchmark are generalized Petri net, which com-plicates the system. In addition, they all relied on time-consuming reachability analysis. Uzam and Zhou ap-ply First-met-bad-marking (FBM) method to the benchmark to achieve a near maximal permissive control policy with the advantage of no weighted control (WC) arcs. To improve the state of the art, it is interesting to synthesize optimal controller with as few weighted arcs as possible since it is unclear how to optimize the control for siphon involving WC arcs, This paper explores the condition to achieve optimal controller with-out WC and defining a new type of siphon, called α-siphon. If the condition is not met, one can apply the technique by Piroddi et al. to synthesize optimal controllers with WC.

关键词： Petri Nets Siphons Controllability FMS S3PR

Role of body mass index in colon cancer patients in Taiwan

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World Journal of Gastroenterology 2012年第31期18卷 4191-4198页

作者： Chih-Chien Chin yi-Hung Kuo Chien-yuh Yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-yi Wang Wen-Shih Huang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalLinko 333Taiwan

AIM： To determine the effect of body mass index （BMI） on the characteristics and overall outcome of colon cancer in Taiwan. METHODS： From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories （in kg/m2） were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival （OS）, disease- free survival （DFS）, and cancer-specific survival （CSS） were compared across the BMI categories.27 kg/m2） patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients （P 〈 0.001）. Underweight patients had higher mortality rate （P = 0.00.7） and lower OS （P 〈 0.001） and DFS （P = 0.002） than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION： In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.

关键词： Body mass index Colon cancer Survival IVlorbidity Outcome

A PAIRING-BASED PUBLICLY VERIFIABLE SECRET SHARING SCHEME

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Journal of Systems Science & Complexity 2011年第1期24卷 186-194页

作者： Tsu-Yang WU yuh-Min TSENG Department of Mathematics National Changhua University of Education Jin-De Campus Chang-Hua 500 Taiwan

A publicly verifiable secret sharing （PVSS） scheme is a verifiable secret sharing scheme with the special property that anyone is able to verify the shares whether they are correctly distributed by a dealer. PVSS plays an important role in many applications such as electronic voting, payment systems with revocable anonymity, and key escrow. Up to now, all PVSS schemes are based on the traditional public-key systems. Recently, the pairing-based cryptography has received much attention from cryp- tographic researchers. Many pairing-based schemes and protocols have been proposed. However, no PVSS scheme using bilinear pairings is proposed. This paper presents the first pairing-based PVSS scheme. In the random oracle model and under the bilinear Diffie-HeUman assumption, the authors prove that the proposed scheme is a secure PVSS scheme.

关键词： Bilinear pairing cryptography random oracle model secret sharing.

Video-assisted thoracoscopic surgery (VATS) for bilateral primary spontaneous pneumothorax

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 335-340页

作者： yi-jen CHEN Shi-ping LUH Kun-yen HSU Cheng-ren CHEN Thomas Chang-yao TSAO Jia-yuh CHEN Department of Medicine Chia-Yi Christian Hospital 600 Chia-Yi Taiwan China Department of Thoracic Surgery Chia-Yi Christian Hospital 600 Chia-Yi Taiwan China Department of Medicine Chung-Shan Medical University 402 Taichung Taiwan China Institute of Life Science National Chung-Cheng University 600 Chia-Yi Taiwan China

Objective： To review our experience of the treatment of bilateral primary spontaneous pneumothorax （PSP） by video-assisted thoracoscopic surgery （VATS）. Materials and methods： Retrospective chart review was followed by an on-clinic or telephone interview. Patients were cared for by one thoracic surgeon in four medical centers or community hospitals in Northern and Central Taiwan. Thirteen patients with bilateral PSP underwent bilateral VATS simultaneously or sequentially from July 1994 to December 2005. Results： Twelve males and one female, with age ranging from 15 to 36 years （mean 23.1 years）, were treated with VATS for bilateral PSP, under the indications of bilateral pneumothoracis simultaneously （n=4） or sequentially （n=9）. The interval between the first and second contra-lateral VATS procedure for non-simultaneous PSP patients ranged from 7 d to 6 years. Eleven of 13 patients （84.6%） had prominent pulmonary bullae/blebs, and underwent bullae resection with mechanical or chemical pleurodesis. The mean operative time was （45.6±18.3） min （range 25-96 min） and （120.6±28.7） min （range 84-166 min） respectively for the non-simultaneous （second VATS for the recurrence of contralateral side after first VATS） and simultaneous （bilateral VATS in one operation） procedures. There was no postoperative mortality. However, prolonged air leakage （〉7 d） occurred in one patient （7.7%） who recovered after conservative treatment. The mean duration of chest tube drainage was 3.1 d and the median follow up period was 3.4 years. Conclusions： VATS is a safe and effective procedure in the treatment of bilateral PSP. Bilateral VATS is only recommended for patients with simultaneously bilateral PSP, because the incidence of recurrence, even with visible bullae, was not so high in my group and in some previous literature. Bilateral VATS in a supine position should only be used in selective cases, because of possible pleural adhesion or hidden bullae on the posterior side.

