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Liu-stain quick cytodiagnosis of ultrasound-guided fine needle aspiration in diagnosis of liver tumors

World Journal of Gastroenterology 2007年第3期13卷 448-451页

作者： Chi-Sin Changchien Jing-Houng Wang chao-hung hung Chien-hung Chen Chuan-Mo Lee Division of Hepato-Gastroenterology Department of Internal Medicine Chang-Gung Memorial Hospital Kaohsiung Medical Center Chang Gung University College of Medicine Taiwan China

AIM： To combine ultrasound-guided fine-needle aspiration （US-FNA） and Liu （Riu） stain to make a quick study on liver tumor lesions. METHODS： Two hundred and twenty-eight aspirations from 232 patients were completely studied. The operator himself made the quick cytodiagnosis of US-FNA smear stained by Liu method within thirty minutes. The US-FNA specimen was also sent to the pathological department for cytological study and cellblock histology. The result of our Uu-stain quick cytodiagnosis in each patient was confirmed by the final cytopathological diagnosis from pathological report. RESULTS： Among 228 samples, the quick cytodiagnosis revealed 146 malignancies, 81 benign lesions and one inadequate specimen. Cytopathological diagnosis from the pathological department revealed 150 malignancies, and 78 benign lesions. Four well-differentiated hepatocellular carcinomas （HCCs） were under-diagnosed by quick cytodiagnosis as benign and 3 benign lesions were over-diagnosed as well-differentiated HCCs. Compared with cytopathological diagnosis, quick cytodiagnosis correctly diagnosed 143 malignancies and 77 benign lesions. Except for the one inadequate specimen in quick cytodiagnosis, the accuracy of quick cytodiagnosis was 96.9% （220/227）, and its sensitivity, specificity and positive and negative predictive values were 97.9%, 95.1%, 97.3% and 96.3%, respectively. CONCLUSION： Liu-stain quick cytodiagnosis is a fast, convenient, safe and effective method for hepatologists in clinic practice to diagnose liver tumor. In few cases of well-differentiated HCC, Liu-stain quick cytodiagnosis has its limitation.

关键词： Liver tumor Cytology Ultrasound guided FNA Liu stain

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Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection

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World Journal of Gastroenterology 2010年第18期16卷 2265-2271页

作者： chao-hung hung Jing-Houng Wang Tsung-Hui Hu Chien-hung Chen Kuo-Chin Chang Yi-Hao Yen Yuanhung Kuo Ming-chao Tsai Chuan-Mo Lee Division of Hepatogastroenterology Department of Internal MedicineChang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of Medicine

AIM:To elucidate the role of insulin resistance(IR) and serum adiponectin level in hepatocellular carcinoma(HCC) associated with chronic hepatitis ***:Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed *** model assessment of IR(HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus(HCV) ***:Among HCC patients,type 2 diabetics(DM) was more prevalent in HCV subjects(35.6%,n = 59) compared to hepatitis B virus(HBV;12.7%,n = 63) or non-HBV,non-HCV cases(7.1%,n = 28).In patients with chronic hepatitis C,HCC subjects had higher blood sugar(P < 0.001),insulin level(P = 0.003) and HOMAIR(P = 0.018) than those with chronic hepatitis and advanced ***,male sex and body mass index were significantly associated with serum adiponectin level,whereas HOMA-IR was *** on stepwise logistic regression analysis,age(OR:1.124,P < 0.001),serum insulin level(OR:1.585,P < 0.001),HOMA-IR(OR:0.495,P = 0.001),DM(OR:11.601,P = 0.002) and male sex(OR:3.877,P = 0.016) were independently associated with *** result was similar even if the diabetic subjects were excluded for ***:Insulin resistance measured by HOMAIR,regardless of the presence of diabetes,is significantly associated with HCC development in patients with chronic HCV infection.

关键词： Hepatitis C virus Hepatocellular carcinoma Insulin resistance Diabetes Adiponectin

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Serum hepatitis B surface antigen levels predict treatment response to nucleos(t)ide analogues

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World Journal of Gastroenterology 2014年第24期20卷 7686-7695页

