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Drug-eluting fully covered self-expanding metal stent for dissolution of bile duct stones in vitro

World Journal of Gastroenterology 2019年第26期25卷 3370-3379页

作者： chao Huang Xiao-Bo Cai li-li Guo Xiao-Sheng Qi Qiang Gao Xin-Jian Wan Department of Gastroenterology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 201620China Shanghai Key Laboratory for Pancreatic Diseases Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 201620China Department of General Surgery Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

BACKGROUND The treatment of difficult common bile duct stones(CBDS)remains a big challenge around the *** stenting is a widely accepted rescue method in patients with failed stone extraction under endoscopic retrograde *** covered self-expanding metal stent(FCSEMS)has gained increasing attention in the management of difficult *** To manufacture a drug-eluting FCSEMS,which can achieve controlled release of stone-dissolving agents and speed up the dissolution of *** Customized covered nitinol stents were *** cholate(SC)and disodium ethylene diamine tetraacetic acid(EDTA disodium,EDTA for short)were used as stone-dissolving *** different types of drug-eluting stents were manufactured by dip coating(Stent I),coaxial electrospinning(Stent II),and dip coating combined with electrospinning(Stent III),*** drugrelease behavior and stone-dissolving efficacy of these stents were evaluated in vitro to sort out the best manufacturing *** the selected stonedissolving stents were further put into porcine CBD to evaluate their *** Stent I and Stent II had obvious burst release of drugs in the first 5 d while Stent III presented controlled and sustainable drug release for 30 *** still buffer,the final stone mass-loss rate of each group was 5.19%±0.69%for naked FCSEMS,2..37%±2.13%for Stent I,2..57%±1.45%for Stent II,and 33.72.±0.67%for Stent *** flowing bile,the final stone mass-loss rate of each group was 5.87%±0.2.%for naked FCSEMS,6.36%±0.48%for Stent I,6.38%±0.37%for Stent II,and 8.15%±0.2.%for Stent *** III caused the most stone mass-loss no matter in still buffer or in flowing bile,which was significantly higher than those of other groups(P0.05)and histopathological examination(P>0.05).CONCLUSION The novel SC and EDTA-eluting FCSEMS is efficient in diminishing CBDS in ***

关键词： Common bile duct stone Drug-eluting stent Fully covered self-expanding metal stent Electrospinning Nanofiber film

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利用网络等值进行图降维的图注意力暂态功角稳定评估模型

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南方电网技术 2024年第4期18卷 30-40页

作者：张建新蔡锱涵李诗旸高琴付超杨欢欢杨荣照邱建中国南方电网电力调度控制中心广州510663 南方电网科学研究院广州510663

省级以上实际大电网节点众多,用于电网暂态稳定评估的深度学习模型输入特征空间面临维数灾,训练成本高且泛化能力难以保证,成为该类方法难以应用于实际大系统的一个瓶颈。针对这一问题,提出了一种面向稳控校核、利用网络等值进行图降维... 详细信息

省级以上实际大电网节点众多,用于电网暂态稳定评估的深度学习模型输入特征空间面临维数灾,训练成本高且泛化能力难以保证,成为该类方法难以应用于实际大系统的一个瓶颈。针对这一问题,提出了一种面向稳控校核、利用网络等值进行图降维的图注意力深度学习暂态功角稳定评估模型。首先,建立全网发电机图,基于转子惯量等决定暂态功角稳定的关键参数构建其节点相似度,并利用节点相似度改进发电机图的边权重;作为一种领域知识嵌入方式,借鉴电网动态等值思路,对待研究稳控系统所涉及区域以外的网络部分,基于发电机图和分层聚类算法进行分区,将所形成分区对应成等效节点形成降维发电机图,并建立原图到降维图节点、边权重参数的映射,实现对原输入空间的降维。最后,以降维图作为输入建立图注意力深度学习模型,实现对复杂网络的暂态功角稳定评估。在南方电网某实际稳控系统算例上进行对比分析,验证了模型的有效性及准确性。

