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World Journal of Clinical Cases 2018年第16期6卷 1202-1205页

作者： Xie-Qun Xu Tao Hong chao-ji zheng Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Schwannoma rarely originates from the recurrent laryngeal nerve, and there are few reports on schwannoma originating from the recurrent nerve in the mediastinum. Herein, we present an extremely rare case of schwannoma originating from the recurrent laryngeal nerve in the *** SUMMARY This is a case report of one patient diagnosed with thyroid cancer with schwannoma originating from the recurrent laryngeal nerve in the neck, which was incidentally found during a thyroidectomy, and a review of the *** Preoperative diagnostic examinations are of less use for detecting schwannoma originating from a recurrent laryngeal nerve in the neck in such small size, which may only incidentally be found during a thyroidectomy. Surgical excision with opening the capsule and shelling out the tumor is the treatment of choice. If the nerve is unable to be preserved, end-to-end recurrent laryngeal nerve anastomosis may be a simple and minimally invasive reconstruction procedure to improve phonation.

关键词： Schwannoma Recurrent laryngeal nerve Thyroid cancer Head and neck Surgery Case report

Application of laparoscopic surgery in gallbladder carcinoma

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World Journal of Clinical Cases 2023年第16期11卷 3694-3705页

作者： Xin Wu Bing-Lu Li chao-ji zheng Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Gallbladder carcinoma(GC)is a rare type of cancer of the digestive system,with an incidence that varies by *** plays a primary role in the comprehensive treatment of GC and is the only known *** with traditional open surgery,laparoscopic surgery has the advantages of convenient operation and magnified field of *** surgery has been successful in many fields,including gastrointestinal medicine and *** gallbladder was one of the first organs to be treated by laparoscopic surgery,and laparoscopic cholecystectomy has become the gold standard surgical treatment for benign gallbladder ***,the safety and feasibility of laparoscopic surgery for patients with GC remain *** the past several decades,research has focused on laparoscopic surgery for *** disadvantages of laparoscopic surgery include a high incidence of gallbladder perforation,possible port site metastasis,and potential tumor *** advantages of laparoscopic surgery include less intraoperative blood loss,shorter postoperative hospital stay,and fewer ***,studies have provided contrasting conclusions over *** general,recent research has tended to support laparoscopic ***,the application of laparoscopic surgery in GC is still in the exploratory ***,we provide an overview of previous studies,with the aim of introducing the application of laparoscopy in GC.

关键词： Gallbladder carcinoma Laparoscopic surgery Open surgery Gallbladder perforation Port site metastases Prognosis

Risk factors for preoperative carcinogenesis of bile duct cysts in adults

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World Journal of Clinical Cases 2021年第22期9卷 6278-6286页

作者： Xin Wu Bing-Lu Li chao-ji zheng Xiao-Dong He Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Bile duct cyst(BDC)is a rare congenital bile duct *** incidence of bile duct malignancy in BDC patients is markedly higher than that in the general ***,few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC *** To analyze the risk factors associated with preoperative carcinogenesis in BDC *** The medical records of BDC patients treated at our hospital between January 2012 and December 2018 were retrospectively *** constructed a database and compared the characteristics of BDC patients with dysplasia and carcinoma against those with benign *** risk factors for preoperative carcinogenesis were identified using univariate and multivariate *** The cohort comprised 109 BDC *** patients had preoperative dysplasia or *** and multivariate analyses showed that gallbladder wall thickness>0.3 cm[odds ratio(OR),6.551;95%confidence interval(CI),1.351 to 31.763;P=0.020]and Todani type IV(OR,7.675;95%CI,1.584 to 37.192;P=0.011)were independent factors associated with preoperative *** BDC is a premalignant *** findings show that gallbladder wall thickness>0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis of *** are therefore useful for deciding on the appropriate treatment strategy,especially in asymptomatic patients.

关键词： Choledochal cyst Carcinoma Dysplasia Risk factors Gallbladder wall Todani type

Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma

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World Journal of Clinical Cases 2020年第8期8卷 1350-1360页

Papillary thyroid microcarcinoma(PTMC)measures 1 cm or less in its longest *** incidence of PTMC is increasing *** is the primary treatment;however,prophylactic central lymph node dissection is controversial,and discrepancies between different guidelines have been *** prophylactic central lymph node dissection may result in hypoparathyroidism and recurrent laryngeal nerve injury in some patients without lymph node metastasis,while simple thyroidectomy may leave metastatic lymph nodes in high-risk *** selectively perform prophylactic lymph node dissections in high-risk patients,it is important to identify predictive factors for lymph node metastases in patients with *** studies have reported on this,but their conclusions are not entirely *** clinicopathologic characteristics have been identified as risk factors for central lymph node metastases,and the most commonly reported factors include age,gender,tumor size and location,multifocality,bilaterality,extrathyroidal extension,and abnormal lymph node found using ***,we provide an overview of previous studies along with a favorable opinion on or against these factors,with the aim of increasing the understanding of this topic among the medical *** addition,current opinions about prophylactic central lymph node dissection are reviewed and discussed.

