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The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu Lin Shen Hui-Fan Liu Xiang-Hui Zou Juan Zhao Yu huang Yu-Fan Zhu Zhao-Yu Li chao Xu Li-hua Luo Zhi-Qiang Luo Min-Hao Wu Lin Cai Xiao-Kun Li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone regeneration.Methods:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO3,PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)matrix.The physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were analyzed.Cell and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in vivo.Results:The incorporation of BaTiO3into the scafold improved its mechanical properties and increased self-generated electricity.Due to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 cells.The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model.The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization.Conclusion:The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation,

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure

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World Journal of Clinical Cases 2024年第17期12卷 3027-3034页

作者： Ji-Jie Xu Jian Dai Qi-Hai Xie Pei-chao Du Cha Li hua Zhou Department of Cardiology&Cardiovascular Research Institute Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western MedicineShanghai 201999China

BACKGROUND Current treatments for chronic heart failure(CHF)are therapeutically ineffective.The optimization of treatments for this disease needs to be explored and analyzed.AIM To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function(CPF)and prognosis.METHODS In total,160 patients with CHF admitted between June 2022 and June 2023 were selected,including 75 receiving perindopril(control group)and 85 receiving Luhong Formula(research group).We conducted comparative analyses on the curative effects of traditional Chinese medicine(TCM)syndromes and cardiac function,CPF[oxygen consumption at the anaerobic threshold(VO2 AT)and at peak exercise(peak VO2)],echocardiographic indexes[left atrial volume index(LAVI),left ventricular muscle mass index(LVMI),left ventricular ejection fraction(LVEF)],and prognosis[major adverse cardiovascular events(MACEs)at 6 months follow-up].RESULTS The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group.In addition,post-treatment VO2 AT,peak VO2,LVMI and LVEF in the research group were significantly higher,whereas LAVI was significantly lower,than those of the control group.Furthermore,fewer patients in the research group developed MACEs at the 6-month follow-up.CONCLUSION Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF,specifically in enhancing CPF and prognosis.

关键词： Luhong formula Chronic heart failure Cardiopulmonary function Cardiac rehabilitation Prognosis

Efficacy and safety of ulinastatin in the treatment of septic shock:a systematic review and meta-analysis

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Medical Data Mining 2024年第1期7卷 1-9页

作者： chao Tong Aheyeerke Halengbieke Teng-Rui Cao Xin huang Jia-Lu Luo Jia-Xin Li Xue-Tong Ni Feng Sun Xing-hua yang School of Public Health Capital Medical UniversityBeijing 100069China Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China

Background:Septic shock is a common systemic inflammatory response syndrome for critical patients in the intensive care unit.Ulinastatin is currently used for the treatment of septic shock.Our study sought to evaluate the efficacy and safety of ulinastatin in the treatment of septic shock patients.Methods:Three English databases(Embase,Medline,and Cochrane Library)and four Chinese databases(China National Knowledge Infrastructure,Wanfang data,SinoMed,and VIP)were searched for published randomized controlled trials.Stata 16.0 software was used to conduct the meta-analysis.Results:A total of 48 articles were included(Chinese article 47,1 in English).The results show that the treatment of ulinastatin could reduce mortality(risk ratio=0.63,95%confidence interval(CI)(0.55,0.72)),multiple organ dysfunction syndrome(risk ratio=0.6,95%CI(0.53,0.68)),length of intensive care unit stay(mean difference(MD)=-3.92,95%CI(-4.65,-3.18)),length of hospital stay(MD=-4.39,95%CI(-6.63,-2.15))and decrease Acute Physiology and Chronic Health Evaluation II score(MD=-4.55,95%CI(-5.63,-3.47))and Sequential Organ Failure Assessment score(MD=-2.02,95%CI(-2.59,-1.44))with P<0.001.Moreover,it lowers TNF-α(standardized mean difference(SMD)=-1.78,95%CI(-2.24,-1.32)),Interleukin-6(SMD=-1.17,95%CI(-1.55,-0.8)),C reactive protein(SMD=-1.49,95%CI(-1.99,-0.99)),hypersensitive C-reactive protein(SMD=-1.9,95%CI(-2.87,-0.94))and procalcitonin(SMD=-0.89,95%CI(-1.12,-0.67))levels in the body.Conclusions:Available evidence shows that ulinastatin reduces case mortality rate,multiple organ dysfunction syndrome,length of intensive care unit stay,and length of hospital stay and decreases Acute Physiology and Chronic Health Evaluation II score and Sequential Organ Failure Assessment score.Moreover,it also lowers TNF-α,Interleukin-6,C reactive protein,hypersensitive C-reactive protein,and procalcitonin levels in the body.