作者： Chien-hung Chen Yi-Chun Chiu Sheng-Nan Lu Chuan-Mo Lee Jing-Houng Wang Tsung-Hui Hu chao-hung hung Division of Hepato-Gastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Quantification of hepatitis B surface antigen(HBsAg)has been suggested to be helpful in the management of chronic hepatitis B(CHB)***(t)ide analogs(NAs)are the therapy of choice for CHB and are used in the majority of CHB *** are able to induce hepatitis B virus(HBV)viral suppression,normalization of alanine aminotransferase(ALT)levels,and improvement in liver *** quantitative assays for serum HBsAg have recently become available,facilitating standardized quantification of serum *** has led to increased interest in the clinical application of quantitative serum HBsAg for predicting therapeutic response to *** studies have shown that a decline in serum HBsAg levels in patients receiving peginterferon may signal successful induction of immune control over HBV,and can therefore be used to predict therapeutic *** treatment typically induces a less rapid decline in HBsAg than interferon treatment;it has been estimated that full HBsAg clearance can require decades of NA ***,a rapid HBsAg decline during NA therapy may identify patients who will show clearance of ***,there is no consensus on the clinical utility of serum HBsAg monitoring for evaluating patient responses to NA *** review focuses on recent findings regarding the potential application of HBsAg quantification in the management of CHB patients receiving NA therapy.

关键词： Alanine aminotransferase Hepatitis B virus Hepatitis B surface antigen Nucleos(t)ide analogs Virological response

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Living donor liver transplantation for Barcelona clinic liver cancer (BCLC) intermediate-stage hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 169-182页

作者： Ming chao Tsai Chee-Chien Yong Chih-Che Lin Wei-Chen Lee Chih-Chi Wang chao-hung hung I-Hsuan Chen Yu-Fan Cheng Chang-Chun Hsiao Tsung-Hui Hu chao-Long Chen Division of Hepato-Gastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung School of Medicine College of MedicineNational Sun Yat-sen UniversityKaohsiung Liver Transplantation Center and Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung Division of Liver and Transplantation Surgery Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan Liver Transplantation Center and Department of Diagnostic Radiology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityDivision of Pulmonary and Critical Care MedicineKaohsiung Chang Gung Memorial HospitalKaohsiung

Background:Barcelona clinic liver cancer(BCLC)stage B(intermediate stage)hepatocellular carcinoma(HCC)is highly heterogeneous;thus,identifying the most effective treatment for individual patients represents a significant clinical ***,transarterial chemoembolization(TACE)is the only recommended treatment ***,we aimed to investigate the patient characteristics and outcomes of living donor liver transplantation(LDLT)for BCLC stage B ***:A total of 516 patients with BCLC stage B HCC who underwent LDLT(n=104)or did not undergo LDLT(non-LDLT;n=412)between 2004 to 2018 were analyzed by propensity score matching(PSM;1:4)*** influencing overall survival(OS)and recurrence were analyzed using Cox’s proportional hazards ***:Patients treated with LDLT achieved better OS than the non-LDLT group,including liver-and non-liver related survival(all P60 years(P=0.006),a neutrophil-lymphocyte ratio(NLR)>4(P=0.016)and>3 locoregional therapies(LRT)before LDLT(P60 years(P3 LRT before LDLT(P=0.001)were independent risk factors for *** a combination of age,NLR,and LRT before liver transplantation(LT),the patients can be divided into low-risk(none of risk),intermediate-risk(one of risk),and high risk(more than two of risk)*** were significant differences in the cumulative HCC recurrence(P<0.001)and mortality(P<0.001)rates among the three ***:LDLT may represent a valuable therapeutic option for selected patients with BCLC stage B HCC.

关键词： Living donor liver transplantation(LDLT) Barcelona clinic liver cancer stage B(BCLC stage B) intermediate stage hepatocellular carcinoma(HCC)

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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih hung Lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

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FPGA sharing in the cloud: a comprehensive analysis

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Frontiers of Computer Science 2023年第5期17卷 1-13页

作者： Jinyang GUO Lu ZHANG JoséROMERO hung chao LI Jieru ZHAO Minyi GUO Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Micro/Nano Electronics Shanghai Jiao Tong UniversityShanghai 200240China

Cloud vendors are actively adopting FPGAs into their infrastructures for enhancing performance and *** cloud services continue to evolve,FPGA(field programmable gate array)systems would play an even important role in the *** this context,FPGA sharing in multi-tenancy scenarios is crucial for the wide adoption of FPGA in the ***,many works have been done towards effective FPGA sharing at different layers of the cloud computing *** this work,we provide a comprehensive survey of recent works on FPGA *** examine prior art from different aspects and encapsulate relevant proposals on a few key *** the one hand,we discuss representative papers on FPGA resource sharing schemes;on the other hand,we also summarize important SW/HW techniques that support effective ***,we further analyze the system design cost behind FPGA ***,based on our survey,we identify key opportunities and challenges of FPGA sharing in future cloud scenarios.