关键词：图深度学习图降维网络等值暂态功角稳定评估仿真计算

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电信运营商数智化转型核心能力评估模型研究与实践

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电信工程技术与标准化 2024年第5期37卷 7-12页

作者：李观马珂张嫚嫚于文超中国移动通信集团设计院有限公司北京100080

当前,电信运营商纷纷探索战略转型,加快了数智化转型步伐。本文深入研究了国内宏观经济形势和行业发展趋势,洞察了5G时代电信运营商数智化转型的机遇和挑战,构建了电信运营商数智化转型核心能力评估模型,并开展了实践应用,进一步总结归... 详细信息

当前,电信运营商纷纷探索战略转型,加快了数智化转型步伐。本文深入研究了国内宏观经济形势和行业发展趋势,洞察了5G时代电信运营商数智化转型的机遇和挑战,构建了电信运营商数智化转型核心能力评估模型,并开展了实践应用,进一步总结归纳出电信运营商数智化转型六大核心能力提升建议,为电信运营商数智化转型提供参考借鉴。

关键词：电信运营商数智化转型核心能力评估

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Anti-Hypertensive Action of Fenofibrate via UCP2.Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway

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Neuroscience Bulletin 2019年第1期35卷 15-24页

作者： Jian Guan Miao Zhao chao He Xue li Ying li Jie Sun Wei Wang Ya-li Cui Qing Zhang Bai-Yan li Guo-Fen Qiao Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Medicine ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China

Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2.UCP2., was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD *** results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2.expression and reduction of oxidative stress.

关键词： Fenofibrate Peroxisome proliferator-activated receptor Mitochondrial uncoupling protein Baroreflex afferent function Blood pressure regulation

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Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis

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Science China(life Sciences) 2017年第11期60卷 1260-1270页

作者： suxu he quanmin wang shuning li chao ran xiaoze guo zhen zhang zhigang zhou key laboratory for feed biotechnology of the ministry of agriclture feed research institutechinese academy of agricutural sciencesBeijing 100081China

Low dose antibiotics have been used as growth promoters in livestock and fish. The use of antibiotics has been associated with reduced pathogen infections in livestock. In contrast, antibiotic growth promoter has been suspected of leading to disease outbreaks in aquaculture. However, this phenomenon is circumstantial and has not been confirmed in experimental conditions. In this study,we showed that antibiotic olaquindox increased the susceptibility of zebrafish to A. hydrophila infection. Olaquindox led to profound alterations in the intestinal microbiota of zebrafish, with a drastic bloom of Enterobacter and diminishing of Cetobacterium. Moreover, the innate immune responses of zebrafish were compromised by olaquindox(Plity was driven by the OLA-altered microbiota and was not dependent on direct antibiotic effect. Taken together, these data indicate that low level of OLA induced gut microbiota dysbiosis in zebrafish, which led to increased pathogen susceptibility.

关键词： antibiotic growth promoter pathogen susceptability gut microbiota fish olaquindox

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A comprehensive review on coupled processes and mechanisms of soil-vegetation-hydrology, and recent research advances

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Science China Earth Sciences 2022年第11期65卷 2083-2114页

作者： Zhongkai li Xiaoyan li Sha ZHOU Xiaofan YANG Yongshuo FU Chiyuan MIAO Shuai WANG Guanghui ZHANG Xiuchen WU chao YANG Yuanhong DENG State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of Natural Resources Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXining 810016China School of Geographical Sciences Qinghai Normal UniversityXining 810016China College of Water Sciences Beijing Normal UniversityBeijing 100875China

