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Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En chen Yu-yang Lu Ruei-Yu Su Hong-Hau Wang chao-yang chen Je-Ming Hu Jung-cheng Kang Kuan-Hsun Lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

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Stercoral perforation of the cecum:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1189-1194页

作者： Hung-Chun Yu Ta-Wei Pu Jung-cheng Kang chao-yang chen Je-Ming Hu Ruei-Yu Su Department of Surgery Taichung Armed Forces General HospitalTaichung 411228Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325Taiwan

BACKGROUND With less than 90 reported cases to date,stercoral perforation of the colon is a rare *** ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall,which is caused by the presence of a stercoraceous *** underscore this urgent surgical situation concerning clinical presentation,surgical treatment,and results,we present the case of a 66-year-old man with a stercoral *** SUMMARY A 66-year-old man with a history of hypertension,hyperlipidemia,and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few *** computed tomography indicated a suspected bezoar(approximately 7.6 cm)in the dilated cecum,accompanied by pericolic fat stranding,mild proximal dilatation of the ileum,pneumoperitoneum,and minimal ***,feculent peritonitis with isolated cecal perforation were ***,a right hemicolectomy with peritoneal lavage was performed.A histopathological examination supported the intraoperative *** In stercoral perforations,a diagnosis should be diligently pursued,especially in older adults,and prompt surgical intervention should be implemented.

关键词： Acute abdomen Colectomy Peritoneal lavage Pneumoperitoneum Bezoars Case report

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Mucinous neoplasm of the appendix:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 944-954页

作者： Hao-cheng Chang Jung-cheng Kang Ta-Wei Pu Ruei-Yu Su chao-yang chen Je-Ming Hu Department of Surgery Tri-Service General HospitalTaipei 114TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTaiwanChina Adventist HospitalTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105TaiwanChina Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325TaiwanChina

BACKGROUND Appendiceal mucinous neoplasms(AMNs),although not classified as rare,are relatively uncommon tumors most often discovered incidentally during colorectal *** identification of AMNs is difficult due to non-specific sym-ptoms,overlapping tumor markers with other conditions,and the potential for *** underscores the urgent need for precision in diagnosis to pre-vent severe *** SUMMARY This case report describes the unexpected discovery and treatment of a low-grade AMN(LAMN)in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma(AC).Preoperatively,non-specific gastroin-testinal symptoms and elevated tumor markers masked the presence of *** tumor,presumed to be an AMN peritoneal cyst intraoperatively,was con-firmed as LAMN through histopathological *** neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile:Positive for Ho-meobox protein CDX-2,Cytokeratin 20,special AT-rich sequence-binding protein 2,and Mucin 2 but negative for cytokeratin 7 and Paired box gene *** profile aids in distinguishing appendiceal and ovarian mucinous *** recovery was uncomplicated,and the patient initiated adjuvant chemotherapy for the colon *** This case highlights the diagnostic complexity of AMNs,emphasizing the need for vigilant identification to avert potential complications,such as pseudomyxoma peritonei.

关键词： Adenocarcinoma Appendiceal neoplasms Low-grade appendiceal mucinous neoplasm Peritoneal neoplasms Pseudomyxoma peritonei Case report

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Modified stapled hemorrhoidopexy for lower postoperative stenosis: A five-year experience

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2787-2795页

作者： Yu-Hong Liu Tzu-Chiao Lin chao-yang chen Ta-Wei Pu Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Stapled hemorrhoidopexy(SH)is currently a widely accepted method for treating the prolapse of internal *** anal stenosis is a critical complication of SH.A remedy for this involves the removal of the circumferential staples of the anastomosis,followed by the creation of a hand-sewn *** studies have reported modified SH procedures to improve *** hypothesized that our modified SH technique may help reduce complications of anal stenosis after *** To compare outcomes of staple removal at the 3-and 9-o’clock positions during modified SH in patients with mixed *** This was a single-center,retrospective,observational *** with grade III or IV hemorrhoids who underwent standard or modified SH at our colorectal center between January 1,2015,and January 1,2020,were *** operation time,blood loss,length of hospital stay,and incidence of minor or major complic-ations were *** Patients with grade III or IV hemorrhoids who underwent standard or modified SH at our colorectal center between January 1,2015 and January 1,2020,were *** time,blood loss,length of hospital stay,and incidence of minor or major complications were *** investigated 187 patients(mean age,50.9 years)who had undergone our modified SH and 313 patients(mean age,53.0 years)who had undergone standard *** the modified SH group,54%of patients had previously undergone surgical intervention for hemorrhoids,compared with the 40.3%of patients in the standard SH *** modified SH group included five(2.7%)patients with anal stenosis,while 21(6.7%)patients in the standard SH group had complications of anal *** was a significant relationship between the rate of postoperative anal stenosis and the modified SH:0.251(0.085-0.741)and 0.211(0.069-0.641)in multiple regression *** modified SH technique is a safe surgical method for advanced grade hemorrhoids and might result in