关键词： cloud FPGA FPGA sharing efficiency design cost

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Wall shear-stress extraction by an optical flow algorithm with a sub-grid formulation

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Acta Mechanica Sinica 2021年第1期37卷 65-79,I0003页

作者： The hung Tran Lin Chen Faculty of Aerospace Engineering Le Quy Don Technical UniversityHanoi10000Vietnam Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing100049China

In this study,we developed a novel optical-flow algorithm for determining the wall shear-stress on the surface of *** algorithm solves the thin-oil-film equation using a numerical scheme that recovers local features neglected by smoothing filters.A variational formulation with a smoothness constraint was applied to extract the global shear-stress *** algorithm was then applied to scalar images generated using direct numerical simulation(DNS)method,which revealed that the errors were smaller than those of conventional *** application of the proposed algorithm to recover the wall shear-stress on a low-aspect-ratio wing and on an axisymmetric boattail model taken as examples in this study showed a strong potential for analysing shear-stress *** to the methods used in previous studies,proposed method reveals more local features of separation line and singular points on object surface.

关键词： Wall shear-stress Optical flow Thin-oil-film equation Sub-grid model

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Preparation and characterization of nano-rare earth composite materials:application in selectivity catalytic oxidation of ammonia and its cytotoxicity study

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Journal of Rare Earths 2010年第S1期28卷 362-366页

作者： Chang-Mao hung Department of Vehicle Engineering Yung-Ta Institute of Technology and Commerce316 Chung-Shan RoadLinloPingtung 909Taiwan

The manufacture,physical characterization,environmental applications and cytotoxicity properties of nanocomposites consisting of CuO/CeO2 nano-rare earth composite materials prepared using the coprecipitation method at molar ratio of 6:4 with aqueous solutions of copper nitrate and cerium nitrate were *** performance of the selective catalytic oxidation of ammonia to N2(NH3-SCO) over a CuO/CeO2 nano-rare earth composite materials in a tubular fixed-bed reactor(TFBR) at temperatures from 423 to 673 K in the presence of oxygen was *** catalytic redox behavior was determined by cyclic voltammetry(CV).The nanocomposite particles were characterized by TEM,with a tiny particle size around 10 nm with high dispersion ***,cell cytotoxicity and the percentage cell survival were determined by using 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethoxyphenol)-2-(4-sulfophenyl)-2H-tetra-zolium(MTS) assay on human lung MRC-5 cell *** results showed that no apparent cytotoxicity was observed when the MRC-5 was exposed to the CuO/CeO2 nanocomposite materials.

关键词： selective catalytic oxidation (SCO) tubular fixed-bed reactor (TFBR) ammonia CuO/CeO2 nanocomposite material cytotoxicity rare earths

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Checking Temporal Duration Properties of Timed Automata

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Journal of Computer Science & Technology 2002年第6期17卷 689-698页

作者：李勇 Dang Van hung State Key Laboratory of Novel Software Technology Department of Computer Science and Technology Nanjing University Nanjing 210093 P.R. China International Institute for Software Technology The United Nations University P.O. Box 3058 Macao SAR P.R. China

In this paper, the problem of checking a timed automaton for a Duration Cal-culus formula of the form Temporal Duration Property is addressed. It is shown that TemporalDuration Properties are in the class of discretisable real-time properties of Timed Automata,and an algorithm is given to solve the problem based on linear programming techniques andthe depth-first search method in the integral region graph of the automaton. The complexityof the algorithm is in the same class as that of the solution of the reachability problem of timedautomata.

关键词： model checking duration calculus timed automata

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Heterogeneous Structure Design to Strengthen Carbon-Containing CoCrFeNi High Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1503-1510页

作者： Xiaomeng Qin Chan hung Shek Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong SAR 999077China

A carbon-containing CoCrFeNi high entropy alloy(HEA)with heterogeneous structures was obtained through thermomechanical treatments,which induced concurrent recrystallization and carbide precipitation in the alloy.A combination of high yield strength(556 MPa)and large uniform elongation(45%)was achieved in the investigated *** enhancement of the strength is attributed to the combined effects of grain refinement,precipitation strengthening and microstructural *** work demonstrated that the heterogeneity design could be realized by thermomechanical processes,which provided a practical strategy for producing HEAs with high performance.

关键词： High entropy alloy Heterogeneous structures Mechanical properties Interstitial

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