关键词： Video-assisted thoracoscopic surgery (VATS) Spontaneous pneumothorax (SP)

Anatomizing the Ocean's Role in Maintaining the Pacific Decadal Variability

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Advances in Atmospheric Sciences 2014年第3期31卷 611-623页

作者： Jia-yuh YU Cheng-Wei CHANG Department of Atmospheric Sciences Chinese Culture University Graduate Institute of Earth Science Chinese Culture University

ABSTRACT The role of ocean dynamics in maintaining the Pacific Decadal Variability （PDV） was investigated based on simulation results from the Parallel Ocean Program （POP） ocean general circulation model developed at the Los Alamos National Laboratory （LANL）. A long-term control simulation of the LANL-POP model forced by a reconstructed coupled wind stress field over the period 1949-2001 showed that the ocean model not only simulates a reasonable climatology, but also produces a climate variability pattem very similar to observed PDV. In the Equatorial Pacific （EP） region, the decadal warming is confined in the thin surface layer. Beneath the surface, a strong compensating cooling, accompanied by a basin-wide-scale overturning circulation in opposition to the mean flow, occurs in the thermocline layer. In the North Pacific （NP） region, the decadal variability nonetheless exhibits a relatively monotonous pattern, characterized by the dominance of anomalous cooling and eastward flows. A term balance analysis of the perturbation heat budget equation was conducted to highlight the ocean＇s role in main- taining the PDV-like variability over the EP and NP regions. The analyses showed that strong oceanic adjustment must occur in the equatorial thermocline in association with the anomalous overturning circulation in order to maintain the PDV-like variability, including a flattening of the equatorial thermocline slpoe and an enhancement of the upper ocean＇s stratification （stability）, as the climate shifts from a colder regime toward a warmer one. On the other hand, the oceanic response in the extratropical region seems to be confined to the surface layer, without much participation from the subsurface oceanic dynamics.

关键词： Pacific decadal variability term balance analysis perturbation heat budget equation

Two-Dimensional Fin Efficiency of Plate Fin-Tube Heat Exchangers Under Partially and Fully Wet Conditions

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Journal of Thermal Science 2002年第3期11卷 249-254页

作者： Jiin-yuh Jang Chien-Nan Lin Natl Cheng Kung Univ Dept Mech Engn Tainan 70101 Taiwan

This paper presents the two-dimensional analysis for the efficiency of continuous plate fin-tube heat exchangers in staggered and in-lined arrangements under the dry, partially wet, and fully wet conditions for different heat transfer coefficient (h = 20 W/m2K to h = 80 W/m2K) and air relative humidity over the full range from φ= 0 % to φ= 100%. It is shown that the fin efficiencies of the staggered arrangement are higher than those for the in-lined arrangement, and the fully wet fin efficiency is 10~20% lower than that for a dry fin. The conventional 1-D sector method underestimates the fin efficiency up to 4 % as compared to the 2-D analysis.

关键词： fin efficiency plate fin-tube partially and fully wet.

C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice

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Genes & Diseases 2023年第3期10卷 643-646页

作者： Chun-Lung Chiu Shiao-Ya Hong ying Tan yuh-Ru Julie Lee yi-Ping Shih Clifford GTepper Su Hao Lo Department of Biochemistry and Molecular Medicine University of California-DavisSacramentoCA 95817USA Department of Plant Biology University of California-DavisDavisCA 95616USA

Tensin-1(TNS1)is a 220 kD focal adhesion protein that binds to actin filaments,integrin receptors,small GTPases,tyrosine-phosphorylated proteins,and lipids.1 These binding activities enable TNS1 to link the actin cytoskeleton to integrins and transduce outside-in and inside-out signals at focal adhesion sites,thereby regulating cell attachment,migration,proliferation,and mechanical sensing.1 Lack of TNS1 in kidney epithelial cells results in multiple lumen,instead of single lumen,phenotypes in the three-dimensional(3D)culture.

关键词： kidney Tensin thereby