关键词： Anal canal Hemorrhoids Prolapse Stapled hemorrhoidopexy Postoperative anal stenosis Modified stapled hemorrhoidopexy

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Treatment of benign rectal stricture caused by repeated anal insertion by endoscopy and balloon dilation:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 91-97页

作者： Shih-Hung Liu Jung-cheng Kang Je-Ming Hu chao-yang chen Kuan-Hsun Lin Ta-Wei Pu Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have diverse etiologies,including various inflammatory *** strictures are usually managed by surgery and *** present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes,resulting in rectal injury and subsequent chronic *** SUMMARY A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody *** patient previously experienced rectal injury due to foreign object insertion for sexual *** revealed benign circumferential narrowing of the *** underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months.A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture *** A history of rectal injury,followed by chronic inflammation,should be considered in patients with benign rectal *** with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.

关键词： Chronic rectal inflammation Colonoscopy Benign rectal stricture Foreign body insertion Rectal injury Case report

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Cooperative Sensing and Distributed Control of a Diffusion Process Using Centroidal Voronoi Tessellations

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Numerical Mathematics(Theory,Methods and Applications) 2010年第2期3卷 162-177页

作者： Haiyang chao yang-Quan chen Center for Self Organizing and Intelligent Systems Electrical and Computer Engineering Department Utah State University Logan UT 84322 USA.

This paper considers how to use a group of robots to sense and control a diffusion *** diffusion process is modeled by a partial differential equation (PDE),which is a both spatially and temporally variant *** robots can serve as mobile sensors,actuators,or *** Voronoi Tessellations based coverage control algorithm is proposed for the cooperative sensing *** the diffusion control problem,this paper considers spraying control via a group of networked mobile robots equipped with chemical neutralizers,known as smart mobile sprayers or actuators,in a domain of interest having static mesh sensor network for concentration *** paper also introduces the information sharing and consensus strategy when using centroidal Voronoi tessellations algorithm to control a diffusion *** information is shared not only on where to spray but also on how much to spray among the mobile *** from using CVT and information consensus seeking for sensing and control of a diffusion process are demonstrated in simulation results.

关键词： Consensus centroidal Voronoi tessellations diffusion process distributed control mobile actuator and sensor networks.

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Novel therapeutic targets for pancreatic cancer

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World Journal of Gastroenterology 2014年第31期20卷 10825-10844页

作者： Shing-Chun Tang yang-chao chen School of Biomedical Sciences Faculty of Medicine the Chinese University of Hong Kong Shenzhen Research Institute The Chinese University of Hong Kong

Pancreatic cancer has become the fourth leading cause of cancer death in the last two decades. Only 3%-15% of patients diagnosed with pancreatic cancer had 5 year survival rate. Drug resistance, high metastasis, poor prognosis and tumour relapse contributed to the malignancies and difficulties in treating pancreatic cancer. The current standard chemotherapy for pancreatic cancer is gemcitabine, however its efficacy is far from satisfactory, one of the reasons is due to the complex tumour microenvironment which decreases effective drug delivery to target cancer cell. Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overexpression of cyclooxygenase-2, inactivation of p16INK4A and loss of p53 activities occurred in pancreatic cancer. Co-administration of gemcitabine and targeting the molecular pathological events happened in pancreatic cancer has brought an enhanced therapeutic effectiveness of gemcitabine. Therefore, studies looking for novel targets in hindering pancreatic tumour growth are emerging rapidly. In order to give a better understanding of the current findings and to seek the direction in future pancreatic cancer research; in this review we will focus on targets suppressing tumour metastatsis and progression, KRAS activated downstream effectors, the relationship of Notch signaling and Nodal/Activin signaling with pancreatic cancer cells, the current findings of non-coding RNAs in inhibiting pancreatic cancer cell proliferation, brief discussion in transcription remodeling by epigenetic modifiers (e.g., HDAC, BMI1, EZH2) and the plausible therapeutic applications of cancer stem cell and hyaluronan in tumour environment.

