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Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

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Nano Research 2016年第10期9卷 3003-3017页

作者： Teng Liu Yu chao Min Gao chao Liang qian Chen Guosheng Song Liang Cheng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University 199 Ren'ai Road Suzhou 215123 China

The clinical translation of many inorganic nanomaterials is severely hampered by toxicity issues because of the long-term retention of these nanomaterials in the body. In this study, we developed a bio-clearable theranostic agent based on ultra-small MoS2 nanodots, which were synthesized by a facile bottom-up approach through one-step solvothermal decomposition of ammonium tetrathiomolybdate. After modification by glutathione （GSH）, the obtained MoS2-GSH nanodots exhibited sub-10-nm hydrodynamic diameters without aggregation in various physiological buffers. Without showing appreciable in vitro toxicity, such MoS2-GSH nanodots with strong near-infrared （NIR） absorbance could induce remarkable photothermal ablation of cancer cells. Upon intravenous （i.v.） injection, efficient tumor accumulation of MoS2-GSH nanodots was observed by photoacoustic imaging, and further confirmed by analysis of the biodistribution of Mo. Notabl）4 the MoS2-GSH nanodots, in contrast to conventional MoS2 nanoflakes with larger sizes, showed rather efficient body clearance via urine, where the majority of the injected dose was cleared within just seven days. Photothermal ablation of tumors on mice was then realized with the MoS2-GSH nanodots, achieving excellent therapeutic efficacy. This study presents a new type of ultra-small nanoparticle with efficient tumor homing/treatment abilities, as well as rapid body clearance behavior, making it promising for cancer theranostics without long-term toxiciW concerns.

关键词： ultra-small MoS2 nanodots photoacoustic imaging rapid body clearance photothermal therapy

Cancer metastasis: issues and challenges

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Chinese Journal of Cancer 2017年第3期36卷 108-111页

作者： chao-Nan qian Yan Mei Jian Zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Center for Translational Medicine Guangxi Medical University and Key Laboratory of Longevity and Aging.related Diseases Ministry of Education Nanning 530021 Guangxi P. R. China Department of Biology Southern University of Science and Technology School of Medicine Shenzhen 518055 Guangdong P. R.China Department of Urology University of Pittsburgh School of MedicinePittsburgh PA 15232 USA

Metastasis is the major cause of treatment failure in cancer patients and of cancer?related *** editorial discusses how cancer metastasis may be better perceived and *** on big?data analyses,a collection of150 important pro?metastatic genes was *** The Cancer Genome Atlas datasets to re?analyze the effect of some previously reported metastatic genes—e.g.,JAM2,PPARGC1A,SIK2,and TRAF6—on overall survival of patients with renal and liver cancers,we found that these genes are actually protective factors for patients with *** role of epithelial–mesenchymal transition(EMT)in single?cell metastasis has been well?***,in metastasis caused by cancer cell clusters,EMT may not be necessary.A novel role of epithelial marker E?cadherin,as a sensitizer for chemoresistant prostate cancer cells by inhibiting Notch signaling,has been *** editorial also discusses the obstacles for developing anti?metastatic drugs,including the lack of high?throughput technologies for identifying metastasis inhibitors,less application of animal models in the pre?clinical evaluation of the leading com?pounds,and the need for adjustments in clinical trial design to better reflect the anti?metastatic efficacy of new *** are confident that by developing more effective high?throughput technologies to identify metastasis inhibitors,we can better predict,prevent,and treat cancer metastasis.

关键词： Metastasis E-cadherin EMT JAM2 PPARGC1A SIK2 TRAF6

Twenty years after:the beautiful hypothesis and the ugly facts

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Chinese Journal of Cancer 2016年第2期35卷 97-99页

作者： Francesco Pezzella Kevin Gatter chao-Nan qian Nuffield Division of Clinical Laboratory Science Radcliffe Department of MedicineJohn Radcliffe HospitalUniversity of Oxford State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center

The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between vessels and *** need blood perfusion but there are mounting evidences that angiogenesis alone does not explain it in all the *** this editorial,for a special issue on tumor and vessels published in the Chinese Journal of Cancer,we briefly introduce the history of the evidences that solid tumors can sometimes obtain blood perfusion by alternative approaches other than sprouting angiogenesis,i.e.,vessel co-option and vasculogenic *** editorial provides also the links to several most recently published discoveries and hypotheses on tumor interaction with blood vessels.

关键词： Angiogenesis, Vasculogenic mimicry, Vessel co-option, Treatment resistance, Targeted therapy

New frontiers in proton therapy:applications in cancers

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Cancer Communications 2019年第1期39卷 557-563页

作者： Tai-Ze Yuan Ze-Jiang Zhan chao-Nan qian Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045GuangdongP.R.China Department of Radiation Oncology Cancer Center of Guangzhou Medical UniversityGuangzhou 510095GuangdongP.R.China

Proton therapy offers dominant advantages over photon therapy due to the unique depth-dose characteristics of proton,which can cause a dramatic reduction in normal tissue doses both distal and proximal to the tumor target *** turn,this feature may allow dose escalation to the tumor target volume while sparing the tumor-neighboring susceptible organs at risk,which has the potential to reduce treatment toxicity and improve local control rate,quality of life and *** dosimetric studies in various cancers have demonstrated the advantages over photon therapy in dose ***,it has been observed that proton therapy confers to substantial clinical advantage over photon therapy in head and neck,breast,hepatocellular,and non-small cell lung *** such,proton therapy is regarded as the standard modality of radiotherapy in many pediatric cancers from the technical point of ***,due to the limited clinical evidence,there have been concerns about the high cost of proton therapy from an economic point of *** the treatment expenses for late radiation-induced toxicities,cost-effective analysis in many studies have shown that proton therapy is the most cost-effective option for brain,head and neck and selected breast *** studies are warranted to better unveil the cost-effective values of proton therapy and to develop newer ways for better protection of normal *** review aims at reviewing the recent studies on proton therapy to explore its benefits and cost-effectiveness in *** strongly believe that proton therapy will be a common radiotherapy modality for most types of solid cancers in the future.