关键词： effectiveness meta-analysis randomized controlled trial septic shock ulinastatin

“雅颂之音”与“讽谕之鸣”:论礼乐复兴视域下的宋初文学

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新疆大学学报（哲学社会科学版） 2024年第1期52卷 131-138页

作者：罗超华山东大学文学院山东济南250100

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化... 详细信息

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化的礼仪书写,但若将之置于宋初礼乐复兴视域下进行更深层次解读,则于某些赋颂中可观觇士大夫政治主体意识的觉醒迹象,且雅颂主旋律中讽喻之声的鸣起,又宣示了宋初文人对唐人风雅观的进一步开拓。这些被程式化书写遮蔽的内容,实质是政治与文学的合奏交响,二者间表里经纬的错综关系及由此生成的强力互动,正体现出此间特殊的文学生态。

关键词：礼乐宋代雅颂文学风气儒道

考虑氨能与广义储能的多能耦合系统低碳协调运行

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电力建设 2024年第7期45卷 122-133页

作者：潘超杨铖唐华兰冰孟涛现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林省吉林市132012 国网吉林省电力有限公司电力科学研究院长春市130021

针对可再生能源消纳问题,研究了氨能与广义储能参与的多能耦合系统低碳协调运行方式,利用氨能和燃煤机组煤氨混燃相结合的技术来优化系统碳排放。首先考虑氨能参与的多能流交互与广义储能的灵活调控特性,构建了以运行费用最小、可再生... 详细信息

针对可再生能源消纳问题,研究了氨能与广义储能参与的多能耦合系统低碳协调运行方式,利用氨能和燃煤机组煤氨混燃相结合的技术来优化系统碳排放。首先考虑氨能参与的多能流交互与广义储能的灵活调控特性,构建了以运行费用最小、可再生能源利用率最大、碳排放量最小为目标函数的综合效益评价指标。提出基于能流关联的碳流拓扑分析方法,利用碳流信息作为综合效益评估的辅助决策手段。最后对实际区域系统进行仿真分析,通过氨能与广义储能的协同调控,有效改善了系统的综合效益。

关键词：氨能广义储能多能耦合能流关联低碳

Color liquid crystal grating based color holographic 3D display system with large viewing angle

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Light(Science & Applications) 2024年第1期13卷 103-112页

作者： Di Wang Yi-Long Li Fan Chu Nan-Nan Li Zhao-Song Li Sin-Doo Lee Zhong-Quan Nie chao Liu Qiong-hua Wang School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China Display Technology Research Center Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea Key Lab of Advanced Transducers and Intelligent Control System Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China

Holographic 3D display is highly desirable for numerous applications ranging from medical treatments to military affairs.However,it is challenging to simultaneously achieve large viewing angle and high-fidelity color reconstruction due to the intractable constraints of existing technology.Here,we conceptually propose and experimentally demonstrate a simple and feasible pathway of using a well-designed color liquid crystal grating to overcome the inevitable chromatic aberration and enlarge the holographic viewing angle,thus enabling large-viewing-angle and color holographic 3D display.The use of color liquid crystal grating allows performing secondary diffraction modulation on red,green and blue reproduced images simultaneously and extending the viewing angle in the holographic 3D display system.In principle,a chromatic aberration-free hologram generation mechanism in combination with the color liquid crystal grating is proposed to pave the way for on such a superior holographic 3D display.The proposed system shows a color viewing angle of~50.12°,which is about 7 times that of the traditional system with a single spatial light modulator.This work presents a paradigm for achieving desirable holographic 3D display,and is expected to provide a new way for the wide application of holographic display.