关键词： Pancreatic cancer CTHRC1 RAC1 RalGEF-RAl Notch Signaling Nodal/Activin Signaling NDRG1 Hypoxic condition DR5 PAR2 HER3 IAP Non-coding RNA HDAC BMI1 EZH2 Pancreatic cancer stem cell Tumour microenvironment

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Clinical significance of exosomes as potential biomarkers in cancer

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World Journal of Clinical Cases 2019年第2期7卷 171-190页

作者： Chi-Hin Wong yang-chao chen School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shenzhen Research Institute The Chinese University of Hong Kong

BACKGROUND Exosomes are microvesicles, measuring 30-100 nm in diameter. They are widely distributed in body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins and lipids, and may serve as novel biomarkers in *** To summarize the performance of exosomal biomarkers in cancer diagnosis and *** Relevant publications in the literature were identified by search of the "PubMed"database up to September 11, 2018. The quality of the included studies was assessed by QUADAS-2 and REMARK. For assessment of diagnostic biomarkers,47 biomarkers and 2240 patients from 30 studies were *** Our results suggested that these exosomal biomarkers had excellent diagnostic ability in various types of cancer, with good sensitivity and specificity. For assessment of prognostic markers, 50 biomarkers and 4797 patients from 42 studies were included. We observed that exosomal biomarkers had prognostic values in overall survival, disease-free survival and recurrence-free *** Exosomes can function as potential biomarkers in cancer diagnosis and prognosis.

关键词： Exosome Biomarker Cancer Diagnosis Prognosis

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Application of multi-algorithm ensemble methods in high-dimensional and small-sample data of geotechnical engineering:A case study of swelling pressure of expansive soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1896-1917页

作者： chao Li Lei Wang Jie Li yang chen School of Urban Railway Transportation Shanghai University of Engineering ScienceShanghai201620China Discipline of Civil and Infrastructure Engineering RMIT UniversityMelbourne3001Australia School of Naval Architecture and Civil Engineering Shanghai Jiao Tong UniversityShanghai200240China

Geotechnical engineering data are usually small-sample and high-dimensional,which brings a lot of challenges in predictive *** paper uses a typical high-dimensional and small-sample swell pressure(P_(s))dataset to explore the possibility of using multi-algorithm hybrid ensemble and dimensionality reduction methods to mitigate the uncertainty of soil parameter *** on six machine learning(ML)algorithms,the base learner pool is constructed,and four ensemble methods,Stacking(SG),Blending(BG),Voting regression(VR),and Feature weight linear stacking(FWL),are used for the multi-algorithm ***,the importance of permutation is used for feature dimensionality reduction to mitigate the impact of weakly correlated variables on predictive *** results show that the proposed methods are superior to traditional prediction models and base ML models,where FWL is more suitable for modeling with small-sample datasets,and dimensionality reduction can simplify the data structure and reduce the adverse impact of the small-sample effect,which points the way to feature selection for predictive *** on the ensemble methods,the feature importance of the five primary factors affecting P_(s) is the maximum dry density(31.145%),clay fraction(15.876%),swell percent(15.289%),plasticity index(14%),and optimum moisture content(13.69%),the influence of input parameters on P_(s) is also investigated,in line with the findings of the existing literature.

关键词： Expansive soils Swelling pressure Machine learning(ML) Multi-algorithm ensemble Sensitivity analysis

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An observed nocturnal ozone transport event in the Sichuan Basin,Southwestern China

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Journal of Environmental Sciences 2024年第4期138卷 10-18页

作者： Ruyue Guo Guangming Shi Dan Zhang yang chen chao Peng Chongzhi Zhai Fumo yang Department of Environmental Science and Engineering Sichuan UniversityChengdu 610065China College of Carbon Neutrality Future Technology Sichuan UniversityChengdu 610065China National Engineering Research Center on Flue Gas Desulfurization Chengdu 610065China Chongqing Academy of Eco-Environmental Science Chongqing 401147China Research Center for Atmospheric Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Key Laboratory for Urban Atmospheric Environment Integrated Observation&Pollution Prevention and Control of Chongqing Chongqing 401147China

The ozone(O_(3))pollution in China drew lots of attention in recent years,and the Sichuan Basin(SCB)was one of the regions confronting worsening O_(3)pollution *** previous studies have shown that regional transport is an important contributor to O_(3)***,very few features of the O_(3)profile during transport have been reported,especially in the border regions between different administrative *** this study,we conducted tethered balloon soundings in SCB during the summer of 2020 and captured a nocturnal O_(3)transport event during the ***,the O_(3)transport occurred in the bottom of the residual layer,between 200 and 500 m above ground ***,the transport pathway was directed from southeast to northwest based on the analysis of the wind field and air mass *** effect of transport in the residual layer on the surface O_(3)concentration was related to the spatial distribution of O_(3).For cities with high O_(3)concentrations in the upwind region,the transport process would bring clean air masses and abate *** downwind lightly polluted cities,the transport process would slow down the decreasing or even increase the surface O_(3)concentration during the *** provided observational facts on the profile features of a transboundary O_(3)transport event between two provincial administrative divisions,which implicated the importance of joint prevention and control ***,the sounding parameters were limited and the quantitative analysis was preliminary,more integrated,and thorough studies of this topic were called for in the future.

关键词： Ozone Sichuan basin Transport event Vertical profile

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