Research on the coupling of soil,vegetation,and hydrological processes is not only a research hotspot in disciplines such as pedology,ecohydrology and Earth system science but also important for achieving sustainable ***,scientists from different disciplines usually study the coupling mechanism of soil-vegetation-hydrological processes at very different space and time scales,and the mechanistic connections between different scales are quite *** article reviewed research advances in coupled soil-vegetation-hydrological processes at different spatial scales—from leaf stomata to watershed and regional scales—and summarized the spatial upscaling methods and modeling approaches of coupled soil-vegetationhydrological *** identify and summarize the following coupling processes:(1)carbon-water exchange in leaf stomata and root-soil interface;(2.changes in soil aggregates and profile hydraulic properties caused by plant roots and water movement;(3)precipitation and soil moisture redistribution by plant canopy and root;(4)interactions between vegetation patches and local hydrological process;(5)links between plant community succession and soil development;and(6)links between watershed/regional water budget and vegetation phenology and ***,the limitations and knowledge gaps in the observations,mechanisms,scaling methods,and modeling approaches of coupled soil-vegetation-hydrological processes were *** achieve a deep integration of various coupling processes across different spatiotemporal scales,future work should strengthen multiscale,multifactor and multiprocess soil-vegetation-hydrology coupling observations and mechanism studies,develop new scaling methods,identify different feedback pathways,and take time-variable plant behavior and soil hydraulic properties into account during modeling.

关键词： Ecohydrological process Soil process Plant-soil feedback Modeling approaches Scaling method

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Remote Sensing Retrieval of Surface Suspended Sediment Concentration in the Yellow River Estuary

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Chinese Geographical Science 2017年第6期27卷 934-947页

作者： ZHAN chao YU Junbao WANG Qing li Yunzhao ZHOU Di XING Qinghui CHU Xiaojing Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone Research Chinese Academy of Sciences Yantai 264003 China The Institute of Coastal Ecology Ludong University Yantai 264025 China University of Chinese Academy of Sciences Beijing 100049 China

Accurate assessment of surface suspended sediment concentration （SSSC） in estuary is essential to address several important issues： erosion, water pollution, human health risks, etc. In this study, an empirical cubic retrieval model was developed for the retrieval of SSSC from Yellow River Estuary. Based on sediments and seawater collected from the Yellow River and southeastern Laizhou Bay, SSSC conditions were reproduced in the laboratory at increasing concentrations within a range common to field observations. Continu- ous spectrum measurements of the various SSSCs ranging from 1 to 5700 mg/1 were carried out using an AvaField-3 spectrometer. The results indicated the good correlation between water SSSC and spectral reflectance （Rrs） was obtained in the spectral range of 72.-900 nm. At SSSC greater than 2.00 mg/L, the 740-900 nm spectral range was less susceptible to the effects of spectral reflectance saturation and more suitable for retrieval of high sediment concentrations. The best correlations were obtained for the reflectance ratio of 82. nm to 490 nm. Informed by the correlation between Rrs and SSSC, a retrieval model was developed （R2.= 0.992.. The novel cubic model, which used the ratio of a near-infrared （NIR） band （740-900 nm） to a visible band （400-600 nm） as factors, provided robust quantifica- tion of high SSSC water samples. Two high SSSC centers, with an order of 103 mg/1, were found in the inversion results around the abandoned Diaokou River mouth, the present Yellow River mouth to the abandoned Qingshuigou River mouth. There was little sedi- ment exchange between the two high SSSC centers due to the directions of the residual currents and vertical mixing.

关键词： surface suspended sediment concentration (SSSC) water spectral reflectance cubic model quantitative remote sensinginversion Yellow River Estuary

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Deficiency of mitochondrial outer membrane protein 64 confers rice resistance to both piercing-sucking and chewing insects in rice

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Journal of Integrative Plant Biology 2020年第12期62卷 1967-1982页

作者： Hui‐Min Guo Hai‐chao li Shi‐Rong Zhou Hong‐Wei Xue Xue‐Xia Miao Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyInnovation Academy for Seed DesignChinese Academy of SciencesShanghai 200032China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

The brown planthopper(BPH)and striped stem borer(SSB)are the most devastating insect pests in rice(Oryza sativa)producing *** for endogenous resistant genes is the most practical strategy for rice insect-resistance ***-five mutants showing high re-sistance against BPH were identified in a rice T-DNA in-sertion population(11,000 putative homozygous lines)after 4 years of large-scale field BPH-resistance phenotype *** analysis showed that deficiency of rice mitochondrial outer membrane protein 64(OM64)gene resulted in increased resistance to *** outer membrane protein 64 protein is located in the outer mitochondrial membrane by subcellular localization and its deficiency constitutively activated hydrogen peroxide(H2.2.signaling,which stimulated antibiosis and tolerance to *** om64 mutant also showed enhanced resist-ance to SSB,a chewing insect,which was due to promotion of Jasmonic acid biosynthesis and related ***-portantly,om64 plants presented no significant changes in rice yield-related *** study confirmed OM64 as a negative regulator of rice herbivore resistance through regulating H2.2.*** outer membrane protein 64 is a potentially efficient candidate to improve BPH and SSB resistance through gene *** the om64 mutant was resistant to both piercing-sucking and chewing insects via a gene deficiency in mitochondria is discussed.

关键词： sativa) fir resistance

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Bimetallic chalcogenides for electrocatalytic CO_(2.reduction

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Rare Metals 2021年第12期40卷 3442-3453页

作者： Qian li Yu-chao Wang Jian Zeng Xin Zhao Chen Chen Qiu-Mei Wu li-Miao Chen Zhi-Yan Chen Yong-Peng Lei School of Material Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Powder Metallurgy Hunan Key Laboratory of Two-Dimensional MaterialsCentral South UniversityChangsha 410083China Energy Materials Computing Center Jiangxi University of Science and TechnologyNanchang 330013China Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Electrocatalytic CO_(2.reduction reaction(CO_(2.RR)converts CO_(2.into valuable chemical fuels,which can effectively alleviate global warming and energy ***,limited by its slow reaction rate and low product selectivity,it is urgent to design efficient,cheap,safe,and highly selective CO_(2.RR *** to the advantages of adjustable electronic structure,abundant active sites,low cost,environmental friendliness and excellent electrochemical performance,bimetallic chalcogenides have aroused great ***,we briefly summarized different bimetallic oxides and sulfides for electrocatalytic CO_(2.RR in the past five *** addition,different hybridizations formed between metal atoms,including intermetallic compounds,heterostructures and metal doping,were *** positive effects on CO_(2.RR catalytic selectivity and activity were deeply ***,we also put forward some views about the future research directions and perspectives in CO_(2.RR *** review aims to provide a reference for the rational design of bimetallic chalcogenides towards electrocatalytic CO_(2.reduction.

关键词： Electrocatalysis CO_(2.reduction Bimetallic chalcogenides Electronic structure

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Hot Deformation Behavior of V-Microalloyed Steel

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Journal of Iron and Steel Research International 2010年第8期17卷 55-60页

作者： REN An-chao JI Yu ZHOU Gui-feng YUAN Ze-xi HAN Bin li Yi Institute of Material Science and Metallurgy Wuhan University of Science and Technology Wuhan 430081 Hubei China Research and Development Center Wuhan Iron and Steel (Group) Co Wuhan 430080 Hubei China International Trade Company Wuhan Iron and Steel (Group) Co Wuhan 430080 Hubei China

Through the expansion curve of continuous cooling transformation at different cooling rates measured by THERMECMASTOR-Z thermal simulator for U75V rail steel,the continuous cooling transformation curve was *** influence on steel microstructure and hardness at different cooling rates was *** softening behavior of isothermal deforming in austenite area of 850-1000 ℃ in the interval of passes was also studied by double-pass compression *** results show that the product of austenite transformation is pearlite when the cooling rate is lower than 10 ℃.When the cooling rate was in the range of 10-50 ℃·s-1,only martensite was *** hardness of the test steel increases with increasing the cooling *** the condition of deformation of 30% and deformation rate of 3 s-1,the relaxation time for complete recrystallization was shorter than 100 s when deformation temperature was higher than 1000 ℃.When deformation temperature was lower than 880 ℃,complete recrystallization of steel was difficult to achieve even if the relaxation time is extended.

关键词： U75V rail steel thermal simulation continuous cooling transformation curve deformation temperature static recrystallization

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