关键词： holographic angle crystal

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声悬浮条件下双水相液滴的蒸发与相分离

物理学报 2024年第3期73卷 153-160页

作者：贺华丹钟琦超解文军西北工业大学物理科学与技术学院西安710129

采用声悬浮无容器处理技术,研究了聚乙二醇-硫酸铵(PEG-AMS)双水相液滴的蒸发与相分离过程.双水相液滴蒸发过程中,液滴赤道直径的平方d^(2)随时间线性减小,同时液滴横纵比γ随时间线性增大.初始处于单相区的液滴随着水分蒸发可以跨越到... 详细信息

采用声悬浮无容器处理技术,研究了聚乙二醇-硫酸铵(PEG-AMS)双水相液滴的蒸发与相分离过程.双水相液滴蒸发过程中,液滴赤道直径的平方d^(2)随时间线性减小,同时液滴横纵比γ随时间线性增大.初始处于单相区的液滴随着水分蒸发可以跨越到双相区,进而发生相分离.声悬浮状态下PEG-AMS双水相液滴的相分离分为3个阶段:首先液滴内部形成富PEG相微滴,然后富PEG相微滴发生碰撞凝并同时向外迁移,最终液滴形成水平分层结构.对比分析了不同横纵比及不同成分的双水相液滴的蒸发和相分离过程,发现横纵比γ越大,富PEG相体积分数越小,则液滴蒸发速率越快;横纵比γ越大,富PEG相体积分数越大,则液滴相分离越快.这些发现有助于深入理解声悬浮条件下液滴的运动特性、蒸发动力学和相分离规律,并为材料的声悬浮无容器制备和加工提供依据.

关键词：声悬浮双水相液滴蒸发相分离

融合改进YOLOv5及Mediapipe的手势识别研究

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计算机工程与应用 2024年第7期60卷 108-118页

作者：倪广兴徐华王超盐城工学院信息工程学院江苏盐城224000 盐城师范学院物理与电子工程学院江苏盐城224000

针对现有手势识别算法计算量大、鲁棒性差等问题,提出一种基于IYOLOv5-Med(improved YOLOv5 Mediapipe)算法的手势识别方法。该算法将改进的YOLOv5算法和Mediapipe方法结合,包括手势检测和手势分析两部分,算法有效降低了训练的时间成本... 详细信息

针对现有手势识别算法计算量大、鲁棒性差等问题,提出一种基于IYOLOv5-Med(improved YOLOv5 Mediapipe)算法的手势识别方法。该算法将改进的YOLOv5算法和Mediapipe方法结合,包括手势检测和手势分析两部分,算法有效降低了训练的时间成本,增加了识别的鲁棒性。手势检测部分,改进了传统YOLOv5算法,利用FastNet重构C3模块,将CBS模块替换为GhostNet中GhostConv模块,在Backbone网络末端加入SE注意力机制模块,改进后的算法,模型体积更小,更适用于资源有限的边缘设备。手势分析部分,提出了一种基于Mediapipe的方法,对手势检测部分定位到的手势区域进行手部关键点检测,并提取相关特征,然后通过朴素贝叶斯分类器进行识别。实验结果证实了提出的IYOLOv5-Med算法的有效性,与传统YOLOv5算法相比,参数量下降34.5%,计算量减少34.9%,模型权重降低33.2%,最终平均识别率达到0.997,且实现方法相对简单,有较好的应用前景。

关键词：手势识别 YOLOv5 Mediapipe FastNet 注意力机制

Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期Mechanics & Astronomy) .卷 191-210页

作者： Yan-Qiu Zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-Chen Xue chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-Wei Wang Xiang-yang Wen Yue Wang Shuo Xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Yunnan Observatories Chinese Academy of Sciences Center for Astronomical Mega-Science Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal University Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal University College of Electronic and Information Engineering Tongji University

As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption lines. For the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems, and identified prominent emission lines in multiple time intervals. The central energy of the Gaussian emission line evolves from about 37 to 6 MeV, with a nearly constant ratio（about 10%） between the line width and central energy. Particularly, we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of –1 and –2, respectively. We suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V line. We find that a standard high latitude emission scenario cannot fully interpret the observation, thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the jet. In this scenario, we can use the emission line to directly, for the first time, measure the bulk Lorentz factor of the jet（Γ） and reveal its time evolution(i.e., Γ～ t-1) during the prompt emission. Interestingly, we find that the flux of the annihilation line in the co-moving frame keeps constant. These discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line