关键词： Proton therapy Radiation therapy Intensity-modulated Systematic review Cancer

Superscattering of water waves

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National Science Review 2023年第7期10卷 91-97页

作者： Zijian Qin chao qian Lian Shen Xiaoping Wang Ido Kaminer Hongsheng Chen Huaping Wang Key Laboratory of Ocean Observation-Imaging Testbed of Zhejiang Province Institute of Marine Electronics Engineering Ocean College Zhejiang University ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab.of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University ZJU-UIUC Institute Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation Zhejiang University Jinhua Institute of Zhejiang University Zhejiang University Department of Electrical Engineering Technion-Israel Institute of Technology

Inspired by the concept of superscattering in optics,we for the first time theoretically predict and experimentally demonstrate the superscattering phenomenon in water *** subwavelength superscatterer is constructed by multi-layered concentric cylinders with an inhomogeneous depth *** superscatterer breaks the long-held single-channel scattering limit by several times and thus significantly enhances the total scattering *** underlying mechanism originates from the near degeneracy of the resonances of multiple *** fabricate the superscatterer prototype and experimentally measure the near-field patterns,which are consistent with theoretical prediction and numerical *** study opens a new avenue to strengthen water-wave scattering and deepen the understanding in water waves,which can be useful for ocean energy harvesting and harbor protection.

关键词： superscattering water wave metamaterials

Viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 919-924页

作者： chao-Xu qian Yuan Zong Qin Chen Zhi-Lan Yuan Department of Ophthalmology the Third People＇s Hospital of Changzhou Changzhou 213001 Jiangsu Province China Department of Ophthalmology Eye Ear Nose ＆ Throat Hospital of Fudan University Shanghai 200031 China Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： To evaluate the long-term outcome of viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma. METHODS： This is a retrospective study. Forty-two eyes of 26 patients with primary congenital glaucoma were enrolled, Intraocular pressure （lOP）, corneal diameter （mm） and cup/disc （C/D） were measured before and after the surgery respectively. Follow-up period was 30mo. RESULTS： The mean preoperative lOP was 30.6：1：7.35 mm Hg. Of the 42 eyes, 2 eyes were required conversion to trabeculectomy for the absence of Schlemm＇s canal. Of remained 40 eyes, 38 eyes （95%） achieved successful lOP control. The average postoperative lOP was 11.69±4.18 mm Hg at 12mo. The mean reduction was 18.91 mm Hg （P〈0.00Ol）. Eighteen （75%） eyes presented a reduction in corneal diameter, and 25 （62.5%） eyes presented a C/D ratio reversal after the surgery. There was no serious complication in any patients over the follow-up period. CONCLUSION： Viscocanalostomy combined with trabeculotomy and mitomycin C is useful in the management of primary congenital glaucoma,

关键词： glaucoma treatment surgery intraocularpressure congenital eye disorders

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基于多指标评估的高速公路桥梁综合评价方法

公路 2024年第5期69卷 433-438页

作者：黄玉冰林杰黄思璐肖强雷斯达乾超越公路建设与养护技术材料及装备交通运输行业研发中心武汉市430050 湖北交投智能检测公司武汉市430050

基于博弈论组合赋权法研究高速公路桥梁综合评价方法,以期提高桥梁管养水平。提出路网桥梁综合评价的指标:路线交通量、桥梁技术状况评分、基础数据(桥梁跨径、使用寿命)、技术状况预测数据。桥梁技术状况评价预测采用灰色神经网络模型... 详细信息

基于博弈论组合赋权法研究高速公路桥梁综合评价方法,以期提高桥梁管养水平。提出路网桥梁综合评价的指标:路线交通量、桥梁技术状况评分、基础数据(桥梁跨径、使用寿命)、技术状况预测数据。桥梁技术状况评价预测采用灰色神经网络模型,得到在不考虑养护情况下桥梁自然退化的预测趋势。通过湖北省内某段高速公路的算例,验证了综合评价方法和预测模型的可行性,得到该段桥梁综合评价结果。

关键词：桥梁工程桥梁技术状况预测桥梁综合评价灰色神经网络博弈法组合赋权

Cerium Salt Promoted Homocoupling Reaction of Dialkylanilines in Water

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Chemical Research in Chinese Universities 2008年第2期24卷 226-230页

作者： YANG Xiang-hua LU Wen-chao LIAO qian XI Chan-juan Key Laboratory for Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Highly regioselective homocoupling of N,N-dialkylanilines can be achieved in water with cerium reagents, in which various N,N,N′,N′-tetraalkylbenzidines are obtained from N,N-dialkylanilines either by direct oxidati... 详细信息

关键词： Homocoupling Regioselectivity Cerium salts N,N-Dialkylaniline N,N,N′,N′-Tetraalkylbenzidine

基于中试研究培养化学工程领域专业学位硕士的探索

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化工高等教育 2024年第3期41卷 106-111页

作者：周玉立项嘉铭钱超潘鹏举浙江大学化学工程与生物工程学院浙江杭州310027 浙江大学衢州研究院浙江衢州324000

针对化学工程专业硕士研究生培养中存在的问题,浙江大学化工学科依托校地合作共建的浙大衢州“两院”及其中试实验实训基地,探索了一种基于中试研究培养专业学位硕士的模式,为我国化学工程领域专业学位硕士的培养提供参考。

关键词：化学工程工程硕士中试研究校地合作