关键词： Papillary thyroid carcinoma Papillary thyroid microcarcinoma Central lymph node dissection Prophylactic Risk factor Prognosis

Ileal duplication mimicking intestinal intussusception:A congenital condition rarely reported in adult

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World Journal of Gastroenterology 2013年第38期19卷 6500-6504页

作者： Bing-Lu Li Xin Huang chao-ji zheng jiao-Lin Zhou Yu-Pei Zhao The First Department of General Surgery Peking Union Medical College Hospital

Intestinal duplication is an uncommon congenital condition in young adults.A 25-year-old man complained of chronic,intermittent abdominal pain for 3 years following previous appendectomy for the treatment of suspected *** discomfort and pain,suggestive of intestinal obstruction,recurred after operation.A tubular mass was palpable in the right lower *** tomography enterography scan identified suspicious intestinal intussusception,while Tc-99m pertechnetate scintigraphy revealed a cluster of strip-like abnormal radioactivity in the right lower *** exploratory laparotomy,a tubular-shaped ileal duplication cyst was found arising from the mesenteric margin of the native ileal segment located 15 cm proximal to the ileocecal *** was performed along with the removal of the duplication disease,and the end-to-end anastomosis was done to restore the gastrointestinal tract *** examination showed ileal duplication with ectopic gastric *** patient experienced an eventless postoperative recovery and remained asymptomatic within 2 years of postoperative follow-up.

关键词： Ileal duplication cyst Adulthood Computed tomography enterography Tc-99m pertechnetate scintigraphy

A long adult intussusception secondary to transverse colon cancer

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World Journal of Gastroenterology 2013年第22期19卷 3517-3519页

作者： Xie-Qun Xu Tao Hong Wei Liu chao-ji zheng XiaoDong He Bing-Lu Li Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

The occurrence of adult intussusception arising from colorectal cancer is quite rare. We present the case of a 76-year-old man with sudden abdominal pain and vomiting. Clinical symptoms included severe abdominal distension and tenderness. Computed tomography scan of the abdomen revealed left-sided colocolic intussusception with a lead point. The patient underwent a left hemicolectomy with right transverse colostomy. Pathologic evaluation revealed moderately differentiated adenocarcinoma invading the muscularis propria; the regional lymph nodes were negative for cancer cells. The postoperative course was uneventful.

关键词： Adult intussusception Colon cancer Surgery Hemicolectomy

Choledochoduodenal fistula caused by migration of endoclip after laparoscopic cholecystectomy

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World Journal of Gastroenterology 2014年第16期20卷 4827-4829页

作者： Tao Hong Xie-Qun Xu Xiao-Dong He Qiang Qu Bing-Lu Li chao-ji zheng Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

The wide use of surgical endoclips in laparoscopic surgery has led to a variety of *** endoclips migrating into the common bile duct after laparoscopic cholecystectomy is rare.A migrated endoclip can cause obstruction,serve as a nidus for stone formation,and cause *** the exact pathogenesis is still unknown,it is probably related to improper clip application,subclinical bile leak,inflammation,and subsequent necrosis,allowing the clips to erode directly into the common bile *** present a case of endoclip migrating into the common bile duct and duodenum,resulting in choledochoduodenal fistula after laparoscopic cholecystectomy and a successful reconstruction of the biliary tract by a hepaticojejunostomy with a Roux-en-Y *** case shows that surgical endoclips can penetrate into the intact bile duct wall through serial maceration,and it is believed that careful application of clips may be the only way to prevent their migration after laparoscopic cholecystectomy.

关键词： Biliary obstruction Laparoscopic cholecystectomy Choledochoduodenal fistula

Mirizzi Syndrome: Our Experience with 27 Cases in PUMC Hospital

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Chinese Medical Sciences Journal 2013年第3期28卷 172-177页

作者： Xie-qun Xu Tao Hong Bing-lu Li Wei Liu Xiao-dong He chao-ji zheng Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To retrospectively evaluate the diagnosis and treatment of Mirizzi syndrome （MS）. Methods Patients who received elective or emergency cholecystectomies in our center during 23 years were retrospectively evaluated. The data reviewed included demography, clinical presentations, diagnostic methods, surgical procedures, postoperative complications, and follow-up.

关键词： Mirizzi syndrome cholecystectomy Roux-en-Y hepatico-jejunostomy

Unsuspected Gallbladder Cancer During or After Laparoscopic Cholecystectomy

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Chinese Medical Sciences Journal 2013年第2期28卷 102-106页

作者： Xie-qun Xu Wei Liu Bing-lu Li Tao Hong chao-ji zheng Chu Wang Yu-pei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To summarize the clinical features and outcomes of unsuspected gallbladder carcinoma （HGC） detected during or after laparoscopic cholecystectomy. Methods Medical records of 8005 patients, who underwent laparoscopic cholecystectomy in Peking Hnion Medical College Hospital between June 1993 and June 2011, were reviewed. Patients that pathologically diagnosed as HGC were retrospectively studied in terms of clinical features, preoperative and postoperative diagnosis, surviving period, and complications. Results In the 8005 patients who received laparoscopic cholecystectomy, 36 （0.45%） were diagnosed as LIGC during （25 patients） or after （11 patients） laparoscopic cholecystectomy. The gallbladder cancer was staged as T1 in 16 patients, T2 in 11 patients, and T3 in 9 patients. The 1-, 3-, and 5-year survival rates of all the patients were 88.9% （32/36）, 63.9% （23/36）, and 58.3% （21/36）. The 5-year survival rates in T1 stage, T2 stage, and T3 stage patients were 100%, 75.0%, and 0.0%, respectively. Conclusions The survival rate of HGC is associated with tumor stage, not with operation approaches. Laparoscopic cholecystectomy is appropriate for T 1 patients.

关键词： laparoscopic cholecystectomy gallbladder neoplasms carcinoma frozensections survival rate

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-Yu Ye Jun-ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct