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Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-Quan Wang Xiao-Long Wu Jing Zhang Si-Ting Wang Yong-Juan Sang Kang Li chao-fan yang Fei Sun chao-Jun Li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang University School of Medicine HangzhouZhejiang 310016China Department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China Liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： Single-cell RNA-seq Single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

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基于VMD-ICA的水下激光雷达抗散射信号处理方法

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物理学报 2024年第9期73卷 110-115页

作者：李朝锋王振刘欣宇杨苏辉徐震樊超阳北京理工大学光电学院北京100081 中国电子科技集团公司第三十四研究所桂林541000

提出一种基于变分模态分解(VMD)与独立元分析(ICA)相结合的水下信号处理方法.该方法运用VMD将一组回波信号分解为多组按照频率高低顺序排列的本征模态信号.然后,将这些模态信号作为ICA的观测矩阵,以确保分离所得目标回波信号的完整性.... 详细信息

提出一种基于变分模态分解(VMD)与独立元分析(ICA)相结合的水下信号处理方法.该方法运用VMD将一组回波信号分解为多组按照频率高低顺序排列的本征模态信号.然后,将这些模态信号作为ICA的观测矩阵,以确保分离所得目标回波信号的完整性.该方法提出将分解所得的各层模态信号与原信号进行相关性和信杂比比较,以确定其分解层数.应用ICA方法对散射与目标回波进行分离,从而恢复强散射水体中的微弱目标回波,大大提高其测距精度.进行不同衰减长度水体的532 nm调频连续光水下测距实验.经实验验证,该信号处理方法在激光输出功率2.3 W时,成功实现对9个衰减长度内目标的测量,使用算法将测距精度由16 cm提升至5 cm以内.

关键词：变分模态分解独立元分析频谱反馈

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Injection of a Self-propelled Polymer into a Small Circular Cavity

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Chinese Journal of Polymer Science 2024年第6期42卷 886-894页

作者： chao Wang Yan-Li Zhou Xiao yang fan Wu Meng-Bo Luo Department of Physics Taizhou UniversityTaizhou318000China Department of Physics Zhejiang UniversityHangzhou310027China

The injection of a polymer chain into a small circular cavity under tangential self-propelled force is studied by using Langevin dynamics *** indicate that the injection dynamics of the active polymer shows strong correlation with the polymer conformation inside the cavity depending on the polymer rigidity(k_(b)).The injection timeτvaries nonmonotonously with increasing k_(b),and reaches its minimum at k_(b)^(*).When k_(b) is small(k_(b)≪k_(b)^(*)),the polymer is nearly random coil in the cavity,and spends a long time at the final stage of the injection process due to the large repulsion between monomers inside the *** k_(b) is moderate(k_(b)∼k_(b)^(*)),the part of polymer inside the cavity forms spiral configuration under the tangential active force,and the whole polymer moves synchronously with a constant velocity during the injection process,leading to a small injection *** k_(b) is large(k_(b)≫k_(b)^(*)),the polymer is nearly straight at the initial stage of the injection process,and takes a long time to bend itself,leading to a large injection time.

关键词： Active Polymer Injection Dynamics Simulation

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Activity Pattern and Habitat Use of Shorebirds in an Artificial Wetland Complex:A Case Study of Breeding Pied Avocet in the Yellow River Delta,China

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Chinese Geographical Science 2024年第4期34卷 618-630页

作者： LI Dong LI Bin XU He fan chao WU yang ZHANG Yuxin HOU Xiyong Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Beijing VMinFull Limited Beijing 100086China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China University of Chinese Academy of Sciences Beijing 100049China School of Information Engineering Zhejiang Ocean UniversityZhoushan 316022China Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China

With the loss of substantial natural wetlands in coastal zones,artificial wetlands provide alternative habitats for many *** management of artificial wetlands used by shorebirds plays an important role in maintaining the stability of shorebird *** tracking technique can obtain high-precision location information of individuals day and night,providing a good technical support for the study of quantitative relationship between waterfowls and their *** this study,satellite tracking method,Remote Sensing(RS)and Geographic Information System(GIS)technology were used to analyze the activity pattern and habitat utilization characteristics of Pied Avocet during breeding period in an artificial wetland complex in the Yellow River Delta(YRD),*** results showed that the breeding Pied Avocets had a small range of activity,with a total core and main home range of 33.10 km^(2) and 216.30 km^(2),*** species tended to forage in the pond and salt pan during the day and night,respectively,with an unfixed staying time in the breeding *** distance between breeding ground and feeding ground was less than 6 *** is emphasized that in addition to improving the conditions of the remaining natural habitats,effective managing artificial habitats is a priority for shorebird *** research could provide reference for the management of artificial wetlands in coastal zones and supply technique support for the protection of shorebirds and their habitats,and alleviate human-bird conflicts and sustainable development of coastal zones.

关键词： satellite tracking home range habitat use artificial wetland coastal zone Pied Avocet Yellow River Delta China

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The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice

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Life Metabolism 2022年第2期1卷 149-160页

作者： Xin-Ying Wang Xin-Ge Zhang Yong-Juan Sang Dan-yang Chong Xiao-Qiang Sheng Hai-Quan Wang chao-fan yang GuiJun Yan Hai-Xiang Sun chao-Jun Li State Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Center for Reproductive Medicine Department of Obstetrics and GynecologyNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjingJiangsu 210093China Ministry of Education Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing UniversityNanjingJiangsu 210093China

Adverse nutritional conditions during the perinatal stage are related to early menopause in adulthood;however,the underlying mechanism is still ***,we revealed that colostrum-activated ketone body elevation during the postnatal stage regulated primordial follicle reservoir size and then affected ovarian *** found that the expression of the ketogenesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(Hmgcs2)was largely enhanced during primordial follicle pool formation after birth and might be activated in the ovaries by *** oxygen species(ROS)elevation in the ovaries leads to follicle apoptosis to deplete damaged follicles,while Hmgcs2 deficiency enhances follicle apoptosis and thus decreases the size of the primordial follicle pool and leads to premature ovarian ageing(POA),which might be related to the activation of cellular endogenous antioxidant *** these defects could be rescued by ketone body administration,which suppressed ROS-activated follicle *** results suggest that the internal metabolic homeostasis of newborn mice is critical for the primordial reservoir and that any intrauterine and perinatal undernutrition could result in POA.

关键词： ketone body primordial follicle pool Hmgcs2 ROS POA

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Numerical simulation of formaldehyde distribution characteristics in the high-speed train cabin

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Building Simulation 2024年第2期17卷 285-300页

作者： fan Wu Hang Dong chao Yu Hengkui Li Qingmin Cui Renze Xu Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangshaHunan410075China Joint International Research Laboratory of Key Technologies for Rail Traffic Safety ChangshaHunan410075China National&Local Joint Engineering Research Center of Safety Technology for Rail Vehicle ChangshaHunan410075China School of Software Henan University of EngineeringZhengzhouHenan451191China

The global concern over indoor air pollution in public vehicles has grown *** a focus on enhancing passengers’comfort and health,this study endeavors to investigate the distribution characteristics of formaldehyde within a high-speed train cabin by employing a computational fluid dynamics(CFD)model which is experimentally validated in a real cabin *** research focuses on analyzing the impact of air supply modes,temperature,relative humidity,and fresh air change rate on the distribution and concentration of *** results demonstrate that the difference in average formaldehyde concentration between the two air supply modes is below 1.3%,but the top air supply mode leads to a higher accumulation of formaldehyde near the sidewalls,while the bottom air supply mode promotes a more uniform distribution of ***,the temperature,relative humidity,and fresh air change rate are the primary factors affecting formaldehyde concentration levels,but they have modest effects on formaldehyde’s distribution pattern within the *** the temperature and relative humidity increase,the changes in formaldehyde concentrations in response to variations in these factors become more ***,the formaldehyde concentration may surpass the standard limit of 0.10 mg/m^(3)if the fresh air change rate falls below 212 m^(3)/*** research provides a systematic approach and referenceable results for exploring formaldehyde pollution in high-speed train cabins.

关键词： indoor air pollution formaldehyde CFD simulation high-speed train ventilation

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An advanced 2D/3D g-C_(3)N_(4)/TiO_(2)@MnO_(2) multifunctional membrane for sunlight-driven sustainable water purification

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Nano Research 2024年第4期17卷 2368-2380页

作者： fan Yu Chunjia Luo Xiaohan Niu Min chao Pengfei Zhang Luke Yan Polymer Materials&Engineering Department School of Materials Science&EngineeringChang’an UniversityXi’an 710064China Key Laboratory of Road Construction Technology and Equipment MOEChang’an UniversityXi’an 710064China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710064China

Graphitic carbon nitride(g-C_(3)N_(4))nanosheets have attracted widespread interest in the construction of advanced separation ***,dense stacking and a single functionality have limited the membrane ***,an advanced two-/three-dimensional(2D/3D)g-C_(3)N_(4)/TiO_(2)@MnO_(2) membrane is constructed by intercalating 3D TiO_(2)@MnO_(2) nanostructures into g-C_(3)N_(4) *** 3D flower-like nanostructures broaden the transport channels of the composite *** membrane can effectively separate five oil-in-water(O/W)emulsions,with a maximum flux of 3265.67±15.01 L·m^(-2)·h^(-1)·bar^(-1) and a maximum efficiency of 99.69%±0.45%for toluene-in-water emulsion(T/W).Meanwhile,the TiO_(2)@MnO_(2) acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes(e^(-)–h^(+)).The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap(2.10 eV).These photoelectric properties give the membrane good degradation of three different pollutants,with about 100%degradation for methylene blue(MB)and malachite green(MG).The photocatalytic antibacterial efficiency of the membrane is also about 100%.After cyclic experiment,the membrane maintains its original separation and photocatalytic *** remarkable multifunctional and self-cleaning properties of the g-C_(3)N_(4) based membrane represent its potential value for complex wastewater treatment.

关键词： graphitic carbon nitride(g-C_(3)N_(4))based membrane three-dimensional(3D)nanostructures self-cleaning multifunction

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GRU-integrated constrained soft actor-critic learning enabled fully distributed scheduling strategy for residential virtual power plant

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Global Energy Interconnection 2024年第2期7卷 117-129页

作者： Xiaoyun Deng Yongdong Chen Dongchuan fan Youbo Liu chao Ma College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China State Grid Sichuan Comprehensive Energy Service Co.Ltd. Chengdu 610072P.R.China

In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is *** the proposed scheme,the GRU-integrated DRL algorithm guides the RVPP to participate effectively in both the day-ahead and real-time markets,lowering the electricity purchase costs and consumption risks for *** Lagrangian relaxation technique is introduced to transform the constrained Markov decision process(CMDP)into an unconstrained optimization problem,which guarantees that the constraints are strictly satisfied without determining the penalty ***,to enhance the scalability of the constrained soft actor-critic(CSAC)-based RVPP scheduling approach,a fully distributed scheduling architecture was designed to enable plug-and-play in the residential distributed energy resources(RDER).Case studies performed on the constructed RVPP scenario validated the performance of the proposed methodology in enhancing the responsiveness of the RDER to power tariffs,balancing the supply and demand of the power grid,and ensuring customer comfort.

关键词： Residential virtual power plant Residential distributed energy resource Constrained soft actor-critic Fully distributed scheduling strategy

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Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATAC-seq and scRNA-seq

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动物学研究 2024年第3期 601页

作者： Hai-Quan Wang Xiao-Long Wu Jing Zhang Si-Ting Wang Yong-Juan Sang Kang Li chao-fan yang Fei Sun chao-Jun Li

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A hybrid WUDT-NAFnet for simultaneous source data deblending

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Petroleum Science 2024年第3期21卷 1649-1659页

作者： chao-fan Ke Shao-Huan Zu Jun-Xing Cao Xu-Dong Jiang chao Li Xing-Ye Liu Key Laboratory of Earth Exploration and Information Technology of Ministry of Education Chengdu University of Technology State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology College of Geophysics Chengdu University of Technology

Simultaneous source technology, which reduces seismic survey time and improves the quality of seismic data by firing more than one source with a narrow time interval, is compromised by the massive blended interference. Therefore, deblending algorithms have been developed to separate this ***, deep learning(DL) has been proved its great potential in suppressing the interference. The most popular DL method employs neural network as a filter to attenuate the blended noise in an iterative estimation and subtraction framework(IESF). However, there are still amplitude distortion and blended noise residual problems, especially when dealing with weak signal submerged in strong interference. To address these problems, we propose a hybrid WUDT-NAFnet, which contains two sub-networks. The first network is a wavelet based U-shape deblending transformer network(WUDTnet), incorporated into IESF as a robust regularization term to iteratively separate the blended interference. The second network is a nonlinear activate free network(NAFnet) designed to recover the event amplitude and further suppress the weak noise residual in IESF. With the hybrid network, the blended noise can be separated purposefully and accurately. Examples using synthetic and field seismic data demonstrate that the WUDTNAFnet outperforms traditional curvelet transform(CT) based method and the deblending transformer(DT) model in terms of deblending. Additionally, for field applications, the data augmentation method of bicubic interpolation is applied to mitigate the feature difference between synthetic and field ***, the trained network exhibits strong signal preservation ability in numerical field example without requiring additional training.

关键词： Simultaneous-source Deblending Deep learning Transformer

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